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This meeting took place in 2018
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Phosphoinositide Biology: New Therapeutic Targets Beyond Class I PI3K (B5)
Organizer(s) Emilio Hirsch, Tamas Balla and Cristina Donini
February 11—15, 2018
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Oct 10, 2017
Abstract Deadline: Nov 8, 2017
Scholarship Deadline: Oct 10, 2017
Discounted Registration Deadline: Dec 12, 2017
Supported by the Directors' Fund
Summary of Meeting:
Phosphoinositides have been recognized since the 1980s as important regulatory lipids supporting signal transduction from G protein-coupled receptors and receptor tyrosine kinases. The discovery of PI 3-kinases and their roles in carcinogenesis and immune regulation has created a fertile ground for translational expansion of the phosphoinositide field with a focus on cancer and inflammation. Most of these advances focused on Class I PI3Ks and PIP3-mediated signaling. However, research on other PI kinases and phosphoinositides has expanded substantially over the years. Class II and -III PI 3-kinases and less characterized 3-phosphorylated phosphoinositides are now rapidly emerging as key controllers of development, trafficking, nutrition-sensing and autophagy. Furthermore, phosphoinositides different from the 3-phosphorylated species are gaining momentum in many aspects of cell physiology and pathology. Exciting new developments include PI 4-kinases controlling vesicular trafficking and non-vesicular lipid transfer between membrane contacts, and new details are emerging on the role of inositol lipid phosphatases in trafficking, endocytosis and ciliary function. The recently recognized roles of PI 4-kinases as obligate host factors for certain RNA viruses, and their importance in parasitic organisms such as Plasmodium falciparum or Legionella pneumophila, have raised significant interest from pharmaceutical companies that now focus on inositol lipids other than the products of PI 3-kinases. By expanding our knowledge of phosphoinositides beyond class I PI3K products, this Keystone Symposia meeting represents a unique opportunity to bolster the rising interest in these under-explored avenues with a strong potential for translational impact.
View Scholarships/Awards
Phosphoinositides have been recognized since the 1980s as important regulatory lipids supporting signal transduction from G protein-coupled receptors and receptor tyrosine kinases. The discovery of PI 3-kinases and their roles in carcinogenesis and immune regulation has created a fertile ground for translational expansion of the phosphoinositide field with a focus on cancer and inflammation. Most of these advances focused on Class I PI3Ks and PIP3-mediated signaling. However, research on other PI kinases and phosphoinositides has expanded substantially over the years. Class II and -III PI 3-kinases and less characterized 3-phosphorylated phosphoinositides are now rapidly emerging as key controllers of development, trafficking, nutrition-sensing and autophagy. Furthermore, phosphoinositides different from the 3-phosphorylated species are gaining momentum in many aspects of cell physiology and pathology. Exciting new developments include PI 4-kinases controlling vesicular trafficking and non-vesicular lipid transfer between membrane contacts, and new details are emerging on the role of inositol lipid phosphatases in trafficking, endocytosis and ciliary function. The recently recognized roles of PI 4-kinases as obligate host factors for certain RNA viruses, and their importance in parasitic organisms such as Plasmodium falciparum or Legionella pneumophila, have raised significant interest from pharmaceutical companies that now focus on inositol lipids other than the products of PI 3-kinases. By expanding our knowledge of phosphoinositides beyond class I PI3K products, this Keystone Symposia meeting represents a unique opportunity to bolster the rising interest in these under-explored avenues with a strong potential for translational impact.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 11 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 15 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 16 in order to fully experience the meeting.
SUNDAY, FEBRUARY 11
MONDAY, FEBRUARY 12
TUESDAY, FEBRUARY 13
WEDNESDAY, FEBRUARY 14
THURSDAY, FEBRUARY 15
FRIDAY, FEBRUARY 16
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Sunday, February 11 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 15 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 16 in order to fully experience the meeting.
SUNDAY, FEBRUARY 11
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Emilio Hirsch,
Fondazione per la Ricerca Biomedica – ONLUS, Italy
*
Tamas Balla,
NICHD, National Institutes of Health, USA
Pietro V. De Camilli,
Yale University School of Medicine, USA
Phosphoinositide Signaling in the Control of Membrane Dynamics and Interactions
Phosphoinositide Signaling in the Control of Membrane Dynamics and Interactions
9:00—11:30 AM
Phosphoinositide Gradients and Lipid Transport at Membrane Contact Sites
Meeting has ended...abstracts no longer viewable online.
*
Gerry Hammond,
University of Pittsburgh, USA
Bruno Antonny,
Institut de Pharmacologie Moleculaire et Cellulaire, France
PI4P as an Energy Source for Cholesterol Transfer by OSBP through the Activity of two PI4-Kinases with Contrasting Membrane-Binding Properties
PI4P as an Energy Source for Cholesterol Transfer by OSBP through the Activity of two PI4-Kinases with Contrasting Membrane-Binding Properties
Coffee Break
Tamas Balla,
NICHD, National Institutes of Health, USA
The Role of PI4KA in Controlling Membrane Lipid Dynamics
The Role of PI4KA in Controlling Membrane Lipid Dynamics
Jen Liou,
University of Texas Southwestern Medical Center, USA
The Role of ER-PM Junctions in Phosphoinositide Homeostasis and Ca2+ Signaling
The Role of ER-PM Junctions in Phosphoinositide Homeostasis and Ca2+ Signaling
Raghu Padinjat,
National Centre for Biological Sciences, India
Short Talk: Tuning of Lipid Transfer Reactions at Membrane Contact Sites in Drosophila Photoreceptors
Short Talk: Tuning of Lipid Transfer Reactions at Membrane Contact Sites in Drosophila Photoreceptors
Jana Humpolickova,
Institute of Organic Chemistry and Biochemistry, Czech Republic
Short Talk: Biophysical Determinants of Liposome-Reconstituted Lipid Transport by ORP5/ORP8
Short Talk: Biophysical Determinants of Liposome-Reconstituted Lipid Transport by ORP5/ORP8
5:00—7:00 PM
PI 4-Kinases as Possible Drug Targets
Meeting has ended...abstracts no longer viewable online.
*
Antonella De Matteis,
Telethon Institute of Genetics and Medicine, Italy
Nihal Altan-Bonnet,
NHLBI, National Institutes of Health, USA
Lipid Blueprints for Viral Replication and Transmission
Lipid Blueprints for Viral Replication and Transmission
Kasturi Haldar,
University of Notre Dame, USA
A Mechanism of Artemisinin Resistance in Plasmodium falciparum Malaria
A Mechanism of Artemisinin Resistance in Plasmodium falciparum Malaria
Cristina Donini,
Medicines for Malaria Venture, Switzerland
MMV048, a Plasmodium PI4K Inhibitor as Potential Malarial Treatment
MMV048, a Plasmodium PI4K Inhibitor as Potential Malarial Treatment
Radim Nencka,
IOCB Prague, Czech Republic
Short Talk: Phosphatidylinositol 4-Kinase IIIβ Inhibitors as Potential Therapeutics
Short Talk: Phosphatidylinositol 4-Kinase IIIβ Inhibitors as Potential Therapeutics
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:15 AM
Inositide Phosphatases in Cancer and Development
Meeting has ended...abstracts no longer viewable online.
*
Amy Kiger,
University of California, San Diego, USA
Gerry Hammond,
University of Pittsburgh, USA
SAC1 Degrades its Lipid Substrate PtdIns4P in the Endoplasmic Reticulum to Maintain a Steep Chemical Gradient with Donor Membranes
SAC1 Degrades its Lipid Substrate PtdIns4P in the Endoplasmic Reticulum to Maintain a Steep Chemical Gradient with Donor Membranes
Jeremy F. Reiter,
University of California, San Francisco, USA
Cilia Have a Distinct Composition of Phosphoinositides and Other Lipids Critical for Signaling
Cilia Have a Distinct Composition of Phosphoinositides and Other Lipids Critical for Signaling
Coffee Break
Christina Anne Mitchell,
Monash University, Australia
Identification of Novel Roles for Inositol Polyphosphate 5-Phosphatases
Identification of Novel Roles for Inositol Polyphosphate 5-Phosphatases
Antonella De Matteis,
Telethon Institute of Genetics and Medicine, Italy
The Phosphoinositides and the Golgi Complex
The Phosphoinositides and the Golgi Complex
John D. York,
Vanderbilt University, USA
Short Talk: Coordinated and Independent Biological Functions of Inositide Phosphatase Activities in Synaptojanins
Short Talk: Coordinated and Independent Biological Functions of Inositide Phosphatase Activities in Synaptojanins
Leonardo Salmena,
University of Toronto, Canada
Short Talk: INPP4B-Associated Leukemic Stem Cell Self-Renewal as a New Target in AML Therapy
Short Talk: INPP4B-Associated Leukemic Stem Cell Self-Renewal as a New Target in AML Therapy
2:30—4:30 PM
Workshop: New and Emerging Paradigms and Possible Drug Targets
*
Cristina Donini,
Medicines for Malaria Venture, Switzerland
Evzen Boura,
Institute of Organic Chemistry and Biochemistry, Czech Republic
Hijacking of PI4KB by Picornaviruses – Structural Insights and the Role of ACBD3
Hijacking of PI4KB by Picornaviruses – Structural Insights and the Role of ACBD3
Brooke M. Emerling,
Sanford Burnham Prebys Medical Discovery Institute, USA
Phosphatidylinositol-5-Phosphate 4-Kinases in the Control of Cellular Lipid Metabolism and Autophagy
Phosphatidylinositol-5-Phosphate 4-Kinases in the Control of Cellular Lipid Metabolism and Autophagy
Michael P. Sheetz,
Mechanobiology Institute, National University of Singapore, Singapore
DNA Damage Causes Rapid Accumulation of Phosphoinositides for ATR Signaling
DNA Damage Causes Rapid Accumulation of Phosphoinositides for ATR Signaling
Carmen Sivakumaren,
Harvard University, USA
Targeting the PIP4K2 Lipid Kinase Family in Cancer using Novel Covalent Inhibitors
Targeting the PIP4K2 Lipid Kinase Family in Cancer using Novel Covalent Inhibitors
Yoko Yoshikawa,
Kobe University Graduate School of Medicine, Japan
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε
5:00—7:15 PM
Structural Insights into Pharmacological Targeting of Lipid Kinases
Meeting has ended...abstracts no longer viewable online.
*
Evzen Boura,
Institute of Organic Chemistry and Biochemistry, Czech Republic
John E. Burke,
University of Victoria, Canada
Structural Basis of Regulation and Inhibition of Phosphatidylinositol 4-Kinase III Beta (PI4KIIIB)
Structural Basis of Regulation and Inhibition of Phosphatidylinositol 4-Kinase III Beta (PI4KIIIB)
Ujjini H. Manjunatha,
Novartis Institute for Tropical Diseases, USA
Cryptosporidium Lipid Kinase Is a Promising Molecular Target to Treat Cryptosporidiosis
Cryptosporidium Lipid Kinase Is a Promising Molecular Target to Treat Cryptosporidiosis
Roger L. Williams,
Medical Research Council, UK
Structural Mechanisms of Regulation of the PI3K Superfamily
Structural Mechanisms of Regulation of the PI3K Superfamily
Chunmei Chang,
University of California, Berkeley, USA
Short Talk: Rubicon Inhibits the PI3KC3 Complex II by Blocking a Membrane Docking Site
Short Talk: Rubicon Inhibits the PI3KC3 Complex II by Blocking a Membrane Docking Site
Raymond Blind,
Vanderbilt University School of Medicine, USA
Short Talk: Intrinsic Kinase Auto-Regulation Mediated by Disordered Domains: Crystallographic and Enzyme Kinetic Analyses of the Human Inositol Polyphosphate Multikinase (IPMK)
Short Talk: Intrinsic Kinase Auto-Regulation Mediated by Disordered Domains: Crystallographic and Enzyme Kinetic Analyses of the Human Inositol Polyphosphate Multikinase (IPMK)
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:15 AM
Phosphoinositides Directing Trafficking for Degradation
Meeting has ended...abstracts no longer viewable online.
*
Volker Haucke,
Leibniz Institut für Molekulare Pharmakologie, Germany
Lois S. Weisman,
University of Michigan, USA
Multiple Mechanisms Dynamically Regulate the Signaling Lipid PI(3,5)P2
Multiple Mechanisms Dynamically Regulate the Signaling Lipid PI(3,5)P2
Coffee Break
Mariella Vicinanza,
Cambridge Institute for Medical Research, UK
PI(5)P Regulates Autophagy
PI(5)P Regulates Autophagy
Ankita Jaykumar,
University of Texas Southwestern Medical Center, USA
Identifying Novel Functions of WNK1 Pathway in Autophagy
Identifying Novel Functions of WNK1 Pathway in Autophagy
Benoit Bilanges,
University College London, UK
Short Talk: Vps34 PI 3-Kinase Inactivation Enhances Insulin Sensitivity through Reprogramming of Mitochondrial Metabolism
Short Talk: Vps34 PI 3-Kinase Inactivation Enhances Insulin Sensitivity through Reprogramming of Mitochondrial Metabolism
Golam Saffi,
Ryerson University, Canada
Short Talk: Lysosome Enlargement during PIKfyve Inhibition Occurs through Lysosome Coalescence Instead of Increased Biosynthesis
Short Talk: Lysosome Enlargement during PIKfyve Inhibition Occurs through Lysosome Coalescence Instead of Increased Biosynthesis
5:00—7:15 PM
Monoinositide Phosphatases
Meeting has ended...abstracts no longer viewable online.
*
Lois S. Weisman,
University of Michigan, USA
Lewis C. Cantley,
Weill Cornell Medicine, USA
Type 2 Phosphatidylinositol-5-Phosphate 4-Kinases in Cancer
Type 2 Phosphatidylinositol-5-Phosphate 4-Kinases in Cancer
Jocelyn Laporte,
Institute of Genetics and Molecular and Cellular Biology, France
Myotubularin Phosphoinositides Phosphatases Implication and Targeting in Neuromuscular Diseases
Myotubularin Phosphoinositides Phosphatases Implication and Targeting in Neuromuscular Diseases
Amy Kiger,
University of California, San Diego, USA
Coordination of Class II PI3-Kinase and Mtm PI3-Phosphatase Functions
Coordination of Class II PI3-Kinase and Mtm PI3-Phosphatase Functions
Elizabeth A. Allen,
University of Massachusetts Medical School, USA
Short Talk: Discovery of a Myotubularin-Related Phosphatase in Autophagy
Short Talk: Discovery of a Myotubularin-Related Phosphatase in Autophagy
Andrew T. Hale,
Vanderbilt University School of Medicine, USA
Short Talk: Coordinated Inositide Lipid-Phosphatase Activities of Synaptojanin Modulate Actin Cytoskeleton Organization
Short Talk: Coordinated Inositide Lipid-Phosphatase Activities of Synaptojanin Modulate Actin Cytoskeleton Organization
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—8:45 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Emilio Hirsch,
Fondazione per la Ricerca Biomedica – ONLUS, Italy
Pier Paolo Pandolfi,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Modes of PI3K Signaling Regulation and Deregulation in Disease Pathogenesis
Novel Modes of PI3K Signaling Regulation and Deregulation in Disease Pathogenesis
8:45—11:30 AM
Beyond Class I PI 3-Kinases
Meeting has ended...abstracts no longer viewable online.
*
Tamas Balla,
NICHD, National Institutes of Health, USA
Emilio Hirsch,
Fondazione per la Ricerca Biomedica – ONLUS, Italy
Class II PI3K Signaling in Cancer
Class II PI3K Signaling in Cancer
Coffee Break
James Dowling,
Hospital for Sick Children, Canada
3-Phosphoinositide Metabolism in Muscle Development, Muscle Disease and as a Therapeutic Target
3-Phosphoinositide Metabolism in Muscle Development, Muscle Disease and as a Therapeutic Target
York Posor,
University College London, UK
Short Talk: PI3K-C2α in dsRNA Sensing and Inflammation
Short Talk: PI3K-C2α in dsRNA Sensing and Inflammation
Antonija Jurak Begonja,
University of Rijeka, Croatia
Short Talk: PI3P Modulates Megakaryocyte Maturation and Platelet Production through Late Endosomes/Lysosomes
Short Talk: PI3P Modulates Megakaryocyte Maturation and Platelet Production through Late Endosomes/Lysosomes
5:00—6:45 PM
PIP Kinases as Emerging Drug Targets
Meeting has ended...abstracts no longer viewable online.
*
Pier Paolo Pandolfi,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Volker Haucke,
Leibniz Institut für Molekulare Pharmakologie, Germany
Phosphoinositide Conversion Directs Vesicular Trafficking
Phosphoinositide Conversion Directs Vesicular Trafficking
Richard A. Anderson,
University of Wisconsin Medical School, USA
Agonist-Stimulated PI3,4,5P3 Generation by Scaffolded Phosphoinositide Kinases
Agonist-Stimulated PI3,4,5P3 Generation by Scaffolded Phosphoinositide Kinases
Atsuo T. Sasaki,
University of Cincinnati, USA
PI5P4Kbeta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
PI5P4Kbeta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.
*
Tamas Balla,
NICHD, National Institutes of Health, USA
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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