Mitochondria, Metabolism and Heart (Z4)

joint with the meeting on Angiogenesis and Vascular Disease (Z3)

Scientific Organizers: Junichi Sadoshima, Toren Finkel and Åsa B. Gustafsson


May 8—12, 2017

Eldorado Hotel & Spa, Santa Fe, New Mexico, USA


Supported by Bayer HealthCare Pharmaceuticals


BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

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Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.

** Meeting has ended **

Discounted Abstract Deadline: January 11, 2017


Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is February 8, 2017)

Global Health Travel Award Deadline:


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: January 11, 2017


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: February 8, 2017


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is January 11, 2017)

Discounted Registration Deadline: March 8, 2017


Registration Fee: 795.00 USD* (includes 150.00 USD discount)
Student Registration Fee: 570.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 945.00 USD*
Student Registration Fee: 720.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that a few meeting participants have received calls and emails from a number of different housing services - "Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website, an established travel agency, or directly with the hotel.

Meeting Summary



Mitochondria play a central role in regulating energy metabolism, redox status and cell death. The homeostasis of mitochondrial function is maintained by multiple mechanisms, collectively called mitochondrial quality control mechanisms. During the past decade, we have witnessed an explosion of research identifying novel mechanisms by which mitochondria control various cellular functions and cells maintain the homeostasis of mitochondria and metabolism in various cell types. Mitochondria are particularly abundant in the heart, and mitochondrial dysfunction and changes in cellular metabolism are commonly observed in failing or stressed hearts. However, there is a significant gap in our understanding of these mechanisms in cardiomyocytes and those in other cell types. The overall learning objectives of this meeting are to: 1) Understand how the novel functions of mitochondria contribute to the development or the prevention of myocardial injury and heart failure, and 2) Discuss how the quality of mitochondria is maintained in adult cardiomyocytes, whose mitochondrial dynamics are quite distinct from other commonly investigated cell types. Special emphasis will be placed on discussing the function and the mechanism of mitophagy; a novel mechanism of cell death mediated through autophagy; interaction between mitochondria dynamics and mitophagy; mitochondrial unfolded protein response (UPR) controlling aging, stress resistance and longevity; the role of metabolic intermediates as signaling mechanisms; and novel biomarkers identified through metabolomics analyses. With a joint session on angiogenesis shared with the meeting on “Angiogenesis and Vascular Disease,” attendees will get a quick overview regarding how mitochondria and metabolism regulate angiogenesis, a critical determinant for physiological versus pathological hypertrophy and ischemic injury. Overall, the audience will obtain better understanding regarding how the function of mitochondria is regulated in the heart, how it affects the overall function of the cardiovascular system, and how one intervenes with mitochondria and metabolism to achieve better treatment for heart failure and other cardiovascular diseases.