Sagebrush Inn & Suites Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2017



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

TGF-ß in Immunity, Inflammation and Cancer (A3)


Organizer(s) Wanjun Chen, Joanne E. Konkel and Richard A. Flavell
January 9—13, 2017
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Sep 20, 2016
Abstract Deadline: Oct 11, 2016
Scholarship Deadline: Sep 20, 2016
Discounted Registration Deadline: Nov 10, 2016

Sponsored by BioLegend, Inc., EMD Serono Research and Development Institute, Inc. and Regeneron Pharmaceuticals, Inc.

Summary of Meeting:
TGF-beta is a key regulator of immune responses, inflammation and cancer. In addition to the well-established effects of TGF-beta on CD4+ T cell differentiation and reprogramming, TGF-beta also plays critical roles in other immune cells. Furthermore, TGF-beta has been implicated in the regulation of the interactions among immune cells, microbiota and epithelial cells. In addition to safeguarding immune homeostasis and suppressing chronic inflammation and autoimmunity, TGF-beta is emerging as a potential checkpoint in anti-tumor immunity. Despite great progress in the field, key questions related to TGF-beta functions in immune responses are still largely undetermined. Therefore, it is imperative to understand the cellular and molecular mechanisms by which TGF-beta controls such diverse immune cells. Elucidation of these pathways would allow us to understand the pathogenesis of chronic inflammation, autoimmunity and cancer and aid development of therapeutic practices in experimental and ultimately clinical settings. This meeting will gather together experts in the fields of both TGF-beta signaling and immunology to discuss new findings and update the pivotal role of TGF-beta in immunity, inflammation and cancer, with the aim to lay out the critical and key questions and outline new directions.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Monday, January 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, January 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, January 14 in order to fully experience the meeting.

MONDAY, JANUARY 9

4:00—8:00 PM
Arrival and Registration

Sagebrush Lobby & Cantina
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sagebrush Lobby & Cantina

TUESDAY, JANUARY 10

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Wanjun Chen, NIDCR, National Institutes of Health, USA

Rik Derynck, University of California, San Francisco, USA
TGF-beta Responses and Control of TGF-beta Responsiveness

9:00—11:30 AM
TGF-beta Superfamily: Basic Mechanisms of Signal Transduction
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Contextual Determinants of TGF-beta Signaling in Normal and Oncogenic Stem Cells

Coffee Break

Stefan Karlsson, Lund University, Sweden
TGF-beta Signaling in Hematopoietic Stem Cells

Peter ten Dijke, Leiden University Medical Center, Netherlands
TGF-beta Receptor Signal Transduction in Breast Cancer

Aristidis Moustakas, Uppsala University, Sweden
Short Talk: Epigenetic Control and Micro-RNA Processing Connect TGFBeta to EMT and Tumor Cell Stemness

Ying E. Zhang, NCI, National Institutes of Health, USA
Short Talk: Direct Regulation of Alternative Splicing by SMAD3 is Essential to the Tumor-Promoting Role of TGF-beta

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
2:30—4:30 PM
Workshop 1: TGF-ß in Fate Decisions and Cellular Functions

Chamisa Ballroom 1
* Akihiko Yoshimura, Keio University, Japan

Amina Dahmani, University of Montreal, Maisonneuve-Rosemont Hospital Research Center, Canada
Transforming Growth Factor-beta Programs Central-Memory Differentiation In Ex-Vivo Stimulated Human T Cells By Modulating Id3 Expression

Matthew Riese, Medical College of Wisconsin, USA
PECAM-1, a TGF-beta Receptor Binding Protein, Contributes to CD8+ T Cell Exhaustion

Fernando Souza-Fonseca-Guimaraes, Walter and Eliza Hall Institute, Australia
TGF-beta Inhibits NK Cell Activation and Cytotoxicity through Repression of the mTOR Pathway

Hongbo Hu, Sichuan University, China
Non-Canonical NF-kappaB: The Regulating Mechanism and Application in Cancer Immunology

Lopa Mishra, George Washington University, USA
An Integrated Approach Towards Dissecting the Dichotomy of the TGF-beta Pathway in Liver Inflammation and Cancer: Insights from a Human Stem Cell Syndrome, TCGA Analyses, and Mouse Models

Claire Gustafson, Stanford University, USA
Age-Related Changes in MicroRNA Expression Alter TGF-beta Signaling in Naïve CD8 T Cells during Human Immune Aging

Lily Huang, Regeneron Pharmaceutical, USA
Inhibition of Activin A Stops the Regrowth of Surgically Resected Heterotopic Bone in a Mouse Model of Fibrodysplasia Ossificans Progressiva and Indicates a New Potential Path to Therapy

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:00 PM
TGF-ß in Hematopoietic Stem Cells and Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Ursula Grohmann, University of Perugia, Italy
TGF-beta, Arg1, and IDO1: An Immunosuppressive Module at Work in Dendritic Cells

Herbert Strobl, Medical University Graz, Austria
TGF-beta1 and BMP Signaling in Langerhans Cells

* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
TGF-beta Controls Th17 Plasticity and Maintains Intestinal Homeostasis

Sylvain Perruche, Etablissement Français du Sang BFC, France
Short Talk: The Resolutive Factors Issued from Apoptotic Cell Clearance Allow the Termination of Ongoing Inflammation

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 1

Chamisa Ballroom 2

WEDNESDAY, JANUARY 11

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:00 AM
TGF-ß in T Cells I
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* John J. O'Shea, NIAMS, National Institutes of Health, USA

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
TGF-beta Induces Dominant Regulators that Promote Unidirectional Development of Foxp3+ Treg

Timothy A. Springer, Immune Disease Institute, Harvard University, USA
A Microglia Context Molecule for TGF-beta Required for Maintenance of Nervous System Function

Coffee Break

Wanjun Chen, NIDCR, National Institutes of Health, USA
TGF-beta Regulates Tregs and Bregs

Akihiko Yoshimura, Keio University, Japan
Induction of Stable TGF-ß-Mediated Regulatory T Cells by Epigenetic Modifications

Yisong Wan, University of North Carolina at Chapel Hill, USA
Short Talk: TGF-beta Signaling in Controlling Diverse T Cell Functions

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:00 PM
TGF-ß in T Cells II
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

John J. O'Shea, NIAMS, National Institutes of Health, USA
TGF-ß and MicroRNA in T Cell Plasticity

Sophie Lucas, de Duve Institute, Belgium
GARP-Dependent Activation of TGF-beta1 Mediates Immunosuppression by Human and Mouse Tregs

Chen Dong, Tsinghua University, China
Smad2 and Smad4 in T Cells

Zihai Li, Medical University of South Carolina, USA
Short Talk: Cancer Promotion and Immune Tolerance Via A Novel gp96-GARP-TGF-beta Switch: Mechanisms and Opportunities

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 2

Chamisa Ballroom 2

THURSDAY, JANUARY 12

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:15 AM
TGF-ß in Emerging Immune Cells
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France

Shannon J. Turley, Genentech, Inc., USA
Regulation of Tumor Immunity by Stromal Cells

Yasmina Laouar, University of Michigan, USA
TGF-beta in Innate Cells Matters

Coffee Break

Joanne E. Konkel, University of Manchester, UK
TGF-beta in Regulatory T Cell Function

Julien C. Marie, INSERM/Cancer Research Center of Lyon, France
TGF-beta Signaling in Peculiar Innate Cells

Victor S. Cortez, Washington University in St. Louis, USA
Short Talk: Transforming Growth Factor-beta and Eomes Conversely Guide the Differentiation of ILC1 and NK Cells

Yuanming Xu, Northwestern University, USA
Short Talk: The E3 Ubiquitin Ligase Hrd1 Regulates TGF-beta Signaling Pathway to Maintain Regulatory T Cells Generation and Suppressive Function

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Chamisa Ballroom 2
1:00—10:00 PM
Poster Viewing

Chamisa Ballroom 2
4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—7:00 PM
TGF-ß in Mucosal Immunity and in Immune Tolerance
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Chen Dong, Tsinghua University, China

Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
LAP-TGF-beta Immune Cells in Mucosal Immunity, Tolerance and Cancer

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
A Give-and-Take Relation between TGF-beta and the Gut Environment Drives the CD4 CTL Fate

Yingzi Cong, University of Texas Medical Branch, USA
TGF-beta Regulation of Host-Microbiota Interaction at Mucosal Surface

Mark A. Travis, University of Manchester, UK
Short Talk: Human Blood Monocyte and Intestinal Macrophage Populations Regulate TGF-beta Activity via Expression of the Integrin Alphav beta8

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
7:30—10:00 PM
Poster Session 3

Chamisa Ballroom 2

FRIDAY, JANUARY 13

7:00—8:00 AM
Breakfast

Sagebrush Lobby & Cantina
8:00—11:15 AM
TGF-ß in Inflammatory Diseases: Mechanisms and Immunotherapy
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Danielle Smyth, University of Glasgow, UK
Short Talk: Identification of a Novel and Potent Mimic of TGF-beta Secreted by the Helminth Parasite Heligmosomoides Polygyrus

* Megan K. Levings, University of British Columbia, Canada
Mechanisms of Suppression by Human Regulatory T Cells

Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
CD3-Antibody, TGF-ß and Type I Diabetes

Coffee Break

Lingyun Sun, Nanjing University Medical School, China
TGF-beta in Mesenchymal Stem Cell-Mediated Immnoregulation in Autoimmune Diseases

Daniel H. Kaplan, University of Pittsburgh, USA
Stromal Cells Control Epithelial Residence of Dendritic Cells and Memory T Cells through Regulated Activation of Latent TGF-b

Vlad Senatorov, University of California, Berkeley, USA
Short Talk: Neuro-Inflammatory Astrocytic TGF-beta Signaling after Blood-Brain Barrier Disruption: A Novel Mechanism Underlying Age-Related Seizure Vulnerability and Cognitive Decline

11:15 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: TGF-ß in Inflammatory Diseases and Cancer

Chamisa Ballroom 1
* Joanne E. Konkel, University of Manchester, UK

* Lingyun Sun, Nanjing University Medical School, China

Gabriela Dveksler, Uniformed Services University of the Health Sciences, USA
Proteins Secreted from the Human Placenta Activate Latent TGF-b and Demonstrate Therapeutic Potential

Piotr Jachimczak, RealTVac, Germany
A Novel Strategy to Treat Advanced, Late-Stage Tumors with Real-Time Tumor Vaccination - RealTVac®

James Gulley, NCI, National Institutes of Health, USA
Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGF-beta, in Advanced Solid Tumors

David F. Vincent, CRUK - Beatson Institute for Cancer Research, UK
Genetic Mouse Models of Bowel Cancer Reveal the Role of TGF-beta Signaling in Intestinal Stem Cell Homeostasis and Cancer

Shaopeng Yuan, Rockefeller University, USA
TGF-beta Responsive Tumor Stem Cell Development and Drug Resistance in Squamous Cell Carcinoma

4:30—5:00 PM
Coffee Available

Chamisa Lobby
5:00—6:45 PM
TGF-ß in Cancer: Signaling in Cancer Cells and Immunotherapy for Cancer
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Peter ten Dijke, Leiden University Medical Center, Netherlands

Lalage M. Wakefield, NCI, National Institutes of Health, USA
Anti-TGF-beta Antibody Therapy: Lessons from Pre-Clinical Cancer Models

Karim A. Benhadji, Eli Lilly and Company, USA
Clinical Development of TGF-b Receptor Inhibitors in Cancer

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Chamisa Ballroom 2

SATURDAY, JANUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

BioLegend, Inc. EMD Serono Research and Development Institute, Inc.
Regeneron Pharmaceuticals, Inc.
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Bio-Techne

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI126781-01

“Funding for this conference was made possible [in part] by 1R13AI126781-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.”


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Eli Lilly and Company


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676