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This meeting took place in 2017



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Maternal-Fetal Crosstalk: Harmony vs. Conflict (T2)


Organizer(s) Jeffrey C. Murray, Louis J. Muglia and Yoel Sadovsky
October 4—8, 2017
Westin Washington, DC City Center • Washington, DC USA
Discounted Abstract Deadline: Jun 6, 2017
Abstract Deadline: Jul 11, 2017
Scholarship Deadline: Jun 6, 2017
Discounted Registration Deadline: Aug 10, 2017

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
The interactions between the mother and the fetus during the progression of normal pregnancy involve trade-offs, or even conflicts, between factors that improve maternal health and those that support fetal development and growth. These may lead to selective evolutionary pressures that differ among species, and result in intriguing differences in reproductive strategies that enhance maternal-fetal biological harmony, and mitigate conflict. Intriguing strategies to balance these pressures include imprinting, coincident with placentation. Adverse pregnancy outcomes, such as miscarriage, preterm birth, preeclampsia and intrauterine growth restriction, are heterogeneous, and gaps remain in understanding how imbalances between maternal and fetal adaptations contribute to these disorders. The goal of this conference is to bring together investigators from diverse disciplines who investigate maternal and fetal factors that shape pregnancy outcomes by exploring how these systems work together or are at odds. The conference will aim to develop these concepts, illuminating developmental, genomic/epigenomic, immune, microbial and metabolic factors, as well as consider how acute exposures during pregnancy, such as infection, shape maternal-fetal outcomes. Understanding the biology underpinning these considerations will contribute to better diagnosis, treatment and disease prevention during pregnancy. The presentations will address critical gaps in our knowledge of maternal/fetal harmony and conflict, and target paths to improve understanding of issues related to social, economic and geographic inequality that predispose some groups to enhanced risk during pregnancy. A better understanding of the biology, development of new collaborative possibilities and paths to improved clinical outcomes are primary goals of the meeting.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Wednesday, October 4 with registration from 17:00 to 20:00, a joint session with Grand Challenges at 13:30 and a networking and welcome mixer at 15:30. Conference events conclude on Sunday, October 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Monday, October 9 in order to fully experience the meeting.

WEDNESDAY, OCTOBER 4

11:00 AM—1:00 PM
Arrival and Registration
Name badge required for admittance to sessions at the Marriott

Westin, Ashlawn North
12:00—12:45 PM
Transportation from the Westin to Marriott
(Shuttles leave every 15 minutes starting at 12:00 pm)

12:30—1:30 PM
Joint Buffet Lunch

Marriott Marquis, Liberty Ballroom
1:30—4:00 PM
Looking Ahead – Partnering for the World We Want (Joint Session with Grand Challenges and Keystone Symposia)
Meeting has ended...abstracts no longer viewable online.
MC: Kedest Tesfagiorgis, Program Officer, Bill & Melinda Gates Foundation
Introduction
Harry Bader, Acting Executive Director, U.S. Global Development Lab, United States Agency for International Development
Welcome Remarks
Mark A. Green, Administrator, United States Agency for International Development
Keystone Symposia Welcome
Diana W. Bianchi, Director, National Institute of Child Health and Human Development
Keynote
Bill Gates, Co-chair and Trustee, Bill & Melinda Gates Foundation
Film Clip: Fighting Ebola: A Grand Challenge for Development Spotlight Talk
Youseph Yazdi, Executive Director, Johns Hopkins Center for Bioengineering Innovation & Design
Keynote
Rex W. Tillerson, United States Secretary of State
Spotlight Talk
Claire Reid, Chief Impact Officer and Founder, Reel Gardening
Spotlight Talk
Rebecca Richards-Kortum, Director, Rice 360° Institute for Global Health
Closing Discussion
Trevor Mundel, President, Global Health Division, Bill & Melinda Gates Foundation
Georg Schütte, State Secretary, Federal Ministry of Education and Research
MC Closing
Kedest Tesfagiorgis, Program Officer, Bill & Melinda Gates Foundation

Marriott Marquis, Marquis Ballroom
4:00—5:00 PM
Networking and Welcome Mixer with Grand Challenges and Keystone Symposia

Marriott Marquis, Mezzanine Foyer
5:00—5:45 PM
Return Transportation from Marriott to Westin
(Shuttles leave every 15 minutes starting at 5:00 pm)

5:00—8:00 PM
Registration Continues

Westin, Ashlawn North
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Westin, Vista Terrace

THURSDAY, OCTOBER 5

7:30—8:30 AM
Breakfast

Monticello Ballroom
8:30—9:30 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Jeffrey C. Murray, Bill & Melinda Gates Foundation, USA

David Haig, Harvard University, USA
Maternal-Fetal Crosstalk: Why all the Noise?

9:30—11:45 AM
The Placenta – Cells to Tissues
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Yoel Sadovsky, Magee-Womens Research Institute, USA

Guillaume Cornelis, Stanford University, USA
When the Placenta Goes Viral: Role of Transposons during Placentation

Coffee Break

Margherita Yayoi Turco, University of Cambridge, UK
Modelling the Maternal-Fetal Interface in vitro

Susan J. Fisher, University of California, San Francisco, USA
Genome-Scale Fluctuations in the Cytotrophoblast Epigenome over Gestation and in Placental Pathologies

Matthew Brook, University of Edinburgh, UK
Short Talk: PABP4 Is Critical for Mammalian Pregnancy: A Unique Mouse Model for the Maternal Origins of IUGR and Stillbirth

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

National Ballroom
1:00—10:00 PM
Poster Viewing

National Ballroom
2:30—4:30 PM
Workshop 1: Immunology of Maternal-Fetal Harmony vs. Conflict

National Ballroom
* Susan J. Fisher, University of California, San Francisco, USA

Rabia Anwar, Max Delbruck Centre, Germany
Trophoblast-Specific Gene Expression Driven by Endogenous Retrovirus LTRs in Normal vs. Pre-Eclamptic (PE) Pregnancy

Marilen Benner, Radboud University Medical Center, Netherlands
Human Uterine Lymphocytes Acquire a More Experienced and Tolerogenic Phenotype during Pregnancy

Ana Claudia Zenclussen, Experimental Obstetrics and Gynaecology, Germany
Safeguarding of Fetal Growth by Uterine Mast Cells and Uterine Natural Killer Cells

Thomas Vauvert Hviid, Zealand University Hospital and University of Copenhagen, Denmark
Immune Markers in the Mid-Luteal Endometrium Are Associated with Normal Fertility and Pregnancy after in vitro Fertilization

Michela Frascoli, University of California, San Francisco, USA
Alloreactive Fetal T Cells Promote Uterine Contractility in Preterm Labor via IFN-γ and TNF−α

Wentong Jia, Institute of Zoology, Chinese Academy of Sciences, China
Association of Maternal KIR and Fetal HLA-C Genotypes with the Risk of Preeclampsia in Chinese Han Pregnant Population

Jeremy Michael Kinder, Cincinnati Children's Hospital, USA
Mother's 'Genetic' Little Helpers: Microchimeric Maternal Cells Promote Reproductive Fitness and Survival of Non-Inherited Traits

Eun Lee, Virginia Commonwealth University, USA
ERAP2 Modulates Trophoblast Cell Death by Natural Killer Cells

4:30—5:00 PM
Coffee Available

National Ballroom Foyer
5:00—7:00 PM
The Rapidly Evolving Placenta
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Louis J. Muglia, Cincinnati Children's Hospital Medical Center, USA

Derek Wildman, University of Illinois at Urbana-Champaign, USA
The Placenta Is at the Crossroads of Maternal-Fetal Conflict and Cooperation

Bernard J. Crespi, Simon Fraser University, Canada
Placental Invasiveness and Maternal-Fetal Conflicts in Evolution, Health and Disease

R. Michael Roberts, University of Missouri, USA
Studying Early-Onset Preeclampsia (EOPE) in a Model for Early-Stage Human Placental Trophoblast

Xu Wang, Auburn University, USA
Short Talk: The Origin and Evolution of Genomic Imprinting in the Placenta from Comparative Genomic Analysis Across Marsupials and Eutherian Mammals

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

National Ballroom/Foyer
7:30—10:00 PM
Poster Session 1

National Ballroom

FRIDAY, OCTOBER 6

7:30—8:30 AM
Breakfast

Monticello Ballroom
8:30—11:45 AM
The Establishment of Pregnancy – Tolerance and Rejection
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Sing Sing Way, Cincinnati Children's Hospital, USA
Maternal-Fetal Immunology during Pregnancy and after Parturition

Sarah A. Robertson, University of Adelaide, Australia
The Immune Response and Female Reproductive Quality Control

Joanna Halkias, University of California, San Francisco, USA
Short Talk: CD161 Promotes Prenatal Immune Suppression of Pro-Inflammatory PLZF+ T Cells

Coffee Break

Moriya Gamliel, Hebrew University, Israel
Human Natural Killer Cells Remember Pregnancy and Enhance Placental Bed Development

Ashley Moffett, University of Cambridge, UK
Maternal Allo-Recognition of the Fetus: For Better, For Worse?

Gabriela Dveksler, Uniformed Services University of the Health Sciences, USA
Short Talk: Pregnancy-Specific Glycoproteins Play a Role in Several Processes Required for Successful Human Pregnancy

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

National Ballroom
1:00—10:00 PM
Poster Viewing

National Ballroom
4:30—5:00 PM
Coffee Available

National Ballroom Foyer
5:00—7:00 PM
Crosstalk between the Maternal and Fetal Microbial Communities
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Laura I. Romero, University of Miami, USA

Daniel DiGiulio, Stanford University, USA
The Vaginal Microbiome Signature of At-Risk Pregnancy

Idit Kosti, University of California, San Francisco, USA
Short Talk: Meta-Analysis of Vaginal Microbiome Data Provides New Insights on Preterm Births

Lenore P. Pereira, University of California, San Francisco, USA
Persistent Cytomegalovirus and Zika Virus Infection in Human Placentas Modulated by Host Antiviral Responses

Carolyn B. Coyne, University of Pittsburgh, USA
Antimicrobial Signaling at the Maternal-Fetal Interface

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

National Ballroom/Foyer
7:30—10:00 PM
Poster Session 2

National Ballroom

SATURDAY, OCTOBER 7

7:30—8:30 AM
Breakfast

Monticello Ballroom
8:30—11:45 AM
Epigenetics and Imprinting in Feto-Placental Harmony and Conflict
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Bernard J. Crespi, Simon Fraser University, Canada

Marika Charalambous, Queen Mary University of London, UK
Communication between Mother and Fetus Mediated by Imprinted Genes

Jon F. Wilkins, Ronin Institute, USA
Canalization, Phenotype Variation and Imprinting in Complex Disease

Coffee Break

Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA
The Effects of Assisted Reproductive Technologies on Placental Development and Epigenetic Regulation in a Mouse Model

Madhumita Basu, Nationwide Children's Hospital, USA
Short Talk: Epigenetic Mechanism for Gene-Environment Interaction in Maternal Hyperglycemia-Mediated Congenital Heart Defects

Richard Saffery, University of Melbourne, Australia
Epigenetic Regulation of Human Placental Function and Pregnancy Outcome

Jyotdeep Kaur, PGIMER, India
Short Talk: Epigenetic Mechanisms Regulate Placental Tumor Suppressor- and Onco-Genes in Normal and Pathological Pregnancies: Search for Novel Fetal DNA Epigenetic Marker

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

National Ballroom
1:00—10:00 PM
Poster Viewing

National Ballroom
4:30—5:00 PM
Coffee Available

National Ballroom Foyer
5:00—7:00 PM
Genomic Communication during Pregnancy
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Louis J. Muglia, Cincinnati Children's Hospital Medical Center, USA

Thuy Ngo, Oregon Health and Science University, USA
Cell-Free Circulating RNA as a Window to Feto-Placental Biology

Yoel Sadovsky, Magee-Womens Research Institute, USA
The Biology of Placental Exosomes and their miRNA Cargo

Nathan D. Price, Institute for Systems Biology, USA
Systems Biology Analysis of Pregnancy Conditions

Terry Morgan, Oregon Health & Sciences University, USA
Short Talk: High-Resolution Flow Cytometry Reveals Placental-Specific Exosomes in Postpartum Blood: Maternal-Placental Crosstalk Six Months after Delivery

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

National Ballroom/Foyer
7:30—10:00 PM
Poster Session 3

National Ballroom

SUNDAY, OCTOBER 8

7:30—8:30 AM
Breakfast

Monticello Ballroom
8:30—11:45 AM
From Uterine Quiescence to Parturition
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Yoel Sadovsky, Magee-Womens Research Institute, USA

Roger Smith, University of Newcastle, Australia
Understanding the Terminal Events in Pregnancy

Sam A. Mesiano, Case Western Reserve University, USA
Progesterone Signaling in Human Parturition: Role of Progesterone Receptor Modifications

Laura Sillers, Children's Hospital of Philadelphia, USA
Short Talk: Altered Acylcarnitine Metabolism in the Placenta in Spontaneous Preterm Birth

Coffee Break

Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Fetal Signals that Control the Timing of Parturition

Caitlin Dunn-Fletcher, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Deletion of Retroviral Element THE1B Abolishes Placental Corticotropin-Releasing Hormone Expression and Restores Normal Birth Timing

Roberto Romero, National Institutes of Health / Wayne State University, USA
Infection, Inflammation and the Transition to Labor

11:45 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Panel: How to Harness Basic and Translational Biology Research to Improve Pregnancy Outcome in Low- and Middle-Income Countries
A panel of experts with both high and low income country experience will explore how the exciting new findings from the biology of maternal/fetal interactions can be rapidly applied to benefit mothers and babies directly. A particular emphasis will be placed on translating high tech findings to low resource settings where the constraints of funding, expertise and training limit the opportunity to use technology to directly and quickly benefit those most in need. The panel will begin with short observations from each of the panel members regarding challenges and opportunities and then proceed with a facilitated discussion by the moderator and with input from question and observations from the audience. The goal is to identify from the conference proceedings specific opportunities that might translate to the most needy.

National Ballroom
* Jeffrey C. Murray, Bill & Melinda Gates Foundation, USA

* Yoel Sadovsky, Magee-Womens Research Institute, USA

* Louis J. Muglia, Cincinnati Children's Hospital Medical Center, USA

Joe Leigh Simpson, March of Dimes, USA

Jane Norman, University of Edinburgh, UK

Sarah A. Robertson, University of Adelaide, Australia

Janna Patterson, Bill & Melinda Gates Foundation, USA

4:30—5:00 PM
Coffee Available

National Ballroom Foyer
5:00—6:45 PM
Epidemiology of Pregnancy Health and Outcomes
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Jeffrey C. Murray, Bill & Melinda Gates Foundation, USA

Louis J. Muglia, Cincinnati Children's Hospital Medical Center, USA
Populations as Laboratories for Biological and Social Discovery in Pregnancy Outcomes

Jane Norman, University of Edinburgh, UK
Pregnancy Stressors and Influences on Parturition

Rachel Freathy, University of Exeter, UK
Genetic and Environmental Determinants of Birth Weight and Links with Later Life Disease

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

National Ballroom
* Jeffrey C. Murray, Bill & Melinda Gates Foundation, USA

* Louis J. Muglia, Cincinnati Children's Hospital Medical Center, USA

* Yoel Sadovsky, Magee-Womens Research Institute, USA

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

National Ballroom/Foyer
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

National Ballroom

MONDAY, OCTOBER 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD093420-01

Funding for this conference was made possible (in part) by 1R13HD093420-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Supported in part by March of Dimes Foundation Grant No. 4-FY17-925

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676