Fairmont Banff Springs Floorplan

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This meeting took place in 2017



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Hematopoiesis (B1)


Organizer(s) Catriona H.M. Jamieson, Andreas Trumpp and Paul S. Frenette
January 31—February 4, 2017
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Oct 4, 2016
Abstract Deadline: Nov 1, 2016
Scholarship Deadline: Oct 4, 2016
Discounted Registration Deadline: Dec 1, 2016

Sponsored by Bayer HealthCare Pharmaceuticals

Summary of Meeting:
Since the discovery that hematopoiesis could be established by a single cell over five decades ago, advances in model systems, sequencing, reprogramming and genome editing technologies have enabled precise molecular characterization of regulators of hematopoiesis. These discoveries have informed and accelerated implementation of clinical trials for a broad of array of benign and malignant hematologic disorders, including bone marrow failure syndromes and leukemia, as well as guided the development of molecular prognostication strategies. This Keystone Symposia meeting will bring together basic, translational and clinical researchers to discuss key regulators of hematopoietic stem and progenitor cell ontogeny, cell fate specification and self-renewal during homeostasis, stress and malignant transformation. The relative importance of cell-autonomous genetic, epigenetic, transcriptional and post-transcriptional hematopoietic regulatory mechanisms as well as local niche or systemic factors will be presented by international leaders in the field of hematopoiesis and stem cell biology. The culmination of innovative genome editing, reprogramming, single-cell sequencing and imaging in different model systems to unravel essential regulators of hematopoiesis will be highlighted. This meeting should provide a vital opportunity for forging collaborations between researchers from disparate disciplines and result in novel insights from a plethora of model systems that will enable investigators to address basic, translational and clinical hematopoiesis research challenges.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Tuesday, January 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, February 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, February 5 in order to fully experience the meeting.

TUESDAY, JANUARY 31

4:00—8:00 PM
Arrival and Registration

Van Horne Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

WEDNESDAY, FEBRUARY 1

7:00—8:00 AM
Breakfast

Van Horne B
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Catriona H.M. Jamieson, University of California, San Diego, USA

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment

9:00—11:30 AM
Development
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Catriona H.M. Jamieson, University of California, San Diego, USA

David Traver, University of California, San Diego, USA
Birth of Stem Cell

Coffee Break

Robert A.J. Signer, University of California, San Diego, USA
Translational Control of Hematopoietic Stem Cells

Nina Cabezas-Wallscheid, German Cancer Research Center, Germany
Short Talk: Vitamin A/Retinoic Acid Signaling Regulates the Dormancy State of Hematopoietic Stem Cells

Leslie Crews, University of California, San Diego, USA
Short Talk: Decoding the RNA Editome of Normal versus Malignant Hematopoietic Progenitor Cell Aging

Linda T. Vo, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Unlocking Definitive Hematopoietic Potential via Epigenetic Modulation

Lucas Greder, University of Oxford, UK
Short Talk: Chromatin Accessibility and Expression Profiling of the Endothelial-to-Hematopoietic Transition

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Van Horne B
1:00—10:00 PM
Poster Viewing

Van Horne B
4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
HSC Versus Progenitor Contribution to Hematopoiesis
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Andreas Trumpp, German Cancer Research Center, Germany

John E. Dick, Princess Margaret Cancer Centre, Canada
Mechanistic Insight Into Human Hematopoietic Lineage Determination

Adolfo Ferrando, Columbia University, USA
Mechanisms of Clonal Evolution and Relapse in Acute Lymphoblastic Leukemia

Alejo Ezequiel Rodriguez Fraticelli, Boston Children's Hospital, USA
Clonal Analysis of Hematopoietic Development

Bilyana Stoilova, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Short Talk: Functional and Transcriptional Heterogeneity of Human Hemopoietic Lympho-Myeloid Progenitors at the Single Cell Level

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B
7:30—10:00 PM
Poster Session 1

Van Horne B

THURSDAY, FEBRUARY 2

7:00—8:00 AM
Breakfast

Van Horne B
8:00—11:15 AM
Microenvironment
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Paul S. Frenette, Albert Einstein College of Medicine, USA
HSC Niche and its Regulation by Long-Range Signals

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Cell Fate is Clone Specific and Epigenetically Constrained: Implications for Concepts of the Bone Marrow Niche

Coffee Break

Emmanuelle Passegué, Columbia University, USA
Niche Maintenance of Malignant Hematopoiesis

Irving L. Weissman, Stanford University, USA
Targeting Don’t Eat Me Signals in Malignant Hematopoiesis

Laura M. Calvi, University of Rochester Medical Center, USA
Short Talk: Age-and Region-Dependent Architectural Remodeling of Niche Constituents in the Hematopoietic Microenvironment Contributes to Hematopoietic Stem Cell Aging

Michael Poulos, Weill Cornell Medical College, USA
Short Talk: Rejuvenation of the Aged Vascular Niche to Enhance Hematopoietic Function

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Van Horne B
1:00—10:00 PM
Poster Viewing

Van Horne B
4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:15 PM
Epigenetics and Transcription
Meeting has ended...abstracts no longer viewable online.

Van Horne A
Andreas Trumpp, German Cancer Research Center, Germany
Human Haematopoietic Stem Cell Differentiation is a Continuous Process without Discrete Progenitor Populations

* Maria E. Figueroa, University of Miami Miller School of Medicine, USA
Epigenetic Deregulation in the Aging Hematopoietic Stem Cell

Scott A. Armstrong, Dana-Farber Cancer Institute, USA
Histone Modifications and Gene Expression in Leukemia

Iannis Aifantis, New York University School of Medicine, USA
The Missing Lncs: Regulation of Blood Cell Transformation by LncRNAs

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B
7:30—10:00 PM
Poster Session 2

Van Horne B

FRIDAY, FEBRUARY 3

7:00—8:00 AM
Breakfast

Van Horne B
8:00—11:00 AM
Directed Differentiation and Expansion
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* E. Camilla Forsberg, University of California, Santa Cruz, USA
Bloody Commitments: Hematopoietic Stem Cell Fate Decisions

Derrick J. Rossi, Harvard University, USA
Diminished Apoptotic Priming Underlies Increased Survival of Aged Hematopoietic Stem Cells in Response to DNA Damage

Coffee Break

Dan S. Kaufman, University of California, San Diego, USA
Pluripotent Stem Cells to Model Human Hemato-Lymphoid Development

Melanie Mumau, Columbia University, USA
Short Talk: NR4A1 Identifies a Population of Multipotent Progenitors in the Spleen that Restrict Erythropoiesis

Gabriela Pregernig, Massachusetts Institute of Technology, USA
Short Talk: GATA1 and The Cohesin Complex Cooperate to Regulate Erythroid Gene expression

Katie Matatall, Baylor College of Medicine, USA
Short Talk: Batf2 is a Mediator of Stress-Induced Terminal Differentiation Driving Hematopoietic Stem Cell Depletion Following Chronic Infection

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Van Horne B
1:00—10:00 PM
Poster Viewing

Van Horne B
4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Genome and Transcriptome Editing in Normal and Malignant Progenitors
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Derrick J. Rossi, Harvard University, USA

Catriona H.M. Jamieson, University of California, San Diego, USA
RNA Editing and Malignant Reprogramming

Carlo M. Croce, Ohio State University, USA
MicroRNA Dysregulation to Identify Therapeutic Targets

Daniel G. Tenen, Cancer Science Institute, Singapore
Regulation of Myeloid Transcription Factors, DNA Methylation and Leukemia by Noncoding RNA

Laura PMH de Rooij, McMaster University, Canada
Short Talk: Unraveling the Importance of RNA Binding Proteins in Leukemic Stem Cells by CRISPR-Cas9 Screening

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B
7:30—10:00 PM
Poster Session 3

Van Horne B

SATURDAY, FEBRUARY 4

7:00—8:00 AM
Breakfast

Van Horne B
8:00—11:15 AM
Hematopoietic Malignancies
Meeting has ended...abstracts no longer viewable online.

Van Horne A
Ravi Majeti, Stanford University, USA
Stem Cells in Human AML

* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Clonal Hematopoiesis during Aging

Coffee Break

Tannishtha Reya, University of California, San Diego, USA
In vivo Imaging of Regulators of Normal and Leukemia Stem Cell Symmetric and Asymmetric Division

Luigi M. Naldini, San Raffaele Telethon Institute, Italy
Genetic Engineering of Hematopoiesis for Treating Human Diseases

Toshio Kitamura, University of Tokyo, Institute of Medical Science, Japan
Short Talk: Disruption of EZH2 Induces Myelodysplastc Syndromes (MDS) in Mice via Derepression of ABC-G2

Virginia Turati, University College London Cancer Institute, UK
Short Talk: Single-Cell Analysis of Clonal Dynamics of childhood ALL

11:15 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—6:45 PM
DNA Damage, Repair and Aging
Meeting has ended...abstracts no longer viewable online.

Van Horne A
* Amy J. Wagers, Harvard University, USA
Intrinsic and Extrinsic Signals Regulating Stem Cell Aging

Michael Milsom, HI-STEM/DKFZ, Germany
A Rude Awakening: Stem Cell Depletion in Response to Stress.

Elaine Mardis, Nationwide Children’s Hospital, Ohio State University, USA
AML Genomics: Clinical Translation from Large-Scale Discovery

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Van Horne A
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Van Horne B

SUNDAY, FEBRUARY 5

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bayer HealthCare Pharmaceuticals

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK112658-01

Funding for this conference was made possible (in part) by 1 R13 DK0109587-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676