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This meeting took place in 2017


Here are the related meetings in 2018:
Myeloid Cells (D2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Mononuclear Phagocytes in Health, Immune Defense and Disease (D3)


Organizer(s) Steffen Jung and Miriam Merad
April 30—May 4, 2017
Hyatt Regency Austin • Austin, Texas USA
Discounted Abstract Deadline: Jan 9, 2017
Abstract Deadline: Jan 31, 2017
Scholarship Deadline: Jan 9, 2017
Discounted Registration Deadline: Feb 28, 2017

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.

Summary of Meeting:
Mononuclear phagocytes (MNP) are immune cells that are uniquely equipped to sense and respond to environmental cues by promoting tissue homeostasis or initiating tissue repair and immunity. MNP also contribute significantly to tissue pathologies, and their manipulation holds considerable therapeutic potential. MNP display major functional specializations. Most macrophages are established before birth and perform tissue-specific functions in organ development and homeostasis. Short-lived classical dendritic cells (DC) are specialized in triggering adaptive T cell immunity. Monocytes complement macrophages and DC as highly plastic cells, in particular during inflammation. While MNP subsets have been identified, individual contributions to health and disease are not well-defined. Breathtaking technological advance in genomic profiling of populations and single cells is revealing the breadth of MNP functions and identifying molecular checkpoints for targeted therapeutic intervention. These molecular efforts are paralleled by astounding progress in imaging capabilities, enabling the study of the cells in their physiological context. This meeting therefore aims to: 1) Cover recent progress in the field, revealing novel and differential contributions of MNP in physiological processes, and identify critical knowledge gaps; 2) Stimulate scientific exchange, in particular between clinicians and researchers, to better translate findings from animal models into human settings and brainstorm regarding novel therapeutic intervention; and 3) Develop novel conceptual frameworks for future studies of MNP in health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 30 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 5 in order to fully experience the meeting.

SUNDAY, APRIL 30

16:00—20:00
Arrival and Registration

Zilker North Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Zilker Terrace Foyer

MONDAY, MAY 1

07:30—08:30
Breakfast

Zilker 1-2
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
* Steffen Jung, Weizmann Institute of Science, Israel

* Miriam Merad, Mount Sinai School of Medicine, USA

Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA
Mononuclear Phagocytes in Homeostasis and Inflammation

09:30—11:45
Mononuclear Phagocyte Development
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
* Steffen Jung, Weizmann Institute of Science, Israel

Florent Ginhoux, Singapore Immunology Network, Singapore
EMBO Young Investigator Lecture: Ontogeny of Mononuclear Phagocytes

Coffee Break

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Monocytes (and Macrophages)

Ido Amit, Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics

Deborah R. Winter, Northwestern University, USA
Short Talk: The Transcriptional Program of Synovial Macrophages in Rheumatoid Arthritis

11:45—14:30
On Own for Lunch

11:45—13:00
Poster Setup

Zilker 1-2
13:00—22:00
Poster Viewing

Zilker 1-2
14:30—16:30
Workshop 1: Monocytes, DC and Macrophages
Recent technical advances in profiling and imaging of MNP in healthy tissue and disease context.

Zilker 3-4
* Chen Varol, Sourasky Medical Center and Tel-Aviv University, Israel

Helen S. Goodridge, Cedars-Sinai Medical Center, USA
Independent Monocyte Production by Granulocyte-Monocyte Progenitors (GMPs) and Monocyte-Dendritic Cell Progenitors (MDPs)

Pierre Guermonprez, Kings College London, UK
The Heterogeneity of Ly6Chi Monocytes Controls their Differentiation into iNOS+ Macrophagesor Monocyte-Derived Dendritic Cells

Alexander Mildner, Max-Delbrueck Center Berlin, Germany
Genomic Characterization of Murine Monocytes Reveals C/EBP-Beta Dependence of Ly6C-Cells

Stefan Uderhardt, National Institutes of Health, USA
Tissue-Resident Macrophages Cloak Tissue Microlesions to Control Neutrophil-Driven Inflammatory Damage

Brian T. Edelson, Washington University School of Medicine, USA
Regulation of Mononuclear Phagocyte IL-10 Production by Bhlhe40 Is Required to Resist Pulmonary Mtb Infection

Roxane Tussiwand, University of Basel, Switzerland
The Expression of IRF8 Defines Plasmacytoid Dendritic Cell Commitment

16:30—17:00
Coffee Available

Zilker North Lobby
17:00—19:00
Mononuclear Phagocyte Maintenance
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
* Deborah R. Winter, Northwestern University, USA

Christopher K. Glass, University of California, San Diego, USA
Exploiting Natural Genetic Variation to Understand Macrophage Identity and Function

Michael H. Sieweke, Centre d'Immunologic Marseille-Luming, France
Transcriptional Control of Macrophage Proliferation

Bart N. Lambrecht, VIB, Ghent University, Belgium
Macrophages, DC and ER Stress

Sarah A. Dick, University Health Network, Canada
Short Talk: Embryonic Macrophages Are Maintained in the Aged Heart and Are Required for Repair

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zilker 1-2
19:30—22:00
Poster Session 1

Zilker 1-2

TUESDAY, MAY 2

07:30—08:30
Breakfast

Zilker 1-2
08:30—11:30
Mononuclear Phagocytes at the Tissue Site
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
* Florent Ginhoux, Singapore Immunology Network, Singapore

Martin Guilliams, Ghent University - VIB, Belgium
Development and Functional Specialization of Liver-Resident Kupffer Cells

Gwendalyn J. Randolph, Washington University, USA
Macrophages in the Serosal Cavity

Coffee Break

Brian D. Brown, Mount Sinai School of Medicine, USA
T Cell and DC Interactions in Tissues

Wolfgang Kastenmüller, University of Bonn, Germany
Intranodal T Cell - DC Interactions during Viral Infection

Sheau Yng Lim, National University of Singapore, Singapore
Short Talk: The Origin and Maintenance of LYVE-1-Expressing Macrophages

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Zilker 1-2
13:00—22:00
Poster Viewing

Zilker 1-2
16:30—17:00
Coffee Available

Zilker North Lobby
17:00—19:00
Mononuclear Phagocytes in Gut Homeostasis and Inflammation
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
* Miriam Merad, Mount Sinai School of Medicine, USA

Carla V. Rothlin, Yale University, USA
TAM Receptor Signaling in Resolution of Inflammation

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Homostatic Immunity and the Microbiota

Michael F. Goldberg, University of Minnesota, USA
Short Talk: Colonization of Different Phagocyte Subsets Underlies the Pathogenesis of a Persistent Phagosomal Infection

Ivaylo I. Ivanov, Columbia University Medical Center, USA
Short Talk: Innate Immune Cells in Regulation of Commensal Th17 Responses

Milena Bogunovic, Pennsylvania State University College of Medicine, USA
Short Talk: Macrophages as Regulators of Intestinal Neuroplasticity

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zilker 1-2
19:30—22:00
Poster Session 2

Zilker 1-2

WEDNESDAY, MAY 3

07:30—08:30
Breakfast

Zilker 1-2
08:00—08:30
Poster Setup

Zilker 1-2
08:30—17:00
Poster Viewing

Zilker 1-2
08:30—11:30
Mononuclear Phagocyte Interactions with the Central and Peripheral Nervous System
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
Marco Colonna, Washington University School of Medicine, USA
Microglia-Driven Pathology, Trem2

Daniel Mucida, Rockefeller University, USA
Tissue Adaptation of Intestinal Macrophages

Coffee Break

* Burkhard Becher, University of Zurich, Switzerland
The T Cell-Myeloid Connection in Chronic Inflammation

Steffen Jung, Weizmann Institute of Science, Israel
Tissue Macrophages in Control of Innervation

Shoutang Wang, Institut Gustave Roussy, France
Short Talk: Lyl-1 Controls Primitive Macrophages and Microglia Development

11:30—12:30
Lunch

Zilker 1-2
12:00—14:30
Poster Session 3

Zilker 1-2
14:30—16:30
Workshop 2: Regulation of DC and Macrophage Function in Health and Disease

Zilker 3-4
* Brian T. Edelson, Washington University School of Medicine, USA

Carl Allen, Baylor College of Medicine, USA
Braf-V600e in Blood and Brain and Response to Braf Inhibition Suggest Hematopoietic Origin of Neurodegeneration in Lch

Caroline Hutter, St. Anna Kinderspital, Austria
Notch Signaling Induces a Langerhans Cell Histiocytosis Gene Expression Signature in Human Monocytes

Margaret E. Warren, Columbia University, USA
Notch Signaling Confers Optimal Phenotype and Function on in vitro-Generated Classical Dendritic Cells

Briana Nixon, Memorial Sloan Kettering Cancer Center, USA
The Role of the Notch Pathway in Tumor-Associated Macrophage Differentiation

Ashley Steed, Washington University in St. Louis, USA
The Role of Type I Interferon during Influenza A Infection

Lucie Van Emmenis, University College London, UK
Characterization of Macrophages in Peripheral Nerve Regeneration

Richard E. Zigmond, Case Western Reserve University, USA
The Role of Mononuclear Phagocytes in Peripheral Nerve Degeneration and Regeneration: A New Perspective

16:30—17:00
Coffee Available

Zilker North Lobby
17:00—19:00
Mononuclear Phagocytes, Inflammation and Therapy
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
* Gwendalyn J. Randolph, Washington University, USA

Gabriel D. Victora, Rockefeller University, USA
Monitoring T Cell-APC Interactions in vivo

Catherine (Lynn) Hedrick, La Jolla Institute for Allergy and Immunology, USA
Monocyte Heterogeneity: Implications for Cancer

Michele De Palma, École Polytechnique Fédérale de Lausanne, Switzerland
Macrophage Reprogramming for Anti-Cancer Therapy

Irit Sagi, Weizmann Institute of Science, Israel
Short Talk: Macrophages Are Context- Dependent Builders or Destroyers of Collagenous Matrix

19:00
On Own for Dinner


THURSDAY, MAY 4

07:30—08:30
Breakfast

Zilker 1-2
08:30—11:30
Molecular Control of Mononuclear Phagocytes
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
* Brian D. Brown, Mount Sinai School of Medicine, USA

Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia, USA
Long Non-Coding RNAs and the Homeostasis Mononuclear Phagocytes

Nir Hacohen, Massachusetts General Hospital, USA
Human DC and Monocytes Revisited

Coffee Break

Boris Reizis, New York University Langone Medical Center, USA
Transcriptional Control of Dendritic Cell Functionality

Philippe J. Benaroch, Institut Curie, INSERM, France
Phagocytes and HIV

Adriana M. Mujal, University of California, San Francisco, USA
Short Talk: Characterizing the Role of CD11b+ Dendritic Cell Subsets in Priming Anti-Tumor CD4 T Cell Responses

11:30—14:30
On Own for Lunch

16:30—17:00
Coffee Available

Zilker North Lobby
17:00—18:45
Mononuclear Phagocytes and Cancer Treatment
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Cancer-Induced Innate Immune Modulation

* Laurence Zitvogel, Institut Gustave Roussy, France
Gut Microbiota Connects Mucosal and Tumoral Immune Responses

Miriam Merad, Mount Sinai School of Medicine, USA
Harnessing the Tumor Myeloid Micro-Environment to Enhance Cancer Treatment

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Zilker 3-4
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zilker 1-2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Zilker 1-2

FRIDAY, MAY 5

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Boehringer Ingelheim Pharmaceuticals, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI131438-01

Funding for this conference was made possible [in part] by AI 131438-01 from the National Institute of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

American Association for the Advancement of Science (AAAS)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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