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This meeting took place in 2019



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Windows on the Brain: Formation and Function of Synapses and Circuits and their Disruption in Disease (A6)


Organizer(s) Kristin Scott, Paola Arlotta, Rui M. Costa and Yimin Zou
January 21—25, 2019
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Oct 17, 2018
Abstract Deadline: Oct 25, 2018
Scholarship Deadline: Oct 17, 2018
Discounted Registration Deadline: Nov 28, 2018

Sponsored by Takeda Pharmaceutical Company Limited

Summary of Meeting:
A fundamental goal of neuroscience is to understand the molecular, cellular and activity-based mechanisms that control the formation and function of neural circuits and determine how these mechanisms become compromised in neurodevelopmental, psychiatric and neurodegenerative disorders. Over the past two decades, molecular neuroscientists have identified key molecules and mechanisms that underlie synapse development, activity and stability. Meanwhile, the study of neuronal circuits has been revolutionized by new methods to visualize and map circuits in living animals, as well as the development of approaches to control neuronal activity. Finally, disease researchers have identified genes associated with neurodevelopmental and psychiatric disorders and neurodegenerative diseases. Animal models of these diseases are proving useful to understand how dysfunction of affected genes and proteins contributes to disease pathology. Although these fields are working on the same process, no small highly interactive “Keystone Symposia-style” meeting brings these three groups together in the same room. This symposium will bring together leaders working on synapse development and function, circuit structure and function, and the study of brain disease, believing with confidence that mutually beneficial insights will emerge from discussing each other’s work.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Monday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, January 26 in order to fully experience the meeting.

MONDAY, JANUARY 21

4:00—8:00 PM
Arrival and Registration

Sagebrush Lobby & Cantina
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sagebrush Lobby & Cantina

TUESDAY, JANUARY 22

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Kristin Scott, University of California, Berkeley, USA

Anirvan Ghosh, Biogen, USA
Molecular Foundations of Neural Circuit Development

9:00—11:30 AM
Patterning and Wiring of the Nervous System
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Tony Koleske, Yale University, USA

Paola Arlotta, Harvard University, USA
Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex

Coffee Break

Nenad Sestan, Yale School of Medicine, USA
Cell Fate Determination in the Cerebral Cortex

Yimin Zou, University of California, San Diego, USA
Polarity Proteins in Axon and Synapse Development

Franck Polleux, Columbia University, USA
Slit-Robo Signaling Links Synapse Specificity with Functional Circuit Wiring

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:00 PM
Synapse Development and Function
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Shernaz X. Bamji, University of British Columbia, Canada

Nils Brose, Max Planck Institute of Experimental Medicine, Germany
Synaptic Vesicle Priming and the Unique Features of Regulated Exocytosis at Nerve Cell Synapses

Tony Koleske, Yale University, USA
Receptor-Mediated Cytoskeletal Control of Dendrite and Synapse Development and Function

Nicola J. Allen, The Salk Institute for Biological Studies, USA
The Role of Astrocytes in Synapse Formation and Function

Daniel Alfonso Colón-Ramos, Yale School of Medicine, USA
Building a Brain: Systematic Examination of the Logic of Brain Connectivity in C. elegans

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 1

Chamisa Ballroom 2

WEDNESDAY, JANUARY 23

8:00—9:00 AM
Breakfast

Sagebrush Lobby & Cantina
9:00—11:30 AM
Activity-Dependent Synapse Formation and Plasticity
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Nicola J. Allen, The Salk Institute for Biological Studies, USA

Anne E. West, Duke University Medical Center, USA
Chromatin Regulation of Synapse Maturation and Plasticity

Graeme W. Davis, University of California, San Francisco, USA
Homeostatic Mechanisms that Regulate Activity

Coffee Break

Shernaz X. Bamji, University of British Columbia, Canada
Post-Translational Palmitoylation and its Regulation of Synaptic Plasticity

Matthew B. Dalva, Thomas Jefferson University, USA
The Nanoscale Organization of Glutamate Receptor Subtypes Is Optimized for Synaptic Function and Plasticity

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
2:30—4:30 PM
Workshop: Synapse Formation and Plasticity

Chamisa Ballroom 1
* Yimin Zou, University of California, San Diego, USA

Ewoud Schmidt, Columbia University, USA
Humanization of SRGAP2C Expression Increases Cortico-Cortical Connectivity in the Mouse Brain

Jaewon Ko, Daegu Gyeongbuk Institute of Science and Technology, South Korea
IQSEC3 Controls Activity-Dependent GABAergic Synapse Development

Seok-Kyu Kwon, Korea Institute of Science and Technology, South Korea
Mitochondrial Fission Regulates Presynaptic Function and Axon Branching by Limiting Axonal Mitochondrial Size

Joshua E. Mayfield, University of California, San Diego, USA
Defining a Role for the Secretory Pathway Kinase Fam20C in the Brain

Christina Chatzi, Oregon Health & Science University, USA
Exercise-Induced Enhancement of Synaptic Function Triggered by the Inverse BAR Protein, Mtss1L

Graziella Di Cristo, University of Montreal, Canada
mTOR Inhibition Restricted to a Postnatal Sensitive Period Rescues the Deficits in GABAergic PV Cell Connectivity and Social Behavior Caused by Loss of Tsc1

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:15 PM
Connectomics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Rui M. Costa, Columbia University, USA

H. Sebastian Seung, Princeton University, USA
Models of Cortical Learning Are Constrained by Functional Connectomics

Anthony Zador, Cold Spring Harbor Laboratory, USA
Sequencing the Connectome

Kristin Scott, University of California, Berkeley, USA
Tracing Gustatory Circuits in the Fly Brain

Fred Shen, University of Michigan, USA
Short Talk: Multimodal Interrogation of Neuron Morphology, Connectivity, and Molecular Identity Using Novel Clearing and Expansion Technology

Hanqing Liu, The Salk Institute for Biological Studies, USA
Short Talk: Single-Cell Epigenomic Profiling Uncovers Regulatory Diversity of Brain Cell Types

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 2

Chamisa Ballroom 2

THURSDAY, JANUARY 24

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:00 AM
Plasticity in Neural Circuits
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Sandeep Robert Datta, Harvard Medical School, USA

Di Lu, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Short Talk: Emergence of Sequence Ensembles of Striatal D1 and D2 Neurons with Distinct Temporal Patterns during Motor Learning

Rui M. Costa, Columbia University, USA
Mechanisms Underlying the Generation and Learning of Novel Actions

Michele Pignatelli, Massachusetts Institute of Technology, USA
Short Talk: Engram Cell Excitability State Determines the Efficacy of Memory Retrieval

Coffee Break

Jun Ding, Stanford University School of Medicine, USA
Short Talk: Regulation of Short-Term and Long-Term Plasticity of Corticostriatal Synapses by Synucleins

Kaitlyn Ellis, University of Utah, USA
Short Talk: Biased Randomness: A Connectivity Mechanism for Associative Brain Centers

Annie Handler, Rockefeller University, USA
Short Talk: Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Synaptic Plasticity in Associative Learning

11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:00 PM
Neural Circuits for Sensory Processing
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Kristin Scott, University of California, Berkeley, USA

M. Eugenia Chiappe, Champalimaud Neuroscience Programme, Portugal
Motor-Context Dependent Active Visual Control of Locomotion

Salil Bidaye, University of California, Berkeley, USA
Central Neurons for Walking Control in Drosophila

Sandeep Robert Datta, Harvard Medical School, USA
A Systematic Representation of Odor Space in Cortex

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2

FRIDAY, JANUARY 25

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:00 AM
Therapeutics for Nervous System Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Chris Towne, Circuit Therapeutics, USA
A Circuit-Based Approach to CNS Drug Discovery: Integrating Optogenetics and Single-Cell Genomics

Yeri J. Song, University of Pennsylvania, USA
Short Talk: Altered Ionotropic Receptor Maturation and Intracortical Connectivity in the Impaired Auditory Critical Periods of Fragile X Knockout Mice

Changuk Chung, Korea Institute of Science and Technology, South Korea
Short Talk: Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice

Coffee Break

Christopher E. Henderson, Biogen Inc., USA
Understanding and Treating ALS

Barbara Terzic, University of Pennsylvania, USA
Short Talk: Cell Type-Specific Dissection of CDKL5 Function in vivo Using Mouse Models

11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—6:45 PM
Modeling Disorders of the Nervous System
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Paola Arlotta, Harvard University, USA

Ravi Jagasia, Roche Innovation Center Basel, Switzerland
UBE3A Modulates Retrotransposon-Derived GAG Proteins Involved Extracellular Vesicle Release in a Angelman's Disease Relevant Manner

Inbal Israely, Columbia University, USA
Short Talk: Spine Competition during Plasticity in Health and Disease

Rebecca Muhle, Yale School of Medicine, USA
Short Talk: Immunohistochemistry and Single-Cell Transcriptome Analysis Reveal Patterns of Neurodevelopmental Risk Gene Expression during Corticogenesis

Bidisha Chattopadhyaya, Centre Hospitalier Universitaire Sainte-Justine, Canada
Short Talk: p75 Neurotrophin Receptor Regulates the Timing of Maturation of Cortical Parvalbumin Cell Connectivity and Promotes Ocular Dominance Plasticity in Adult Visual Cortex

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Chamisa Ballroom 2

SATURDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Takeda Pharmaceutical Company Limited

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 NS108719-01

Funding for this conference was made possible (in part) by 1 R13 NS108719-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Biogen


Circuit Therapeutics


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179