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This meeting took place in 2019


Here are the related meetings in 2020:
Transforming Vaccinology (L2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Approaches to Vaccines and Immune Monitoring (J5)


Organizer(s) Peter D. Kwong, Brandon DeKosky and Jeffrey B. Ulmer
February 10—14, 2019
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 23, 2018
Abstract Deadline: Nov 7, 2018
Scholarship Deadline: Oct 23, 2018
Discounted Registration Deadline: Dec 6, 2018

Supported by Directors' Fund


Summary of Meeting:
Vaccines address public health issues ranging from pandemic outbreaks to childhood disease. Despite this diversity, molecular approaches are beginning to find broad application. This Keystone Symposia conference seeks to bring together antibody aficionados, B cell immunologists, structural biologists, and vaccine developers from government, academia, biotechnology, and major pharmaceutical companies to review the utility of structure-based vaccine design and antibody-based immune monitoring, and in doing so hope to transform standard approaches of vaccine development. This meeting aims (1) to provide examples of the ”antibody-to-vaccine” paradigm for RSV, CMV and other pathogens that have resisted standard vaccinology; (2) to describe procedures whereby B cells can be taught to make the right antibodies; (3) to describe molecular approaches for vaccine improvement; and (4) to discuss how molecular approaches can be used to speed development (as may be needed, for example, in the case of pandemics) and to reduce developmental and regulatory costs (for vaccines in general and in particular to enable provision to the developing world). Overall, we seek to integrate molecular approaches for vaccine development and read-out with other transformative advances including mRNA delivery, next-generation sequencing of B cell transcripts, and control of B cell-T cell interactions. This conference will be held jointly with a Keystone Symposia conference on B Cell-T Cell Interactions and several shared sessions will highlight synergistic areas of research between these communities.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 15 in order to fully experience the meeting.

SUNDAY, FEBRUARY 10

4:00—8:00 PM
Arrival and Registration

Longs Peak Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, FEBRUARY 11

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
8:00—9:00 AM
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Facundo D. Batista, Ragon Institute of MGH, MIT and Harvard, USA

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
The B Cell Immune Response to Infection and Vaccination

9:00—9:30 AM
Coffee Break

Longs Peak Foyer
9:30—11:45 AM
Targeting Appropriate Immune Responses for Structure-Based Design
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Gary J. Nabel, Sanofi, USA

* Erica Ollmann Saphire, The Scripps Research Institute, USA

Dennis R. Burton, The Scripps Research Institute, USA
From Antibody to Vaccine

George Georgiou, University of Texas at Austin, USA
Molecular Definition of Protective Serum Responses from Vaccination and for Immune Monitoring

Peter D. Kwong, NIAID, National Institutes of Health, USA
Antibody-Guided Structure-Based Vaccines: Challenges and Opportunities

Evelien M. Bunnik, University of Texas Health Science Center, USA
Short Talk: Naturally Acquired Protective Humoral Immunity Against Malaria

Nisreen Mamdouh Ahmed Okba, Erasmus MC, Netherlands
Short Talk: Antibody Responses as Blueprint for MERS-CoV Rational Vaccine Design

Andrew McGuire, Fred Hutchinson Cancer Research Center, USA
Short Talk: An Anti-gH/gL Antibody that Neutralizes Dual-Tropic Infection Defines a Site of Vulnerability on Epstein-Barr Virus


Following Session is for B Cell-T Cell Interactions (J6)

9:30—11:30 AM
Tfh Biology
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Carola G. Vinuesa, Australian National University, Australia
Human Tfh Biology

Hai Qi, Tsinghua University, China
Guidance Cues for Tfh Cells

Shane Crotty, La Jolla Institute for Immunology, USA
Tfh Cell and Germinal Center B Cell Responses in the Context of Infections and Vaccines

* Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
Short Talk: PI3 Kinase-Mediated Pathways Orchestrate T and B Cell Contributions to Humoral Responses during Immunization and Infection

Stephanie C. Eisenbarth, Yale University, USA
Short Talk: A Unique Subset of Tfh Cells Drives High-Affinity IgE Production

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Colorado Rockies Ballroom
1:00—10:00 PM
Poster Viewing

Colorado Rockies Ballroom
2:30—4:30 PM
Workshop 1: Molecular Design of Vaccines 

Grays/Longs Peak
* Neil P. King, University of Washington, USA

* Guillaume B.E. Stewart-Jones, National Institutes of Health, USA
Structure-Based Design of Nipah and Parainfluenza Virus F Glycoprotein Vaccines

Bruno Emanuel Correia, École Polytechnique Fédérale de Lausanne, Switzerland
Trivalent Epitope-Focused Vaccine Elicits RSV Neutralization in NHPs

Timothy Caradonna, Ragon Institute, USA
Molecular Grafting of a Complex Broadly Neutralizing Influenza Hemagglutinin Epitope

Syed M. Moin, National Institutes of Health, USA
A Bi-Component Nanoparticle Presenting Group 1 and 2 Influenza Hemagglutinin Stem Trimers Confers Inter-Group Heterosubtypic Protections

Seyhan Boyoglu-Barnum, National Institutes of Health, USA
Computationally Designed Nanoparticles Displaying Influenza Virus Hemagglutinins of Seasonal Vaccine Strains

Cara Chao, NIAID, National Institutes of Health, USA
An Isopeptide-Linking Platform to Incorporate Trimeric Antigens into Self-Assembling Nanoparticle Immunogens

Sean H. Kelly, Duke University, USA
Molecular Design of Mucus-Penetrating Nanovaccines Enables Sublingual Peptide Immunization

Kshitij Wagh, Los Alamos National Laboratory, USA
A Novel Glycan Shield Prediction Strategy Reveals that HIV-1 Env Glycan Shield Completeness at Transmission Determines Development of Neutralization Breadth in Natural Infection


Following Session is for B Cell-T Cell Interactions (J6)

2:30—4:30 PM
Workshop 1: Biology of B Cell-T Cell Interactions

Quandary Peak
* Dirk Baumjohann, Ludwig-Maximilians-University Munich, Germany
T Cell-Expressed MicroRNAs Critically Regulate Germinal Center Tfh and B Cell Function and Maintenance

Numana Bhat, Sanford Burnham Prebys Medical Discovery Institute, USA
Regnase-1 Is Essential for Controlling Aberrant Differentiation of B Cells during Maturation and T Dependent B Cell Response

Takeshi Inoue, Osaka University, Japan
Germinal-Center-Mediated Memory B Cell Development Is Driven by Cooperation of Metabolic Fitness and Survival

Yisi Lu, Yale University, USA
CD4+ Follicular Regulatory T Cells Improve the Protective Antigen-Specific Germinal Center B Cell Responses and Promote Memory

Laura Vella, University of Pennsylvania/CHOP, USA
Cell States in the Thoracic Duct: Circulatory Intermediates of T Follicular Helper Cells between Lymph Nodes and Blood

Tibor Z. Veres, NIAID, National Institutes of Health, USA
Visualizing the Emerging Humoral Immune Response to Vaccines in 3D

Lea Simoni, Boston Children's Hospital, USA
Role of C4A and C4B in SLE Susceptibility and Development

Hai-Hui (Howard) Xue, University of Iowa, USA
Ezh2 Couples Epigenetic and Transcriptional Mechanism to Program Differentiation of Follicular Helper T Cells

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Tackling Difficult Pathogens with Molecular-Based Vaccine Design 
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Bruno Emanuel Correia, École Polytechnique Fédérale de Lausanne, Switzerland

* William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA

Ian A. Wilson, The Scripps Research Institute, USA
Towards a Universal Influenza Virus Vaccine: Is it Better to Target the HA Head or Stem?

Sarah F. Andrews, National Institutes of Health, USA
Identifying Common Antibody Lineages Elicited by Influenza Vaccination

Erica Ollmann Saphire, The Scripps Research Institute, USA
Broad-Spectrum Recognition of the Ebolaviruses

Andrew Flyak, California Institute of Technology, USA
Short Talk: Common Genetic Signatures in HCV bNAbs: Implications for Vaccine Design

Johannes P.M. Langedijk, Janssen Vaccines and Prevention, Netherlands
Short Talk: Stabilization of Conserved Metastable Structural Elements in Class I Fusion Proteins for Optimal Vaccine Design


Following Session is for B Cell-T Cell Interactions (J6)

5:00—7:00 PM
Regulation of the GC Response
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Andre Ballesteros-Tato, University of Alabama at Birmingham, USA
IL-6 Stabilizes the GC-Tfh Cell Response to Influenza by Inhibiting IL-2 Responsiveness

Michelle A. Linterman, Babraham Institute, UK
Aging and the Germinal Centre Response

Di Yu, Australian National University, Australia
Follicular Cytotoxic T Cells: Friends or Foes?

* Peter Sage, Harvard Medical School, USA
Short Talk: TFR Cells Dynamically Regulate Distinct Stages of B Cell Responses

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 1

Colorado Rockies Ballroom

TUESDAY, FEBRUARY 12

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
8:00—9:00 AM
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Hedda Wardemann, German Cancer Research Center, Germany

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Antibody Responses and Antibodies

9:00—9:30 AM
Coffee Break

Longs Peak Foyer
9:30—11:45 AM
B Cell Ontogenies as Vaccine Templates
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Dennis R. Burton, The Scripps Research Institute, USA

* Andrew McGuire, Fred Hutchinson Cancer Research Center, USA

Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
Insight into Developing Immune Systems from Pediatric Studies of HIV Infection

William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA
Germline-Targeting Vaccine Design

Frederick W. Alt, Boston Children's Hospital, USA
Novel Mouse Models for Lineage-Based Vaccine Studies

Maya Sangesland, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Germline-Encoded Affinity Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies Against Influenza Virus

Andrew J. Borst, University of Washington, USA
Short Talk: Germline VRC01 Antibody Recognition of a Modified Clade C HIV-1 Envelope Trimer and a Glycosylated HIV-1 gp120 Core

Amelia Escolano, Rockefeller University, USA
Short Talk: Prime Immunization Expands Precursors of Anti HIV-1 Broadly Neutralizing Antibodies in Mice, Rabbits and Rhesus Macaques


Following Session is for B Cell-T Cell Interactions (J6)

9:30—11:30 AM
Germinal Center Biology
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Gabriel D. Victora, Rockefeller University, USA
Clonal Dynamics of the Antibody Response

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Germinal Center B Cell Confinement Mechanisms

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Selection Mechanisms of Germinal Center Cells into the Memory B Cell Compartment

* Kim Good-Jacobson, Monash University, Australia
Short Talk: Humoral Responses to Chronic Viral and Parasitic Infection are Underpinned by Dysregulation of the Polycomb Repressive Complexes

Mark R. Boothby, Vanderbilt University Medical Center, USA
Short Talk: Imaging & Manipulating Nutrient Micro-Milieux as B Cells Effect Humoral Immunity

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Colorado Rockies Ballroom
1:00—10:00 PM
Poster Viewing

Colorado Rockies Ballroom
2:30—4:30 PM
Workshop 2: Antibody Characterization and B Cell Sequencing

Grays/Longs Peak
* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland

* Laura M. Walker, Adimab LLC, USA

Kathryn Hastie, The Scripps Research Institute, USA
Convergent Structures Reveal Key Residues to Enhance Potency and Breadth for Pan-Lassa Virus Neutralization

Jonathan McDaniel, University of Texas at Austin, USA
R21 Vaccine Elicits Near Germline Serum Antibodies that Potently Inhibit Malaria Infection

Lan Zhang, Merck, USA
Characterization of Potent RSV Neutralizing Antibodies Isolated from Human Memory B Cells and Identification of a Novel RSV/hMPV Cross-Neutralizing Epitope

Bharat Madan, University of Kansas, USA
In vitro Evolution of a Vaccine-Elicited Antibody Identifies New Capabilities for Effective Fusion Peptide-Based HIV Neutralization

Lauren E. Gentles, University of Washington, USA
Complete Antigenic Mapping of an Influenza A Virus Non-Neutralizing Antibody

Goran Bajic, Harvard Medical School, USA
Autoreactivity Profiles of Influenza Hemagglutinin Broadly Neutralizing Antibodies

Pablo Canales Herrerias, Institut Pasteur, France
Characterizing Autoantibody-Producing Cells in Thrombocytopenic Patients for Secretion Rate and Affinity for a Platelet Autoantigen

Karyn McFadden, Amgen, USA
Rapid Discovery of Functional Antibodies from Primary Cells using an Optofluidic Single-Cell Screening Platform


Following Session is for B Cell-T Cell Interactions (J6)

2:30—4:30 PM
Workshop 2: B and T Cell Responses in the Mucosa

Quandary Peak
Yoshimasa Takahashi, National Institute of Infectious Diseases, Japan
Local Germinal Center B Cells Target Conserved Epitopes that Are Occluded in Native Viral Antigen

Adi Biram, Weizmann Institute of Science, Israel
Differential Roles for B Cell Receptor Affinity in Colonization of the Subepithelial Dome and Infiltration into Pre-Existing Germinal Centers within Peyer's Patches

Rebecca A. Elsner, University of Pittsburgh, USA
IL-12 Production during Salmonella Infection Suppresses T Follicular Helper Cell Differentiation

Steven Erickson, University of Chicago, USA
Polyreactive B Cells in the Mucosa

Raud Razzaghi, National Institutes of Health, USA
Regulation of Fas-Mediated Apoptosis in Mucosal Germinal Center B Cells

Jacqueline H.Y. Siu, Cambridge University, UK
Investigating Non-Conventional Memory B Cells in Human Lymphoid Tissues

Marisa Stebegg, University of Cambridge, UK
Faecal Microbiota Transplantation Restores the Reduced Germinal Centre Response in Peyer's Patches of Aged Mice

* Duane R. Wesemann, Harvard Medical School, USA
Naïve Ig Repertoire Polyreactivity Is a Tunable Feature

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Clinical Results from Molecular-Based Vaccines
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Julie Ledgerwood, NIAID, National Institutes of Health, USA

* Drew Weissman, University of Pennsylvania, USA

Sumana Chandramouli, GlaxoSmithKline Vaccines, USA
A Structural Biology Approach to Developing an HCMV Vaccine

Amy S. Espeseth, Merck & Co., USA
mRNA Vaccines Expressing Forms of RSV-F Protein Are Immunogenic and Protective in Preclinical Models of Respiratory Syncytial Virus Infection

Barney S. Graham, NIAID, National Institutes of Health, USA
Clinical Results from the Prefusion-Stabilized RSV F (DS-Cav1) Subunit Vaccine

Katherine Burgomaster, NIAID, National Institutes of Health, USA
Short Talk: Limited Cross-Reactive Antibody Responses Elicited by a ZIKV DNA Vaccine Candidate

Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Short Talk: Enhanced Efficacy of Anti-Liver-Stage Vectored Vaccines using a Prime-Target Immunisation Approach


Following Session is for B Cell-T Cell Interactions (J6)

5:00—7:00 PM
B Cells and Helper T Cells Outside of B Cell Follicles
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Virginia Pascual, Cornell University, USA
Novel Mechanism of Extrafollicular Help in Human SLE

Ziv Shulman, Weizmann Institute, Israel
Syk Proteasomal Degradation Regulates B Cell Fate in Germinal Centers

Troy D. Randall, University of Alabama at Birmingham, USA
Lung-Resident Memory B Cells

Jason Weinstein, Rutgers New Jersey Medical School, USA
Short Talk: STAT4 Regulates Pathogenic IL-21 and IFN-γ Production in T Follicular Helper (Tfh) Cells in Murine and Human Lupus

* Tullia C. Bruno, University of Pittsburgh, USA
Short Talk: Tumor-Infiltrating B Cells Co-Localize with CD4 T Effector Cells within Tertiary Lymphoid Structures to Present Antigen and Educate the Anti-Tumor Immune Response in Human Primary Tumors

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 2

Colorado Rockies Ballroom

WEDNESDAY, FEBRUARY 13

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
8:00—9:30 AM
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA

Facundo D. Batista, Ragon Institute of MGH, MIT and Harvard, USA
Importance of B Cell-T Cell Interactions in Mouse Vaccine Models

Hedda Wardemann, German Cancer Research Center, Germany
Development and Clonal Evolution of Human Memory B Cell Antibody Responses

9:30—10:00 AM
Coffee Break

Longs Peak Foyer
10:00—11:45 AM
Immune Monitoring of B Cell Responses
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Frederick W. Alt, Boston Children's Hospital, USA

* Brandon DeKosky, University of Kansas, USA

Michael Joseph Mina, Brigham and Women's Hospital / Harvard Medical School / School of Public Health, USA
Comprehensive Profiling of the Anti-Pathogen Antibody Repertoire with Phage Display and Deep Neural Networks for Infectious Disease and Vaccine Surveillance

Margaret E. Ackerman, Dartmouth College, USA
Measuring and Mining Serum Antibody Responses to Understand Protection from Infection

Gwo-Yu Chuang, NIAID, National Institutes of Health, USA
Short Talk: Delineating the Sequence Signature of a Multi-Donor Class of Human Antibodies that Broadly Neutralizes Influenza Viruses for Immune Monitoring of Vaccination Studies

Colin Havenar-Daughton, La Jolla Institute for Immunology, USA
Short Talk: Longitudinally Tracked, Rapid, Robust Antigen-Specific Germinal Center Responses and Somatic Hypermutation in Non-Human Primates After a Single Nanoparticle Vaccine Immunization

David B. Weiner, Wistar Institute, USA
Short Talk: Immunogenicity and Protection with A Low-Dose Intradermal Vaccine INO-4700 Against Middle East Respiratory Syndrome in Non-Human Primates


Following Session is for B Cell-T Cell Interactions (J6)

10:00—11:30 AM
B Cell Responses in Infectious Disease
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Patrick C. Wilson, University of Chicago, USA
The B Cell Response to Influenza and Vaccination

Katherine Kedzierska, University of Melbourne, Australia
B Cell and T Follicular Helper Cell Responses during Influenza Virus Infection and Vaccination

* Ian A. Cockburn, Australian National University, Australia
Short Talk: Chronic Antigen Exposure and Potent Antibody Feedback Limit Memory Responses to a Major Malaria Vaccine Candidate

Daniel Lingwood, Havard Medical School, USA
Short Talk: Natural Gene-Encoded Affinity for Cognate Antigen Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies against Influenza Virus

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Colorado Rockies Ballroom
1:00—10:00 PM
Poster Viewing

Colorado Rockies Ballroom
2:30—4:30 PM
Workshop 3: Molecular Probing of the Elicited Vaccine Response

Grays/Longs Peak
* Pierre Bruhns, Institut Pasteur, France

* George Georgiou, University of Texas at Austin, USA

Maryam Mukhamedova, NIAID, National Institutes of Health, USA
Characterization of RSV Antibody Repertoire to B Cells Elicited by Prefusion RSV F Subunit Protein (DS-Cav1)-Vaccinated Adult Volunteers

Raffaello Verardi, NIAID, National Institutes of Health, USA
Structural Studies of Human Norovirus Antibodies Isolated from Vaccines Reveal Basis for Broad Reactivity

Christopher Andrew Cottrell, The Scripps Research Institute, USA
Immunofocusing Antibody Responses to Target the HIV Env Fusion Peptide (FP) Epitope in Non-Human Primates (NHPs)

Zizhang Sheng, Columbia University, USA
Developmental Pathways for Vaccine-Induced Neutralizing Antibodies Targeting the HIV-1 Fusion Peptide Suggest a Low Barrier to Elicitation

Rajagopal Murugan, German Cancer Research Institute, Germany
Maturation of the Memory B Cell Response to Plasmodium Falciparum Circumsporozoite Protein (PfCSP) through Clonal Selection, Not Affinity Maturation

Elisabetta Frigimelica, GlaxoSmithKline Vaccines S.r.l., Italy
Characterization of the Human Antibody Repertoire Following Immunization with Meningococcus B Vaccine

Murillo Silva, Massachusetts Institute of Technology, USA
Saponin-MPLA Nanoparticulate Adjuvants Alter Lymph Flow and Enhance Early Antigen Acquisition by B Cells


Following Session is for B Cell-T Cell Interactions (J6)

2:30—4:30 PM
Workshop 3: B Cell-T Cell Interactions in Disease

Quandary Peak
Davide Angeletti, University of Gothenburg, Sweden
Outflanking B Cell and Antibody Immunodominance to Target Subdominant Influenza A Virus Epitopes

Rachael Bashford-Rogers, University of Oxford, UK
Mapping B Cell Receptor Repertoires in Six Immune-Mediated Diseases

Blair L. DeBuysscher, Fred Hutchinson Cancer Research Center, USA
Mapping the HIV Envelope-Specific B Cell Population in HIV-Unexposed Individuals

Marco De Giovanni, Ospedale San Raffaele Srl, Italy
Spatiotemporal Regulation of Type I Interferon Determines Antiviral CD4+ T Cell Polarization

* Joanna R. Groom, Walter and Eliza Hall Institute of Medical Research, Australia
TFH/TH1 Common Precursor Requires CXCR3-Dependent Interactions at the T:B Boarder

Shi-Hsia Hwa, Africa Health Research Institute, South Africa
Effects of Monoclonal Antibodies from TB Patient Lymph Node and Healthy Donor Blood on Mycobacterium tuberculosis Growth and Macrophage Infection

Amber Papillion, University of Alabama, USA
Interleukin 6 Prevents the Premature Contraction of the T Follicular Helper (Tfh) Cell Response to Influenza by Precluding IL-2 Responsiveness of GC-Tfh Cells

William T. Yewdell, Memorial Sloan Kettering Cancer Center, USA
Striking Features of the Memory B Cell Response to Influenza Infection

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Optimizing Vaccine Responses
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Peter D. Kwong, NIAID, National Institutes of Health, USA

* Ian A. Wilson, The Scripps Research Institute, USA

Neil P. King, University of Washington, USA
Computational Design of Protein Nanomaterials for Next-Generation Vaccine Design

Günther Staffler, AFFiRiS AG, Austria
Towards a Heart Attack Vaccine: PCSK9 as a Immunogen

Pierre Bruhns, Institut Pasteur, France
Monitoring Plasmablast Responses at the Single Cell Level

Sonia M. Maciejewski, NIAID, National Institutes of Health, USA
Short Talk: Distinct Correlates of Protection Among Closely Related ZIKV DNA Vaccines Identify a Critical Role for Antibody Quality Following Vaccination

Kimberly M. Cirelli, La Jolla Institute for Immunology, USA
Short Talk: Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance


Following Session is for B Cell-T Cell Interactions (J6)

5:00—7:00 PM
Memory Humoral Responses
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Marc K. Jenkins, University of Minnesota Medical School, USA
Memory T and B Cell Responses

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Heterogeneity of Memory B Cell Compartments

Marion Pepper, University of Washington, USA
Memory B Cells in Plasmodium Infection

* Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: A Splenic IgM Memory Subset Harboring Anti-Bacterial Specificities is Sustained from Persistent Mucosal Germinal Center Reactions

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 3

Colorado Rockies Ballroom

THURSDAY, FEBRUARY 14

7:00—8:00 AM
Breakfast

Colorado Rockies Ballroom
8:00—11:15 AM
Vaccines: Better, Faster and Less Expensive!
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Amy S. Espeseth, Merck & Co., USA

* Barney S. Graham, NIAID, National Institutes of Health, USA

Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Developing Vaccines against Pandemics and for the Developing World

Laura M. Walker, Adimab LLC, USA
Generation of Broad and Potent Neutralizing Antibodies to Speed Pandemic Responses

Coffee Break

* Jeffrey B. Ulmer, GlaxoSmithKline Vaccines, USA

* David B. Weiner, Wistar Institute, USA

Brandon DeKosky, University of Kansas, USA
Paired Heavy-Light Chain Sequencing and Display for Immune Monitoring of Vaccination and Natural Infection

Julie Ledgerwood, NIAID, National Institutes of Health, USA
Immune Monitoring to Increase the Likelihood of Phase 2 Success

Ami Patel, Wistar Institute, USA
Short Talk: Infection to Protection: An in vivo Approach for Rapid Delivery of DNA-Encoded Monoclonal Antibodies (DMAbs) Isolated Directly from Ebola Virus Disease Survivors and Other Infectious Diseases

Julia Lederhofer, NIAID, National Institutes of Health, USA
Short Talk: Augmented Immune Responses by Co-Immunization of Commercial Seasonal Influenza Vaccine and the HA Stem-Based Universal Influenza Vaccine Candidates

Daniel R. Ellis, University of Washington, USA
Short Talk: Co-Display of Multiple Antigenic Variants on Computationally-Designed Protein Nanomaterials as a Versatile Vaccine Platform


Following Session is for B Cell-T Cell Interactions (J6)

8:00—11:00 AM
Humoral Autoimmunity and Allergic Responses
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Rachel Ettinger, Viela Bio, USA
VIB4920, a Novel CD40L Antagonist, Decreased Disease Activity and Improved Biomarkers of Immune Activation in a Phase 1b, Proof-of-Concept Study in Rheumatoid Arthritis

Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Epitope Spreading in Autoimmune Germinal Centers

Coffee Break

* Maria A. Curotto de Lafaille, New York University School of Medicine, USA
Biology of IgE Affinity Maturation

Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone: Single Cell RNA and DNA Sequencing

Fleur du Pre, University of Oslo and Oslo University Hospital, Norway
Short Talk: A Celiac Disease Patient-Derived Anti-TG2 Antibody Is not Tolerized in Mice

Brigette Boast, Australian National University, Australia
Short Talk: ARPC1B-/- Mice Suggest a New Role for DOCK8 in the Murine Germinal Center Response

11:15 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—6:45 PM
Reducing Vaccine Risks and Costs
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Margaret E. Ackerman, Dartmouth College, USA

* Rino Rappuoli, GlaxoSmithKline Vaccines, Italy

Jeffrey B. Ulmer, GlaxoSmithKline Vaccines, USA
Molecular Approaches to Streamlining Vaccine Discovery and Development

Drew Weissman, University of Pennsylvania, USA
Advantages of an mRNA Vaccine Approach

Gary J. Nabel, Sanofi, USA
Innovation in Antibody Structure and Design to Optimize Protection and Improve Efficacy: Vaccine Implications


Following Session is for B Cell-T Cell Interactions (J6)

5:00—6:45 PM
T-Dependent B Cell Differentiation
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Brian J. Laidlaw, University of California, San Francisco, USA
Short Talk: Transcriptional Regulation of Memory B Cell Development Following Viral Infection

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Ikaros Prevents Autoimmunity by Promoting Anergy Induction and Restraining Toll-Like Receptor Signaling in B Cells

Robert Brink, Garvan Institute of Medical Research, Australia
Constant Region-Based Selection in the Germinal Center Reaction

* Kai-Michael Toellner, University of Birmingham, UK
Short Talk: CCL19/CCL21 Direct Memory B Cell Reentry in Reactive Lymph Nodes

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak

Following Session is for B Cell-T Cell Interactions (J6)

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Colorado Rockies Ballroom

FRIDAY, FEBRUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support from these exhibitors at this conference:

MicroMedicine 10x Genomics
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI143056-01

Funding for this conference was made possible (in part) by 1R13AI143056-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Adimab, Inc.


AFFiRiS AG


GlaxoSmithKline


Merck & Co., Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179