Clarion Hotel Sign Floorplan

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This meeting took place in 2019



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Proteomics and its Application to Translational and Precision Medicine (D3)


Organizer(s) Matthias Mann, Emma K. Lundberg, Albert J.R. Heck and Mathias Uhlén
April 7—11, 2019
Clarion Hotel Sign • Stockholm, Sweden
Discounted Abstract Deadline: Dec 12, 2018
Abstract Deadline: Jan 9, 2019
Scholarship Deadline: Dec 12, 2018
Discounted Registration Deadline: Feb 6, 2019

Organized in collaboration with Knut and Alice Wallenberg Foundation
and Science for Life Laboratory

Sponsored by BioLegend, Inc., Novo Nordisk A/S, Roche and Thermo Fisher Scientific Inc.

Summary of Meeting:
Proteomics methods have advanced tremendously in just the last few years. Apart from increasingly powerful mass-spectrometric methods, global antibody based methods, chemical biology approaches and genetics/genomics approaches and their combinations are now offering a rich toolbox to study the proteome in many different dimensions. Given this background and the recent completion of in depth proteomes, it is now time to apply proteomics in a more translational context to patient derived primary cells, organoids, xenograft models and indeed to the clinic. MS based proteomics, in particular, interaction proteomics in combination with chemical and structural proteomics, is making crucial contributions to drug development and deeper molecular understanding of disease mechanisms. The analysis of post-translational modifications has become orders of magnitude more comprehensive, quantitative and accessible, now enabling in-vivo and time-resolved studied of a large range of signaling processes. In combination with genome engineering, this opens up entirely new perspectives in precision investigation of deregulated signaling processes in models of oncology, immunology or metabolic diseases. Finally, proteomic profiling of body fluids has matured to a degree that it enables informative ‘phenotyping’ of humans in health and disease, supporting ‘wellness’ and patient stratification/biomarker studies.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 7 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 11 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 12 in order to fully experience the meeting.

SUNDAY, APRIL 7

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, APRIL 8

08:00—08:30
Poster Setup

B 3
08:30—19:00
Poster Viewing

B 3
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Matthias Mann, Max Planck Institute of Biochemistry, Germany

Madan Babu Mohan, MRC Laboratory of Molecular Biology, UK
Data Science Approaches to Biological Systems

09:30—12:00
In Depth Proteomics of Normal and Diseased Tissues
Meeting has ended...abstracts no longer viewable online.
The proteomics tool box for personalized medicine

B 1-2
* Matthias Mann, Max Planck Institute of Biochemistry, Germany

Joshua J. Coon, University of Wisconsin, USA
Comprehensive Tissue Proteomics

Coffee Break

Angus I. Lamond, University of Dundee, UK
A Deep Dive in to the Human iPS Cell Proteome

Emma K. Lundberg, SciLifeLab Stockholm and School of Biotechnology, KTH, Sweden
Dissecting Spatiotemporal Single Cell Variations of the Human Proteome

Georg Borner, Max Planck Institute of Biochemistry, Germany
Short Talk: Spatial Proteomics Reveals the Mechanistic Basis of AP-4 Deficiency Syndrome

Tony Ly, University of Edinburgh, UK
Short Talk: Proteomic Analysis of Cell State Transitions using PRIMMUS

12:00—13:00
Lunch

B3/Atrium
12:30—15:00
Poster Session 1

B 3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Large-Scale Study of Signaling Pathways
Meeting has ended...abstracts no longer viewable online.
The proteomics tool box for personalized medicine

B 1-2
* Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland

Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
The Human Transportome

Jesper V. Olsen, University of Copenhagen, Denmark
Defining Critical Switches in Cancer Progression by Phospho-Proteomics

Bernhard Küster, Technische Universität München, Germany
The Target Landscape of Clinical Kinase Drugs

Hidetaka Kosako, Tokushima University, Japan
Short Talk: BioID-Based Screening of Biotinylation Sites Globally Identifies STING Interactors

Paolo Cifani, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Pathway-Scale Targeted Mass Spectrometry for High-Resolution Functional Profiling of Cell Signaling

19:00
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


TUESDAY, APRIL 9

08:00—08:30
Poster Setup

B 3
08:30—19:00
Poster Viewing

B 3
08:30—11:45
Chemical Proteomics and Drug Discovery
Meeting has ended...abstracts no longer viewable online.
Proteomics networks and drug discovery

B 1-2
* Ileana M. Cristea, Princeton University, USA

Alexander Makarov, Thermo Fisher, Germany
Mass Spectrometry Based Proteomics from Ion’s Perspective

Yasushi Ishihama, Kyoto University, Japan
Toolbox for Phosphoproteomics in Cancer Signaling

Coffee Break

Michael B. Yaffe, Massachusetts Institute of Technology, USA
Proteomics and Cell Signaling

Marcus Bantscheff, GlaxoSmithKline, Germany
Proteomics for Drug Target Discovery

Jing Yang, National Center for Protein Sciences, Beijing, China
Short Talk: Chemoproteomic Profiling of Cysteine Redox Networks

Nils Kurzawa, European Molecular Biology Laboratory, Germany
Short Talk: Robust Statistical Inference of Small Molecule-Protein Interactions from 2D Thermal Proteome Profiles

Ireshyn S. Govender, Council for Scientific and Industrial Research, South Africa
Short Talk: Novel Urinary Proteome Profiling Methods and its Application in Biomarker Discovery for Tenofovir-Induced Kidney Injury

11:45—13:00
Lunch

B3/Atrium
12:30—15:00
Poster Session 2

B 3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Complexes and Networks
Meeting has ended...abstracts no longer viewable online.
Proteomics networks and drug discovery

B 1-2
* Mathias Uhlen, KTH Royal Inst of Technology, Sweden

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Mass Spectrometric Exploration of the Proteotype

Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
A Proteomics View of mTOR Signaling in Humans

Ileana M. Cristea, Princeton University, USA
Deciphering the Complexity of Viral Infection using Proteomics

Evgenia Shishkova, University of Wisconsin-Madison, USA
Short Talk: Multi-Omic Profiling of a Large CRISPR Knockout Collection Elucidates Functions of Uncharacterized Mitochondrial Proteins and their Role in Human Disease

Alicia Lundby, University of Copenhagen, Denmark
Short Talk: Deciphering Cardiac Disease Associated Ion Channel Networks by Quantitative Proteomics

19:00
On Own for Dinner


WEDNESDAY, APRIL 10

08:30—11:45
Cancer and Other Diseases
Meeting has ended...abstracts no longer viewable online.
Proteomics in disease

B 1-2
* Judith A. Steen, Boston Children's Hospital, Harvard Medical Center, USA

Tamar Geiger, Tel Aviv University, Israel
Unraveling Breast Cancer Heterogeneity through MS-Based Microproteomics, from Whole Tumor Analysis towards Single Cell Single Cell Proteomics

Marie Classon, , USA
Epigenetics/Resistant Cancer

Coffee Break

Anthony W. Purcell, Monash University, Australia
Diversification of Tumour Antigen Presentation through Unexpected Proteolysis

Nevan J. Krogan, University of California, San Francisco, USA
Using Systems Approaches to Understand the Mechanism of Disease

Lukas Käll, KTH - Royal Institute of Technology, Sweden
Short Talk: A Combined Identification and Quantification Error Model of Label-Free Protein Quantification

Alberto Santos, Novo Nordisk Foundation Center for Protein Research, Denmark
Short Talk: Graph-Centric Knowledge Mining of Clinical Proteomics Data

Richard Scheltema, Utrecht University, Netherlands
Short Talk: Uncovering the Molecular Architecture of Human Fibrin Clots by Cross-Linking Mass Spectrometry

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

B 3
12:00—14:30
SciLifeLab Lunch Seminar: Proteomics and its Application to Translational and Precision Medicine (Must Register in Advance)
Register here to secure your lunch. There will also be an opportunity to register for the seminar on site at Clarion Hotel Sign, however we will not be able to offer you lunch.
More information about the program and registration: https://www.scilifelab.se/events/keystone-lunch-seminar-proteomics-and-its-application-to-translational-and-precision-medicine/

B 1-2
13:00—22:00
Poster Viewing

B 3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Neurodegenerative and Immunological Diseases
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Tamar Geiger, Tel Aviv University, Israel

Judith A. Steen, Boston Children's Hospital, Harvard Medical Center, USA
Large Scale Proteome Mapping of Brain Tissue from Neurodegenerative Diseases Informs Mechanism

Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin Mediated Regulation of Transcription Factor Stability

Paola Picotti, ETH Zürich, Switzerland
Proteomes in 3D

Alessandro Ori, Leibniz Institute on Aging - Fritz Lipmann Institute, Germany
Short Talk: Comprehensive Characterization of Protein Abundance, Stability and Aggregation during Vertebrate Brain Aging

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
19:30—22:00
Poster Session 3

B 3

THURSDAY, APRIL 11

08:30—11:45
Biomarkers and Patient Stratification
Meeting has ended...abstracts no longer viewable online.
Integrative Omics for prevention and personalized treatment

B 1-2
* Albert J.R. Heck, Utrecht University, Netherlands
Protein Assemblies Investigated by Native and Top-Down Mass Spectrometry

N. Leigh Anderson, SISCAPA Assay Technologies, Inc., USA
Biomarker Changes in Time: High-Precision Measurement of Protein Panels in Longitudinal Dried Blood Spots

Coffee Break

Andy N. Hoofnagle, University of Washington, USA
Clinical Proteomics for Biomarker Discovery

Matthias Mann, Max Planck Institute of Biochemistry, Germany
Plasma Proteomics Profiling as a Universal Phenotyping Approach in Humans

Lovisa Aakesson, KTH - Royal Institute of Technology, Sweden
Short Talk: Large-Scale Mapping of the Human Nucleolar Proteome

Joseph E. Aslan, Oregon Health & Science University, USA
Short Talk: Quantitative Phosphoproteomic Profiling and Causality Pathway Mapping the Platelet Response to Vascular Injury

Henrik J. Johansson, Karolinska Institutet, Sweden
Short Talk: Breast Cancer Quantitative Proteome and Proteogenomic Landscape

11:45—17:00
On Own for Lunch

15:00—16:30
Workshop: Precision Medicine from Proteomics

B 1-2
* Michael P. Snyder, Stanford University School of Medicine, USA

Roman Fischer, Oxford University, UK
Multi-Omic Prognostic Signatures in Esophageal Cancer Immunotherapy – A Precision Analysis

Mariya Mardamshina, Tel Aviv University, Israel
Topological-Proteomics of Breast Cancer Intra-Tumor Heterogeneity Reveals Diversity within Single Tumors

Lili Niu, University of Copenhagen, Denmark
Plasma Proteome Profiling Discovers Novel Proteins Associated with Non-Alcoholic Fatty Liver Disease

Jing Zhu, Utrecht University, Netherlands
Personalized Human Milk Proteomics Profiling Reveals Early Signatures of Immunogenic responses

Maria Reinecke, Technische Universität München, Germany
Systematic Discovery of the Targets of 1,000 Kinase Inhibitors

Jochen M. Schwenk, KTH - Royal Institute of Technology, Sweden
Insights From Profiling Human Plasma Proteomes

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Integrative Omics for Prevention and Personalized Treatment
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Emma K. Lundberg, SciLifeLab Stockholm and School of Biotechnology, KTH, Sweden

Mathias Uhlen, KTH Royal Inst of Technology, Sweden
The Human Protein Atlas – Implications for Human Biology, Drug Development and Precision Medicine

Michael P. Snyder, Stanford University School of Medicine, USA
Big Data and Health

Mara Monetti, Pfizer, USA
Expression of PNPLA3 I148M Variant Alters Lipid Droplet Proteome

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

B 1-2
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

B 3

FRIDAY, APRIL 12

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

BioLegend, Inc. Knut and Alice Wallenberg Foundation
Novo Nordisk A/S Roche
Science for Life Laboratory Thermo Fisher Scientific Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

PharmaFluidics
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

ACS Chemical Biology ACS Pharmacology & Translational Science
eLife Molecular & Cellular Proteomics

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179