GPCR Structure and Function: Taking GPCR Drug Development and Discovery to the Next Level (B8)

Scientific Organizers: Roger K. Sunahara and Christian Felder


February 16—20, 2018

Eldorado Hotel & Spa, Santa Fe, New Mexico, USA


Sponsored by Novo Nordisk A/S


BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

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DEADLINES:
Scholarship Deadline: Oct 17, 2017 [details]
Discounted Abstract Deadline: Oct 17, 2017 [details]
Abstract Deadline: Nov 15, 2017 [details]
Discounted Registration Deadline: Dec 18, 2017 [details]

Click here to view Cancellation Policy

Submit an Abstract Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2018-B8 "GPCR Structure and Function: Taking GPCR Drug Development and Discovery to the Next Level" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On October 17, 2017 100.00 USD*
- 50.00 USD discount
Abstract Deadline
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After October 17, 2017 until January 5, 2018 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
October 17, 2017 n/a
Discounted NON-STUDENT Registration
More details
Before and On December 18, 2017 820.00 USD
(includes 200.00 discount)
Regular NON-STUDENT Registration
More details
After December 18, 2017 1020.00 USD
Discounted STUDENT Registration
More details
Before and On December 18, 2017 595.00 USD
(includes 200.00 discount)
Regular STUDENT Registration
More details
After December 18, 2017 795.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: October 17, 2017


Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is November 15, 2017)

Global Health Travel Award Deadline:


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: October 17, 2017


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: November 15, 2017


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is October 17, 2017)

Discounted Registration Deadline: December 18, 2017


Registration Fee: 820.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 595.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 1020.00 USD*
Student Registration Fee: 795.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that a few meeting participants have received calls and emails from a number of different housing services - "Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website, an established travel agency, or directly with the hotel.

Meeting Summary



G protein-coupled receptors (GPCRs) are a critical family of cell surface receptors that detect extracellular stimuli, facilitate intercellular communication and regulate cellular homeostasis. As such, GPCRs remain highly relevant drug discovery targets addressing key unmet medical needs. Recent advances in understanding GPCR signaling networks, coupled with the unraveling of structural details of GPCRs, their signaling partners, and in some cases their signaling complexes, have enhanced our understanding of GPCR function. These advances have provided researchers the basic tools to interrogate critical but diverse aspects of GPCR signaling, such as receptor conformation, receptor-effector specificity and the role of receptor subcellular distribution, in signaling efficacy. All of these factors may influence ligand binding and therefore have impact on drug discovery. The availability of atomic-resolution structures of GPCRs alongside the introduction of functional coupling (e.g., biased signaling) is providing the potential for physiologically tailored and therefore disease-specific therapies. However, challenges remain as the design of small molecule tools and potential drugs is both labor-intensive and very costly, requiring large chemical library screening campaigns. In addition, improvements are still needed in GPCR ligand selectivity, signaling specificity and appropriate kinetics to achieve maximal efficacy and reasonable safety. Rational ligand design could significantly reduce both time and cost of drug discovery. Viable approaches are currently being explored through the combination of molecular dynamic simulations, GPCR crystallization and biophysical analysis. Drug efficacy and safety improvements are slow to emerge and can be addressed by the development of physiologically relevant GPCR ligands. Targeting allosteric sites, hetero- and homo-dimers and specific signaling pathways could provide such context- and disease-specific regulation. This conference will highlight the latest developments in GPCR structure/function, ligand discovery and design, intracellular signaling pathways and their impact on modern drug discovery.