Diabetes Mellitus - Drivers of Type 2 Diabetes: From Genes to Environment (S1)

Scientific Organizers: Kyong Soo Park, Young-Bum Kim and Zoltan P. Arany


October 7—11, 2018

Grand Hilton Seoul, Seoul, South Korea


Supported by the Directors' Fund


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Meeting Summary



The prevalence of diabetes mellitus is increasing worldwide and is a major threat to global public health that requires urgent action. Over the last few decades, significant advances have been made in terms of identifying novel susceptibility genes and signaling pathways that play pivotal roles in the pathogenesis of diabetes and its related metabolic disorders. However, a major gap in understanding the current global epidemic of diabetes is the lack of knowledge regarding how molecular interactions between the environment and the susceptibility genes are regulated within an altered metabolic milieu. This meeting will address these unresolved gaps in the etiopathogenesis of diabetes and focus on the latest advances that are linked to the molecular drivers of diabetes mellitus. Topics include: systemic regulation of adipocytes in diabetes; microvesicles, noncoding RNA, and intercellular communications; physiological drivers in hunger and energy homeostasis; epigenetics and metabolic control in diabetes; novel signaling players related to insulin resistance; adaptation of beta cell to chronic metabolic stress; environmental triggers in diabetes and metabolic diseases; and molecular targets for nutrient sensing and signaling. The organizers anticipate that this meeting will bring about a major shift in addressing the causes of diabetes mellitus, as the topics emphasized in this meeting have not yet been explored widely. Through the novel discoveries of diabetes research presented at this meeting, we hope to provide evidence-based insight to favorably impact people with diabetes across the world.