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This meeting took place in 2017
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Kinases: Next-Generation Insights and Approaches (C4)
Organizer(s) Reid M. Huber, John Kuriyan and Ruth H. Palmer
March 5—9, 2017
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Nov 3, 2016
Abstract Deadline: Dec 7, 2016
Scholarship Deadline: Nov 3, 2016
Discounted Registration Deadline: Jan 11, 2017
Sponsored by Genentech, Inc. and Incyte Corporation
Summary of Meeting:
Decades of both basic and applied research have unequivocally established the importance of the kinase family of phosphotransferase enzymes in virtually every aspect of organismal homeostasis. From the initial characterization of ATP-dependent phosphorylation in the liver by Gene Kennedy in 1954, our understanding of the family has grown from the diverse perspectives of enzymology, biochemistry, biophysics, structural biology, genetics, cellular biology, pharmacology and physiology. Importantly, these advancements have yielded transformative therapeutic approaches to disease, most notably in the field of cancer where kinase inhibition is helping to fulfill the promise of precision medicine. Yet even today, our perspectives on the complexity of this class of enzymes continues to evolve, and many of the most exciting advancements in the field are being made by applying modern-day insights and technological approaches to the diverse roles the enzymes can play in health and human disease. This meeting is devoted to exploring this innovative leading edge of kinase research, and will bring together leading researchers from academic, clinical and pharmaceutical settings to explore and define the new horizons in the field of kinase biology.
View Scholarships/Awards
Decades of both basic and applied research have unequivocally established the importance of the kinase family of phosphotransferase enzymes in virtually every aspect of organismal homeostasis. From the initial characterization of ATP-dependent phosphorylation in the liver by Gene Kennedy in 1954, our understanding of the family has grown from the diverse perspectives of enzymology, biochemistry, biophysics, structural biology, genetics, cellular biology, pharmacology and physiology. Importantly, these advancements have yielded transformative therapeutic approaches to disease, most notably in the field of cancer where kinase inhibition is helping to fulfill the promise of precision medicine. Yet even today, our perspectives on the complexity of this class of enzymes continues to evolve, and many of the most exciting advancements in the field are being made by applying modern-day insights and technological approaches to the diverse roles the enzymes can play in health and human disease. This meeting is devoted to exploring this innovative leading edge of kinase research, and will bring together leading researchers from academic, clinical and pharmaceutical settings to explore and define the new horizons in the field of kinase biology.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 10 in order to fully experience the meeting.
SUNDAY, MARCH 5
MONDAY, MARCH 6
TUESDAY, MARCH 7
WEDNESDAY, MARCH 8
THURSDAY, MARCH 9
FRIDAY, MARCH 10
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 10 in order to fully experience the meeting.
SUNDAY, MARCH 5
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
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Reid M. Huber,
Third Rock Ventures, USA
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John Kuriyan,
University of California, Berkeley, USA
*
Ruth H. Palmer,
University of Gothenburg, Sweden
Richard M. Marais,
Cancer Research UK Manchester Institute, UK
How Far Are We from Implementing Precision Medicine in Melanoma?
How Far Are We from Implementing Precision Medicine in Melanoma?
09:00—11:15
Pathways of Kinase Function
Meeting has ended...abstracts no longer viewable online.
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René H. Medema,
Netherlands Cancer Institute, Netherlands
Tony Hunter,
The Salk Institute for Biological Sciences, USA
pHisphorylation in Cell Signaling
pHisphorylation in Cell Signaling
Coffee Break
Susan S. Taylor,
University of California, San Diego, USA
Lessons Learned from PKA: from Motifs to the Dynamic Assembly of Isoform-specific Macromolecular Switches
Lessons Learned from PKA: from Motifs to the Dynamic Assembly of Isoform-specific Macromolecular Switches
Ruth H. Palmer,
University of Gothenburg, Sweden
Regulation of Anaplastic Lymphoma Kinase Signaling during Development and in Neuroblastoma
Regulation of Anaplastic Lymphoma Kinase Signaling during Development and in Neuroblastoma
Kazuki Hattori,
University of Tokyo, Japan
Short Talk: ASK1 Signaling Regulates Brown Adipocyte Maturation
Short Talk: ASK1 Signaling Regulates Brown Adipocyte Maturation
17:00—19:00
Kinases In Cancer Development and Progression
Meeting has ended...abstracts no longer viewable online.
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Ruth H. Palmer,
University of Gothenburg, Sweden
Charles A C Williams,
University of Dundee, UK
Short Talk: Erk5 is a Key Regulator of ES Cell Pluripotency: Identification of Klf2 as a Novel Erk5 Substrate
Short Talk: Erk5 is a Key Regulator of ES Cell Pluripotency: Identification of Klf2 as a Novel Erk5 Substrate
René H. Medema,
Netherlands Cancer Institute, Netherlands
Mitotic Checkpoint Kinases in Cancer Development and Treatment
Mitotic Checkpoint Kinases in Cancer Development and Treatment
Roger J. Daly,
Monash University, Australia
Short Talk: Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases
Short Talk: Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases
Oliver Hantschel,
Swiss Federal Institute of Technology Lausanne, Switzerland
Short Talk: Differential Signaling Networks of Bcr-Abl p210 and p190 Kinases in Leukemia Cells Defined by Functional Proteomics
Short Talk: Differential Signaling Networks of Bcr-Abl p210 and p190 Kinases in Leukemia Cells Defined by Functional Proteomics
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Franchise Targets in Drug Discovery
Meeting has ended...abstracts no longer viewable online.
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Dorothee Kern,
Brandeis University, HHMI, USA
Reid M. Huber,
Third Rock Ventures, USA
Janus Activated Kinases – Past, Present and Future
Janus Activated Kinases – Past, Present and Future
Andrew Wylie,
KSQ Therapeutics, USA
Targeting an Old Dog with New Tricks – BCR-ABL1 and ABL001
Targeting an Old Dog with New Tricks – BCR-ABL1 and ABL001
Coffee Break
Pasi A. Jänne,
Harvard Medical School, USA
EGFR – Third-Generation Approaches to Drug Discovery
EGFR – Third-Generation Approaches to Drug Discovery
Shiva Malek,
Genentech, Inc., USA
Kinases as Molecular Switches: Catalytic and Non-Catalytic Functions of RAF Reveal Novel Insights into Oncogenic Activation
Kinases as Molecular Switches: Catalytic and Non-Catalytic Functions of RAF Reveal Novel Insights into Oncogenic Activation
Tamer Ahmed,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: Mechanism-Based Strategies to Overcome Intrinsic and Acquired RAF Inhibitor Resistance in BRAF-Mutant Tumors
Short Talk: Mechanism-Based Strategies to Overcome Intrinsic and Acquired RAF Inhibitor Resistance in BRAF-Mutant Tumors
17:00—19:00
Emerging Pathways in Kinase Inhibitor Discovery
Meeting has ended...abstracts no longer viewable online.
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Christoph Lengauer,
Blueprint Medicines, USA
Giordano M. Caponigro,
Novartis Institutes for BioMedical Research, USA
CDK4/6
CDK4/6
Michael Rothenberg,
Loxo Oncology, USA
Developing Inhibitors Against Uncommon Oncogenic Kinases
Developing Inhibitors Against Uncommon Oncogenic Kinases
Shohei Koide,
New York University Langone Health, USA
Developing Novel Inhibition Strategies using Monobodies
Developing Novel Inhibition Strategies using Monobodies
Vitaliy V. Bondar,
Baylor College of Medicine, USA
Short Talk: p21-Activated Kinases Modulate ATXN1 Levels Providing Potential Therapeutic Entry Point for Spinocerebellar Ataxia Type 1
Short Talk: p21-Activated Kinases Modulate ATXN1 Levels Providing Potential Therapeutic Entry Point for Spinocerebellar Ataxia Type 1
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Next-Generation Approaches to Kinase Inhibition
Meeting has ended...abstracts no longer viewable online.
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Reid M. Huber,
Third Rock Ventures, USA
Christoph Lengauer,
Blueprint Medicines, USA
Crafting Highly Selective Kinase Inhibitors - From Impossible to the Clinic
Crafting Highly Selective Kinase Inhibitors - From Impossible to the Clinic
Dorothee Kern,
Brandeis University, HHMI, USA
Ancient Origins of Allosteric Activation in Kinases – Exploitation for Novel Cancer Drugs
Ancient Origins of Allosteric Activation in Kinases – Exploitation for Novel Cancer Drugs
Coffee Break
Soumya S. Ray,
Schrödinger, USA
Short Talk: Role of Active Site Water Molecules in Designing Potent Selective Kinase Inhibitors
Short Talk: Role of Active Site Water Molecules in Designing Potent Selective Kinase Inhibitors
David E. Puleo,
Yale University, USA
Short Talk: Identification and Characterization of Small Molecule Binders of the JAK2 Pseudokinase Domain
Short Talk: Identification and Characterization of Small Molecule Binders of the JAK2 Pseudokinase Domain
Johanna Elisabeth Mayrhofer,
University of Innsbruck, Austria
Short Talk: Recording of RAF Kinase:Drug Interactions in vivo
Short Talk: Recording of RAF Kinase:Drug Interactions in vivo
14:30—16:30
Workshop: Emerging Methodological Approaches to Kinase Research
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Shiva Malek,
Genentech, Inc., USA
Tarjani M. Thaker,
University of California, San Francisco, USA
Defining the HER2 Interactome by Proximity-Based Extracellular Tagging
Defining the HER2 Interactome by Proximity-Based Extracellular Tagging
Katelyn B. Connell,
Biodesy, USA
A High-Throughput Method for Inhibitor-Induced Conformational Changes in kinases
A High-Throughput Method for Inhibitor-Induced Conformational Changes in kinases
Rodrigo Maillard,
Georgetown University, USA
Investigating the Conformational Landscape of Protein Kinase A with Optical Tweezers
Investigating the Conformational Landscape of Protein Kinase A with Optical Tweezers
Khalil A. Davis,
Francis Crick Institute, UK
Genetically Encoded Photocrosslinking Amino Acids for In-Cell Kinase Substrate Identification
Genetically Encoded Photocrosslinking Amino Acids for In-Cell Kinase Substrate Identification
Michael Z. Lin,
Stanford University School of Medicine, USA
Quantitative Control of Cell Signaling by Single-Chain Photoswitchable Kinases
Quantitative Control of Cell Signaling by Single-Chain Photoswitchable Kinases
Matthew Robers,
Promega Corporation, USA
Kinome-Wide Profiling of Target Engagement and Residence Time in Living Cells Using NanoBRET
Kinome-Wide Profiling of Target Engagement and Residence Time in Living Cells Using NanoBRET
17:00—19:00
Kinase Inhibitor Resistance
Meeting has ended...abstracts no longer viewable online.
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Natalia Jura,
University of California, San Francisco, USA
Rani E. George,
Dana-Farber Cancer Institute, USA
Differential Mechanisms of ALK Inhibitor Resistance
Differential Mechanisms of ALK Inhibitor Resistance
Matthew A. Smith,
Moffitt Cancer Center, USA
Using Proximity Ligation Assays to Interrogate RTK Activity in Cancers
Using Proximity Ligation Assays to Interrogate RTK Activity in Cancers
Ethan Ahler,
University of Washington, USA
Short Talk: High-Throughput Mutagenesis Reveals Novel Mechanisms of Drug Resistance in the Oncogene Src Kinase
Short Talk: High-Throughput Mutagenesis Reveals Novel Mechanisms of Drug Resistance in the Oncogene Src Kinase
James Duncan,
Fox Chase Cancer Center, USA
Short Talk: Exploring the "Dark" Kinome Using Chemical Proteomics
Short Talk: Exploring the "Dark" Kinome Using Chemical Proteomics
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Kinase Signaling and Subcellular Context
Meeting has ended...abstracts no longer viewable online.
*
Susan S. Taylor,
University of California, San Diego, USA
John Kuriyan,
University of California, Berkeley, USA
Specificity in Kinase Pathways Downstream of the T Cell Receptor
Specificity in Kinase Pathways Downstream of the T Cell Receptor
John D. Scott,
University of Washington, USA
Guiding Signals through Anchored Enzyme Complexes
Guiding Signals through Anchored Enzyme Complexes
Coffee Break
Natalia Jura,
University of California, San Francisco, USA
New Insights into Control of HER3 Receptor Pseudokinase Signaling
New Insights into Control of HER3 Receptor Pseudokinase Signaling
Chris Phillips,
AstraZeneca, UK
Short Talk: Mechanistic Insights into ATM Activation from Cryo-Electron Microscopy: Open and Closed Dimers
Short Talk: Mechanistic Insights into ATM Activation from Cryo-Electron Microscopy: Open and Closed Dimers
Andrei V. Karginov,
University of Illinois at Chicago, USA
Short Talk: Mimicking Transient Activation of Protein Kinases in Living Cells
Short Talk: Mimicking Transient Activation of Protein Kinases in Living Cells
17:00—18:45
Systems and Synthetic Biology of Kinases
Meeting has ended...abstracts no longer viewable online.
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John Kuriyan,
University of California, Berkeley, USA
Forest M. White,
Massachusetts Institute of Technology, USA
High Temporal Resolution Analysis of Phosphorylation Mediated Signaling Networks
High Temporal Resolution Analysis of Phosphorylation Mediated Signaling Networks
James E. Ferrell Jr.,
Stanford University, USA
A Second Bistable Switch in Mitosis
A Second Bistable Switch in Mitosis
Emily F. Ruff,
University of Minnesota, USA
Short Talk: Novel Allosteric FRET Assays for Mechanistic Studies and Inhibitor Screening of Aurora A Kinase
Short Talk: Novel Allosteric FRET Assays for Mechanistic Studies and Inhibitor Screening of Aurora A Kinase
Zhong Yao,
University of Toronto, Canada
Short Talk: A Global Analysis of The Receptor Tyrosine Kinase - Protein Phosphatase Interactome
Short Talk: A Global Analysis of The Receptor Tyrosine Kinase - Protein Phosphatase Interactome
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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