Grand Hilton Seoul Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Diabetes: Innovations, Outcomes and Personalized Therapies (X3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Drivers of Type 2 Diabetes: From Genes to Environment (S1)


Organizer(s) Kyong Soo Park, Young-Bum Kim and Zoltan P. Arany
October 7—11, 2018
Grand Hilton Seoul • Seoul, South Korea
Discounted Abstract Deadline: Jun 25, 2018
Abstract Deadline: Jul 10, 2018
Scholarship Deadline: Jun 25, 2018
Discounted Registration Deadline: Aug 7, 2018

Supported by Directors' Fund

Summary of Meeting:
The prevalence of diabetes mellitus is increasing worldwide and is a major threat to global public health that requires urgent action. Over the last few decades, significant advances have been made in terms of identifying novel susceptibility genes and signaling pathways that play pivotal roles in the pathogenesis of diabetes and its related metabolic disorders. However, a major gap in understanding the current global epidemic of diabetes is the lack of knowledge regarding how molecular interactions between the environment and the susceptibility genes are regulated within an altered metabolic milieu. This meeting will address these unresolved gaps in the etiopathogenesis of diabetes and focus on the latest advances that are linked to the molecular drivers of diabetes mellitus. Topics include: systemic regulation of adipocytes in diabetes; microvesicles, noncoding RNA, and intercellular communications; physiological drivers in hunger and energy homeostasis; epigenetics and metabolic control in diabetes; novel signaling players related to insulin resistance; adaptation of beta cell to chronic metabolic stress; environmental triggers in diabetes and metabolic diseases; and molecular targets for nutrient sensing and signaling. The organizers anticipate that this meeting will bring about a major shift in addressing the causes of diabetes mellitus, as the topics emphasized in this meeting have not yet been explored widely. Through the novel discoveries of diabetes research presented at this meeting, we hope to provide evidence-based insight to favorably impact people with diabetes across the world.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, October 7 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, October 11 with a closing plenary session from 16:00 to 18:15, followed by a social hour and entertainment. We recommend return travel on Friday, October 12 in order to fully experience the meeting.

SUNDAY, OCTOBER 7

4:00—8:00 PM
Arrival and Registration

Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, OCTOBER 8

9:00 AM—12:00 PM
Epigenetics and Metabolic Control in Diabetes
Meeting has ended...abstracts no longer viewable online.

Convention Hall DE
* Markus Stoffel, ETH Zürich, Switzerland

* Kyong Soo Park, Seoul National University College of Medicine, South Korea
Diabetes in Asia

Juleen R. Zierath, Karolinska Institutet, Sweden
Skeletal Muscle Mediators and Exercise-Induced Adaptations Governing Insulin Sensitivity: Turning Back Time on Diabetes Pathogenesis

Yoshihiro Ogawa, Kyushu University, Japan
Role of DNA Methylation in Early Life and its Impact in Later Life

Coffee Break

Charlotte A. Ling, Lund University, Sweden
Epigenetic Mechanisms Linking Environmental Factors and Type 2 Diabetes

Hyunki Kim, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: PRMT1-Dependent Histone Arginine Methylation Regulates Mature β Cell Identity

Heshan Peiris, Stanford University School of Medicine, USA
Short Talk: Conditional Genetics and Human Islet Studies to Discover Diabetes Risk Gene Function

12:00—1:30 PM
On Own for Lunch

12:00—1:00 PM
Poster Setup

Convention Hall ABC
1:00—9:30 PM
Poster Viewing

Convention Hall ABC
1:30—3:30 PM
Workshop 1

Convention Hall DE
* Gary J. Schwartz, Albert Einstein College of Medicine, USA

* Allison W. Xu, University of California, San Francisco, USA

Yun-Hee Lee, Seoul National University, South Korea
Micro-Environmental Regulation of in vivo Beige Adipogenesis by Gap Junctional Interactions between Adipocyte Progenitors and Macrophages

Meilian Liu, University of New Mexico Health Sciences Center, USA
Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway

Hyun Cheol Roh, Beth Israel Deaconess Medical Center, USA
Warming Induces Significant Reprogramming of Beige, But Not Brown, Adipocyte Cellular Identity

Haiyan Zhou, Central South University, China
DsbA-L Deficiency in CD4+ T Cells Promote Diet-Induced Thermogenesis through Inhibiting IFN-γ Production

Jee Hyung Sohn, Seoul National University, South Korea
Plin1 Deficiency Promotes Inflammatory Responses in Lean Adipose Tissue through Lipid Dysregulation

Samuel Klein, Washington University School of Medicine, USA
Does Roux-en-Y Gastric Bypass Surgery have Weight Loss Independent Therapeutic Effects on Multi-Organ Insulin Sensitivity and β-cell Function in People with Type 2 Diabetes?

3:30—4:00 PM
Coffee Available

Foyer
4:00—6:00 PM
Environmental Triggers in Diabetes and Metabolic Diseases
Meeting has ended...abstracts no longer viewable online.

Convention Hall DE
* Juleen R. Zierath, Karolinska Institutet, Sweden

* Chen-Yu Zhang, Nanjing University, China

Chirag J. Patel, Harvard Medical School, USA
Challenges and Opportunities in Mapping the Exposome of Type 2 Diabetes

Kristin L. Eckel-Mahan, University of Texas Health Science Center, USA
Mechanisms Underlying Diet-Induced Circadian Reprogramming

David D. Moore, Baylor College of Medicine, USA
Regulation of Liver Energy Balance by Nutrient-Sensing Nuclear Receptors

Raffaele Gerlini, Helmholtz Zentrum München, Germany
Short Talk: Paternal Overweight Determines Transgenerational Glucose Intolerance via Polycomb

6:00—7:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Convention Hall ABC
6:30—9:00 PM
Poster Session 1

Convention Hall ABC

TUESDAY, OCTOBER 9

8:00—9:00 AM
Poster Setup

Convention Hall ABC
9:00 AM—6:00 PM
Poster Viewing

Convention Hall ABC
9:00 AM—12:00 PM
Physiological Drivers in Hunger and Energy Homeostasis
Meeting has ended...abstracts no longer viewable online.

Convention Hall DE
* Young-Bum Kim, Harvard Medical School, USA

* Catherine Postic, INSERM, Institut Cochin, France

Gary J. Schwartz, Albert Einstein College of Medicine, USA
Gut-Brain Communication in the Integrated Control of Energy and Glucose Homeostasis

Min-Seon Kim, University of Ulsan College of Medicine, South Korea
Hypothalamic Inflammation in Diet-Induced Obesity

Coffee Break

Allison W. Xu, University of California, San Francisco, USA
Gene-Diet Interaction in the Regulation of Energy Balance and Macronutrient Preference

Vincent Prevot, INSERM, University of Lille, France
Role of Hypothalamic Tanycytes in Metabolic Homeostasis

Henriette R. Frikke-Schmidt, University of Michigan, USA
Short Talk: Exploring GFRAL Neuroanatomy and Function

Qiwei Zhai, Shanghai Institute of Nutrition and Health, SIBS, CAS, China
Short Talk: Short-Term Tamoxifen Treatment Has Long-Term Effects on Metabolism in High-Fat Diet Mice Involved with Nmnat2 in POMC Neurons

12:00—1:30 PM
Lunch

Convention Hall ABC
1:00—3:30 PM
Poster Session 2

Convention Hall ABC
3:30—4:00 PM
Coffee Available

Foyer
4:00—6:00 PM
Microvesicles, Noncoding RNA and Intercellular Communications
Meeting has ended...abstracts no longer viewable online.

Convention Hall DE
* Kohjiro Ueki, Research Institute, National Center for Global Health and Medicine, Japan

Chen-Yu Zhang, Nanjing University, China
Pancreatic Islet-Released miR-29 Family Members Travel to Liver and Contribute to Hepatic Insulin Resistance

Markus Stoffel, ETH Zürich, Switzerland
MicroRNA Networks in Metabolic Tissues

Soazig Le Lay, INSERM, University of Angers, France
Extracellular Vesicles Derived from Adipocytes and Obesity-Associated Metabolic Dysfunctions

Prakash Nagarkatti, University of South Carolina, USA
Short Talk: MicroRNA-30 Regulates Pro-Inflammatory Adipose Tissue Macrophage-Polarization through Notch Signaling and Provides a Therapeutic Target for Metabolic Disease

6:00 PM
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


WEDNESDAY, OCTOBER 10

9:00 AM—12:00 PM
Novel Signaling Players Linking to Insulin Resistance
Meeting has ended...abstracts no longer viewable online.

Convention Hall DE
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

* In-Kyu Lee, Kyungpook National University Hospital, South Korea

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Class of Signaling Lipids with Beneficial Metabolic Effects

Kohjiro Ueki, Research Institute, National Center for Global Health and Medicine, Japan
Role of Hepatic Activin B in the Control of Glucose Homeostasis

Coffee Break

Andrew C. Adams, Eli Lilly and Company, USA
FGF21 Signaling in Insulin Action

Young-Bum Kim, Harvard Medical School, USA
ApolipoproteinJ (ApoJ) Is a Novel Regulator of Insulin Resistance

Raziel Rojas-Rodriguez, University of Massachusetts Medical School, USA
Short Talk: A Placenta-Adipose Tissue Signaling Mechanism Supports Maternal Metabolism and Protects Against Gestational Diabetes

Ara Koh, Gothenburg University, Sweden
Short Talk: Mechanistic Studies of the Impact of Microbially Produced Histidine-Derived Metabolites on Insulin Signaling

12:00—4:00 PM
On Own for Lunch

12:00—1:00 PM
Poster Setup

Convention Hall ABC
1:00—9:00 PM
Poster Viewing

Convention Hall ABC
3:30—4:00 PM
Coffee Available

Foyer
4:00—6:00 PM
Adaptation of Beta Cells to Chronic Metabolic Stress
Meeting has ended...abstracts no longer viewable online.

Convention Hall DE
* Moon-Kyu Lee, Sungkyunkwan University School of Medicine, South Korea

* Susumu Seino, Kobe University Graduate School of Medicine, Japan
Beta-cell Glutamate: A Critical Amplifying Signal in Insulin Secretion

Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Pancreatic Beta-Cell Identity and Function in Diabetes

Yuval Dor, Hebrew University-Hadassah Medical School, Israel
The Effect of Glucose on Beta Cell Regeneration

Jinsook Son, Columbia University, USA
Short Talk: Analysis of Beta Cell Dedifferentiation using Single-Cell RNA-Seq of Human Type 2 Diabetics

6:00—7:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Convention Hall ABC
6:30—9:00 PM
Poster Session 3

Convention Hall ABC

THURSDAY, OCTOBER 11

9:00 AM—12:00 PM
Molecular Targets for Nutrient Sensing and Signaling
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

* Seung-Hoi Koo, Korea University, South Korea

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Autophagy and Nutrient Sensing

Zoltan P. Arany, University of Pennsylvania, USA
Diabetes and Branched Chain Amino Acid Metabolism

Coffee Break

Kyong Soo Park, Seoul National University College of Medicine, South Korea
SUMO-Specific Protease 2 (SENP2) as a Novel Regulator of Fatty Acid Metabolism

Feifan Guo, Institute for Nutritional Sciences, China
Central and Peripheral Mechanisms Underlying Glucocorticoid-Increased Adiposity

Paula Ortega-Prieto, INSERM U1016, France
Short Talk: Importance of the OGT-ChREBP-PPARalpha Axis in Hepatic Glucose Sensing

Cholsoon Jang, Princeton University, USA
Short Talk: Intestinal Fructose Metabolism and Fatty Liver

12:00—1:30 PM
On Own for Lunch

1:30—3:30 PM
Workshop 2: Novel Therapeutic Targets for Diabetes Mellitus

Grand Ballroom
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Bhagirath Chaurasia, University of Utah, USA
Targeting a Double-Bond in Ceramides to Treat Insulin Resistance and Steatohepatitis

Mitzi Nagarkatti, University of South Carolina, USA
Cannabinoid Receptor 1 Blockade Attenuates Metabolic Inflammation and High-Fat Diet-Induced Obesity through Regulation of Gut Microbial Dysbiosis

Yong Jae Lee, CKD Research Institute, South Korea
CKD-508: A New Potent Therapy for Dyslipidemia

Melissa L. Borg, Karolinska Institutet, Sweden
CRHR2 Agonist Improves Skeletal Muscle Insulin Sensitivity and Muscle Function in Diet-Induced Obese Mice

KyeongJin Kim, Columbia University, USA
Kctd17, a Novel Regulator in Obesity-Induced Insulin Resistance and Fatty Liver

Saswata Talukdar, Merck Research Laboratories, USA
Evolving Mechanisms and Continued Challenges of the FGF21 Pathway as a Therapeutic Agent

In-Kyu Lee, Kyungpook National University Hospital, South Korea
PDK4 Mediates Skeletal Muscle Insulin Resistance by Increasing MAM Formation

3:30—4:00 PM
Coffee Available

Foyer
4:00—6:00 PM
Systemic Regulation of Adipocytes in Diabetes
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Zoltan P. Arany, University of Pennsylvania, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
The Adipocyte in Systemic Energy Regulation

Aimin Xu, University of Hong Kong, China
Neuroimmune Interactions in the Browning of White Adipose Tissue

David E. James, University of Sydney, Australia
New Insights into Insulin Resistance

Mark I. McCarthy, University of Oxford, UK
The Genetic and Epigenomic Architecture of Type 2 Diabetes

6:00—6:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
6:15—7:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Grand Ballroom Foyer
7:00—10:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Grand Ballroom

FRIDAY, OCTOBER 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

AstraZeneca Bioneer Corporation
Boehringer Ingelheim Pharmaceuticals, Inc. Chong Kun Dang Bio
Dalim Biotech DNA Link
Handok Hanmi Pharmaceuticals

Special thanks to
Korean Diabetes Association
LG Chem
Macrogen, Inc. Takeda California
Yuhan
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Eli Lilly and Company


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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