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This meeting took place in 2017



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Asthma: From Pathway Biology to Precision Therapeutics (B3)


Organizer(s) Clare M. Lloyd, John V. Fahy and Sally Wenzel-Morganroth
February 12—16, 2017
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 13, 2016
Abstract Deadline: Nov 16, 2016
Scholarship Deadline: Oct 13, 2016
Discounted Registration Deadline: Dec 14, 2016

Supported by AstraZeneca and Theravance Biopharma

Summary of Meeting:
Asthma affects people from childhood to old age and causes significant public health problems with great economic consequences. The type 2 inflammation pathway is considered the dominant mechanism of asthma, but clinical trials of recently developed treatments targeting this pathway indicate that large numbers of asthmatics do not benefit from this therapeutic approach. This limited effect of type 2 inhibitors, coupled with recent advances in our understanding of the clinical diversity of asthma, underscores the heterogeneous nature of the underlying disease mechanisms. The aims of this meeting are to focus on the heterogeneous disease biology of asthma and to explore how treatments can advance from a one-size-fits-all paradigm to one in which asthmatics receive personalized treatments based on biomarkers that classify their specific disease mechanism. The meeting program will combine cutting-edge presentations on the molecular mechanisms of inflammation and remodeling in asthma with others that address the complexity of clinical phenotypes of asthma, and will include updates on the application of new technologies to develop biomarkers to guide personalized treatment. Anticipated outcomes include greater understanding of mechanisms of disease other than type 2 inflammation and appreciation of the need to forge stronger collaborations between clinical and basic scientists to advance the goal of personalized asthma treatment. The overarching goal of the meeting is to bring together world-class researchers with expertise in immunology, cell biology and asthma disease biology to permit exchange of ideas and facilitate development of new scientific directions and therapeutic approaches for asthma.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 17 in order to fully experience the meeting.

SUNDAY, FEBRUARY 12

4:00—8:00 PM
Arrival and Registration

Keystone Lodge Lobby
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

MONDAY, FEBRUARY 13

7:00—8:00 AM
Breakfast

Divide & Ten Mile
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* Clare M. Lloyd, Imperial College London, UK

Avrum Spira, Boston University, USA
The Airway Transcriptome for Precision Lung Cancer Detection

9:00—11:30 AM
Asthma: Progress, Pathogenesis and Phenotypes
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* Joseph R. Arron, Genentech, Inc., USA

Wendy C. Moore, Wake Forest School of Medicine, USA
Cluster Phenotypes and Personalized Medicine in the Clinic

Coffee Break

John V. Fahy, University of California, San Francisco, USA
Role of IL-6 and Systemic Inflammation in Asthma Pathogenesis

Fernando D. Martinez, University of Arizona, USA
Early Origins of Asthma

Kedir N. Turi, Vanderbilt University, USA
Short Talk: Identification of Infant Acute Respiratory Illness Cytokine-Response Subgroups Associated with Recurrent Wheezing Phenotype

Zala Rojnik, AstraZeneca, Sweden
Short Talk: IL-6 Trans-Signaling Gene Signature Reveals an Asthma Subtype with Increased Mucosal Infiltration of Immune Cells

11:30 AM—2:30 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Divide & Ten Mile
1:00—10:00 PM
Poster Viewing

Divide & Ten Mile
2:30—4:30 PM
Workshop 1: Phenotyping Methods/Cluster Analysis

Arapahoe
* Lauren E. Cohn, Yale University, USA

Anthony Bosco, Telethon Kids Institute, Australia
Persistent Activation of Interlinked Th2-Airway Epithelial Gene Networks in Sputum-Derived Cells from Aeroallergen-Sensitized Symptomatic Atopic Asthmatics

Peter McErlean, Kings College London, UK
Epigenetic Landscape of the Asthmatic Airways

Johan Kolmert, Karolinska Institutet, Sweden
Urinary Eicosanoid-Based Sub-Phenotyping in the U-BIOPRED Severe Asthma Cohort Demonstrates Phenotype Stability between Baseline and Longitudinal Sampling

Michael Peters, University of California, San Francisco, USA
Sputum RNA-Seq Analysis Reveals Novel Asthma Endotypes Characterized by Cell-Type Specific Signatures

Marc Massanari, Circassia, USA
Impact of FeNO on Treatment Decisions: Results from the ASTH2MA (ASsessment of TH2 inflamMAtion) Survey

Xiting Yan, Yale University School of Medicine, USA
Longitudinal RNA Sequencing Data of Induced Sputum in Asthma Patients Reveals Stable Transcriptional Endotypes of Asthma Associated with Asthma Severity

Samir Kelada, University of North Carolina at Chapel Hill, USA
Meta- and Sub-type Analysis of Airway Epithelia Gene Expression in Asthma

4:30—5:00 PM
Coffee Available

Gallery
5:00—7:00 PM
Complex Phenotypes and How to Approach Them
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* Sally Wenzel-Morganroth, University of Pittsburgh, USA

Eric P. Xing, Carnegie Mellon University, USA
Toward Personalized Pan-Omic Association Analysis under Complex Structures

Anne Dixon, University of Vermont College of Medicine, USA
Obesity and Asthma

Sejal Saglani, Imperial College London, UK
Severe Therapy Resistant Asthma in Children: Translational Approaches to Uncover Sub-phenotypes

Kapil Gadkar, Genentech, Inc., USA
Short Talk: A Mechanistic Systems Pharmacology Model for Evaluating Potential Drugs for Treatment of Asthma

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Divide & Ten Mile
7:30—10:00 PM
Poster Session 1

Divide & Ten Mile

TUESDAY, FEBRUARY 14

7:00—8:00 AM
Breakfast

Divide & Ten Mile
8:00—11:15 AM
Regulation and Treatment of Type 2 Inflammation in the Airway
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* John V. Fahy, University of California, San Francisco, USA

Andrew D. Luster, Massachusetts General Hospital, USA
Regulatory T Cell Subsets in Type 2 Airway Inflammation

Clare M. Lloyd, Imperial College London, UK
Epithelial Cells as Master Regulators of Pulmonary Inflammation

Coffee Break

Anne I. Sperling, University of Chicago, USA
Differences in Asthma and Atopy Risk are Associated with Altered Immune Phenotypes: Studies in Amish and Hutterite Farm Children

Carla V. Rothlin, Yale University, USA
Negative Regulation of Type 2 Immunity

Irma Tindemans, Erasmus MC, Netherlands
Short Talk: Notch Signaling in T Cells is Essential for Allergic Airway Inflammation, but Expression of the Notch Ligand Jagged on Dendritic Cells and Lymph Node Stromal Cells is Dispensable

Rafael de Queiroz Prado, NIAID, National Institutes of Health, USA
Short Talk: IL-4R-Alpha Signaling in Myeloid Cells Regulates Neutrophil-Induced Inflammation in Asthma

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Divide & Ten Mile
1:00—10:00 PM
Poster Viewing

Divide & Ten Mile
4:30—5:00 PM
Coffee Available

Gallery
5:00—7:00 PM
Novel Pathways Underlying Complex Phenotypes of Asthma
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* Anuradha Ray, University of Pittsburgh School of Medicine, USA

Bruce D. Levy, Brigham and Women's Hospital, USA
Regulation of Airway Innate Immunity by Specialized Pro-Resolving Mediators

Prescott G. Woodruff, University of California, San Francisco, USA
Non-type 2 Inflammatory Pathways in Asthma

Max A. Seibold, National Jewish Health, USA
Dual RNA-seq Reveals Respiratory Virus Infection in Asthmatic Children without Respiratory Illness is Associated with Changes in the Airway Transcriptome

Padraic Fallon, Trinity College Dublin, Ireland
Short Talk: A Mouse Model of Spontaneous IL-17 Dependent Asthma

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Divide & Ten Mile
7:30—10:00 PM
Poster Session 2

Divide & Ten Mile

WEDNESDAY, FEBRUARY 15

7:00—8:00 AM
Breakfast

Divide & Ten Mile
8:00—11:15 AM
Influence of Pathogenic and Protective Microbes
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* Clare M. Lloyd, Imperial College London, UK

Benjamin J. Marsland, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
Influence of the Microbiome on the Development of Asthma

Anuradha Ray, University of Pittsburgh School of Medicine, USA
Infections and Immune Responses Impacting Asthma Inception and Severity

Coffee Break

Nathan W. Bartlett, University of Newcastle, Australia
Mechanisms of Virus Induced Exacerbations of Asthma

Roland W. Kolbeck, MedImmune, LLC, USA
Targeted Treatment of Inflammatory Mediators of Asthma

Henry J. McSorley, Queen's Medical Research Institute, UK
Short Talk: A Helminth-Derived Suppressor of the IL-33 Pathway

Daniel J. Spakowicz, Yale University, USA
Short Talk: Using Microbial Composition within Sputum Transcriptome Data to Stratify Patients by Asthma Severity

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Divide & Ten Mile
1:00—10:00 PM
Poster Viewing

Divide & Ten Mile
4:30—5:00 PM
Coffee Available

Gallery
5:00—7:00 PM
How Does Tissue Remodeling Influence Disease Phenotype?
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* Steve Georas, University of Rochester Medical Center, USA

James G. Martin, McGill University, Canada
Airway Smooth Muscle Hypercontractility in Asthma

Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Transcriptional Networks Linking Goblet Cell Differentiation and Innate Immunity in the Pathogenesis of Asthma

Philip Hansbro, University of Newcastle, Australia
Understanding Pathogenesis to Develop New Therapies for Severe Asthma

Mikael Adner, Karolinska Institutet, Sweden
Short Talk: Interleukin-13 Induces Glucocorticoid-Insensitive Hyperreactivity of Human Small Airways

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Divide & Ten Mile
7:30—10:00 PM
Poster Session 3

Divide & Ten Mile

THURSDAY, FEBRUARY 16

7:00—8:00 AM
Breakfast

Divide & Ten Mile
8:00—11:15 AM
Biomarkers for Personalized Treatment
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* Roland W. Kolbeck, MedImmune, LLC, USA

Joseph R. Arron, Genentech, Inc., USA
The Virtuous Cycle: Biomarkers and Translational Research in Asthma Drug Development

David Beebe, University of Wisconsin, USA
Potential of Microfluidic Technology to Identify Biomarkers of Specific Disease Phenotypes

Coffee Break

Peter Ghazal, University of Edinburgh, Edinburgh Medical School, UK
The Inflammatory Response in Early Life

Erin Duncan Gordon, University of California, San Francisco, USA
Genetic Biomarkers to Guide Precision Medicine in Asthma: IL1RL1 Asthma Risk Variants

Sudipto Saha, Bose Institute, India
Short Talk: Plasma Apolipoproteins - Potential Biomarkers in Atopic Asthma Based on LC-MS/MS Study  

Anna J. James, Karolinska Institutet, Sweden
Short Talk: Local and Systemic Periostin Levels Both Reflect Processes of Relevance to Asthma

11:15 AM—2:30 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: Modeling Complex Diseases in vivo and in vitro

Arapahoe
* Philip Hansbro, University of Newcastle, Australia

Tibor Z. Veres, University of Turku, Finland
Allergen-Induced CD4+ T-Cell Cytokine Production within Airway Mucosal DC-T-Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells

Daniel Camacho, University of Chicago, USA
IRF4(+) Dendritic Cells Promote Th2 Initiation in Response to Allergen

Sangwoon Chung, Ohio State University, USA
FoxO1, A Potential Link Player Between Alternatively Activate Macrophages and Asthmatic Lung inflammation

Stokes S. Peebles, Vanderbilt University Medical Center, USA
Glucagon Like Peptide-1 Receptor Signaling Inhibits Both Lung Innate and Adaptive Immunity Mediated Allergic Inflammation to Inhaled Aeroallergen

Nora A. Barrett, Brigham and Women's Hospital, USA
LTE4/GPR99 Regulation of Respiratory Epithelial Cell Function  

Heleen Vroman, Erasmus MC, Netherlands
TNFAIP3 Levels in Lung Dendritic Cells Instruct Th2 or Th17 Cell Differentiation in Eosinophilic or Neutrophilic Asthma

4:30—5:00 PM
Coffee Available

Gallery
5:00—6:45 PM
Doing Better Going Forward
Meeting has ended...abstracts no longer viewable online.

Arapahoe
* John V. Fahy, University of California, San Francisco, USA

* Clare M. Lloyd, Imperial College London, UK

Steven M. Rowe, University of Alabama at Birmingham, USA
Transformative Treatments - How the Cystic Fibrosis Community Did It

Jennifer Davidson Hamilton, Regeneron Pharmaceuticals, Inc., USA
Targeted Therapeutics: What Have They Taught Us About Pathomechanisms in Asthma?

Sally Wenzel-Morganroth, University of Pittsburgh, USA
Evolving Phenotypes to Endotypes: Is Precision Medicine Achievable in Asthma?

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Arapahoe
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Divide & Ten Mile
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Divide & Ten Mile

FRIDAY, FEBRUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AstraZeneca Theravance Biopharma

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL135875-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

SCIREQ Scientific Respiratory Equipment Inc.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


MedImmune


Regeneron Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676