Keystone Resort Floorplan

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This meeting took place in 2019


Here are the related meetings in 2020:
Tumor Metabolism (C2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tumor Metabolism (B5)


Organizer(s) Lewis C. Cantley, Karen H. Vousden and Jeffrey A. Engelman
February 24—28, 2019
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 23, 2018
Abstract Deadline: Nov 27, 2018
Scholarship Deadline: Oct 23, 2018
Discounted Registration Deadline: Jan 8, 2019

Organized in collaboration with Cancer Research UK

Sponsored by Akebia Therapeutics and Cell Research

Summary of Meeting:
The fact that tumor cells have altered metabolism compared to their tissues of origin has been known for more than 90 years. Some commonly used chemotherapies, such as methotrexate, target metabolic enzymes. Over the past decade there has been a revival of interest in developing new therapies that target metabolic vulnerabilities of tumor cells. Dramatic improvements in technologies for monitoring tumor metabolism by mass spectrometry and by multiple modes of imaging have revealed that tumors evolve diverse alterations in metabolism in order to grow in the primary tissue and in metastatic sites. This conference will bring together scientists with a wide spectrum of expertise who are world leaders in this rapidly moving field. The conference includes talks from pharmaceutical scientists who are developing first-in-class drugs that target metabolic enzymes. In addition there will be presentations from academic scientists who are studying not only changes in metabolism in tumor cells, but also changes in metabolism in cells in the tumor microenvironment and in the whole body. The conference will also include poster sessions, short talks chosen from poster abstracts and plenty of time for discussion of each talk.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.

SUNDAY, FEBRUARY 24

4:00—8:00 PM
Arrival and Registration

Longs Peak Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, FEBRUARY 25

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Lewis C. Cantley, Weill Cornell Medicine, USA

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Requirements and Vulnerabilities of Cancer Cells

9:00 AM—12:15 PM
Cancer Cell Metabolism
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Dafna Bar-Sagi, New York University School of Medicine, USA

Joshua D. Rabinowitz, Princeton University, USA
Folate and NADH Metabolism

Coffee Break

Christian Metallo, University of California, San Diego, USA
Coordinating Flux through Amino Acid and Lipid Metabolism in Cancer

Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA
Therapeutic Interventions that Alter Metabolism

Kevin Marks, Agios Pharmaceuticals, USA
Targeting Metabolic Vulnerabilities in Cancer

Gerta Hoxhaj, Harvard School of Public Health, USA
Short Talk: Acute Stimulation of NADP Synthesis through Akt-Mediated Phosphorylation of NAD Kinase

Won Dong Lee, Technion – Israel Institute of Technology, Israel
Short Talk: SDH-Deficient Cells Increase Mitochondrial Reductive Flux through IDH2 Followed by a Reversal of CS Flux to Support Pyrimidine Biosynthesis

Shivani K. Thaker, University of California, Los Angeles, USA
Short Talk: Ketohexokinase Is Important for Lung Tumor Growth

12:15—5:00 PM
On Own for Lunch

12:15—1:00 PM
Poster Setup

Longs/Quandary Peaks
1:00—10:00 PM
Poster Viewing

Longs/Quandary Peaks
2:30—4:30 PM
Workshop: Nutrient Transport and Dependencies

Grays Peak
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Ariel Bensimon, CeMM – Research Center for Molecular Medicine, Austria
Functional Integration of the Core Cancer Transportome

Kivanc Birsoy, Rockefeller University, USA
Nutrient Dependencies of Cancer Cells

Ayelet Erez, Weizmann Institute of Science, Israel
c-MYC Induces Arginine Metabolism to Promote Cancer Survival under Glucose Starvation

Nora Kory, Massachusetts Institute of Technology, USA
SFXN1 Is A Mitochondrial Serine Transporter Required for One-Carbon Metabolism

Alexander Muir, Massachusetts Institute of Technology, USA
Absolute Quantification of Tumor Nutrients in Murine Models of Pancreatic and Lung Adenocarcinoma

Pankaj Kumar Singh, University of Nebraska Medical Center, USA
Metabolic Regulation of Therapy Outcome by Endoplasmic Reticulum Stress in Pancreatic Cancer

Ross Weber, Rockefeller University, USA
Loss of Mitochondrial Transporter SFXN1 Enables Cell Proliferation under Limited Cysteine

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:15 PM
Feeding the Cancer
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA

Eileen P. White, Rutgers University, USA
Autophagy Maintains Host and Tumor Metabolism and an Anti-Cancer Immune Response

Dafna Bar-Sagi, New York University School of Medicine, USA
Function and Regulation of Protein Scavenging in Mutant Ras Tumors

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway

Sanjeethan C. Baksh, Rockefeller University, USA
Short Talk: Extracellular Serine Dependence Restricts Differentiation in Oncogenic Stem Cells

Jihye Yun, Baylor College of Medicine, USA
Short Talk: High-Fructose Corn Syrup Enhances Intestinal Tumor Growth

Oliver Maddocks, University of Glasgow, UK
Short Talk: IDO1-Driven Tryptophan Utilisation Can Augment One-Carbon Metabolism in Pancreatic Cancer and Stromal Cells

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 1

Longs/Quandary Peaks

TUESDAY, FEBRUARY 26

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—11:15 AM
Metabolism, Microenvironment and Metastasis
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Elena Piskounova, Weill Cornell Medicine, USA

Martin O. Bergo, Karolinska Institutet, Sweden
Antioxidant Stimulation of Lung Cancer Metastasis

Richard White, Memorial Sloan Kettering Cancer Center, USA
A Role for Adipocytes in the Melanoma Microenvironment

Coffee Break

Aimee L. Edinger, University of California, Irvine, USA
Starving Cancer Cells to Death by Limiting Nutrient Access

Karen H. Vousden, Francis Crick Institute, UK
Metabolic Control of ROS and Tumour Progression

Stefan M. Schieke, University of Wisconsin-Madison, USA
Short Talk: Metabolic Dynamics Modulate Cancer Progression Through mROS/HIF-1a Axis

Christopher J. Halbrook, University of Michigan, USA
Short Talk: Macrophage-Epithelial Metabolic Crosstalk Impairs Chemotherapy in Pancreatic Cancer

Xiaobo Li, H.Lee Moffitt Cancer Center, USA
Short Talk: TAp63 Regulated lncRNA and its Downstream Effector in Human Breast Cancer Cell Metabolism

11:15 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Longs/Quandary Peaks
1:00—10:00 PM
Poster Viewing

Longs/Quandary Peaks
4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:15 PM
The Metabolism of ROS and Survival
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Gina DeNicola, Moffitt Cancer Center, USA

Navdeep S. Chandel, Northwestern University, USA
Mitochondria Metabolism and Cancer

Thales Papagiannakopoulos, New York University School of Medicine, USA
Uncovering Metabolic Bottlenecks in KRAS-Driven Lung Cancer

Timothy Humpton, Beatson Institute for Cancer Research, UK
ROS and Mitophagy Dependencies in Pancreatic Cancer

Veerle W.L.E. Daniels, Dana-Farber Cancer Institute, USA
Short Talk: Metabolic Perturbation Sensitizes Triple-Negative Breast Cancer Cells to BH3 Mimetics

Kenneth Olive, Columbia University, USA
Short Talk: Modulation of Cystine Import Induces Pancreatic Cancer-Selective Ferroptosis

George Poulogiannis, Institute of Cancer Research, UK
Short Talk: iKnife Couples Oncogenic PIK3CA with an Arachidonic Acid-Mediated Eicosanoid Storm

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, FEBRUARY 27

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—11:00 AM
Metabolism Outside the Tumor
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Kathryn E. Wellen, University of Pennsylvania, USA

Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Perturbations and Human Disease

Katja A. Lamia, The Scripps Research Institute, USA
Connecting Circadian Clocks and Cancer

Coffee Break

Vuk Stambolic, University Health Network, Canada
Obesity and Cancer

Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Metabolic Adaptation in Hemopoietic Malignancies

Julian J. Lum, British Columbia Cancer Agency, Canada
Short Talk: Autophagy Suppresses CD8+ T Cell Antitumor Responses through Glucose-Dependent Changes in Transcription

Steven Zhao, University of Pennsylvania, USA
Short Talk: Dietary Fructose Promotes de novo Lipogenesis from Microbiome-Derived Acetate

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Longs/Quandary Peaks
1:00—10:00 PM
Poster Viewing

Longs/Quandary Peaks
4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:15 PM
Metabolic Adaptation and the Response to Therapy
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA

Alec Kimmelman, New York University Langone Medical Center, USA
Identifying Metabolic Dependencies in Pancreatic Cancer

Lewis C. Cantley, Weill Cornell Medicine, USA
PI 3-Kinase and Cancer Metabolism

Kathryn E. Wellen, University of Pennsylvania, USA
Acetyl-CoA Metabolism in Chromatin Regulation and Tumorigenesis

Lei Shi, Massachusetts General Hospital, USA
Short Talk: Leveraging Reprogrammed Metabolism to Define Selective Vulnerabilities of IDH1 Mutated Cholangiocarcinoma Cells

Sindhu Carmen Sivakumaren, Dana-Farber Cancer Institute, USA
Short Talk: Targeting the PI5P4K Lipid Kinase Family in Cancer using Novel Covalent Inhibitors

Liang Zhao, Johns Hopkins University School of Medicine, USA
Short Talk: Inhibition Proximal Glycolysis and Disruption of Krebs Cycle by Broad-Targeting Glutamine Metabolism for Cancer Therapy

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 3

Longs/Quandary Peaks

THURSDAY, FEBRUARY 28

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—11:00 AM
Modeling Cancer Metabolism
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Karen H. Vousden, Francis Crick Institute, UK

Sarah-Maria Fendt, VIB Leuven, Belgium
Nutrient Metabolism in Cancer Cells

Costas A. Lyssiotis, University of Michigan, USA
Metabolic Networks in the Tumor Microenvironment

Coffee Break

Saverio Tardito, Beatson Institute for Cancer Research, Scotland
Reformulating Cell Culture Medium to Improve the Metabolic Fidelity of in vitro Models of Cancer

Jason R. Cantor, Morgridge Institute for Research, University of Wisconsin-Madison, USA
Short Talk: Use of Physiologic Media to Explore Genetic Dependencies in Cancer

Henry Däbritz, CRUK Beatson Institute, Scotland
Short Talk: Oncogenic Hras and Loss of Succinate Dehydrogenase B Synergise to Drive Kidney Neoplasia in a Genetically Engineered Mouse Model

Ashley Solmonson, University of Texas Southwestern Medical Center, USA
Short Talk: Inborn Errors of Metabolism: Evaluating Critical Metabolic Regulators of Mammalian Development

11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—6:45 PM
Imaging Cancer Metabolism in vitro and in vivo
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Oliver Maddocks, University of Glasgow, UK

Kevin M. Brindle, University of Cambridge, UK
Imaging Tumor Metabolism with Hyperpolarized 13C-Labeled Metabolites – From Mouse to Man

Vsevolod V. Belousov, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS, Russia
Imaging and Manipulating Redox in Cells

Tamara Maric, École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Novel Bioluminescent Probe for Non-Invasive Imaging and Quantification of Glucose Uptake in vitro and in vivo

Daria Ezerina, VIB/VUB, Belgium
Short Talk: Novel Fluorescent Biosensors for Real-Time in vivo Detection of Metabolites

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs/Quandary Peaks

FRIDAY, MARCH 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Akebia Therapeutics Organized in collaboration with Cancer Research UK
Cell Research
 

We gratefully acknowledge additional support from these exhibitors at this conference:

Don Whitley Scientific Limited HypOxygen
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA232443-01

Funding for this conference was made possible (in part) by 1 R13 CA232443-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cayman Chemical Company eLife

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179