Lee Shau Kee Lecture Centre, Centennial Campus, The University of Hong Kong Floorplan

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This meeting took place in 2018



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Framing the Response to Emerging Virus Infections (S2)


Organizer(s) Ralph A. Tripp, Suresh Mahalingam, John W. Lowenthal, Andrew G. Bean and Malik Peiris
October 14—18, 2018
Lee Shau Kee Lecture Centre, Centennial Campus, The University of Hong Kong • Pok Fu Lam, Hong Kong
Discounted Abstract Deadline: Jun 27, 2018
Abstract Deadline: Jul 17, 2018
Scholarship Deadline: Jun 27, 2018
Discounted Registration Deadline: Aug 14, 2018

Organized in collaboration with the Croucher Foundation and The University of Hong Kong

Summary of Meeting:
Emerging and re-emerging viruses have the potential to cause high morbidity and mortality and range from localized outbreaks to epidemics. Due to their emerging nature, most aspects of the biology and infectious potential of these viruses are poorly understood. Our continuing struggle to respond to a procession of pandemics including SARS, avian influenza, MERS, Ebola and more recently Zika, highlights key gaps in our knowledge and should serve to motivate our re-thinking on how we can better prepare and deal with future unknown viral threats. This meeting will focus on important areas such as surveillance, diagnostics and countermeasures and other important advances in new technologies and how they are being applied to research. Furthermore, we will discuss how to facilitate the translation of research, data and candidate treatments through the development pipeline in a timely and cost-effective manner. The key themes to be covered include the need to understand why zoonotic diseases matter, their association with agriculture, the importance of surveillance and early detection, and the difficulties of dealing with diseases that involve both medical and veterinary communities. The conference will bring together experts in virology, immunology, vaccinology, epidemiology with those that seek to transfer knowledge between these groups, veterinarians and industry and government. Further, this meeting would bring together individuals involved in the control of these diseases in government and non-government organizations, as well as people involved in study of zoonosis and countermeasures. The creation of global networks and sharing of information will ensure that we are better prepared for future outbreaks.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, October 14 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, October 18 with a closing plenary session from 13:30 to 18:30, followed by dinner. We recommend return travel on Friday, October 19 in order to fully experience the meeting.

SUNDAY, OCTOBER 14

4:00—8:00 PM
Arrival and Registration

Hotel Jen Lobby
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Hotel Jen Lobby

MONDAY, OCTOBER 15

8:00—9:00 AM
Poster Setup

Lecture Hall LG 2
9:00 AM—5:30 PM
Poster Viewing

Lecture Hall LG 2
9:00—10:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Malik Peiris, University of Hong Kong, Hong Kong

Gabriel M. Leung, Dean of Medicine, University of Hong Kong, Hong Kong
Opening Remarks

Peter Daszak, EcoHealth Alliance, USA
Emerging Infectious Disease Threats

10:00 AM—12:30 PM
Mosquito-Borne Viruses - Biology and Host Interactions
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Lisa E. Gralinski, University of North Carolina, USA

Scott C. Weaver, University of Texas Medical Branch, USA
Urban Arboviruses: History, Evolution and Mechanisms of Emergence

Coffee Break

Suresh Mahalingam, Griffith University, Australia
Alphavirus Inflammatory Disease Mechanisms and Approaches to Therapy

Michael S. Diamond, Washington University School of Medicine, USA
Host Factors Required for Alphavirus Infection: The Identification of Mxra8 as an Entry Receptor

Ali Zaid, Griffith University Gold Coast, Australia
Short Talk: Specific Inhibition of NLRP3 in Chikungunya Disease Reveals a Role for Inflammasome in Alphavirus-Induced Inflammation

Kar Muthumani, Wistar Institute, USA
Short Talk: Synthetic Nucleic Acid Antibody Prophylaxis + DNA Vaccine Confers Rapid and Durable Protective Immunity against Zika Virus

12:30—1:30 PM
Networking Lunch

Lecture Hall LG 2
1:00—3:00 PM
Poster Session 1

Lecture Hall LG 2
3:00—3:30 PM
Coffee Available

Lecture Hall LG 2
3:30—5:30 PM
ZIKA Virus Countermeasures
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Suresh Mahalingam, Griffith University, Australia

Raman Rao, Takeda Pharmaceutical Company, Singapore
Zika Vaccine Development Strategies for Emergency Preparedness

Mauro Martins Teixeira, Universidade Federal de Minas Gerais, Brazil
The Role of Glutamate Receptors in the Pathogenesis of Zika

Natalie A. Prow, University of South Australia, Australia
A New Replication-Defective, Vaccinia-Derived, CHO-Manufactured Vaccine Vector System (SCV) Is Effective in Preclinical Studies against Zika and Chikungunya Viruses

Mingyuan Li, University of Hong Kong, Hong Kong
Short Talk: Activated ADP-Ribosylation Factor 4 (ARF4) Is Required for ZIKA Virus (ZIKV) Infectious Cycle


TUESDAY, OCTOBER 16

8:30—9:00 AM
Poster Setup

Lecture Hall LG 2
9:00 AM—5:00 PM
Poster Viewing

Lecture Hall LG 2
9:00—10:30 AM
Ebola Virus: Biology and Host Interactions
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Erica Ollmann Saphire, The Scripps Research Institute, USA

Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA
Human Ebola Virus Disease Pathogenesis Revealed by Multi-Platform ‘Omics Analysis

Andrea Marzi, NIAID, National Institutes of Health, USA
Animal Models of Ebolaviruses

Adam Joseph Hume, Boston University, USA
Short Talk: The Use of Minigenome Systems as Tools to “Fill in the Blanks” for Uncultured Emerging Viruses and Facilitate Virus Rescue: A Lloviu Virus Case Study

Beatriz Escudero Pérez, Bernhard Nocht Institute for Tropical Medicine, Germany
Short Talk: Comparative Pathogenesis of Ebola and Reston Virus in Humanized Mice

Coffee Break

10:50 AM—12:30 PM
Ebola Virus: Vaccines and Therapeutics
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Andrea Marzi, NIAID, National Institutes of Health, USA

Erica Ollmann Saphire, The Scripps Research Institute, USA
Structural Studies to Guide the Development of Broadly Reactive Antibodies Against Ebolaviruses and Lassa Virus

John Misasi, NIAID, National Institutes of Health, USA
Short Talk: ChAd3-Based Ebola Vaccination Induces Protective Antibody Classes

Sarah Elliott, Wistar Institute, USA
Short Talk: A Synthetic Micro-Consensus DNA Vaccine Induces Potent Immune Responses Against Diverse Strains of Marburgvirus

Danielle P. Porter, Gilead Sciences, USA
Short Talk: Broad Spectrum Antiviral Remdesivir for the Treatment of Emerging Viral Infections with High Outbreak Potential

12:30—1:30 PM
Lunch

Lecture Hall LG 2
1:00—3:00 PM
Poster Session 2

Lecture Hall LG 2
2:30—3:00 PM
Coffee Available

Lecture Hall LG 2
3:00—5:00 PM
Zoonotic Influenza and MERS
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Andrew G. Bean, Commonwealth Scientific and Industrial Research Organization, Australia

Yi Guan, University of Hong Kong, Hong Kong
Zoonotic Influenza Viruses from China: An Increasing Pandemic Threat?

Bart L. Haagmans, Erasmus MC, Netherlands
MERS-Coronavirus: From Discovery to Intervention

Malik Peiris, University of Hong Kong, Hong Kong
MERS-Coronaviruses in Africa - Is There a Zoonotic Threat?

LaiGiea Nicole Seng, University of Hong Kong, Hong Kong
Short Talk: Virulence Determinants of Novel Influenza A (H7N9) Virus in Mammals

Sabiha Jahan Akhee, University of Hong Kong, Hong Kong
Short Talk: Deubiquitylase OTUB1 Plays Critical Role in Influenza A Virus Infection and Immune Response

6:00—6:30 PM
Transportation to Optional Dinner

6:30—9:30 PM
Optional Dinner Gathering at Jumbo Kingdom


WEDNESDAY, OCTOBER 17

9:00 AM—12:30 PM
MERS
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* John W. Lowenthal, Deakin University, Australia

KY Yuen, University of Hong Kong, Hong Kong
Host Cellular Protein Facilitating Viral Replication

Ralph S. Baric, University of North Carolina at Chapel Hill, USA
Rapid Response Strategies to Control Emerging Coronavirus Infections

Dong-Yan Jin, University of Hong Kong, Hong Kong
Short Talk: Suppression of Type I Interferon Production by Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein through Interaction with HSP70 Chaperone

Lisa E. Gralinski, University of North Carolina, USA
Short Talk: Using a Reduced Complexity Cross to Identify Host Susceptibility Factors to SARS-CoV Infection

Coffee Break

* Bart L. Haagmans, Erasmus MC, Netherlands

John W. Lowenthal, Deakin University, Australia
A Strategy for Developing a MERS Camel Vaccine in Order to Protect Humans

Jincun Zhao, Guangzhou Institute of Respiratory Disease, China
Immune Responses in MERS-CoV Infected Mice and Humans

Stalin Raj Victor, Indian Institute of Science Education and Research, India
Short Talk: Chimeric Camel-Human Heavy Chain Antibodies Protect Mice from MERS-CoV Infection

Neeltje van Doremalen, NIAID, National Institutes of Health, USA
Short Talk: The Omics of Sex-Specific MERS-CoV Severity in a Transgenic Mouse Model

12:30—1:00 PM
Poster Setup

Lecture Hall LG 2
12:30—5:00 PM
On Own for Lunch and Recreation

1:00—9:30 PM
Poster Viewing

Lecture Hall LG 2
4:30—5:00 PM
Coffee Available

Lecture Hall LG 2
5:00—7:00 PM
Emerging Disease Detection and Surveillance
Meeting has ended...abstracts no longer viewable online.

Grand Hall
Marion P.G. Koopmans, Erasmus MC, Netherlands
Challenges and Opportunities in Emerging Disease Detection

Gavin J.D. Smith, Duke-NUS Medical School, Singapore
Surveillance for Risk Assessment and Prediction

Linfa Wang, Duke-NUS Medical School, Singapore
From SARS to SADS: EIDs Caused by Bat Coronaviruses

Anna Uehara, Duke-NUS Medical School, Singapore
Short Talk: Serologic Evidence of Bat Orthoreovirus in Singapore

Kenrie Pui Yan Hui, University of Hong Kong, Hong Kong
Short Talk: Tropism and Pathogenesis of the Avian Influenza A/H7N9 Virus in ex vivo and in vitro Cultures of the Human Respiratory Tract and Human Airway Organoids

7:00—8:00 PM
Social Hour with Lite Bites

Lecture Hall LG 2
7:30—9:30 PM
Poster Session 3

Lecture Hall LG 2

THURSDAY, OCTOBER 18

9:00 AM—12:00 PM
Influenza: Immunity and Vaccines
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Ralph A. Tripp, University of Georgia, USA

Leo Poon, University of Hong Kong, Hong Kong
Universal Influenza Vaccines

Andrew G. Bean, Commonwealth Scientific and Industrial Research Organization, Australia
Tailoring the Avian Host Immune Response for Enhanced Vaccine Production

Sophie A. Valkenburg, University of Hong Kong, Hong Kong
Short Talk: ADCC Antibodies Are a Protective Immune Correlate in a Household Model of Influenza Transmission

Matloob Husain, University of Otago, New Zealand
Short Talk: The Identification of Human Histone Deacetylases, HDAC1 and HDAC2 as Novel Anti-Influenza Viral Factors

Coffee Break

* Linfa Wang, Duke-NUS Medical School, Singapore

Ted M. Ross, University of Georgia, USA
Broadly Protective Influenza Vaccines: Protection Against Mismatched Strains

Li-meng Yan, University of Hong Kong, Hong Kong
Short Talk: Combined Use of Live-Attenuated and Inactivated Influenza Vaccines to Enhance Heterosubtypic Protection

Timothy Uyeki, Centers for Disease Control and Prevention, USA
Short Talk: Clinical Research Is a Major Gap in the Response to Emerging Respiratory Viral Infections

12:00—1:30 PM
Lunch

Lecture Hall LG 2
1:30—3:45 PM
Vaccine and Therapeutic Strategies
Meeting has ended...abstracts no longer viewable online.

Grand Hall
* Marion P.G. Koopmans, Erasmus MC, Netherlands

Stephen Whitehead, NIAID, National Institutes of Health, USA
Evaluation of Live Attenuated Vaccines for Dengue and Zika Viruses (and their Challenge Models)

Ralph A. Tripp, University of Georgia, USA
Novel Strategies to Improve Vaccine Yield

Coffee Break

Adam Taylor, Griffith University, Australia
Short Talk: Novel Delivery of a Live-Attenuated Chikungunya Virus Vaccine Candidate

James Duehr, Icahn School of Medicine, USA
Short Talk: Characterization of Humoral Immunity Generated against Andes Virus GnGc

Danielle E. Anderson, Duke-NUS Medical School, Singapore
Short Talk: SEC61B Is a Cellular Host Factor Required for Mumps Virus Replication in Humans and Bats

Laura Riva, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Identification of Chemical Compounds Inhibiting Ebola Virus Replication

3:45—4:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grand Hall
5:30—6:30 PM
Social Hour

Cafe Malacca, Hotel Jen
6:30—8:00 PM
Buffet Dinner

Cafe Malacca, Hotel Jen

FRIDAY, OCTOBER 19

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Croucher Foundation The University of Hong Kong

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI140574-01

Funding for this conference was made possible (in part) by 1 R13 AI140574-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

GeneTex, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Takeda Pharmaceutical Company Limited


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