Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2017


Here are the related meetings in 2018:
Tuberculosis: Translating Scientific Findings for Clinical and Public Health Impact (X7)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

New Developments in Our Basic Understanding of Tuberculosis (A5)


Organizer(s) Samuel M. Behar and Valerie Mizrahi
January 14—18, 2017
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Discounted Abstract Deadline: Sep 21, 2016
Abstract Deadline: Oct 18, 2016
Scholarship Deadline: Sep 21, 2016
Discounted Registration Deadline: Nov 15, 2016

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.

Summary of Meeting:
As a contagious disease, tuberculosis remains endemic in many countries and among vulnerable populations. In these settings, it is a major cause of morbidity and mortality. During the past two decades, there has been a renewed effort to develop vaccines and new antibiotics. However, new discoveries that have transformed our understanding of host susceptibility, immunity and disease pathogenesis have not kept pace with the progress of clinical trials. There is a need for new approaches that can limit the impact of tuberculosis around the world. This symposium will focus on fundamental questions about the host-pathogen interaction, bringing together scientists working on the bacterium and the host in model systems, as well as those trying to address basic questions in human immunology and disease. While answering these questions may not be a prerequisite to clinical progress, an improved mechanistic understanding of the survival and subversion strategies that Mycobacterium tuberculosis employs to evade therapy and host immunity will facilitate development of better strategies to treat and prevent tuberculosis. Specifically, the goals of the meeting are to: 1) Articulate a set of priority questions and goals to guide a basic research agenda for the field; 2) Integrate successful approaches employed by leading scientists in other fields that can address knowledge gaps in immunity to tuberculosis; 3) Highlight new technical advances that make possible more sophisticated human experimental biology including defining the critical questions that need to be answered to expedite clinical advances.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Saturday, January 14 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 18 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, January 19 in order to fully experience the meeting.

SATURDAY, JANUARY 14

4:00—8:00 PM
Arrival and Registration

British/Columbia Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

SUNDAY, JANUARY 15

7:30—8:30 AM
Breakfast

Pacific Ballroom
8:30—9:30 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Samuel M. Behar, University of Massachusetts Medical School, USA

* Valerie Mizrahi, University of Cape Town, South Africa

Mark M. Davis, Stanford University, USA
The Pursuit of Basic Human Immunology

9:30 AM—12:00 PM
Bacterial Evasion of Immunity
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Larry S. Schlesinger, Ohio State University, USA

Carl F. Nathan, Weill Cornell Medical College, USA
Overcoming Phenotypic Tolerance of Mycobacterium Tuberculosis

Coffee Break

Carolyn R. Bertozzi, Stanford University, USA
Bioorthogonal Chemistry to Probe Host-Pathogen Interactions

Vojo Deretic, University of New Mexico Health Sciences Center, USA
The Cell Biology of the Host-Pathogen Interaction: Autophagy and Mtb

Volker Briken, University of Maryland, USA
Short Talk: The Cell Wall Lipid PDIM Mediates Phagosomal Escape and Host Cell Exit of Mycobacterium Tuberculosis

Chiara Toniolo, École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Cell-to-Cell Phenotypic Heterogeneity in the Interactions between Macrophages and Mycobacterium Tuberculosis

12:00—2:30 PM
On Own for Lunch

12:00—1:00 PM
Poster Setup

Pacific Ballroom
1:00—10:00 PM
Poster Viewing

Pacific Ballroom
2:30—4:30 PM
Workshop: Human Immunology

British/Columbia Ballroom
* Thomas J. Scriba, University of Cape Town, South Africa

Malika Davids, University of Cape Town, South Africa
A Human Lung-Orientated Approach to Correlates of Risk in Tuberculosis

Baoxue Ge, Shanghai Pulmonary Hospital, China
Genetic Susceptibility for Tuberculosis

Carolin Turner, University College London, UK
Transcriptional T Cell Subset Signatures to Dissect the Human Tissue Response in Tuberculosis

Sharee Ann Basdeo, Trinity Translational Medicine Institute, Ireland
The Shift to Warburg Metabolism in M. Tuberculosis-Infected Human Macrophages Directs Subsequent Adaptive T Cell Responses

Cecilia Sofie Lindestam Arlehamn, La Jolla Institute for Allergy and Immunology, USA
Differential Recognition of MTB-Specific Epitopes as a Function of Treatment

Steven G. Smith, London School of Hygiene and Tropical Medicine, UK
BCG-Induced Trained Immunity Profiling in Infants Identifies Epidermal Growth Factor, Interleukin-6 and Platelet-Derived Growth Factor-AA/AB as Biomarkers

Patrizia Amelio, Centre Hospitalier Universitaire Vaudois, Switzerland
Skewed Th2 Functional Profile of Mycobacterium Tuberculosis-Specific CD4 T Cells in Patients with Active Tuberculosis from Helminth Endemic Area

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
How Infected Macrophages Kill Mtb
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Joel D. Ernst, New York University School of Medicine, USA

Maziar Divangahi, McGill University, Canada
How to Win Against TB: Host Resistance Versus Host Tolerance

Larry S. Schlesinger, Ohio State University, USA
Linking M. tuberculosis Recognition with Human Macrophage Defense Functions

Brian C. VanderVen, Cornell University, USA
Lipid Assimilation by M. Tuberculosis

Matthew Knight, University of California, Berkeley, USA
Short Talk: Macrophage Lipid Droplet Formation is Mediated by HIF-1alpha during TB Infection

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
7:30—10:00 PM
Poster Session 1

Pacific Ballroom

MONDAY, JANUARY 16

7:30—8:30 AM
Breakfast

Pacific Ballroom
8:30—11:45 AM
T Cell Immunity
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Andrea M. Cooper, University of Leicester, UK

Samuel M. Behar, University of Massachusetts Medical School, USA
The Role of IL-21 in Protective Immunity to TB

Jeroen W. van Heijst, Academic Medical Center, Netherlands
T Cell-Intrinsic Limitations in the Recognition of Mycobacterium tuberculosis

Coffee Break

Chyung-Ru Wang, Northwestern University Feinberg School of Medicine, USA
Group1 CD1-Restricted T Cells in Mycobacterium Tuberculosis Infection

Thomas J. Scriba, University of Cape Town, South Africa
Differentiation and Function of M. tuberculosis-Specific CD4 T Cells: Implications for TB Vaccine Design

David M. Lewinsohn, Oregon Health & Science University, USA
Short Talk: Analysis of the MR1 Ligandome from Mycobacterially-Infected Cells Reveals Unexpected Diversity and is Associated with Discrete TCR Recognition

Justin Greene, Oregon Health and Science University, USA
Short Talk: MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Pacific Ballroom
1:00—10:00 PM
Poster Viewing

Pacific Ballroom
4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Failure of T Cell Immunity
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* David M. Lewinsohn, Oregon Health & Science University, USA

Joel D. Ernst, New York University School of Medicine, USA
Mycobacterial Evasion of CD4 T Cell Recognition and Activation

Daniel L. Barber, NIAID, National Institutes of Health, USA
Protective and Non-Protective CD4 T Cell Responses Against M. tuberculosis Infection

Anne O'Garra, Francis Crick Institute, UK
IL-10 and T Cell Inhibition

Shannon L. Russell, African Health Research Institute, South Africa
Short Talk: Metabolic Reprogramming during Chronic Mycobacterium Tuberculosis Infection Promotes Maladaptive T Cell Responses and Exhaustion

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
7:30—10:00 PM
Poster Session 2

Pacific Ballroom

TUESDAY, JANUARY 17

7:30—8:30 AM
Breakfast

Pacific Ballroom
8:30—11:45 AM
The Genetics of Host-Pathogen Interactions
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Sabine Ehrt, Weill Cornell Medical College, USA

Erwin Schurr, Research Institute of the McGill University Health Centre, Canada
Human Genetics of Tuberculosis Infection and Disease

Clare M. Smith, University of Massachusetts Medical School, USA
Systems Genetics of the Host-Pathogen Interaction

Coffee Break

Eric J. Rubin, Harvard School of Public Health, USA
Scents and Scentsibility

David M. Tobin, Duke University Medical Center, USA
Genetics of Mycobacterial Dissemination and Bone Disease

Amy K. Barczak, Massachusetts General Hospital, USA
Short Talk: Unraveling Mtb Strategies for Intracellular Survival by Combined Analysis of Host and Pathogen Phenotypes

Mark R. Cronan, Duke University, USA
Short Talk: Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

11:45 AM—12:45 PM
Grantsmanship Workshop presented by NIAID
NIAID Workshop Objectives: Come find out what happens to your applications after you submit it to the NIH. NIAID staff will provide attendees with an overview of NIH peer-review, and provide some grantsmanship tips. NIAID Program Officers and Scientific Review Officers will explain their role in shepherding your grants/proposals through the process. Staff will also provide attendees with resources that will alert them to NIAID funding opportunities and discuss specific opportunities targeted to research in mycobacterial diseases. Finally, time permitting staff will discuss various career opportunities within the NIH.

British/Columbia Ballroom
11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Pacific Ballroom
1:00—10:00 PM
Poster Viewing

Pacific Ballroom
4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Biology at the Host Pathogen Interface
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Valerie Mizrahi, University of Cape Town, South Africa

Priscille Marie Brodin, CIIL Institut Pasteur, France
EMBO Young Investigator Lecture: Cellular Players Involved in Survival of Phagosomal Mycobacterium Tuberculosis

Clifford V. Harding, Case Western Reserve University, USA
Mycobacterium tuberculosis (Mtb) Regulation of Immune Responses via Toll-Like Receptor 2 (TLR2)-Dependent ERK Signaling and Potential Roles of Lipoglycans in Immune Evasion

Paul T. Elkington, University of Southampton, UK
Studying the Host-Pathogen Interaction in a 3-Dimensional Bioengineered Human Cell Culture Model

Rustin Lovewell, University of Massachusetts Medical School, USA
Short Talk: The Relationship between Neutrophils and Mycobacterium tuberculosis in Different Disease States

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
7:30—10:00 PM
Poster Session 3

Pacific Ballroom

WEDNESDAY, JANUARY 18

7:30—8:30 AM
Breakfast

Pacific Ballroom
8:30—11:45 AM
T Cell Memory: A Prerequisite to Vaccine Efficacy
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Samuel M. Behar, University of Massachusetts Medical School, USA

Andrea M. Cooper, University of Leicester, UK
T Cell Memory to TB – Do We Know What We Want? Do We Know How to Get It?

David Masopust, University of Minnesota, USA
Resident Memory T Cells

Coffee Break

Stephen M. Carpenter, University of Massachusetts Medical School, USA
Dysfunction of Memory T Cells during Infection

Jacqueline M. Achkar, Albert Einstein College of Medicine, USA
Protective Roles of Antibodies in M. tuberculosis Infection

Julie G. Burel, La Jolla Institute, USA
Short Talk: Transcriptomic Profiling of Memory CD4 T Cells Reveals Novel Immune Signatures of Latent Tuberculosis

Patricia A. Darrah, NIAID, National Institutes of Health, USA
Short Talk: Aerosol or Intravenous BCG Immunization Induces Robust Tissue Resident T Cell Immunity in the Lungs of Nonhuman Primates

11:45 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—6:45 PM
Bugs and Drugs: New Biological Insights Relating to Therapy
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Eric J. Rubin, Harvard School of Public Health, USA

Veronique Anne Dartois, Public Health Research Institute, USA
The Impact of Lesion Diversity on Therapy

Valerie Mizrahi, University of Cape Town, South Africa
Metabolic Vulnerabilities in M. tuberculosis: Lessons from Guanine Nucleotide Metabolism

Dirk Schnappinger, Cornell University, USA
Genetic Analyses of Essential M. tuberculosis Genes

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Pacific Ballroom

THURSDAY, JANUARY 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI126784-01

Funding for this conference was made possible [in part] by 1 R13 AI 126784 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676