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This meeting took place in 2017



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Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease (X5)


Organizer(s) Thirumala-Devi Kanneganti, Vishva M. Dixit and Mohamed Lamkanfi
March 19—23, 2017
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Nov 17, 2016
Abstract Deadline: Dec 20, 2016
Scholarship Deadline: Nov 17, 2016
Discounted Registration Deadline: Jan 19, 2017

Sponsored by AbbVie Inc., Genentech, Inc. and Merck & Co., Inc.


Summary of Meeting:
Understanding of the signaling mechanisms by which pattern recognition receptors (PRRs) sense microbial infections and cellular stress engage innate immune responses is moving at an unprecedented rate. Developments in the past few years shed new light on how NOD-like receptors and inflammasomes are activated to promote cytokine production and cell death responses in the context of autoimmunity and microbial infection. Other findings clarified how extracellular and intracellular receptors of the Toll-like receptor, PYHIN/IFI, and helicase families respond to infections. In addition, intricate communication between PRRs and microbial commensals has emerged as a critical mechanism controlling immunity, and several fine-tuning mechanisms modulating PRR-induced immune responses have been discovered. Finally, a wealth of clinical information supporting the key roles of PRRs not only in host-microbe interactions, but also chronic autoinflammatory and autoimmune diseases in patients has emerged. This has spurred important translational medicine efforts to bring new therapies and diagnostics to the clinic. This conference unites an international group of academic and industry immunologists and microbiologists who study basic mechanisms of PRR signaling and their interaction with microbes in inflammatory disease models with clinicians and geneticists addressing the etiology of autoinflammatory and autoimmune diseases in patients. Gathering experts from these disparate research communities offers a unique opportunity to discuss new concepts of innate immune signaling and formulate novel approaches for modulating pathological mechanisms in human inflammatory diseases.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 24 in order to fully experience the meeting.

SUNDAY, MARCH 19

4:00—8:00 PM
Arrival and Registration

Van Horne Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

MONDAY, MARCH 20

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—9:30 AM
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

* Alan Sher, NIAID, National Institutes of Health, USA

Anne O'Garra, Francis Crick Institute, UK
Type I IFN Regulation of Cytokine Networks and Consequences for Infection

Daniel Kastner, National Institutes of Health, USA
PRR Signaling and Inflammatory Disease

Coffee Break

9:50 AM—12:15 PM
Nucleic Acid Recognition Pathways Regulating Type I IFN Induction (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Cytosolic Recognition of DNA through cGAS/STING Pathway

Sun Hur, Harvard Medical School, USA
Cytosolic Sensing of Viral RNA by the RIG-I-Like Receptors

Gregory M. Barton, University of California, Berkeley, USA
Endosomal Recognition of Self-Nucleic Acids

Vishva M. Dixit, Genentech, Inc., USA
Inflammasome Signaling

12:15—2:30 PM
On Own for Lunch

12:15—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
2:30—4:30 PM
Workshop 1: PRRs in Inflammatory Diseases

Van Horne A/B
* Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA

* Eicke Latz, University of Bonn, Germany

Sreya Ghosh, University of Massachusetts Medical School, USA
The PYHIN Protein IFI205 Regulates Immune Signaling by Controlling Expression of the Inflammasome Adaptor ASC

Mena Abdel-Nour, University of Toronto, Canada
The eIF2 alpha Kinase HRI Senses Protein Aggregation and Facilitates Signaling of Innate Immune Receptors

José Santos, University of Basel, Switzerland
Novel GBP-Dependent Mechanisms of Inflammasome Activation

Matthew James George Eldridge, Imperial College London, UK
The Atypical Ubiquitin E2 Conjugase UBE2L3 is an Indirect Caspase-1 Target and controls IL-1Beta Secretion by Inflammasomes

Nidhi Jain, Cedars-Sinai Medical Center, USA
NLRP12 Mutation Causes C57BL/6J Strain-Specific Defect in Neutrophil Recruitment

Nina Van Opdenbosch, VIB-University of Ghent, Belgium
Defective Caspase-1 Recruitment Licenses ASC Specks to Engage Non-Inflammatory Caspase-8-Driven Apoptosis in Macrophages and Intestinal Epithelial Cells

Charlotte Macleod, University of Cambridge, UK
Determining the Stoichiometry of the TLR-4 Adaptor Protein Mal/TIRAP using TIRF Microscopy

Scott W. Canna, Children's Hospital of Pittsburgh, University of Pittsburgh, USA
Chronic IL-18 of Diverse Origins Defines and Drives the Hyperinflammatory State Known as Macrophage Activation Syndrome

2:30—4:30 PM
Workshop 1: Innate Signals for Type I IFN Induction

Van Horne C
* Paul J. Hertzog, Hudson Institute of Medical Research, Australia

* Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA

John Ty Crowl, University of Washington, USA
Loss of Sumoylation Triggers a Spontaneous Type I Interferon Response Independent of Cytosolic Nucleic Acid Sensing Pathways

Martin R. Jakobsen, Aarhus University Faculty of Health Science, Denmark
IFI16 Dictates DNA Sensing in Human Macrophages by Promoting Production and Function of cGAMP

Stefanie Luecke, Aarhus University, Denmark
Length-Dependent Sensing of Low-Abundance dsDNA by cGAS

Jennifer Lumb, Stanford University, USA
Unbiased Haploid Genetic Screen Uncovers a Novel RNA Binding Immune Regulator

Nathalie M. Grandvaux, Université de Montréal, Canada
Characterization of a Delayed Transcriptional Program Induced in Response to the Synergistic Action of IFNBeta+TNFalpha Reveals Novel STAT2 and IRF9-Dependent Pathways

Jennie B. Altman, Icahn School of Medicine at Mount Sinai, USA
Non-Canonical Type I IFN Signaling in ISG15-/- and USP18-/- Cells

Antje Blumenthal, University of Queensland, Australia
Spatiotemporal Regulation of TLR4 Signaling and Promotion of Type I IFN Responses by the RP105-PI3K p110delta Innate Immune Signaling Axis

Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Ppp1r15a/GADD34 Controls Heterogeneity of Type-I Interferon Production in Response to dsRNA

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Nucleic Acids in TLR and NLR Signaling
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Mohamed Lamkanfi, Ghent University, Belgium

Jonathan C. Kagan, Boston Children's Hospital, USA
Initiation and Regulation of Innate Immune Signal Transduction

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Novel Regulators of PRR-Driven Transcriptional Responses

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Inflammasomes and Pathogen Sensing

Osamu Takeuchi, Institute for Virus Research, Kyoto University, Japan
Short Talk: Spatiotemporal Regulation of Inflammatory mRNAs in Innate Immune Responses

5:00—7:00 PM
Mendelian Interferonopathies and IFN-Deficiencies
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Virginia Pascual, Cornell University, USA

Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA
Loss of Type I Interferon Negative Regulation in Humans

Min Ae Lee-Kirsch, Technische Universität Dresden, Germany
Defective Intracellular Nucleic Acid Waste Management in Type 1 Interferon-Driven Autoinflammation and Autoimmunity

Raphaela Theresia Goldbach-Mansky, NIAID, LCID, National Institutes of Health, USA
Novel Insights into the Pathogenesis and Treatment Approaches of the Type I-IFN-Mediated Autoinflammatory Diseases, CANDLE and SAVI

Joaquín M. Espinosa, University of Colorado Boulder, USA
Short Talk: Trisomy 21 Consistently Activates the Interferon Response: Understanding Down Syndrome as an Interferonopathy

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 1

Mezzanine 2

TUESDAY, MARCH 21

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
Recent Insights in Inflammasome Signaling
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Vishva M. Dixit, Genentech, Inc., USA

Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA
Cardiolipin Promotes Mitochondrial Localization of NLRP3 and Caspase-1

Mohamed Lamkanfi, Ghent University, Belgium
Inflammasome Regulation in Auto-Inflammation

Coffee Break

Kim Newton, Genentech, Inc., USA
Regulation of Inflammation and Cell Death by RIPK1

Feng Shao, National Institute of Biological Sciences, China
Pyroptosis in Anti-Bacterial Immunity: Sensing & Execution

Bharat Behl, University of Connecticut Health Center, USA
Short Talk: Molecular Determinants of Noncanonical Inflammasome Activation by LPS

Olaf Groß, Universitätsklinikum Freiburg, Germany
Short Talk: Caspase-1 Mutant Mouse Reveals a Central Role of Caspase-1 Protease Activity and GSDMD in Fate Decisions After Inflammasome Activation

8:00—11:15 AM
Type I IFN Regulation of Viral Infection and Cancer
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Ana Fernandez-Sesma, Mount Sinai School of Medicine, USA
Modulation of Innate Immunity by Dengue Virus: Feeling the STING

Andreas Wack, Francis Crick Institute, UK
Unique and Overlapping Roles of Type I and Type III Interferons in Influenza Infection

Coffee Break

John W. Schoggins, University of Texas Southwestern Medical Center, USA
Cell Intrinsic Modulation of Viral and Bacterial Infection by IFN-Stimulated Genes

Thomas J. Braciale, University of Virginia, USA
Innate Immune Control of Respiratory Virus Infection

Gaya Amarasinghe, Washington University School of Medicine, USA
Short Talk: Control of Type I IFN Signaling in Negative Sense RNA Viruses

Jason Waithman, Telethon Kids Institute, Australia
Short Talk: IFNalpha Subtypes Drive Distinct Anti-Cancer Activities

11:15 AM—2:30 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mezzanine 2
11:15 AM—12:15 PM
Meet the Editors

Van Horne A/B
* Teodoro Pulvirenti, Journal of Experimental Medicine, USA

1:00—10:00 PM
Poster Viewing

Mezzanine 2
2:30—4:30 PM
Workshop 2: PRRs in Inflammatory Diseases

Van Horne A/B
* Dmitry M. Shayakhmetov, Emory University, USA

* Denise M. Monack, Stanford University, USA

T. Sam Xiao, Case Western Reserve University, USA
Structures of GSDMD C-Terminal Domain Suggest Mechanisms of Autoinhibition

Igor E. Brodsky, University of Pennsylvania, USA
Role of Caspase-8 Enzymatic Activity in Control of TLR-Induced Macrophage Gene Expression

Damien Arnoult, Hopital Paul Brousse, France
The Golgi Apparatus Acts as a Platform for TBK1 Activation After Viral RNA Sensing

Randilea Nichols, University of California, Berkeley, USA
NLRC4 Inflammasome Activation in Neutrophils is Sufficient to Cause Systemic Inflammatory Disease

Rosalie Heilig, University of Basel, Switzerland
The Role of Gasdermin D in IL-1Beta Release

Cindy Chiang, University of Chicago, USA
The Human Papillomavirus E6 Oncoprotein Inhibits TRIM25- and RIG-I-Mediated Innate Immune Signaling

Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Innate Immune Sensing of Cytosolic Chromatin Fragments through cGAS Promotes Cellular Senescence

2:30—4:30 PM
Workshop 2: Role of Type I IFNs in Control and Enhancement of Infection

Van Horne C
* Thomas J. Braciale, University of Virginia, USA

* Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA

Charles S. Dela Cruz, Yale University, USA
Chitinase-Like Protein Chi3l1 Modulates Type I Interferon Response through TLR9-AP3-IRF7 Axis during Streptococcus Pneumoniae Lung Infection

Ren Sun, University of California, Los Angeles, USA
Genome-Wide Identification of Anti-Interferon Functions in Influenza A Virus

Lindsey Cook, Washington University in St. Louis, USA
Differential Roles of Type I Interferons in Chikungunya Virus Infection

Bastian Opitz, Charité University Medicine Berlin, Germany
A Common Loss-of-Function Variant of STING Affects cGAS-Dependent Antibacterial Defense

Laura Sinigaglia, Institut Pasteur, France
Transfer of Yellow Fever Virus RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Interferon Production

Nick Parekh, Penn State College of Medicine, USA
cGAS Mediates a Protective Local Response to Dermal Vaccinia Infection Independent of Control of Virus Replication

Susan Pereira Ribeiro, Case Western Reserve University, USA
Different Interferon Signatures Characterize Two Subclasses of Immune Non-responder Subjects

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Interfering with Pathogenic TLR and NLR Signaling
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Gabriel Nuñez, University of Michigan, USA

Dana Philpott, University of Toronto, Canada
Nod2 Signaling

Dmitry M. Shayakhmetov, Emory University, USA
Non-canonical Regulated Necrotic Death and Sensing Danger

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Intracellular Innate Immune Receptors: Regulators of Inflammation, Cancer and Immunity

Vikram R. Rao, Pfizer, USA
Short Talk: IRAK4 Kinase Inhibitors: Emerging Biology and Therapeutic Implications

5:00—7:00 PM
Type I IFN Regulation of Viral Infection
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Andreas Wack, Francis Crick Institute, UK

Netanya Sandler Utay, University of Texas Medical Branch at Galveston, USA
Type I Interferons: Barrier or Pathway to HIV Disease?

Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Regulation of Influenza Virus Sensing and Antiviral Responses by Host and Virus Factors

Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Interactions of Cellular Proteins with Viral Nucleic Acids

Ricardo Rajsbaum, University of Texas Medical Branch, USA
Short Talk: Friend and Foe in the Regulation of IFN Pathways: Pro-Viral and Anti-Viral Functions of the Host E3-Ubiquitin Ligase TRIM6

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 2

Mezzanine 2

WEDNESDAY, MARCH 22

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
PRR Signaling in Bacterial and Viral Infection
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Russell E. Vance, University of California, Berkeley, USA
Activation of Inflammasomes by Bacterial Pathogens

Amal Amer, Ohio State University, USA
Unconventional Functions of Inflammasomes

Coffee Break

Denise M. Monack, Stanford University, USA
Inflammasomes and Bacterial Infections

Christian Holm, Aarhus University, Denmark
Short Talk: Nitro-Fatty Acids Can Suppress STING Signaling

Peng Li, National Institute of Biological Sciences, China
Short Talk: Ubiquitination and Degradation of GBPs by Shigella Ipha9.8 Effector to Suppress Host Defenses

Valesca Lindenberg, Institute of Medical Microbiology and Hospital Hygiene, Germany
Short Talk: Extensive Characterization of mGBPs Localization Chlamydia trachomatis Infection

Katelyn Susanne Burleigh, University of Washington, USA
Short Talk: Uncovering the Mechanism of E1A Antagonism of the cGAS-STING Pathway

8:00—11:15 AM
Type I IFN Regulation of Bacterial Infection and Disease
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Alan Sher, NIAID, National Institutes of Health, USA

Thomas J. Scriba, University of Cape Town, South Africa
IFN Signatures that Predict Human Tuberculosis

Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
The Dichotomy between Interleukin 1 and Type I Interferon during Mycobacterium Tuberculosis Infection Exposes Distinct and Opposing Classes of Inflammation

Coffee Break

Craig R. Roy, Yale University School of Medicine, USA
Modulation of Type I Interferon Production during Infection by Vacuolar Pathogens

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Human Dendritic Cell Subsets Differentially Respond to Vaccines

Terje Espevik, Norwegian University of Science and Technology, Norway
Short Talk: CD150 Positively Regulates TRAM Recruitment to E.coli Phagosomes and Type I IFN Secretion

Beiyun Caitlin Liu, Tufts University, USA
Short Talk: Host-Intrinsic Interferon Signaling Licenses GBP-Mediated Attack on Cytosolic Bacteria

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Inflammasome and NF-kB Regulatory Mechanisms
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Christian Stehlik, Northwestern University, USA
Inflammasome Inhibition

Eicke Latz, University of Bonn, Germany
Inflammasomes in Health and Disease

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Reprogramming in Innate Immunity and Inflammation

Ali A. Zarrin, Genentech, Inc., USA
Short Talk: TPL2 Kinase Activates MEK-1/2 and/or MEK-3/6 to Regulate Inflammatory Pathways in Myeloid Cells

5:00—7:00 PM
Role of Type I IFN in Complex Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Virginia Pascual, Cornell University, USA
Pathogenic Functions of Type I IFN in SLE

* Richard M. Siegel, NIAMS, National Institutes of Health, USA
Interferon, Anti-Interferon Antibodies and NK Cells in Systemic Autoimmunity

Robert C. Axtell, Oklahoma Medical Research Foundation, USA
Immunological Heterogeneity in Neurological Autoimmunity: Lessons from Studying Type I Interferon Responses

Mari L. Shinohara, Duke University, USA
Short Talk: Type-I Interferons and the NLRP3 Inflammasome in CNS Autoimmunity

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 3

Mezzanine 2

THURSDAY, MARCH 23

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:45 AM
Interactions between Microbiota and the Innate Immune System
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Mihai G. Netea, Radboud University, Netherlands

Daniel Graham, Massachusetts General Hospital, USA
Host Genetics and Microbe Interactions in Human Disease

Kathy D. McCoy, University of Calgary, Canada
Intestinal Commensal Microbiota and Education of the Innate Immune System

Coffee Break

Gabriel Nuñez, University of Michigan, USA
Control of Pathogen Colonization by Host Immunity and the Microbiota in the Gut

Andrew T. Gewirtz, Georgia State University, USA
Microbial-Mediated Protection from Infectious Disease

Prosper N. Boyaka, Ohio State University, USA
Regulation of Mucosal Immunity by Toxins and Microbiota

Grace Yi Chen, University of Michigan, USA
Short Talk: NLRP6 Limits Colonization of Akkermansia to Protect Against the Development of Colitis and Colon Tumorigenesis

Felix Yarovinsky, University of Rochester Medical Center, USA
Short Talk: Loss of Paneth Cell Autophagy Leads to Catastrophic Susceptibility to Acute Gastrointestinal Inflammation

8:00—11:15 AM
Mechanisms Underlying Divergent Functions of Type I IFNs
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Anne O'Garra, Francis Crick Institute, UK

Jae U. Jung, Keck School of Medicine of University of Southern California, USA
TRIM-Mediated Control of Type I IFN Pathway

Marco Colonna, Washington University School of Medicine, USA
Targeting Type I IFN Activity through Plasmacytoid DC

Coffee Break

Laurel L. Lenz, University of Colorado, USA
Role of Type I - Type II IFN Crosstalk in Macrophage Effector Function

Gideon Schreiber, Weizmann Institute, Israel
The Molecular Basis for Differential Activity of Type I Interferons

Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Short Talk: Systems Biology of Type I Interferon Responses

Ronald L. Rabin, US Food and Drug Administration, USA
Short Talk: A Potential Modulatory Role for IFNalpha1 Dependent on its Low Affinity for IFNAR2

11:45 AM—5:00 PM
On Own for Lunch

2:30—4:00 PM
Workshop 3: PRRs in Inflammatory Diseases

Van Horne A/B
* Amal Amer, Ohio State University, USA

* Dana Philpott, University of Toronto, Canada

Eric P. Hanson, National Institutes of Health, USA
A Novel NEMO Isoform Mediates Enhanced Antiviral Activity and Autoinflammatory Disease via Stabilization of IKKepsilon

Kiva V. Brennan, Trinity College Dublin, Ireland
Designing Vaccines for the Paediatric Population; Potential for Cytosolic Nucleic Acids as Vaccine Adjuvants

Nesrin Ozoren, Bogazici University, Turkey
ASC Specks as Vaccine Technology

Jingjin Ding, National Institute of Biological Sciences, China
LPS Binding to Caspase-11/4/5 Triggers Pyroptosis by Releasing the Pore-Forming Activity of GSDMD

Orna Rabinovich-Ernst, NIAID, National Institutes of Health, USA
An Arrayed Genome-Wide RNAi Screen for the Discovery of Novel Inflammasome Regulators

Thomas A. Kufer, University of Hohenheim, Germany
Roles of NLRP10 in Innate and Adaptive Immunity

2:30—4:30 PM
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignancy

Van Horne C
* Raphaela Theresia Goldbach-Mansky, NIAID, LCID, National Institutes of Health, USA

* Marco Colonna, Washington University School of Medicine, USA

Kebin Liu, Medical College of Georgia, USA
Jak-STAT-Mediated Chronic Inflammation Impairs Cytotoxic T Lymphocyte Activation to Decrease Anti-PD-1 Immunotherapy Efficacy in Pancreatic Cancer

Jacquelyn Gorman, Seattle Children's Research Institute, USA
The IFIH1A946T Coding Variant Mediates an Interferon Program that Limits Viral Infection but Increases the Risk for Autoimmunity

Mark E. Kleinman, University of Kentucky, USA
Epigenetic Regulation of Type I IFN Response in Age-Related Macular Degeneration

Elisaveta Voynova, Medimmune, USA
Blockade of Critical Immune Regulators Results in Different Roads to Pathogenesis in Primary Sjögren’s Syndrome

Mona Motwani, University of Massachusetts, USA
The cGAS-STING Pathway Restrains Systemic Autoimmunity

Simone Caielli, Baylor Institute for Immunology Research, USA
Oxidized Mitochondrial DNA is a Powerful Activator of Human pDCs and Induces a Lupus-Specific CD4 T Cell Phenotype

Stephen Rubino, Brigham and Women's Hospital, USA
Activated Microglia Induce Type 1-interferon Dependent Neurodegeneration

4:00—4:30 PM
Navigating the Peer Review Process
Information will be provided about how to understand the NIH peer review system with a focus on recent changes to the review process. Anyone interested in learning more about preparing an NIH grant application and tips about the review of grant applications is welcome to attend.

Van Horne A/B
* Tina M. McIntyre, National Institutes of Health, USA

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—6:45 PM
Innate Immune Receptors and Metabolism
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Prosper N. Boyaka, Ohio State University, USA

Marcia A. Munoz, Garvan Institute of Medical Research, Australia
Short Talk: Defective Protein Prenylation Is a Diagnostic Biomarker for Mevalonate Kinase Deficiency

Je-Wook Yu, Yonsei University College of Medicine, South Korea
Short Talk: 25-Hydroxycholesterol Contributes to Cerebral Inflammation of X-Linked Adrenoleukodystrophy (X-ALD) through Activation of the NLRP3 Inflammasome

Vishwa Deep Dixit, Yale University, USA
Metabolic Control of Inflammasomes

Mihai G. Netea, Radboud University, Netherlands
Metabolic Basis for Trained Innate Immunity

5:00—6:45 PM
Tailoring Type I IFN Interventions to Achieve Cure
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Geraldine P. Grouard-Vogel, Neovacs, France
Overexpression of IFNalpha and Derived Diseases: Innovative Approach with a Therapeutic Vaccine IFNalpha Kinoid

Gary P. Sims, MedImmune Inc, USA
Novel Pathogenic Role for IgE in SLE, and Pharmacological Blockade of Type I IFN Receptor in Patients

John J. O'Shea, NIAMS, National Institutes of Health, USA
Targeting Type I IFN Signaling Pathways

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Alan Sher, NIAID, National Institutes of Health, USA

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mezzanine 2

FRIDAY, MARCH 24

 
Departure


*Session Chair †Invited, not yet responded.



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