Granlibakken Tahoe Floorplan

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This meeting took place in 2018



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Ubiquitin Signaling (A8)


Organizer(s) David Komander and Sylvie Urbé
January 28—February 1, 2018
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Oct 2, 2017
Abstract Deadline: Oct 31, 2017
Scholarship Deadline: Oct 2, 2017
Discounted Registration Deadline: Dec 1, 2017

Sponsored by Cell Research

Summary of Meeting:
These are exciting times for ubiquitin research: potential targets for small molecule inhibitors are emerging in a variety of human diseases and being exploited by the pharmaceutical industry. At the same time, new enzymes regulating ubiquitin modifications are still being discovered, and the complexity of ubiquitin modifications continues to increase with the emerging cross-talk between post-translational modifications. This conference will focus on the latest insights in the large area of cellular regulation mediated by ubiquitin and ubiquitin-like modifiers. Key goals are to provide overviews and updates on emerging frontiers, and encourage efforts to exploit the ubiquitin system to provide new treatments for human diseases. Rather than being organized around key enzymes in the cascade, sessions will focus on biological areas, ensuring a balanced mix of mechanistic and physiology aspects. The meeting will feature both key opinion leaders on ubiquitination who are known to present unpublished results and leading researchers from peripheral fields who will contribute new ideas. A short selection of company-associated academic speakers will provide insights into the translational opportunities in this area.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:15, followed by dinner and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.

SUNDAY, JANUARY 28

16:00—20:00
Arrival and Registration

Pre Function
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
18:00—20:00
Light Meal - Provided by Granlibakken

Granhall

MONDAY, JANUARY 29

07:00—08:00
Breakfast

Granhall
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* David Komander, MRC Laboratory of Molecular Biology, UK

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Celebrating 20 Years of Cullin Neddylation

09:00—11:30
The Ubiquitin Code I - Ubiquitin Chains
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* David Komander, MRC Laboratory of Molecular Biology, UK

Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
How Thalidomide Analogues Recruit Zinc-Finger Degrons to the CRL4-CRBN Ubiquitin Ligase

Coffee Break

David Toczyski, University of California, San Francisco, USA
Genetic Analysis Reveals Functions of Atypical Polyubiquitin Chains

Steve Cappell, NCI, National Institutes of Health, USA
Short Talk: Emi1 Switches from being a Substrate to an Inhibitor of APC/C-Cdh1 to Start the Cell Cycle

Achim Werner, NIDCR, National Institutes of Health, USA
Short Talk: Multisite Phosphorylation Regulates Ubiquitin-dependent Neural Crest Formation

Raymond J. Deshaies, California Institute of Technology and Cleave Biosciences
Vms1/Ankzf1: A Novel Peptidyl-tRNA Hydrolase that Releases Nascent Chains from Stalled Ribosomes

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop 1: New Methods

Mountain/Lake
* Ingrid E. Wertz, Genentech, Inc., USA
Reactive Site-centric Chemoproteomics Identifies a Structurally Distinct Class of Deubiquitinase Enzymes

Norihito Shibata, National Institute of Health Sciences, Japan
Strategy for Protein Degradation against Oncoprotein BCR-ABL

Kristin Riching, Promega Corporation, USA
Monitoring Functional Mechanisms of Protein Degradation in Living Cells

Yu Ye, University of Cambridge, UK
Targeting Protein Aggregates with the Proteasome in vitro and in vivo

Itay Koren, Harvard Medical School, USA
Discovering Degrons using a Synthetic Human Peptidome

* Benedikt M. Kessler, University of Oxford, UK
Expanding the Cancer Cell DUBome for Small Molecule Drug Profiling using Advanced Chemoproteomics

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
The Ubiquitin Code II - Ub/Ubl Modifications
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Sylvie Urbé, University of Liverpool, UK

Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
Ubiquitin-like Protein Conjugation Complexes and Genome Integrity

Jon Huibregtse, University of Texas at Austin, USA
The Extracellular Signaling Function of ISG15 and Cytokine Secretion

Neil Hunter, University of California, Davis, USA
Short Talk: Delineation and Analysis of the SUMO-Modified Proteome during Meiosis

Mark W. Hochstrasser, Yale University, USA
Distinct Toxin-Antidote Modules Underlie Reproductive Manipulation of Insect Hosts by Intracellular Wolbachia Bacteria

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour

Bay

TUESDAY, JANUARY 30

07:00—08:00
Breakfast

Granhall
08:00—11:15
Ubiquitin in the Host's Response to Infection
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany

Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin in Inflammation

Mads Gyrd-Hansen, University of Oxford, UK
Deubiquitinases in Innate Immune Signalling

Coffee Break

Catherine L. Day, University of Otago, New Zealand
TRAFs and the Assembly of Ubiquitin Chains

Nicolas Bidère, INSERM, France
Short Talk: Regulation of Ciliogenesis and Cell Death by CYLD and Centriolar Satellites

Fuminori Tokunaga, Osaka City University, Japan
Short Talk: Characterization of a Novel LUBAC Inhibitor, HOIPIN-1

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin in Host Responses

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Genetic Disorders
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Agata Smogorzewska, Rockefeller University, USA

Ivona Aksentijevich, NHGRI, National Institutes of Health, USA
NF-kappaB Pathway in Autoinflammatory Diseases: Ubiquitination meets Autoinflammation

Ryan Potts, St. Jude Children's Research Hospital, USA
MAGE Proteins in Cancer

Alessandra Rufini, University of Tor Vergata, Italy
Short Talk: The E3 Ligase RNF126 as a New Therapeutic Target for Friedreich Ataxia

Miratul Muqit, University of Dundee, UK
Parkinson’s Disease Ubiquitin Signaling Pathways in Mice and Man

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

WEDNESDAY, JANUARY 31

07:00—08:00
Breakfast

Granhall
08:00—11:15
Protein Degradation in Diseases
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Mark W. Hochstrasser, Yale University, USA

Daniel J. Finley, Harvard University and Proteostasis, Inc.
Reciprocal Regulation between Ubp6 and the Proteasome

Andreas Matouschek, University of Texas at Austin, USA
Selecting Proteins for Proteasomal Degradation

Coffee Break

Leo James, MRC Laboratory of Molecular Biology, UK
Trim-Away: Targeted Degradation of Pathogens and Proteins by the Cytosolic Antibody Receptor TRIM21

Sumana Sanyal, Hong Kong University-Pasteur Institut, Hong Kong
Short Talk: Host Cellular Ubiquitylation Profiling Reveals a Critical Role for Lipid Droplet Metabolism during Flavivirus Infections

John Hanna, Harvard Medical School, USA
Short Talk: Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity

Craig M. Crews, Yale University and Arvinas, Inc.
PROTACs: Induced Protein Degradation as a Therapeutic Strategy

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop 2: Drug Discovery

Mountain/Lake
* Lawrence R. Dick, Takeda, USA
Targeting the Proteasome for Antimalarial Drug Discovery

Thomas Kodadek, The Scripps Research Institute, USA
Mining DNA-Encoded Combinatorial Libraries of Electrophilic Compounds for Selective, Covalent Inhibitors of Deubiquitylases

Peter Tsvetkov, Whitehead Institute, USA
A New Way Cancer Cells Cope with Proteotoxic Stress

Panagiotis Ntziachristos, Northwestern University, USA
USP7 Cooperates with Oncogenes to Drive the Oncogenic Transcriptional Program in Acute Lymphoblastic Leukemia

Marjolein Kikkert, Leiden University Medical Center, Netherlands
Potent and Selective Inhibition of MERS Coronavirus Papain-like Protease by Engineered Ubiquitin Variants

* Jeanine Harrigan, Mission Therapeutics, UK
Development of DUB Inhibitors for the Treatment of Human Disease

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Regulation of Autophagy and Mitophagy by Ubiquitin
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Miratul Muqit, University of Dundee, UK

Sylvie Urbé, University of Liverpool, UK
Regulation of Basal Mitophagy by Deubiquitylases

J. Wade Harper, Harvard Medical School, USA
Digitizing Ubiquitin Signaling for Mitophagy

Kalle Gehring, McGill University, Canada
Short Talk: Parkin and PINK1 at the Crossroads of Cell Signaling by Phosphorylation and Ubiquitination

Richard J. Youle, NINDS, National Institutes of Health, USA
Synthetic Phenotypes in Mice Lacking PINK1 and Parkin-Mediated Mitophagy

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 3

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

THURSDAY, FEBRUARY 1

07:00—08:00
Breakfast

Granhall
08:00—11:15
Nuclear Roles of Ubiquitin
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Finding the Right Target

Niels Mailand, University of Copenhagen, Denmark
Regulation of Chromatin Ubiquitylation in the DNA Damage Response

Coffee Break

Agata Smogorzewska, Rockefeller University, USA
Ubiquitin Shuttle Proteins and the Stress Response at the Replication Fork

John L. Nitiss, University of Illinois, USA
Short Talk: Ubiquitylation Regulates Repair of Topoisomerase Induced DNA Damage

* Christine Katrin Schmidt, University of Manchester, UK
Short Talk: Talk Title to be Announced

Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
Mechanistic Insights into Histone Deubiquitination

11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
New Paradigms in Ubiquitin Modification(s)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Sylvie Urbé, University of Liverpool, UK

Ivan Dikic, Goethe University Medical School, Germany
Catalysis and Inhibition of Phosphoribosyl-Dependent Ubiquitination

Yuxin Mao, Cornell University, USA
Short Talk: The Molecular Mechanism of Phosphoribosyl-ubiquitination Mediated by a Single Legionella Effector

Satpal Virdee, University of Dundee, UK
A New Class of Threonine-specific E3 Ligase

David Komander, MRC Laboratory of Molecular Biology, UK
New Tools to Study Ubiquitin Chain Architecture

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
19:15—20:15
Dinner

Granhall
19:15—20:15
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

FRIDAY, FEBRUARY 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Cell Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676