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This meeting took place in 2018



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Therapeutic Targeting of Hypoxia-Sensitive Pathways (V1)


Organizer(s) Chris W. Pugh, Pablo Wappner, Johanna Myllyharju and Moira K. Whyte
April 10—14, 2018
University of Oxford Mathematical Institute • Oxford, UK
Discounted Abstract Deadline: Dec 11, 2017
Abstract Deadline: Jan 10, 2018
Scholarship Deadline: Dec 11, 2017
Discounted Registration Deadline: Feb 13, 2018

Sponsored by Akebia Therapeutics

Summary of Meeting:
Tissue oxygen gradients contribute to morphogenesis and in health cells in different tissues function under differing ambient oxygen conditions. Diseases or environmental challenges can reduce oxygen supply or increase demand, resulting in tissue hypoxia. Adaptive mechanisms have evolved that range from almost instantaneous acute ventilatory changes, through transcriptional events entrained in hours, to epigenetic events with slower effects and genetic adaptations selected across species and over generations. The role of the 2-oxoglutarate dependent dioxygenase enzyme family in influencing many, but not all, of these pleiotropic processes is increasingly recognized, and drugs targeting these enzymes are being evaluated in both experimental and clinical settings. The conference aims to combine the Keystone Symposia brand with the European HypoxiaNET consortium to bring together experts in hypoxia biology from clinical, academic and industrial backgrounds, including trainees, to: 1) Address gaps in our knowledge of responses to hypoxia across these time-frames and in different tissues; 2) Benefit the field by sharing techniques and reagents to enhance therapeutic targeting of the hypoxic response in general, including via inhibition of oxygen-sensitive enzymes; 3) Consider the utility of harnessing these pathways in organ dysfunction, in regenerative medicine and to influence immune and inflammatory responses; and 4) Disseminate outcomes of ongoing clinical trials and enhance plans for future trials. The most important anticipated outcome from the conference is that, through sharing knowledge, enhancing collaborations and training participants from diverse backgrounds, the likelihood of successful manipulation of hypoxia pathways to produce clinical benefits in a variety of fields including, but not restricted to, renal anemia will be significantly enhanced.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Tuesday, April 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Sunday, April 15 in order to fully experience the meeting.

TUESDAY, APRIL 10

4:00—8:00 PM
Arrival and Registration

South Mezzanine
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

South Mezzanine

WEDNESDAY, APRIL 11

8:30—9:30 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Chris W. Pugh, University of Oxford, UK

* Pablo Wappner, Fundacion Instituto Leloir, Argentina

* Johanna Myllyharju, University of Oulu, Finland

* Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK

Peter J. Ratcliffe, University of Oxford, UK
New Horizons in Hypoxia Biology and Therapeutics

9:30 AM—12:00 PM
Acute Oxygen-Sensing
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Roland H. Wenger, University of Zürich, Switzerland

Mark A. Krasnow, Stanford University School of Medicine, USA
Acute Oxygen Sensing in the Lungs and Carotid Body

Coffee Break

Francesco Licausi, Scuola Superiore Sant'Anna, Italy
Harnessing the Oxygen Sensing Mechanism of Plants

Betty A. Eipper, University of Connecticut Health Center, USA
Peptidylglycine alpha–Amidating Monooxygenase (PAM), a Conserved Secretory Pathway Enzyme, Is Sensitive to Physiologically Relevant Changes in Oxygen

David Macias, University of Cambridge, UK
Short Talk: HIF-2α Is Essential for Carotid Body Development and Function

Christopher Turnbull, University of Oxford, UK
Short Talk: Overnight Supplemental Oxygen Abolishes the Rise in Morning Blood Pressure Caused by CPAP withdrawal in OSA

12:00—5:00 PM
On Own for Lunch

12:00—1:00 PM
Poster Setup

South Mezzanine
1:00—10:00 PM
Poster Viewing

South Mezzanine
2:00—4:30 PM
Workshop 1: New Techniques for Oxygen Measurement

Mathematical Institute, L1
* Joachim Fandrey, University Duisburg-Essen, Germany

Giovanni E. Mann, King's College London, UK
Defining Physiological Normoxia in vitro for Clinical Translation of Cell Physiology

Christine Janz, ibidi GmbH, Germany
Intra- and Extracellular Oxygen Measurement on a Live Cell Imaging System Using ibidi OPAL

Peter A. Robbins, University of Oxford, UK
In-Airway Molecular Flow Sensing Using Laser Absorption Spectroscopy: What Is It and Why Is It Useful?

Andrew D. Farmery, University of Oxford, UK
Polymer Fibre-Optic Oxygen Sensors

Margaret Ashcroft, University of Cambridge, UK
CHCHD4 Confers Sensitivity to HIF Pathway Inhibitors

4:30—5:00 PM
Coffee Available

South Mezzanine
5:00—7:00 PM
Hypoxia and Organ (dys)Function
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Peppi Koivunen, University of Oulu, Finland

Johanna Myllyharju, University of Oulu, Finland
Transmembrane Prolyl 4-Hydroxylase (P4H-TM/PHD4) – Further Light into the Roles of this Enigmatic Enzyme

Dörthe M. Katschinski, Georg August University, Germany
The HIF-PHD Pathway in the Cardiovascular System

Volker H. Haase, Vanderbilt University, USA
Oxygen Sensing in the Kidney

Joanne Holliday, University of Nottingham, UK
Short Talk: Ablation of Factor Inhibiting HIF (FIH1) Modulates Cardiac Function and Improves Hypoxic Tolerance

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

South Mezzanine
7:30—10:00 PM
Poster Session 1

South Mezzanine

THURSDAY, APRIL 12

8:30—11:45 AM
Hypoxia and Development
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Cormac Taylor, University College Dublin, Ireland

Dino A. Giussani, University of Cambridge, UK
Heart Disease Link to Fetal Hypoxia: An Intergenerational Perspective

Josh Bonkowsky, University of Utah, USA
Hypoxia and Connectivity in the Developing Vertebrate Nervous System

Coffee Break

Ernestina Schipani, University of Michigan, USA
Impairment of Mitochondrial Respiration Promotes Survival of HIF-1alpha Deficient Chondrocytes in vivo

Pablo Wappner, Fundacion Instituto Leloir, Argentina
Novel Mechanisms of HIF Regulation: Genetic Lessons from Drosophila

Emma U. Hammarlund, Lund University, Sweden
Short Talk: Pseudohypoxia-Activated Pathways Were Essential for Vertebrate Evolution in Earth's Oxic Niche

Tiffany M. Bernardo, University of Pittsburgh, USA
Short Talk: Hypoxia, PPARγ, and Lactate Metabolism in Placental Development and Injury

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

South Mezzanine
1:00—10:00 PM
Poster Viewing

South Mezzanine
4:30—5:00 PM
Coffee Available

South Mezzanine
5:00—7:00 PM
Clinical Inhibitors of HIF Hydroxylases and HIFs
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK

Martin Richard Späth, University Hospital of Cologne, Germany
Short Talk: Molecular Correlates of Hypoxic Preconditioning and PHD-Inhibition in Renal Ischemia Reperfusion Injury

Christopher J. Schofield, University of Oxford, UK
Inhibiting 2-Oxogluterate Oxygenases for Therapeutic Benefit

Chris W. Pugh, University of Oxford, UK
Inducible Phd2 Knockdown in the Mouse Reveals Immunological Effects that Warrant Consideration in the Context of Pharmacological Inhibition of this Enzyme in the Clinic

Kyoji Yamaguchi, Daiichi Sankyo Co. Ltd, Japan
Short Talk: DS-1093a, A Novel HIF Prolyl Hydroxylase Inhibitor, Has Therapeutic Potential in a Wide Range of Diseases

Thomas Kietzmann, University of Oulu, Finland
Short Talk: The Epidermal Growth Factor Receptor (EGFR) Adaptor Protein CIN85 Is a Novel Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2 (PHD2)

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

South Mezzanine
7:30—10:00 PM
Poster Session 2

South Mezzanine

FRIDAY, APRIL 13

8:30—11:30 AM
Immune and Inflammatory Effects of Hypoxia
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Edurne Berra, CIC bioGUNE, Spain

Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK
Hypoxia and Regulation of Inflammatory Cell Migration

Yun-Cai Liu, La Jolla Institute for Allergy and Immunology, USA
VHL-HIF-Glycolytic Pathway in Immune Regulation

Coffee Break

Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK
Hypoxia and Regulation of Inflammation and Anti-Microbial Responses

Randall S. Johnson, University of Cambridge, UK
Hypoxia and its Role in the Interaction of the Innate and Adaptive Immune Systems

Einav Gross, Hebrew University of Jerusalem, Israel
Short Talk: Innate Immunity Regulation by Neuronal Oxygen Sensors in the Nematode Caenorhabditis elegans

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

South Mezzanine
1:00—10:00 PM
Poster Viewing

South Mezzanine
2:30—4:30 PM
Workshop 2: Chromatin and Epigenetics

Mathematical Institute, L1
* Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK

Sophie Cowman, University of Liverpool, UK
Alteration of DNA Repair Activity in Hypoxic Brain Tumours Underlies Treatment Resistance

Minoru Kobayashi, Kyoto University, Japan
A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of its Downstream Genes

Tamas Ordog, Mayo Clinic, USA
Hypoxia-Inducible Factor 1 alpha (HIF1A) Stimulates Neuronal Nitric Oxide Synthase (Nos1) Transcription by Modifying Spatial Chromatin Organization

Ilaria Maria Cristina Orlando, University of Zurich, Switzerland
Regulatory DNA Elements Modulating Oxygen-Regulated Erythropoietin Gene Expression

Catherine Turgeon, Université Laval, Canada
PRMT1-Mediated DOCK6 Arginine Methylation Represses Hypoxia-Inducible Factor-1 (HIF-1) Expression

Michael Batie, University of Liverpool, UK
The Role of Chromatin Structure and JmjC Histone Demethylases in the Hypoxic Response

4:30—5:00 PM
Coffee Available

South Mezzanine
5:00—7:00 PM
Hypoxia and Stem Cell Function
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Pablo Wappner, Fundacion Instituto Leloir, Argentina

Kamil R. Kranc, University of Edinburgh, UK
Hypoxia Signaling in Normal and Malignant Haematopoiesis

Paul R. Riley, University of Oxford, UK
The Role of Hypoxia and HIF-Signaling in Epicardial Activation during Neonatal Cardiac Regeneration

Edurne Berra, CIC bioGUNE, Spain
Harnessing the Intricate Crosstalk in Hypoxia Signaling Pathways

Jong Park, University of Maryland, Baltimore County, USA
Short Talk: Role of Lactate-NDRG1 Signaling in Low Oxygen Tolerance

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

South Mezzanine
7:30—10:00 PM
Poster Session 3

South Mezzanine

SATURDAY, APRIL 14

8:30—11:30 AM
Tissue Degeneration, Regeneration and Programming
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Johanna Myllyharju, University of Oulu, Finland

Peppi Koivunen, University of Oulu, Finland
HIF Prolyl 4-Hydroxylase Inhibition in Fatty Liver Diseases

Sean P. Colgan, University of Colorado Denver, USA
Hypoxia and HIF as Regulators of Barrier Function in the Mucosa

Coffee Break

Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Redox Regulation of Cardiomyocyte Renewal

Tracey A. Rouault, NICHD, National Institutes of Health, USA
Translational Regulation of HIF2 alpha and Erythropoiesis by the IRE-IRP System

James A. Nathan, Cambridge Institute for Medical Research, UK
Short Talk: The Endolysosomal Vacuolar-ATPase Complex Controls HIF Signaling by Restricting Iron Availability

11:30 AM—12:30 PM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Chris W. Pugh, University of Oxford, UK

* Pablo Wappner, Fundacion Instituto Leloir, Argentina

* Johanna Myllyharju, University of Oulu, Finland

* Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Do Histone Demethylases Directly Sense Oxygen to Control Chromatin Structure and Cell Fate?

12:30—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 3: Physiology and Metabolism

Mathematical Institute, L1
* Thomas Kietzmann, University of Oulu, Finland

Penny Anne Gowland, University of Nottingham, UK
Assessing Oxygenation in vivo with MR

Franziska Dengler, University of Leipzig, Germany
Hypoxia in Jejunum Epithelium: Fast Adaptation of Glucose Transport

Paul Grevitt, Barts Cancer Institute, UK
Identification of Novel Regulators of HIFs

Amalia Ruiz-Serrano, University of Zürich, Switzerland
Deletion of the FIH Substrate OTUB1 in Mice Affects Viability, Energy Metabolism and Oxygen Physiology

Julián Aragonés Lopez, Research Institute Princesa, Spain
Role of Hif2α-Epo Pathway in Airway Response to Oxygen FluctuatioNS

Gijsbert Jacob van Belle, Universitätsmedizin Göttingen, Germany
Hypoxia-Stimulated Membrane Trafficking Requires T-Plastin

4:30—5:00 PM
Coffee Available

South Mezzanine
5:00—6:45 PM
Epigenetic and Pan-Genomic Effects of Hypoxia
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
* Chris W. Pugh, University of Oxford, UK

Raul Mostoslavsky, Harvard Medical School, USA
Linking Epigenetics, Metabolism and Cancer: Lessons from SIRT6

Skirmantas Kriaucionis, University of Oxford, UK
TET Proteins and 5-Hydroxymethylcytosine in Transcription

Joaquín M. Espinosa, University of Colorado Boulder, USA
Mechanisms of Transcriptional Regulation during the Hypoxic Response

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mathematical Institute, L1
7:00—8:30 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

South Mezzanine

SUNDAY, APRIL 15

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Akebia Therapeutics

We gratefully acknowledge additional support from these exhibitors at this conference:

Don Whitley Scientific Limited
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL142299-01

Funding for this conference was made possible (in part) by 1R13HL142299-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Baker Ruskinn Dove Medical Press Ltd

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676