Whistler Conference Centre Floorplan

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This meeting took place in 2017


Here are the related meetings in 2018:
B Cells: Mechanisms in Immunity and Autoimmunity (E4)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

B Cells and T Follicular Helper Cells – Controlling Long-Lived Immunity (D2)


Organizer(s) Stuart G. Tangye, Ignacio Sanz and Hai Qi
April 23—27, 2017
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Dec 21, 2016
Abstract Deadline: Jan 24, 2017
Scholarship Deadline: Dec 21, 2016
Discounted Registration Deadline: Feb 23, 2017

Sponsored by Arena Pharmaceuticals, Inc., BioLegend, Inc. and Merck & Co., Inc.

Summary of Meeting:
B cells are fundamental for the development of long-lived immunological memory following exposure to infectious pathogens and, consequently, for the success of the vast majority of currently-available vaccines. The differentiation of B cells into the effector cells of serological memory – memory B cells and plasma cells – occurs in germinal centers. However this process critically requires a specialized subset of CD4+ T cells termed T follicular helper (Tfh) cells. The integration of signals required to generate germinal center B cells, memory and plasma cells, and Tfh cells are strictly controlled. This is to ensure the efficient selection of antigen-specific high-affinity effector cells, and to prevent the development of immune dyscrasias associated with GCs, such as autoimmunity, immune deficiency and malignancy – conditions that can develop when the complexities of lymphocyte differentiation in germinal centers are dysregulated. Despite the substantial advances that have been made in understanding the cellular, biochemical and molecular requirements for the generation of effective T-dependent B-cell responses, major questions regarding these processes remain. Answers to such questions are needed so as to be able to harness the intrinsic function of memory B cells, plasma cells and Tfh cells in order to enhance immunity in immunocompromised individuals, improve vaccine design and develop novel vaccines for infectious pathogens, as well as to attenuate humoral immune responses in the setting of autoantibody-mediated autoimmune diseases. This meeting will bring together basic and clinical immunologists to address unanswered questions and to discuss the latest cutting-edge breakthroughs in the biology of B cells and Tfh cells to facilitate development of new translational strategies of regulating their behavior in human immunopathologies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, April 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 27 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 28 in order to fully experience the meeting.

SUNDAY, APRIL 23

4:00—8:00 PM
Arrival and Registration

Grand Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

MONDAY, APRIL 24

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia

Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Actively Acquired Tolerance in the Antibody System - The Iliad and The Odyssey

9:00—11:00 AM
B Cells, Infections and Vaccines
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Hai Qi, Tsinghua University, China

William Schief, IAVI and The Scripps Research Institute, USA
HIV Vaccine Strategies to Guide B Cell Maturation

Coffee Break

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Molecular Requirements for Generating Long-Lived Humoral Immunity in Humans: Lessons from Human Genetic Diseases

Jenny L. Johnson, St. Jude Children's Research Hospital, USA
Short Talk: The Role of Germinal Centers in Generating Antibodies to Conserved Influenza Epitopes

Deepak Rao, Brigham and Women's Hospital, USA
Short Talk: Plasticity of Circulating PD-1hi Follicular and Peripheral Helper T Cells

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
2:30—4:30 PM
Workshop 1: B Cell Memory and Plasma Cells

Sea to Sky B/C
* Kathryn A. Pape, University of Minnesota, USA

* Robert C. Rickert, Pfizer, USA

Kerstin Narr, University of Basel, Switzerland
Interferon-Driven Deletion of Antiviral B Cells at the Onset of Chronic Infection

Daniel Lingwood, Havard Medical School, USA
DC-Dependent Control Over the Initiation of Humoral Immunity

Mary M. Tomayko, Yale University School of Medicine, USA
B Cell Memory Formation Requires Bone Morphogenetic Protein Receptor Ia

Deborah L. Burnett, Garvan Institute of Medical Research, Australia
Somatic Hypermutation Serves Two Independent Functions: Antibody Maturation Away from Binding Self and towards Binding Foreign

Joshua F. Koenig, McMaster University, Canada
Long-Lived Memory B Cells Maintain Th2 Humoral Immunity for a Lifetime

Sandra Nielsen, Stanford University, USA
Human Immune Responses to Controlled Necator Americanus (Hookworm) Infection

Deepta Bhattacharya, Washington University School of Medicine, USA
Metabolic Control of Plasma Cell Lifespan and Antibody Secretion

Nicolas Hipp, University of Rennes1, France
T Cell Help Mediated by IL-2 Orchestrates BACH2 Downregulation that Allows Plasma Cell Differentiation

4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
Transcriptional Regulation of B Cells and Tfh Cells
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Betty Diamond, Feinstein Institute for Medical Research, USA

Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
The Regulation of Gene Expression in B Cells

Amy Weinmann, University of Alabama at Birmingham, USA
Molecular Regulators of CD4 T Cell Differentiation

Jason Weinstein, Yale University, USA
Short Talk: The Transcriptional Regulators STAT4 and T-bet Cooperate in Follicular Helper T Cells to Fine-Tune the Viral Specific Humoral Response

Ari M. Melnick, Weill Cornell Medical College, USA
Epigenetic Switches Controlling the Germinal Center Reaction

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 1

Sea to Sky A

TUESDAY, APRIL 25

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:15 AM
Tfh Programming and Flexibility
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Ignacio Sanz, Emory University, School of Medicine, USA

Hai Qi, Tsinghua University, China
Germinal Center T-B Communications

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Tfh Differentiation and B Cell Responses in the Context of Vaccines and Infections

Coffee Break

Elissa K. Deenick, Garvan Institute of Medical Research, Australia
Short Talk: Over Activation of PI3K Causes Defects in B-Cell Development and Differentiation

Silvia Preite, National Institutes of Health, USA
Short Talk: Dissecting the Role of Phosphotidylinositol 3-Kinase (PI3K) δ in the Germinal Center Reaction through a Mouse Model of Hyperactivated PIK3CD

Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
Circulating Tfh1 Cells in Influenza Vaccination

Dirk Baumjohann, Ludwig-Maximilians-University Munich, Germany
Short Talk: MicroRNAs are Essential for the Maintenance of Tfh Cell Identity and Germinal Centers

Luis Graca, University of Lisbon, Portugal
Short Talk: T Follicular Helper (Tfh) and T Follicular Regulatory (Tfr) Cells Have Different TCR-Specificity

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
Lymphocyte Signaling and Diseases
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Robert Brink, Garvan Institute of Medical Research, Australia

David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Signaling Defects Causing Immune Dysregulation

Gail A. Bishop, University of Iowa, USA
TRAF3 Inhibits B Cell Survival and Differentiation via Multiple Mechanisms

Robert C. Rickert, Pfizer, USA
Metabolic Checkpoints and the B Cell Life Cycle

Christopher D. C. Allen, University of California, San Francisco, USA
Short Talk: IgE Responses Are Regulated by Constitutive Activity of the IgE B Cell Receptor

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 2

Sea to Sky A

WEDNESDAY, APRIL 26

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:15 AM
Autoimmunity and Immunodeficiency - Mice and Man
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* David M. Tarlinton, Monash University, Australia

Robert Brink, Garvan Institute of Medical Research, Australia
Circumvention of Normal Antigenic Controls by Rogue Germinal Center B Cells

Qiang Pan-Hammarström, Karolinska Institutet, Sweden
DNA Repair Defects and Primary Immunodeficiency

Coffee Break

David M. Tarlinton, Monash University, Australia
Guiding B Cells In and Out of Germinal Centers: Many Are Called but Few Are Chosen

Alessandra Pernis, Hospital for Special Surgery, USA
Short Talk: Regulation of CD11c+ Tbet+ B Cells in Systemic Autoimmunity

Corey Tan, University of California, San Francisco, USA
Short Talk: Nur77 Expression Marks Autoreactive B Cells in vivo and Enforces Tolerance

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Unexpected Roles of Dendritic Cells in Regulating Extrafollicular (EF) Plasmablast Responses

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Sea to Sky A
1:00—10:00 PM
Poster Viewing

Sea to Sky A
4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
GCs, Tfh Cells and Disease
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Kim Good-Jacobson, Monash University, Australia

Laura Pasqualucci, Columbia University, USA
Genetic-Driven Epigenetic Dysregulation in B Cell Non-Hodgkin Lymphoma

Karin Tarte, Université de Rennes 1 - U917 Inserm, France
GC B-Cell Malignancies and the Tumor Microenvironment

Stephanie C. Eisenbarth, Yale University, USA
Short Talk: Dock8 Deficiency Reveals the Role of Dendritic Cell Subsets in Tfh Cell Priming

Marcus R. Clark, University of Chicago, USA
Quantifying adaptive cell networks in human inflammation

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
7:30—10:00 PM
Poster Session 3

Sea to Sky A

THURSDAY, APRIL 27

7:00—8:00 AM
Breakfast

Sea to Sky A
8:00—11:15 AM
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Gail A. Bishop, University of Iowa, USA

Peter Sage, Harvard Medical School, USA
T Follicular Regulatory Cells and Regulation of Humoral Immunity

Ignacio Sanz, Emory University, School of Medicine, USA
A New Effector B Cell Pathway with Defective Negative Regulation of TLR7 Signaling in Human SLE

Coffee Break

Betty Diamond, Feinstein Institute for Medical Research, USA
B Cell-Mediated Autoimmunity and Therapeutics

Kathryn A. Pape, University of Minnesota, USA
Short Talk: A Single Heavy Chain Variable Segment Determines the Size, Quality, and Longevity of the Memory B Cell Response to a Protein Antigen

Patrick C. Wilson, University of Chicago, USA
Identification of Influenza-Induced Precursors for Long-Lived Plasma Cells in Humans

Jenna Guthmiller, University of Oklahoma Health Sciences Center, USA
Short Talk: B Cell-Intrinsic and -Extrinsic IL-10 Signaling Promotes Germinal Center B Cell Responses and Protective Anti-Plasmodium Humoral Immunity

11:15 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: Molecular Regulation of the Germinal Center Response

Sea to Sky B/C
* Elissa K. Deenick, Garvan Institute of Medical Research, Australia

* Christopher D. C. Allen, University of California, San Francisco, USA

Roza I. Nurieva, MD Anderson Cancer Center, USA
STAT1 Is Required for Tfh Lineage Maintenance through Regulation of IL-21 Expression

Amanda Mener, Emory University, USA
Complement Serves as a Switch between CD4 Independent and Dependent Antibody Responses

Mark Andrew Noviski, University of California, San Francisco, USA
Differential Responsiveness of IgM and IgD to Self-Antigens

Kira V. Rubtsova, National Jewish Health and University of Colorado, USA
T-Bet Expression in B Cells Drives Lupus-Like Autoimmunity and the Formation of Spontaneous Germinal Centers

Ankur Saini, Cincinnati Children's Hospital Medical Center, USA
Convergent Genomic Actions of NFATs and IRF4,8 in Activated B Lymphocytes

Chris Scharer, Emory University, USA
Ezh2 Is Required for the Division-Specific Epigenetic Programming of Plasma Cell Differentiation

Mridu Acharya, Benaroya Research Institute, USA
Alpha(v) Integrins Engage Autophagy Proteins to Regulate Toll-Like Receptor Signaling in B Cells

David Glass, Stanford University, USA
Comprehensive Single Cell Phenotyping of Human B Cells Reveals Broad Heterogeneity within Previously Defined Compartments

4:30—5:00 PM
Coffee Available

Grand Foyer
5:00—7:00 PM
Germinal Center Dynamics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Shane Crotty, La Jolla Institute for Allergy and Immunology, USA

Tri Giang Phan, Garvan Institute of Medical Research, Australia
Optimal Search Strategies for B Cell Encounter with Antigen and T Cell Help in Primary and Secondary Antibody Responses

Kim Good-Jacobson, Monash University, Australia
Transcriptional and Epigenetic Regulation of B Cell Differentiation

Jonatan Ersching, Rockefeller University, USA
Short Talk: Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Guidance Cues for T-Dependent B Cell Activation and Differentiation

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky A

FRIDAY, APRIL 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Arena Pharmaceuticals, Inc. BioLegend, Inc.
Merck & Co., Inc.
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI128965-01

“Funding for this conference was made possible [in part] by AI 128965-01 from the National Institute of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.”


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

American Association for the Advancement of Science (AAAS)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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