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This meeting took place in 2019
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Cellular Plasticity: Reprogramming, Regeneration and Metaplasia (J3)
Organizer(s) Jason C. Mills, Maike Sander and Ben Z. Stanger
January 27—31, 2019
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 17, 2018
Abstract Deadline: Oct 25, 2018
Scholarship Deadline: Oct 17, 2018
Discounted Registration Deadline: Nov 28, 2018
Sponsored by Novartis Institutes for BioMedical Research
Summary of Meeting:
Traditionally, differentiated cells were thought to be post-mitotic. However, now we know mature cells in diverse tissues can reprogram, re-enter the cell cycle, and spawn other lineages (e.g., they revert back to stem cells or adopt other identities). The scientific and health implications are substantial. For one, cellular plasticity might be harnessed to regenerate damaged tissue (e.g., insulin-secreting cells, liver, gut), but repeated reprogramming events – as cells respond to inflammation/injury – can also cause tissue derangement (metaplasia) that predisposes to cancer. Furthermore, cancer cells can harness such plasticity mechanisms to subvert therapy. Thus, defining the mechanisms that allow mature cells to switch identities holds great promise for understanding disease pathogenesis and developing new therapies. This conference gathers the diverse, dynamic field of plasticity/reprogramming together for the first time with the aim of understanding if similar mechanisms underlie plasticity in diverse organs and organisms. The hypothesis is that cellular reprogramming occurs via evolutionarily conserved cellular processes as fundamental to a multicellular organism as apoptosis. Specifically, the conference aims to: 1) Elucidate mechanisms of plasticity in diverse adult tissues; 2) Explore plasticity’s evolutionary context; 3) Elucidate its role in metaplasia/cancer; and 4) Investigate how it can be harnessed therapeutically.
View Scholarships/Awards
Traditionally, differentiated cells were thought to be post-mitotic. However, now we know mature cells in diverse tissues can reprogram, re-enter the cell cycle, and spawn other lineages (e.g., they revert back to stem cells or adopt other identities). The scientific and health implications are substantial. For one, cellular plasticity might be harnessed to regenerate damaged tissue (e.g., insulin-secreting cells, liver, gut), but repeated reprogramming events – as cells respond to inflammation/injury – can also cause tissue derangement (metaplasia) that predisposes to cancer. Furthermore, cancer cells can harness such plasticity mechanisms to subvert therapy. Thus, defining the mechanisms that allow mature cells to switch identities holds great promise for understanding disease pathogenesis and developing new therapies. This conference gathers the diverse, dynamic field of plasticity/reprogramming together for the first time with the aim of understanding if similar mechanisms underlie plasticity in diverse organs and organisms. The hypothesis is that cellular reprogramming occurs via evolutionarily conserved cellular processes as fundamental to a multicellular organism as apoptosis. Specifically, the conference aims to: 1) Elucidate mechanisms of plasticity in diverse adult tissues; 2) Explore plasticity’s evolutionary context; 3) Elucidate its role in metaplasia/cancer; and 4) Investigate how it can be harnessed therapeutically.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 1 in order to fully experience the meeting.
SUNDAY, JANUARY 27
MONDAY, JANUARY 28
TUESDAY, JANUARY 29
WEDNESDAY, JANUARY 30
THURSDAY, JANUARY 31
FRIDAY, FEBRUARY 1
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 1 in order to fully experience the meeting.
SUNDAY, JANUARY 27
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
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Jason C. Mills,
Washington University, USA
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Nicolas Tapon,
Francis Crick Institute, UK
09:00—11:30
Plasticity and Signaling in Development and Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.
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Michael B. O'Connor,
University of Minnesota, Twin Cities, USA
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Anna Mae Diehl,
Duke University, USA
Jayaraj Rajagopal,
Massachusetts General Hospital, USA
The Airway Epithelial Ensemble
The Airway Epithelial Ensemble
Coffee Break
Valentina Greco,
Yale School of Medicine, USA
Principles of Tissue Dynamics and Function Captured by Live Imaging
Principles of Tissue Dynamics and Function Captured by Live Imaging
Erin N. Sanders,
Stanford University, USA
Short Talk: Real-Time Kinetics of Notch-Mediated Fate Decisions during Organ Renewal
Short Talk: Real-Time Kinetics of Notch-Mediated Fate Decisions during Organ Renewal
Shiyan Yu,
Rutgers University-Newark, USA
Short Talk: Injury Induces Paneth Cell Plasticity
Short Talk: Injury Induces Paneth Cell Plasticity
11:30—12:30
Meet the Editors (Joint)
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?
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Daniel Klimmeck,
EMBO Journal, Germany
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Sheila Chari,
Cell Press, USA
Iain Dickson,
Nature Reviews, UK
John F. Foley,
Science Signaling, USA
Seema Grewal,
Development, UK
Marie Bao,
Cell Press, USA
Jessie Ann Le Good,
Nature Communications, UK
14:30—16:30
Workshop
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Chay T. Kuo,
Duke University School of Medicine, USA
Lorin Olson,
Oklahoma Medical Research Foundation, USA
Mosaic Mutant Analysis Identifies PDGFRa/PDGFRb as Regulators of Adipocyte Progenitor Cell Plasticity
Mosaic Mutant Analysis Identifies PDGFRa/PDGFRb as Regulators of Adipocyte Progenitor Cell Plasticity
Feng Chen,
University of California, San Francisco, USA
Resolving the Contribution of Adult Liver Stem/Progenitor Cells to Hepatocyte Regeneration with a Dual AAV Vector System for Inducing Liver Injury and Lineage Tracing
Resolving the Contribution of Adult Liver Stem/Progenitor Cells to Hepatocyte Regeneration with a Dual AAV Vector System for Inducing Liver Injury and Lineage Tracing
Kenji Ito,
University of Tokyo, Japan
Cancer Drug Screening Based on Refractoriness of Cancer Cell Reprogramming
Cancer Drug Screening Based on Refractoriness of Cancer Cell Reprogramming
Enric Llorens-Bobadilla,
Karolinska Institute, Sweden
Programming Future Fate Decisions in the Glial Scar to Promote Spinal Cord Injury Repair
Programming Future Fate Decisions in the Glial Scar to Promote Spinal Cord Injury Repair
Agnieszka B. Bialkowska,
Stony Brook University, USA
Krüppel-Like Factor 5 Plays an Important Role in Acinar-to-Ductal Metaplasia of the Pancreas
Krüppel-Like Factor 5 Plays an Important Role in Acinar-to-Ductal Metaplasia of the Pancreas
Oscar Pellon-Cardenas,
Rutgers University, USA
CDX2 Loss Disrupts the Differentiation-Proliferation Balance during Initiation and Progression of Intestinal Tumors
CDX2 Loss Disrupts the Differentiation-Proliferation Balance during Initiation and Progression of Intestinal Tumors
Lianghui Zhang,
University of Illinois at Chicago, USA
Differential Pathogen Response Mechanisms and Single Cell Heterogeneity in Endothelial Regeneration
Differential Pathogen Response Mechanisms and Single Cell Heterogeneity in Endothelial Regeneration
14:30—16:30
Workshop
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Silvia Santos,
Francis Crick Institute, UK
Julie B. Sneddon,
University California, San Francisco, USA
Cell Fate Determination in Human Pancreatic Endocrine Development
Cell Fate Determination in Human Pancreatic Endocrine Development
Micha Sam Brickman Raredon,
Yale University, USA
Cross-Species scRNAseq Analysis of Cell-Cell Connectomics in Lung
Cross-Species scRNAseq Analysis of Cell-Cell Connectomics in Lung
Jarod Zepp,
University of Pennsylvania, USA
Epithelial to Mesenchymal Crosstalk during the Postnatal Phase of Lung Development Coordinates Lineage Commitment and Niche Formation
Epithelial to Mesenchymal Crosstalk during the Postnatal Phase of Lung Development Coordinates Lineage Commitment and Niche Formation
Oliver Wessely,
Cleveland Clinic Foundation, USA
A Design-of-Experiment Approach Towards Differentiation of Human Pluripotent Stem Cells into Definitive Kidney Cell Lineages
A Design-of-Experiment Approach Towards Differentiation of Human Pluripotent Stem Cells into Definitive Kidney Cell Lineages
Akiko Mammoto,
Medical College of Wisconsin, USA
Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth through YAP1
Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth through YAP1
17:00—19:00
Stem Cell Recruitment and Metaplasia
Meeting has ended...abstracts no longer viewable online.
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Eunyoung Choi,
Vanderbilt University Medical Center, USA
Calvin Kuo,
Stanford University, USA
Intestinal Stem Cell Niches
Intestinal Stem Cell Niches
James R. Goldenring,
Vanderbilt University Medical Center, USA
Inflammatory Regulation of Metaplasia Induction in the Stomach
Inflammatory Regulation of Metaplasia Induction in the Stomach
Jason C. Mills,
Washington University, USA
Reserve Stem Cells Recruited by Paligenosis, an Evolutionarily Conserved Program
Reserve Stem Cells Recruited by Paligenosis, an Evolutionarily Conserved Program
Melissa Hirose Wong,
Oregon Health & Science University, USA
Short Talk: Macrophage-Cancer Stem Cell Fusion Underlies Cancer Cell Plasticity and Potentiates Metastatic Spread of Disease
Short Talk: Macrophage-Cancer Stem Cell Fusion Underlies Cancer Cell Plasticity and Potentiates Metastatic Spread of Disease
17:00—19:00
Quantitative Approaches and Signaling Networks
Meeting has ended...abstracts no longer viewable online.
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Anna Kicheva,
Institute of Science and Technology Austria, Austria
Michael Elowitz,
California Institute of Technology, USA
Communication and Computation in Protein Circuits
Communication and Computation in Protein Circuits
Ertugrul M. Ozbudak,
Cincinnati Children's Hospital Medical Center, USA
Spatial Fold-Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish
Spatial Fold-Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish
Mary N. Teruel,
Stanford University, USA
Control of Cell Differentiation by Timing and Phase-Shifting of Physiological Oscillators
Control of Cell Differentiation by Timing and Phase-Shifting of Physiological Oscillators
Jared Toettcher,
Princeton University, USA
Short Talk: Cellular Optogenetics Reveals Principles of Cell Fate Control in the Early Drosophila Embryo
Short Talk: Cellular Optogenetics Reveals Principles of Cell Fate Control in the Early Drosophila Embryo
Amanda L. Zacharias,
Cincinnati Children's Hospital Medical Center, USA
Short Talk: Comprehensive Quantitative Analysis of Nuclear β-catenin in C. elegans Embryos Identifies a Novel Memory Mechanism for Gene Expression Diversification
Short Talk: Comprehensive Quantitative Analysis of Nuclear β-catenin in C. elegans Embryos Identifies a Novel Memory Mechanism for Gene Expression Diversification
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Cancer and Plasticity
Meeting has ended...abstracts no longer viewable online.
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Blair B. Madison,
Washington University, USA
Arjun Raj,
University of Pennsylvania, USA
Controlling Cellular Plasticity in Cancer
Controlling Cellular Plasticity in Cancer
Ben Z. Stanger,
University of Pennsylvania, USA
Epithelial-Mesenchymal Plasticity in Cancer Cell Invasion and Metastasis
Epithelial-Mesenchymal Plasticity in Cancer Cell Invasion and Metastasis
Coffee Break
Carla F. Kim,
Boston Children's Hospital, USA
Regulation of Progenitor Cells in the Adult Lung
Regulation of Progenitor Cells in the Adult Lung
Rohit Chandwani,
Weill Cornell Medicine, USA
Short Talk: Chromatin Dynamics in vivo Reveal the Complexity of Cell Fate Transitions in Pancreatic Cancer Initiation
Short Talk: Chromatin Dynamics in vivo Reveal the Complexity of Cell Fate Transitions in Pancreatic Cancer Initiation
Ellen M. Langer,
Oregon Health & Science University, USA
Short Talk: The Prolyl Isomerase PIN1 Plays a Critical Role in Pancreatic Stellate Cell Plasticity to Impact Tumor Development
Short Talk: The Prolyl Isomerase PIN1 Plays a Critical Role in Pancreatic Stellate Cell Plasticity to Impact Tumor Development
Karuna Ganesh,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Regenerative Origin of Metastasis-Initiating Cells
Short Talk: Regenerative Origin of Metastasis-Initiating Cells
08:00—11:00
Signaling Dynamics
Meeting has ended...abstracts no longer viewable online.
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Dan Shaye,
University of Illinois at Chicago, USA
Deborah L. Gumucio,
University of Michigan, USA
Dynamic Roles for WNT5a During Morphogenesis of the Mouse Fetal Intestine
Dynamic Roles for WNT5a During Morphogenesis of the Mouse Fetal Intestine
Coffee Break
Raphael Kopan,
University of Cincinnati College of Medicine, USA
A Role for Notch Dimerization and CSL Binding-Site Architecture in Mammalian Development and Tissue Maintenance
A Role for Notch Dimerization and CSL Binding-Site Architecture in Mammalian Development and Tissue Maintenance
Victoria Ng,
Vanderbilt University, USA
Short Talk: The USP46 Complex Promotes Wnt Signaling by Blocking Receptor Turnover
Short Talk: The USP46 Complex Promotes Wnt Signaling by Blocking Receptor Turnover
Sergi Regot,
Johns Hopkins University, USA
Short Talk: Single Cell Analysis of MAPK Signaling Dynamics in Multicellular Systems
Short Talk: Single Cell Analysis of MAPK Signaling Dynamics in Multicellular Systems
David Sprinzak,
Tel Aviv University, Israel
Short Talk: Localized Feedbacks on Fat4-Ds1 Complexes Underlie Planar Cell Polarity
Short Talk: Localized Feedbacks on Fat4-Ds1 Complexes Underlie Planar Cell Polarity
Kaelyn Sumigray,
Duke University School of Medicine, USA
Short Talk: Morphogenesis and Compartmentalization of the Mammalian Intestine
Short Talk: Morphogenesis and Compartmentalization of the Mammalian Intestine
17:00—19:00
Reprogramming Cells to Assemble and Repair Organs
Meeting has ended...abstracts no longer viewable online.
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Sydney Shaffer,
University of Pennsylvania, USA
Takanori Takebe,
Yokohama City University / Cincinnati Children's Hospital Medical Center, Japan
Next-Gen Organoids from Pluripotency
Next-Gen Organoids from Pluripotency
Purushothama Rao Rao Tata,
Duke University School of Medicine, USA
Short Talk: Stem Cells and Reserve Stem Cells in the Lung
Short Talk: Stem Cells and Reserve Stem Cells in the Lung
Qiong Wang,
City of Hope/BRI, USA
Short Talk: Reversible Dedifferentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation
Short Talk: Reversible Dedifferentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation
17:00—19:00
Morphogen Gradients in Growth and Patterning
Meeting has ended...abstracts no longer viewable online.
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Kaelyn Sumigray,
Duke University School of Medicine, USA
Caroline S. Hill,
Francis Crick Institute, UK
Self-Organizing Pattern Formation in Endoderm Specification in Zebrafish
Self-Organizing Pattern Formation in Endoderm Specification in Zebrafish
Anna Kicheva,
Institute of Science and Technology Austria, Austria
Coordination of Progenitor Specification and Growth in the Developing Spinal Cord
Coordination of Progenitor Specification and Growth in the Developing Spinal Cord
Jean-Paul B. Vincent,
Francis Crick Institute, UK
Coordination of Growth and Patterning in a Developing Epithelium
Coordination of Growth and Patterning in a Developing Epithelium
Jennifer Kong,
Stanford University, USA
Short Talk: Molecular Mechanisms that Regulate Target Cell Sensitivity to Hedgehog Morphogens
Short Talk: Molecular Mechanisms that Regulate Target Cell Sensitivity to Hedgehog Morphogens
Shinji Takada,
National Institute for Basic Biology, Japan
Short Talk: Extracellular Dynamics and Diffusion Range of Wnt Protein Complex in Xenopus Embryos
Short Talk: Extracellular Dynamics and Diffusion Range of Wnt Protein Complex in Xenopus Embryos
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Plasticity and Signaling in Regeneration and Tumorigenesis (Joint)
Meeting has ended...abstracts no longer viewable online.
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Caroline S. Hill,
Francis Crick Institute, UK
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Thea D. Tlsty,
University of California, San Francisco, USA
Jeffrey L. Wrana,
Mount Sinai Hospital, Canada
Revival Stem Cells Regenerate the Intestine
Revival Stem Cells Regenerate the Intestine
Maike Sander,
University of California, San Diego, USA
Deconstructing Endodermal Organ Development to Reconstruct Organs From Stem Cells
Deconstructing Endodermal Organ Development to Reconstruct Organs From Stem Cells
Coffee Break
Stacey S. Huppert,
Cincinnati Children’s Hospital Medical Center, USA
Building a Functional Biliary System via Hepatocyte Plasticity
Building a Functional Biliary System via Hepatocyte Plasticity
Owen J. Sansom,
Beatson Institute of Cancer Research, UK
Reserve Stem Cells and Intestinal Tumorigenesis: Foetal Progenitors and Microbiome in Colorectal Cancer
Reserve Stem Cells and Intestinal Tumorigenesis: Foetal Progenitors and Microbiome in Colorectal Cancer
Margaret E. Magaletta,
University of Massachusetts Medical School, USA
Short Talk: Single Cell Transcriptomic Analysis Resolves Dynamics of Developing Pharyngeal Endoderm
Short Talk: Single Cell Transcriptomic Analysis Resolves Dynamics of Developing Pharyngeal Endoderm
P. Duc Si Dong,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Biliary Paucity Due Jagged/Notch Loss is Reversible via a Novel Non-Hepatic Multipotent Cell Population
Short Talk: Biliary Paucity Due Jagged/Notch Loss is Reversible via a Novel Non-Hepatic Multipotent Cell Population
11:00—12:00
Panel: Nomenclature in Cell Plasticity: "Plasticity," "Dedifferentiation," "Transdifferentiation," "Reprogramming," "Reversion," "Paligenosis" – Can We Agree What These Mean?
This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia?
James R. Goldenring,
Vanderbilt University Medical Center, USA
Anna Mae Diehl,
Duke University, USA
Jason C. Mills,
Washington University, USA
17:00—19:00
Transcriptional Regulation of Cell Plasticity
Meeting has ended...abstracts no longer viewable online.
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Janel Kopp,
University of British Columbia, Canada
Ramesh A. Shivdasani,
Dana-Farber Cancer Institute, USA
Epigenetic Regulation of Gut Development and Plasticity
Epigenetic Regulation of Gut Development and Plasticity
Scott T. Magness,
University of North Carolina at Chapel Hill, USA
Sox9 Regulates Reserve Intestinal Stem Cell Function
Sox9 Regulates Reserve Intestinal Stem Cell Function
Michele A. Battle,
Medical College of Wisconsin, USA
Transcriptional Regulation of Barrett’s Metaplasia
Transcriptional Regulation of Barrett’s Metaplasia
William Zacharias,
Cincinnati Children's Hospital, USA
Short Talk: Defining the Gene Regulatory Networks Underlying Regenerative Capacity in Alveolar Epithelial Progenitor Cells
Short Talk: Defining the Gene Regulatory Networks Underlying Regenerative Capacity in Alveolar Epithelial Progenitor Cells
17:00—19:00
Cell Competition and Mechanical Interactions
Meeting has ended...abstracts no longer viewable online.
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Tadanori Mammoto,
Medical College of Wisconsin, USA
Eugenia Piddini,
University of Bristol, UK
Mechanical Cell Competition: Mechanisms and Implications for Epithelial Biology
Mechanical Cell Competition: Mechanisms and Implications for Epithelial Biology
Miguel Torres,
Centro Nacional de Investigaciones Cardiovasculares, Spain
Cell Competition in Mammalian Development and Tissue Homeostasis
Cell Competition in Mammalian Development and Tissue Homeostasis
Nicolas Tapon,
Francis Crick Institute, UK
Growth Control and Hippo Signaling in the Drosophila Abdomen
Growth Control and Hippo Signaling in the Drosophila Abdomen
Giulia Pilia,
Uppsala Universitet, Sweden
Short Talk: Ack1 Is a Mechanoresponsive Kinase Required for Regulation of Yap/Taz
Short Talk: Ack1 Is a Mechanoresponsive Kinase Required for Regulation of Yap/Taz
Anne-Marie Pret,
University of Versailles St Quentin-en-Yvelines, France
Short Talk: JAK/STAT Signaling and Epithelial Homeostasis in Drosophila
Short Talk: JAK/STAT Signaling and Epithelial Homeostasis in Drosophila
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Injury, Inflammation and Regeneration
Meeting has ended...abstracts no longer viewable online.
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Leonard Augenlicht,
Albert Einstein College of Medicine, USA
Irene Miguel-Aliaga,
Imperial College London, UK
Sex Differences in Organ Plasticity
Sex Differences in Organ Plasticity
Coffee Break
Juanita L. Merchant,
University of Arizona College of Medicine, USA
How Do Immune Cells Reprogram the Epithelium?
How Do Immune Cells Reprogram the Epithelium?
Anil K. Rustgi,
University of Pennsylvania, USA
Metaplasia in Esophagus and Pancreas
Metaplasia in Esophagus and Pancreas
Peter J. Dempsey,
University of Colorado Denver, USA
Short Talk: Cellular Plasticity of Defa4-Cre-Expressing Paneth Cells
Short Talk: Cellular Plasticity of Defa4-Cre-Expressing Paneth Cells
Won Jae Huh,
Vanderbilt University Medical Center, USA
Short Talk: Transforming Growth Factor-α (TGFα) Overexpression Induces Spasmolytic Polypeptide Expressing Metaplasia
Short Talk: Transforming Growth Factor-α (TGFα) Overexpression Induces Spasmolytic Polypeptide Expressing Metaplasia
08:00—11:00
Developmental Signaling and Disease
Meeting has ended...abstracts no longer viewable online.
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Thijs Jasper Hagenbeek,
Genentech, Inc., USA
Feng Cong,
Novartis Institutes for BioMedical Research, USA
Drug Discovery for the Wnt, TGFß/BMP, and HIPPO Pathways
Drug Discovery for the Wnt, TGFß/BMP, and HIPPO Pathways
Coffee Break
Kun-Liang Guan,
University of California, San Diego, USA
Hippo Signaling in Cancer
Hippo Signaling in Cancer
Vincent Idone,
Regeneron Pharmaceuticals Inc., USA
Activin Ligand Traps in Bone Disease Treatment
Activin Ligand Traps in Bone Disease Treatment
Zlatko Trajanoski,
Medical University of Innsbruck, Austria
Short Talk: Perturbation Biology of Colorectal Cancer Organoids Reveals Patient-Specific Signaling Rewiring and Interference with Immunity
Short Talk: Perturbation Biology of Colorectal Cancer Organoids Reveals Patient-Specific Signaling Rewiring and Interference with Immunity
Dominique Celeste Mitchell,
University of California, San Francisco, USA
Short Talk: Small Molecule Activation of LKB1 Reveals Multiphasic Hippo Pathway Signal Buffering
Short Talk: Small Molecule Activation of LKB1 Reveals Multiphasic Hippo Pathway Signal Buffering
17:00—18:45
Applications of Cell Plasticity
Meeting has ended...abstracts no longer viewable online.
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Nicholas Zachos,
Johns Hopkins University School of Medicine, USA
Joe Q. Zhou,
Harvard Stem Cell Institute, USA
Making Insulin-Secreting Cells from Intestine
Making Insulin-Secreting Cells from Intestine
Darrell N. Kotton,
Boston University, USA
Pluripotent Stem Cell Models of Lung Development and Disease
Pluripotent Stem Cell Models of Lung Development and Disease
Wendy M. McKimpson,
Columbia University, USA
Short Talk: Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment
Short Talk: Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment
17:00—18:45
Integration of Developmental Signaling Pathways
Meeting has ended...abstracts no longer viewable online.
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Raphael Kopan,
University of Cincinnati College of Medicine, USA
Liliana Attisano,
University of Toronto, Canada
NUAK2, a Feed Forward Regulator of the Hippo Pathway during Tumorigenesis
NUAK2, a Feed Forward Regulator of the Hippo Pathway during Tumorigenesis
Norbert Perrimon,
Harvard Medical School, USA
Insights on the Role of Ion Channels in the Drosophila Gut Epithelium
Insights on the Role of Ion Channels in the Drosophila Gut Epithelium
Lukasz Bugaj,
University of Pennsylvania, USA
High-Throughput Multicolor Optogenetics for the Systematic Dissection of Signal Dynamics and Integration
High-Throughput Multicolor Optogenetics for the Systematic Dissection of Signal Dynamics and Integration
Andrei V. Karginov,
University of Illinois at Chicago, USA
Short Talk: Interrogation of Signaling Pathways using Light-Regulated Protein Kinases
Short Talk: Interrogation of Signaling Pathways using Light-Regulated Protein Kinases
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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