Snowbird Resort Floorplan

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This meeting took place in 2017


Here are the related meetings in 2018:
The Resolution of Inflammation in Health and Disease (C6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Injury, Inflammation and Fibrosis (C8)


Organizer(s) Tatiana Kisseleva, Michael Karin and Andrew M. Tager
March 26—30, 2017
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Nov 28, 2016
Abstract Deadline: Jan 9, 2017
Scholarship Deadline: Nov 28, 2016
Discounted Registration Deadline: Jan 23, 2017

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc., Regeneron Pharmaceuticals, Inc. and Theravance Biopharma. This activity was supported by an educational grant from Celgene Corporation.

Summary of Meeting:
Fibrosis is a common response of many organs to chronic injury and inflammation. This leads to destruction of organ architecture with loss of function. Until recently, there have been no therapies to slow the progression of fibrosis and to maintain normal organ function. Recent advances have provided new insights into the pathogenesis of fibrosis, new drug targets, and new drugs in clinical studies. This conference will bring together basic biologists and translational and clinical researchers to discuss core mechanisms underlying inflammation and fibrosis, to compare and contrast fibrotic diseases, preclinical models, the potential for regeneration and regression of fibrosis, and potential therapies. The interaction between the host genetics, the environment and the microbiome in the pathogenesis of fibrotic diseases will be addressed. Also, non-invasive methods to assess fibrosis including advanced imaging and intermediate biomarkers will be discussed. This conference will be a unique opportunity for investigators who are focused on organ-specific diseases – i.e., medical subspecialists – to participate in cross-disciplinary, multi-organ discussions in order to gain new insights into their research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 30 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 31 in order to fully experience the meeting.

SUNDAY, MARCH 26

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, MARCH 27

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Tatiana Kisseleva, University of California, San Diego, USA

Michael Karin, University of California, San Diego, USA
Inflammation in NASH

09:00—11:45
Predisposition to Fibrosis: Genetic and Epigenetic Contributions to Fibrosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Michael Karin, University of California, San Diego, USA

David A. Schwartz, University of Colorado Denver, USA
Idiopathic Pulmonary Fibrosis: A Genetic Disease that Involves Mucociliary Dysfunction of the Peripheral Airways

Coffee Break

Mary Armanios, Johns Hopkins University School of Medicine, USA
Mechanisms of Telomere-Mediated Pulmonary Fibrosis

Pura Munoz Canoves, Universitat Pompeu Fabra, Spain
Senescence of the Muscle Stem Cell Population in Injured Aged Muscles

Alexander R. Abbas, Genentech, Inc., USA
Short Talk: Peripheral Blood Telomere Shortening Predicts Lung Function Decline in Idiopathic Pulmonary Fibrosis

Ty Dale Troutman, University of California, San Diego, USA
Short Talk: Natural Genetic Variation Reveals Encoded Programs Employed by Kupffer Cells During Liver Fibrosis

Gisli Jenkins, University of Nottingham, UK
Short Talk: A Novel Polymorphism Linked to Altered Expression of AKAP13 is Associated with Susceptibility to IPF

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Getting Fibrosis Started: Epithelial Senescence and/or Injury
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* David A. Brenner, University of California, San Diego, USA

Joseph V. Bonventre, Brigham and Women's Hospital, Harvard Medical School, USA
Maladaptive Proximal Tubule Repair: KIM-1 and Epithelial Cell Cycle Arrest and Senescence

Quentin M. Anstee, Newcastle University, UK
The Genetics of Non-Alcoholic Fatty Liver Disease

Katalin Susztak, University of Pennsylvania, USA
Integrative Analysis of Metabolic and Genetic Settings in Chronic Kidney Disease

Christy Trussoni, Mayo Clinic, USA
Short Talk: Senescent Cholangiocytes Contribute to Macrophage Recruitment in Primary Sclerosing Cholangitis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Wasatch

TUESDAY, MARCH 28

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Shaping Fibrotic Responses: The Role of Inflammation in Tissue Repair
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* John Varga, Feinberg School of Medicine, USA

Thomas A. Wynn, Pfizer, USA
Potential Pitfalls of Anti-Fibrotic Therapy: Rebound Inflammation and Failed Regeneration

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Environment Regulates Pro-Inflammatory and Pro-Fibrogenic Macrophages

Coffee Break

Shizuo Akira, Osaka University, Japan
Critical Role of Trib1 in Differentiation of Tissue-Resident M2-Like Macrophages

Jörg H.W. Distler, University of Erlangen-Nuremberg, Germany
Targeting TGFbeta-Dependent Fibroblast Activation

Richard H. Gomer, Texas A&M University, USA
Short Talk: A Positive Feedback Loop Involving Sialidases Drives Pulmonary Fibrosis

Thomas Fabre, University of Montreal Hospital Research Center, CRCHUM, Canada
Short Talk: Type III Inflammation Drives Liver Fibrosis Progression by Regulating TGF-Beta Signaling Through Activation of Mapks

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
14:30—16:30
Workshop 1

Ballroom 1-3
* Thomas A. Wynn, Pfizer, USA

Shaik Ohidar Rahaman, University of Maryland, USA
TRPV4 Channel Regulates Dermal Fibrosis and is Associated with Scleroderma

Sang Jun Lee, Ionis Pharmaceuticals, USA
Evaluation of Antisense Oligonucleotide against CHOP in Rodent Models with ER Stress Dysfunction

Matthew L. Meizlish, Yale University, USA
Macrophages and Fibroblasts Sense Variations in Collagen Density within 3-Dimensional Matrix Environment

Jason Seidman, University of California, San Diego, USA
Kupffer Cells Regulate Liver Inflammation and Fibrosis Through NCoR

Sneha Sitaraman, University of Cincinnati College of Medicine, USA
Expression of Disease-Associated Surfactant Protein C Mutation Increases Susceptibility to Fibrosis

Angela Zeigler, University of Virginia, USA
Predicting Drivers and Modulators of Fibroblast Phenotype During Myocardial Infarction Healing

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Creating The Scar: Factors Regulating Systemic Responses to Fibrosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Shizuo Akira, Osaka University, Japan

Natalie J. Torok, University of California, Davis, USA
NADPH Oxidases in Non-Alcoholic Steatohepatitis

Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
Fra-2/AP-1 Mediates Fibroblast Activation and Fibrosis Development

Rob Knight, University of California, San Diego, USA
Spatial Mapping of the Human Microbiome

Edward Marsh, Yale University, USA
Short Talk: Spatiotemporal Organization of Fibroblast-Fibroblast Networks in Homeostasis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Wasatch

WEDNESDAY, MARCH 29

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Amplifying Fibrosis: Activation of Fibrogenic Myofibroblasts
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Natalie J. Torok, University of California, Davis, USA

Dean Sheppard, University of California, San Francisco, USA
Molecular Signatures of Collagen-Producing Cells in Multiple Models of Pathologic Tissue Fibrosis

Rebecca G. Wells, University of Pennsylvania, USA
Fibrosis in the Extrahepatic Bile Ducts

Coffee Break

David A. Brenner, University of California, San Diego, USA
Origin of Myofibroblasts in Fibrotic Liver

Lester F. Lau, University of Illinois at Chicago, USA
The Matricellular Protein CCN1 in Tissue Injury Repair

Chih-Wei Chen, Friedrich-Alexander-University Erlangen-Nuremberg, Germany
Short Talk: Wnt5a Promotes Tissue Fibrosis by PCP-Dependent Activation of Latent TGFbeta

Resat Cinar, NIAAA, National Institutes of Health, USA
Short Talk: Cannabinoid CB1 Receptor Overactivity Contributes to the Pathogenesis of IPF and its Dual-Targeting with Inducible Nitric Oxide Synthase Improves Anti-Fibrotic Efficacy

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
14:30—16:30
Workshop 2

Ballroom 1-3
* Rebecca G. Wells, University of Pennsylvania, USA

Scott M. MacDonnell, Regeneron Pharmaceuticals, Inc., USA
Identification of Distinct Cell Populations from Fibrotic Mouse Kidneys using Single Cell Sequencing

Sunny Kataria, Institute for Stem Cell Biology and Regenerative Medicine, India
Cellular and Molecular Heterogeneity of Fibroblast Responses in Mouse Model of Dermal Fibrosis 

Guobao Chen, Johns Hopkins University, USA
IL-17A-Driven Post-Cardiac Injury Remodeling is Dependent on its Signaling to Sca-1+ Cardiac Fibroblasts

Richard Lee Gieseck III, NIAID, National Institutes of Health, USA
Enhanced Protection from Fibrosis and Inflammation by Dual-Blockade of IL-13 and IFNgamma

Kevin M. Hart, NIAID, National Institutes of Health, USA
Type-2 Immunity is Protective in Metabolic Disease but Exacerbates NAFLD Collaboratively with TGF-Beta

Greg S. Gojanovich, University of Hawaii, USA
Neurofibromin 1 Loss in Tcf21+ Fibroblasts Accelerates Heart Failure Following TAC

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Tumor-Associated Stroma: Parallels with Fibrosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Dean Sheppard, University of California, San Francisco, USA

Gian Paolo Dotto, University of Lausanne, Switzerland
Multistep Cancer-Associated Fibroblast Activation: A Notch/CSL-Gli Regulatory Axis

Andrew D. Rhim, University of Michigan Medical School, USA
Pancreatic Cancer Stroma: A Loud, Crowded, and Complex Field

Shuang Liang, University of California, San Diego, USA
Short Talk: NADPH Oxidase 1 Promotes the Development of Hepatocellular Carcinoma

Valerie LeBleu, MD Anderson Cancer Center, USA
Short Talk: Functional Role of Tumor Immunity and Fibrosis in Pancreas Cancer

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Wasatch

THURSDAY, MARCH 30

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:30
Halting Fibrosis: Inducing Regression of Fibrosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Katalin Susztak, University of Pennsylvania, USA

Tatiana Kisseleva, University of California, San Diego, USA
Myofibroblast Reversion to an Inactive Phenotype during Regression of Liver Fibrosis

David Lagares, Massachusetts General Hospital, USA
Mitochondrial Priming by Matrix Stiffness Sensitizes Myofibroblasts to BH3 Mimetic-Induced Apoptosis in Scleroderma Fibrosis

Coffee Break

Gyongyi Szabo, University of Massachusetts Medical School, USA
Inter-Relationship Between TLR Signaling and Inflammasome Activation in NASH

Jorge Moscat, Sanford Burnham Prebys Institute, USA
Control of Fibrosis and Inflammation by Stromal p62 in Tumor Progression

Holger Willenbring, University of California, San Francisco, USA
Hepatic Reprogramming of Myofibroblasts as a Therapeutic Strategy for Liver Fibrosis

Fiona E. McCann, Oxford University, UK
Short Talk: Localised Inhibition of Histone Acetylation May Offer a Novel Therapeutic Strategy to Down Regulate the Myofibroblast Phenotype in Dupuytren's Disease 

11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:45
New Directions in Patient Evaluation and Treatment
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Gyongyi Szabo, University of Massachusetts Medical School, USA

Robert Lafyatis, University of Pittsburgh Medical Center, USA
Fibroblast and Macrophage Transcriptomes Indicate Pathogenic Pathways in Systemic Sclerosis

David Shapiro, Intercept Pharmaceuticals, Inc., USA
Therapeutic Bile Acids - Longer Levers in Liver Disease?

Jeremy S. Duffield, Vertex Pharmaceuticals, USA
MicroRNAs as Potential Therapeutic Targets in Fibrotic Diseases

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1-2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 1-2

FRIDAY, MARCH 31

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Boehringer Ingelheim Pharmaceuticals, Inc. Regeneron Pharmaceuticals, Inc.
Theravance Biopharma
This activity was supported by an educational grant from Celgene Corporation


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK112608-01

Funding for this conference was made possible (in part) by DK 112608 -01 from NIH. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government


We gratefully acknowledge additional support for this conference from:

Charles River

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Intercept Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Journal of Inflammation (published by BioMed Central Ltd)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676