Keystone Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2017



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Obesity and Adipose Tissue Biology (J4)


Organizer(s) Marc L. Reitman, Ruth E. Gimeno and Jan Nedergaard
January 22—26, 2017
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Sep 22, 2016
Abstract Deadline: Oct 25, 2016
Scholarship Deadline: Sep 22, 2016
Discounted Registration Deadline: Nov 22, 2016

Sponsored by MedImmune, Nestlé Institute of Health Sciences and Novo Nordisk A/S. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.

Joint Meeting: Diabetes (J3)

Summary of Meeting:
Obesity is a growing worldwide epidemic, increasing co-morbid conditions, such as diabetes. The joint meetings on “Obesity and Adipose Tissue Biology” and “Diabetes: Emerging Concepts in Metabolic Signaling and Disease” are aimed to foster cross-talk between these research areas. Adipose tissue is an endocrine organ that is both controlled by and sends signals to the brain and other organs. In addition, obesity causes an inflammatory state in the adipose tissue. The recognition that brown/beige adipose tissue is active in adult humans has triggered interest in understanding the physiology and relative importance of these tissues. Exercise and bariatric surgery are known to elicit profound metabolic benefits in type 2 diabetes, although the underlying mechanisms remain unclear. This meeting will bring together cell biologists, biochemists, geneticists, physiologists, drug developers and clinical researchers, thereby facilitating knowledge exchange and interactions leading to elucidation of better treatments for obesity and diabetes. Specifically, it will examine recent advances in understanding of brown/beige adipose tissue function; obesity-induced adipose inflammation; control of adipose tissue, appetite, and energy metabolism; endocrine and paracrine signaling via secreted factors; molecular mechanisms of metabolic signaling; emerging topics, including long noncoding RNA and gut microbiome; and approaches to drug development and the treatment of obesity and diabetes.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 22 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 26 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, January 27 in order to fully experience the meeting.

SUNDAY, JANUARY 22

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JANUARY 23

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—09:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Jiandie Lin, University of Michigan Medical School, USA

* Marc L. Reitman, NIDDK, National Institutes of Health, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Journal of Lipid Research Lectureship: Adipose Origin and Expansion

Richard D. DiMarchi, Indiana University, USA
Chemical Biotechnology Applied to Metabolic Diseases

Coffee Break

09:50—12:15
Brown/Beige Fat Activation and Function (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Antonio J. Vidal-Puig, University of Cambridge, UK

Jan Nedergaard, Stockholm University, Sweden
Brown Adipose Physiology

Aaron M. Cypess, NIDDK, National Institutes of Health, USA
Activation of Brown Adipose Tissue in Humans

Ajay Chawla, University of California, San Francisco, USA
Innate Immune Licensing of Thermogenesis

Patrick Seale, University of Pennsylvania, USA
Regulators of Brown and Beige Fat Activity

12:15—14:30
On Own for Lunch

12:15—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
14:30—16:30
Workshop 1: Drug Discovery/Development in Obesity (Joint)

Grays/Long Peak
Bei Shan, Lilly China Research and Development Center, China

Michelle L. Boland, Medimmune, USA
MEDI0382, a Dual GLP-1/Glucagon Receptor Agonist, is More Effective on Alleviating Non-Alcoholic Steatohepatitis (NASH) Compared to Liraglutide in a Mouse Model of NASH

Andrea Galmozzi, The Scripps Research Institute, USA
Chemoproteomics-driven Discovery of PGRMC2 as a New Regulator of Adipocyte Physiology with Therapeutic Potential in Obesity-Linked Diabetes

Hua V. Lin, Eli Lilly & Co., USA
GPR142 Agonists Improve Beta Cell Proliferation and Survival

Kfir Sharabi, Dana-Farber Cancer Institute, USA
Small Molecule Screen Identifies Selective PGC-1alpha Gluconeogenic Inhibitors that Ameliorate Diabetic Symptoms

Cholsoon Jang, Princeton University, USA
A Metabolite of Branched Chain Amino Acids Drives Vascular Fatty Acid Transport and Insulin Resistance

Zheng Sun, Baylor College of Medicine, USA
Dissociation of Muscle Glucose Utilization from Exercise Endurance by Circadian Epigenomic Regulator HDAC3

Jonathan Z. Long, Dana-Farber Cancer Institute, USA
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

Nicolai Jacob Wewer Albrechtsen, University of Copenhagen, Denmark
An Insulinotropic Glucagon Variant Identified in Man

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Adipose Tissue Development
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Insights from the Epigenomic Analysis of Human and Murine Adipose Tissue

Christian Wolfrum, ETH Zürich, Switzerland
Adipose Tissue Stem Cells

Silvia Corvera, University of Massachusetts Medical School, USA
Origin and Function of Human Brite/Beige Adipocytes

Zachary Sebo, Yale University, USA
Short Talk: A Sexually Dimorphic Mesodermal Fate Map for Adipose Tissue

Rana K. Gupta, University of Texas Southwestern Medical Center, USA
Short Talk: Visceral Adipocyte Differentiation from Mural Adipose Precursors Protects Against Pathological Adipose Tissue Expansion and Insulin Resistance in Obesity


Following Session is for Diabetes (J3)

17:00—19:00
Exercise and Type 2 Diabetes
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Clay F. Semenkovich, Washington University School of Medicine, USA

Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Exercise Regulation of Adipose Tissue

Juleen R. Zierath, Karolinska Institutet, Sweden
The Role of Diet and Exercise in the Epigenetic Landscape of Type 2 Diabetes

Christoph Handschin, University of Basel, Switzerland
Regulation of Physiological and Dietary Ketone Body Homeostasis and Diabetic Hyperketosis by Muscle PGC-1alpha and Exercise

Xingxing Kong, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: Brown Fat Dysfunction Induces Skeletal Muscle Myopathy via an IRF4-Myostatin-Mediated Pathway

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 1

Colorado Rockies Ballroom

TUESDAY, JANUARY 24

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:15
Interorgan Metabolic Crosstalk via Secreted Factors (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Christoph Handschin, University of Basel, Switzerland

Takashi Kadowaki, University of Tokyo, Japan
Adiponectin Receptors: A Major Treatment Target in Type 2 Diabetes and Obesity-Linked Diseases

Jiandie Lin, University of Michigan Medical School, USA
The Brown Fat Secretome: Metabolic Functions Beyond Thermogenesis

Coffee Break

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
The Diverse Metabolic Actions of FGF21

Yonghao Yu, University of Texas Southwestern Medical Center, USA
Large Scale Proteomic Analysis Identifies IGFBP5 as a Secreted mTORC1 Target that Mediates mTORC1-Dependent Feedback Inhibition of IGF-1 Signaling

Russell A. Miller, Pfizer Inc., USA
Short Talk: Glucagon Stimulates Hepatic Glutamine Utilization by Increasing Metabolic Flux through GLS2

Lucas BonDurant, University of Iowa, USA
Short Talk: FGF21 Signals Directly to Adipose Tissues to Acutely Enhance Insulin Sensitivity

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Adipose Inflammation; Adipokines
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Ajay Chawla, University of California, San Francisco, USA

Ruth E. Gimeno, Eli Lilly & Company, USA
Pharmacological Approaches to Adipose Tissue Function

Anthony W. Ferrante, Columbia University, USA
Induction of Adipose Tissue Inflammation

Alyssa H. Hasty, Vanderbilt University, USA
Macrophages as Adipose Tissue "Ferrostats"

Prashant Rajbhandari, University of California, Los Angeles, USA
Short Talk: Interleukin-10 Signaling Alters Chromatin Architecture in Adipose to Regulate Thermogenesis and Energy Expenditure

Min Jeong Choi, Chungnam National University, South Korea
Short Talk: Secretory Factors Induced by Adipocyte Mitochondrial OxPhos Dysfunction Modulate Systemic Metabolism by Influencing the Adipose Immune Environment


Following Session is for Diabetes (J3)

17:00—19:00
Long Noncoding and MicroRNAs and Metabolism
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Jiandie Lin, University of Michigan Medical School, USA

Lori Sussel, University of Colorado, USA
Non-Coding Gene Regulation of the Pancreatic Islet

Lei Sun, Duke-NUS Graduate Medical School Singapore, Singapore
Regulatory Role of Long Noncoding RNAs in Adipose

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
A Role for MicroRNAs in Diabetes and Its Complications

Congcong He, Northwestern University, USA
Short Talk: Differential Roles of Autophagy in Insulin Production and Sensitivity

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 2

Colorado Rockies Ballroom

WEDNESDAY, JANUARY 25

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:15
Gut Microbiome and Bariatric Surgery (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
Patrice D. Cani, Université Catholique de Louvain, Belgium
Specific Gut Microbiota and Intestinal Sensors: Focus on Novel Mechanisms Affecting Glucose and Energy Metabolism

* Randy J. Seeley, University of Michigan, USA
Gut Endocrine Signaling in Bariatric Surgery

Coffee Break

Helen Raybould, University of California, Davis, USA
The Microbiota-Gut-Brain Axis in the Control of Food Intake and Body Weight

Fredrik Bäckhed, University of Gothenburg, Sweden
Does Altered Gut Microbiome after Bariatric Surgery Contribute to Improved Metabolism?

Jantje M. Gerdes, Helmholtz Zentrum München, Germany
Short Talk: EphA/ephrin Signaling in Pancreatic Islets is Regulated by Primary Cilia

Chieh Jason Chou, Nestlé Institute of Health Sciences SA, Switzerland
Short Talk: The Effect of Diets on the Metabolic Benefits Associated with Post Bariatric Surgery Microbiota

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Neural Control of Adipose/Adipose Function
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Jan Nedergaard, Stockholm University, Sweden

Heike Münzberg, Pennington Biomedical Research Center, USA
Central Circuits of Thermoregulatory Leptin Action

Rudolf Zechner, University of Graz, Austria
Adipose Triglyceride Lipase

Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Brown Fat and Lipid Metabolism

Peter K. Jackson, Stanford University, USA
Short Talk: Linking Monogenic and Complex Obesity to Primary Cilia: The Cep19 Obesity Protein Regulates a Conserved GTPase Cycle Coupling Cargo to the IFT-B Complex for Ciliary Transport of the BBSome and GPCRs

Qi Wu, Baylor College of Medicine, USA
Short Talk: Deciphering an AgRP-Dorsal Raphe Neural Circuit in Exclusive Control of Energy Expenditure


Following Session is for Diabetes (J3)

17:00—19:00
Substrate Flux and Metabolic Signaling
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Clay F. Semenkovich, Washington University School of Medicine, USA
Lipid-Mediated Metabolic Signaling

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Role of Hepatic Acetyl CoA in the Regulation of Hepatic Gluconeogenesis in Normal and Diabetic States

Christopher B. Newgard, Duke University Medical Center, USA
Metabolic Flux and Homeostais

Hongyuan Yang, University of New South Wales, Australia
Short Talk: Understanding Congenital Generalized Lipodystrophy

19:15—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 3

Colorado Rockies Ballroom

THURSDAY, JANUARY 26

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
Genetics and Systems Biology
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA

Umut Ozcan, Boston Children's Hospital, Harvard Medical School, USA
Role of Endoplasmic Reticulum Stress in Development of Obesity and Type 2 Diabetes

Ruth J.F. Loos, Mount Sinai School of Medicine, USA
The Genetics of Obesity - Going Beyond Common Variation and Common Phenotypes

Coffee Break

Jose C. Florez, Massachusetts General Hospital, USA
Pharmacogenetics of Type 2 Diabetes

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Transcriptional Regulation of Metabolism

Yi Chen, Dana-Farber Cancer Institute, USA
Short Talk: Potassium Current Through KCNK3 Regulates Brown Adipose Thermogenesis and Obesity


Following Session is for Diabetes (J3)

08:00—11:15
Mechanisms of Nutrient Signaling
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA

Antonio J. Vidal-Puig, University of Cambridge, UK
Adipose Tissue Expandability, Lipotoxicity and the Metabolic Syndrome

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Metabolic Signaling in Physiology and Disease

Coffee Break

Hei Sook Sul, University of California, Berkeley, USA
Regulation of Fat Metabolism

Jun Wu, University of Michigan, USA
Beige-Fat-Specific Regulation in Mouse and Human

Feng Liu, University of Texas Health Science Center, USA
Short Talk: DsbA-L Suppresses Inflammation and Promotes Beiging and Thermogenesis by Improving Mitochondrial Function

Adilson L. Guilherme, University of Massachusetts Medical School, USA
Short Talk: Suppression of Adipocyte Fatty Acid Synthase in Adult Mice Enhances Adipose Sympathetic Activity and Browning to Improve Glucose Homeostasis in Obese Mice

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Adipose Thermogenesis and a Little Bit More

Grays/Longs Peak
* Barbara Cannon, Stockholm University, Sweden

* Matthias Blüher, University of Leipzig, Germany

Erin L. Brown, Johns Hopkins Medical Institute, USA
Regulation of Adipose Tissue Thermogenic Capacity by Estrogen-Related Receptors

Shunbun Kita, Graduate School of Medicine, Osaka University, Japan
Adiponectin/T-Cadherin System Regulates Exosome Biogenesis and Systemic Plasma Exosome Level

Pegah Poursharifi, University of Montreal-CRCHUM, Canada
ABHD6 Negatively Regulates Thermogenic Adaptive Responses under Cold Stress

Pingwen Xu, Baylor College of Medicine, USA
Ventral Medial Hypothalamus ERalpha Neurocircuits in the Regulation of Thermogenesis and Physical Activity

Ludger Scheja, University Medical Center Hamburg-Eppendorf, Germany
Carbohydrate Response Element Binding Protein Regulates de novo Lipogenesis in Brown Adipose Tissue and Adaptive thermogenesis

Roland H. Stimson, University of Edinburgh, Scotland
Direct Measurement of in vivo Substrate Utilisation by Human Brown Adipose Tissue

Claudio Villanueva, University of Utah School of Medicine, USA
Global Analysis of Plasma Lipids Identifies Liver-Derived Acyl-Carnitines as a Fuel Source for Brown Fat Thermogenesis

Mary N. Teruel, Stanford University, USA
Transcription Factor Dynamics Define a Circadian Code for Fat Cell Differentiation


Following Session is for Diabetes (J3)

14:30—16:30
Workshop 2: Metabolic Regulation in Physiology and Disease

Quandary Peak
* Dave Bridges, University of Michigan, USA

Constanza J. Cortes, University of California, San Diego, USA
Skeletal Muscle Control of Systemic Metabolism: A Role for Transcription Factor E-B (TFEB) Signaling

Zhuoxian Meng, University of Michigan, USA
Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

Tiemin Liu, University of Texas Southwestern Medical Center, USA
5-HT2C Receptors in Brainstem Neurons Regulate Glucose Homeostasis

Fajun Yang, Albert Einstein College of Medicine, USA
Cyclin C Regulates Brown Fat Development and Function

Yanhui Zhang, University of Iowa, USA
SWELL1 is a Regulator of Adipocyte Size, Insulin Signaling and Glucose Homeostasis

Andrew C. Shin, Texas Tech University, USA
Insulin Receptor Signaling in POMC, but not AgRP, Neurons Controls Adipose Tissue Insulin Action

Jakob G. Knudsen, University of Oxford, UK
Glucagon Secretion is Dependent on Alpha-Cell Fatty Acid Oxidation

Meilian Liu, University of New Mexico Health Science Center, USA
Adipose mTORC1 Suppresses Beige Fat Development via Autophagy-Dependent Mechanisms

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Treatment of Obesity
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Ruth E. Gimeno, Eli Lilly & Company, USA

Steven R. Smith, Florida Hospital, USA
Clinical Obesity Treatment - Quantitative Bioenergetics

Matthias Blüher, University of Leipzig, Germany
New Developments in Treatment of Obesity

Marc L. Reitman, NIDDK, National Institutes of Health, USA
Role of Body and Environmental Temperature in Energy Homeostasis and Drug Development

Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: The Use of a Beta3-Adrenergic Receptor Agonist in Humans Stimulates BAT Glucose Disposal, but not Thermogenesis

Minna Lahesmaa, Turku PET Centre, Finland
Short Talk: Cannabinoid CB1 Receptors in Human Brown Adipose Tissue during Cold Exposure


Following Session is for Diabetes (J3)

17:00—18:45
Emerging Topics in Diabetes
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Stephan Kissler, Joslin Diabetes Center, USA
Immune Dysregulation Underlying Type 1 Diabetes

Ralph A. DeFronzo, University of Texas Health Sciences Center at San Antonio, USA
The Kidney and Glucose Homeostasis: Implications for Therapy

Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
Diabetes Trialog: Genes, Sex and the Microbiome

19:15—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak

Following Session is for Diabetes (J3)

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Clay F. Semenkovich, Washington University School of Medicine, USA

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Colorado Rockies Ballroom

FRIDAY, JANUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bill & Melinda Gates Foundation MedImmune
Nestlé Institute of Health Sciences Novo Nordisk A/S

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Adipogen International eLife
Journal of Lipid Research Research Diets, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK104611-03

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Eli Lilly and Company


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676