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This meeting took place in 2018



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Atherosclerosis: Lessons Learned and Concepts Challenged (B2)


Organizer(s) Laura F. Michael, Gerard Pasterkamp and Sekar Kathiresan
February 4—8, 2018
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Oct 5, 2017
Abstract Deadline: Nov 7, 2017
Scholarship Deadline: Oct 5, 2017
Discounted Registration Deadline: Dec 7, 2017

Sponsored by Amgen Inc., MedImmune and Novo Nordisk A/S

Summary of Meeting:
Atherosclerosis is a chronic, systemic disease process whereby fatty deposits, inflammation and fibrosis accumulate in arterial vessel walls. Organ systems, including heart, brain and kidneys, as well as extremities, can be damaged, leading to atherosclerosis-driven clinical outcomes. According to the American Heart Association, 15.5 million Americans have coronary heart disease, of which 7.6 million experienced myocardial infarction. These statistics are reflective of global incidence. Treatment of atherosclerosis often begins with robust cholesterol-lowering treatments, yet many patients continue to experience cardiovascular events. Recent attempts to provide cardiovascular protection to such patients have included anti-inflammatory and HDL-raising therapeutic approaches that have yielded little benefit. Building knowledge of atherosclerosis disease etiology, defining unique attributes of patient differences as simple as sex or genetic inheritance, and using technology to identify patients with early disease is foundational for the scientific community to develop urgently needed therapeutics. The current concept of acute coronary syndrome (“the vulnerable plaque”) and widely applied animal models are debated because clinical presentation, underlying pathology and pathogenetic mechanisms are subject to change due to improved medical treatment. The goals of this meeting are to: 1) Challenge current dogma of atherosclerosis etiology and explore intra-organ cross-talk that may underlie disease evolution; 2) Consider emerging risk factors and their origins as intervention targets; and 3) Explore cutting-edge technologies to discover new therapeutic targets and approaches for drug development. By bringing together scientists from preclinical to clinical settings and from industry to academic institutions, this conference will nurture discussions to translate breakthrough discoveries into therapeutics.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 4 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 9 in order to fully experience the meeting.

SUNDAY, FEBRUARY 4

4:00—8:00 PM
Arrival and Registration

Sagebrush Lobby & Cantina
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sagebrush Lobby & Cantina

MONDAY, FEBRUARY 5

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:00 AM
The Natural History of Atherosclerotic Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Daniel J. Rader, University of Pennsylvania, USA

Peter Libby, Brigham and Women's Hospital, USA
Requiem for the Vulnerable Plaque, Challenging Current Concepts

Sekar Kathiresan, Massachusetts General Hospital, USA
Inherited Basis for Myocardial Infarction

Coffee Break

Gerard Pasterkamp, University Medical Center Utrecht, Netherlands
Geno-Phenotyping of the Vulnerable Plaque and Patient

Philippe Boucher, University of Strasbourg, France
Short Talk: Wnt5a Decreases mTORC1/SREBP2 Activity and Promotes Endosomal Cholesterol Trafficking to the ER in Mice and in Human Vascular Smooth Muscle Cells

Sumeet A. Khetarpal, University of Pennsylvania, USA
Short Talk: A Human APOC3 Missense Variant and Monoclonal Antibody Accelerate apoC-III Clearance and Lower Triglyceride-rich Lipoprotein Levels

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
2:30—4:30 PM
Workshop 1

Chamisa Ballroom 1
* Ira G. Schulman, University of Virginia Health System, USA

Liam Brunham, University of British Columbia, Canada
Genetic Regulation of HDL Cholesterol Levels during Sepsis

Ruchi Gupta, MedImmune/AstraZeneca, USA
LOX-1: The Cause of and Solution to Inflammation and Lipid Accumulation in Atherosclerosis

Anna Kerstin Emy Hultgardh, Lund University, Sweden
IL-22 Deficiency Reduces Formation of Advanced Atherosclerotic Carotid Plaques in ApoE-Deficient Mice

Ashok Kumar Kumawat, Orebro University, Sweden
Targeting IL-6/IL17A in Vascular Inflammation using Affibody Molecules

Mulugeta Melkie Zegeye, Orebro University, Sweden
Activation of JAK/STAT3 and PI3K Pathways Are Crucial for MCP-1 Induction by IL6 Trans-Signaling in Human Endothelial Cells

Sean Allen, Northwestern University, USA
Targeted Inhibition of NF-κB in Mouse Models of Atherosclerosis Results in Sex-Dependent Immunomodulation

Anna Mathew, University of Michigan, USA
Myeloperoxidase-Derived Oxidants Damage Artery Wall Proteins in an Animal Model of Chronic Kidney Disease-Accelerated Atherosclerosis

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:00 PM
Lipoprotein Risk Factors
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Laura F. Michael, Eli Lilly and Company, USA

Kiran Musunuru, University of Pennsylvania, USA
Therapeutic Genome Editing as a Cure for Atherosclerosis

Anne Tybjærg-Hansen, Copenhagen University Hospital, Denmark
Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights from Epidemiology, Genetics, and Biology

Daniel J. Rader, University of Pennsylvania, USA
Functionalizing HDL Cholesterol

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 1

Chamisa Ballroom 2

TUESDAY, FEBRUARY 6

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:00 AM
Diabetes, Obesity and Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Siddhartha Jaiswal, Stanford University, USA

J. Mark Brown, Cleveland Clinic, USA
Selective Small Molecule Inhibition of Gut Microbial Enzymes for the Treatment of Cardiometabolic Disorders

Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Protective Role of Brown Adipose in Atherosclerosis Development

Coffee Break

Laura F. Michael, Eli Lilly and Company, USA
Diabetes and Atherosclerosis: Anti-Diabetic Agents that Improve Cardiovascular Outcomes

Robert C. Bauer, Columbia University, USA
Short Talk: Adipose Knockout of Tribbles-1, a GWAS Locus for Coronary Artery Disease, Reduces Plasma Lipids and Increases Circulating Adiponectin

Brian Parks, University of Wisconsin-Madison, USA
Journal of Lipid Research Junior Investigator Award: Short Talk: Leveraging Mouse Liver Co-Expression Networks and Human Lipid GWAS Data to Identify and Validate Cholesterol Metabolism Genes

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:00 PM
The Inflammation Hypothesis
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Katey Rayner, University of Ottawa, Canada

Ziad Mallat, University of Cambridge, UK
Immune Modulation in Atherosclerosis

Jan Nilsson, Lund University, Sweden
Autoimmunity, Injury and Repair as Potential Targets for Intervention in Atherosclerosis

Paul M. Ridker, Brigham and Women's Hospital, Harvard Medical School, USA
Anti-inflammatory Therapies for Chronic Atherosclerosis

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, FEBRUARY 7

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:15 AM
The Milieu Exterieur
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gerard Pasterkamp, University Medical Center Utrecht, Netherlands

Salim Yusuf, McMaster University, Canada
How Can We Reduce Premature CVD Globally in a Generation?

Sudha B. Biddinger, Boston Children's Hospital, Harvard Medical School, USA
Beyond Hyperglycemia: Novel Mediators of Diabetes-Associated Cardiovascular Disease

Coffee Break

Seppo Yla-Herttuala, University of Eastern Finland, Finland
Epigenetics, VEGFs and Noncoding RNAs in Atherosclerosis and Angiogenesis

Robert E. Gerszten, Beth Israel Deaconess Medical Center, USA
Translating Exercise into Reduced Atherosclerosis Burden

Brian Bennett, US Department of Agriculture, USA
Short Talk: Genetic and MicroRNA Association with the Cardiometabolic Disease Risk Factor TMAO

Michael C. Petriello, University of Kentucky, USA
Short Talk: Serum Levels of Dioxin-Like Pollutants Are Positively Associated with the Cardiometabolic Disease Risk Biomarker Trimethylamine-N-oxide in Leaner Individuals

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
2:30—4:30 PM
Workshop 2

Chamisa Ballroom 1
* Dominique P.V. de Kleijn, University Medical Center Utrecht, Netherlands

Camilla Gustafsen, Aarhus University, Denmark
Heparan Sulfate Proteoglycans Present PCSK9 to the LDL Receptor

Fan E. Mo, National Cheng Kung University, Taiwan
CCN1 and Its Receptor Integrin alpha6beta1 Instigate a Vicious Circle to Accelerate Disturbed Flow-Induced Atherosclerosis

Andrew J. Morris, University of Kentucky, USA
Functional Validation of PPAP2B Gene Variants as Determinants of Coronary Artery Disease Risk

Edward R. O'Brien, University of Calgary, Canada
Natural Antibodies to HSP27 Are Novel Biomarkers for Cardiovascular Health: HSP27 Immunization Attenuates PCSK9 Transcription and Atherogenesis

Ira G. Schulman, University of Virginia Health System, USA
Regulation of HDL Function and Inflammation by Liver X Receptors

Tapan Shah, Rutgers New Jersey Medical School, USA
Sex Specific Differences in Post-Transcriptional Gene Regulation of BMP2 in Cardiovascular Calcification

Vincent J. Venditto, University of Kentucky, USA
Anti-ApoA-I Antibody Profiles Predict Cardiovascular Disease Outcomes in Patients and in a Mouse Model of Atherosclerosis

Hong Yang, Meharry Medical College, USA
Upregulation of ABCA1 Transcription and Inhibition of ABCA1 Protein Degradation by VLDLR/apoER2 Pathway

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:15 PM
Crosstalk Among Organs
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jan Nilsson, Lund University, Sweden

Viktoria Gusarova, Regeneron Pharmaceuticals, USA
ANGPTL3 Blockade as a Therapeutic Approach for Treatment of Dyslipidemia and Atherosclerosis

Lilach O. Lerman, Mayo Clinic, USA
New Concepts in Atherosclerotic Renovascular Disease: Current Status

Joachim Herz, University of Texas Southwestern Medical Center, USA
Multitasking Therapeutics: What Brain Development, Alzheimer’s Disease and Atherosclerosis Have in Common

Johan Lars Markus Björkegren, Icahn School of Medicine at Mount Sinai, USA
Cardiometabolic Risk Loci Share Downstream Cis- and Trans-Gene Regulation Across Tissues and Diseases

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 3

Chamisa Ballroom 2

THURSDAY, FEBRUARY 8

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—9:00 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Sekar Kathiresan, Massachusetts General Hospital, USA

Jesper Gromada, Regeneron Pharmaceuticals, USA
PCSK9 and ANGPTL3 Inhibitors: A New Era of Lipid-Lowering Therapies

9:00—11:15 AM
Models and Biomarkers for Atherosclerotic Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Viktoria Gusarova, Regeneron Pharmaceuticals, USA

Jacob Fog Bentzon, Centro Nacional de Investigaciones Cardiovasculares, Spain
Gene-Modified Minipigs: Applications in Atherosclerosis Imaging

Coffee Break

Lesca Miriam Holdt, University Hospital, LMU Munich, Germany
Circular RNA in Atherosclerosis

Katey Rayner, University of Ottawa, Canada
New Inflammatory Drivers and Biomarkers of Atherosclerosis

Kelsey E. Jarrett, Baylor College of Medicine, USA
Short Talk: Somatic Genome Editing of Ldlr with AAV-CRISPR Is a Rapid Method for Atherosclerosis Investigation

11:15 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 3

Chamisa Ballroom 1
* Thomas Beyer, Eli Lilly and Company, USA

Maria Ines Azambuja, Universidade Federal do Rio Grande do Sul, Brazil
The Information that We Need to Advance Knowledge on Atherogenesis Exists and It Is Stored as Levels and Trends of Mortality over the Last Century: Influenza is the Key to Retrieve It

Dominique P.V. de Kleijn, University Medical Center Utrecht, Netherlands
Diagnosis of Atherosclerotic Coronary Heart Disease using Plasma Extracellular Vesicle Proteins

Trine Pagh Ludvigsen, Novo Nordisk A/S, Denmark
Effect of Statin Treatment Compared to Dietary Cessation on Aortic Plaque Size and Inflammation in a Diet-Induced Atherosclerotic Göttingen Minipig Model

Ananthi Rajamoorthi, St. Louis University School of Medicine, USA
Therapeutic Silencing of CIDEC/Fsp27 Is Atheroprotective in Ldlr-/- Mice

Divya Sagar, MedImmune, USA
Soluble LOX-1: A Potential Biomarker for SLE and Cardiovascular Comorbidity

James Wingrove, CardioDx, USA
The Added Value of a Multi-Omics Approach for the Evaluation of Patients with Suspected Obstructive Coronary Artery Disease

Jifeng Zhang, University of Michigan, USA
Attenuated Atherosclerosis in Human Apolipoprotein A-II knockin Rabbits

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—6:45 PM
Emerging Fields of Research
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Sekar Kathiresan, Massachusetts General Hospital, USA

Marlys L. Koschinsky, Western University, Canada
Lipoprotein(a): Ready for Prime Time?

Hester den Ruijter, University Medical Center, Utrecht, Netherlands
Sex Differences in Cardiovascular Disease

Siddhartha Jaiswal, Stanford University, USA
Clonal Hematopoiesis in Aging and Atherosclerotic Cardiovascular Disease

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Chamisa Ballroom 2

FRIDAY, FEBRUARY 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Amgen Inc. MedImmune
Novo Nordisk A/S
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 HL140612-01

Funding for this conference was made possible (in part) by 1 R13 HL140612-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Journal of Lipid Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Regeneron Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676