Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Innate Immune Receptors: Roles in Immunology and Beyond (M1)
Innate and Non-Classical Immune Cells in Cancer Immunotherapy (C5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Regulation and Dysregulation of Innate Immunity in Disease (B9)


Organizer(s) Lynda M. Stuart, Kathryn J. Moore and Kate L. Jeffrey
February 18—22, 2018
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Discounted Abstract Deadline: Oct 18, 2017
Abstract Deadline: Nov 16, 2017
Scholarship Deadline: Oct 18, 2017
Discounted Registration Deadline: Dec 18, 2017

Supported by the Directors' Fund

Summary of Meeting:
The innate immune system is fundamental to protect us from pathogens. Although the core components were first elucidated in model organisms such as Drosophila and mice, exactly how they are regulated in human health and contribute to disease remains to be fully defined. Over the past several years, our ability to study the innate immune response has been enabled by a number of transformative tools that can be used to assess gene expression, cellular physiology and gene function. Such technological advances have begun to reveal new components of the innate immune system and have led to a better understanding of its regulation and dysregulation. Importantly, these new insights have allowed us to better understand the pathophysiological basis of certain human diseases and to identify new therapeutic targets to alleviate them. This conference aims to gather different viewpoints in the field of innate immunity to discuss advances in signaling and regulatory networks and to understand how their dysregulation contributes to immunopathologies and auto-inflammatory conditions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 18 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 22 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 23 in order to fully experience the meeting.

SUNDAY, FEBRUARY 18

4:00—8:00 PM
Arrival and Registration

British/Columbia Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

MONDAY, FEBRUARY 19

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:30—9:30 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Lynda M. Stuart, Bill & Melinda Gates Foundation, USA

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammation by Noncoding RNAs and Nucleic Acid Binding Proteins

9:30—11:45 AM
Looking for More: Screening in the Innate Immune System
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Kathryn J. Moore, New York University Medical Center, USA

* Kate L. Jeffrey, Massachusetts General Hospital, Harvard Medical School, USA

Carl L. Hansen, University of British Columbia, Canada
Single-Cell Analysis for Deep Screening of Human Antibody Responses

Coffee Break

Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Transposon Mutagenesis Screens for Host Resistance

Michael Bassik, Stanford University, USA
Systematic Exploration of Endocytosis and Phagocytosis Pathways Using Genome-Wide CRISPR/Cas9 Screens and Genetic Interaction Maps

Iain D.C. Fraser, NIAID, National Institutes of Health, USA
Short Talk: Genome-Wide Screening Combined with an Iterative Bioinformatic Analysis Model Identifies Critical Roles for Protein Degradation and Alternative Splicing in TLR-Induced Macrophage Activation

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Columbia Ballroom
1:00—10:00 PM
Poster Viewing

Columbia Ballroom
4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Gene Regulatory Networks in Innate Immunity
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

* Jose Ordovas-Montanes, Massachusetts Institute of Technology, USA

Julian C. Knight, University of Oxford, UK
Insights into Regulation of Innate Immune Responses Leveraging Human Genetic Variation

Alex K. Shalek, Massachusetts Institute of Technology, USA
Learning More by Looking at Less – Single Cell Analyses of Pathogen Responses

Matthew L. Albert, Genentech, Inc., USA
Geographical Variations in the Human Innate Immune Response to Pathogens

Hiroyuki Oshiumi, Kumamoto University, Japan
Short Talk: miR-451a in Blood-Circulating Extracellular Vesicles Controls the Innate Immune Response of Macrophages

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Columbia Ballroom
7:30—10:00 PM
Poster Session 1

Columbia Ballroom

TUESDAY, FEBRUARY 20

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:30—11:45 AM
Epigenetic Regulation of Host Defense
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Eicke Latz, University of Bonn, Germany

Kate L. Jeffrey, Massachusetts General Hospital, Harvard Medical School, USA
Loss of Epigenome Reader SP140 Disrupts Macrophage Transcriptional Programs and Contributes to Crohn’s Disease

Gioacchino Natoli, Humanitas University, Italy
Genomic Landscapes in Inflammation

Coffee Break

Mélanie Hamon, Institut Pasteur, France
Streptococcus Pneumoniae-Induced Epigenetic Alterations

Stephen T. Smale, University of California, Los Angeles, USA
Molecular Mechanisms Regulating Stimulus-Specific Transcriptional Cascades

Steven Z. Josefowicz, Rockefeller University, USA
Short Talk: Signaling to Chromatin for a Rapid and Robust Inflammatory Response

Annette E. Neele, University of Amsterdam, Netherlands
Short Talk: Fine-Tuning of DNA Methylation during the Differentiation and Activation of Human Macrophages

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Columbia Ballroom
1:00—10:00 PM
Poster Viewing

Columbia Ballroom
3:00—4:30 PM
Workshop 1

British Ballroom
* Daniel Mucida, Rockefeller University, USA

* Mélanie Hamon, Institut Pasteur, France

Aditya Murthy, Genentech, Inc., USA
Selective Autophagy of the Innate Adaptor TRIF Regulates Inflammatory Signaling

Travis K. Hughes, Harvard Medical School and MIT, USA
Understanding the Multi-Cellular Ecosystem of M. tuberculosis granulomas using High-Throughput Single-Cell mRNA Sequencing

Jin Billy Li, Stanford University, USA
ADAR1 RNA editing mediated dsRNA sensing by MDA5

Hans-Christian Reinecker, Massachusetts General Hospital, USA
The GEF-H1 Innate Immune Pathway Controls Anti-Tumor Immunity by Signaling Microtubule Depolymerization in Dendritic Cells

Jose Ordovas-Montanes, Massachusetts Institute of Technology, USA
Barrier Dysfunction in Human Type 2 Immunity Arises from an Altered Basal Progenitor Cell State and Reduced Epithelial Cellular Diversity

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Innate Defense at the Mucosa
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Javier E. Irazoqui, University of Massachusetts Medical School, USA

* Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA

Ramnik Xavier, Massachusetts General Hospital and Broad Institute, USA
Microbiome and Mucosal Immunity

P'ng Loke, New York University School of Medicine, USA
Alternatively Activated Macrophages of Tissue or Monocyte Origin

Daniel Mucida, Rockefeller University, USA
Tissue Adaptation of Intestinal Macrophages

Le Son Tran, Monash University, Australia
Short Talk: NOD1 Sensing of Helicobacter Pylori Infection Mediates Processing of Pro-Interleukin-18 in Gastric Epithelial Cells to Maintain Tissue Homeostasis

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Columbia Ballroom
7:30—10:00 PM
Poster Session 2

Columbia Ballroom

WEDNESDAY, FEBRUARY 21

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:30—11:30 AM
Entraining Immunity
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Kate L. Jeffrey, Massachusetts General Hospital, Harvard Medical School, USA

* Steven Z. Josefowicz, Rockefeller University, USA

Mihai G. Netea, Radboud University, Netherlands
Trained Immunity: A Memory for Innate Host Defense

Judith E. Allen, University of Manchester, UK
Macrophage Education on Site

Coffee Break

Eicke Latz, University of Bonn, Germany
Innate Immune Memory of Western Diet

Musa M. Mhlanga, University of Cape Town, South Africa
Immune Genes Are Primed for Rapid Transcription by Proximal lncRNAs Located in Preformed Nuclear Compartments

Vanessa Frodermann, Massachusetts General Hospital, USA
Short Talk: Voluntary Exercise Reduces Hematopoiesis

11:30 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Metabolic Control of Innate Immune Cells
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Fred Sheedy, Trinity College Dublin, Ireland

Kathryn J. Moore, New York University Medical Center, USA
Noncoding RNAs Coordinate the Physiology of Innate Immune Cells

Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Control of Myeloid Responses

Javier E. Irazoqui, University of Massachusetts Medical School, USA
TFEB: From Lysosome Storage to Innate Defense

Sonia Sharma, La Jolla Institute for Allergy & Immunology, USA
Short Talk: Metabolic-Epigenetic Dysregulation of Cell-Intrinsic Innate Immunity in a Disease of Systemic Inflammation

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Columbia Ballroom

THURSDAY, FEBRUARY 22

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:30—11:45 AM
In the Balance: Immunodeficiencies and Auto-Inflammation
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

* Adam Lacy-Hulbert, Benaroya Research Institute, USA

Fred Sheedy, Trinity College Dublin, Ireland
Defective Immunity Against TB via the Modulation of Macrophage Metabolism by Anti-Inflammatory MiR-21

Andrew Oberst, University of Washington, USA
The RIP Kinases as Modulators of Inflammation and Immunity

Coffee Break

Kim Newton, Genentech, Inc., USA
Cell Death as a Driver of Inflammation

Virginia Pascual, Cornell University, USA
Adding New Pieces to the Human SLE Puzzle

Hachung Chung, Rockefeller University, USA
Short Talk: Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown during the IFN Response

Liudmila Andreeva, Gene Center Munich, LMU Munich, Germany
Short Talk: GAS Forms DNA-Protein Ladders for Cooperative Sensing of Long and TFAM/HMGB-Bound DNA

11:45 AM—5:00 PM
On Own for Lunch

3:00—4:30 PM
Workshop 2

British Ballroom
* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

* Kim Newton, Genentech, Inc., USA

Zack Grimmett, University of California, San Francisco, USA
Changes in Expression of Gasdermin-Family Proteins during Monocyte to Macrophage Differentiation May Confer Susceptibility to Inflammatory Cell Death

Rosario Luque Martin, University of Amsterdam, Netherlands
A Screening Approach to Identify Epigenetic Compounds that Modulate Macrophage Activation

Cole M. Dovey, Stanford University, USA
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis Downstream of RIPK3

Chris Cox, Genentech, Inc., USA
Interleukin 1 Controls Susceptibility to Intestinal Pathogens by Directing a Stromal-Stem Cell Axis Required for Epithelial Regeneration

Sophie Elisabeth Zahalka, Medical University of Vienna, Austria
Exploring Trained Immunity in Lung Infection

Hao-Sen Chiang, National Taiwan University, Taiwan
DNase I Treatment Suppresses Experimental Colitis in Mice by Reducing Colonic Neutrophil Extracellular Trap Formation

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—6:45 PM
Pyroptosis, Necroptosis and Inflammatory Death
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Kathryn J. Moore, New York University Medical Center, USA

* Judith E. Allen, University of Manchester, UK

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulation of Inflammasome Activation and Cell Death

Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Phagocyte Responses to Dying Cells

Vishva M. Dixit, Genentech, Inc., USA
Gasdermin-D: How to Punch Holes in a Dying Cell

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Columbia Ballroom
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Columbia Ballroom

FRIDAY, FEBRUARY 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI136364-01

Funding for this conference was made possible (in part) by 1 R13 AI136364-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Adipogen International Kenneth Rainin Foundation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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