Granlibakken Tahoe Floorplan

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This meeting took place in 2017



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Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity (C6)


Organizer(s) Franck Mauvais-Jarvis, Deborah Clegg and Arthur P. Arnold
March 19—22, 2017
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Nov 15, 2016
Abstract Deadline: Dec 19, 2016
Scholarship Deadline: Nov 15, 2016
Discounted Registration Deadline: Jan 18, 2017

Supported by the Directors' Fund

Summary of Meeting:
There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is the generation of data that risks being relevant to only half of the population. This is a timely moment to study sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men. The goal of this meeting is to fill a need in the scientific community by connecting interdisciplinary groups of scientists who normally would not have an opportunity to interact. This group includes investigators studying sex differences, the role of sex hormones, the systems biology of sex and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. Leaders of the pharmaceutical industry will present their views on sex-specific drug discovery. The meeting is expected to generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level, and to provide the methods to study them. It is intended to be a catalyst of a process that will lead to gender-specific treatments of metabolic diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Wednesday, March 22 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Thursday, March 23 in order to fully experience the meeting.

SUNDAY, MARCH 19

4:00—8:00 PM
Arrival and Registration

Pre Function
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
6:00—8:00 PM
Light Meal - Provided by Granlibakken

Granhall

MONDAY, MARCH 20

7:00—8:00 AM
Breakfast

Granhall
8:00—9:00 AM
Welcome (Organizers) and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
David C. Page, Whitehead Institute for Biomedical Research, USA
Sex and Disease: Do Males and Females Read their Genomes Differently?

9:00—11:45 AM
Sex Differences in Metabolic Homeostasis I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Andrea L. Hevener, University of California, Los Angeles, USA

Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA
Sex Differences in Adipose Biology

Coffee Break

Charles T. Roberts, Oregon National Primate Research Center, USA
Sex-Specific Effects of Androgens on Adipose Tissue Biology

Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
Regulation of Diabetes by Genes, Sex and the Microbiome

Karlton R. Larson, University of California, Davis, USA
Short Talk: Sex Differences in the Metabolic Response to Dietary Protein Dilution and FGF21

Brian Finan, Novo Nordisk, USA
Short Talk: GLP-1/GIP/Glucagon Triagonism Corrects Metabolic Disease in Female Mice

Margreet Vonk Noordegraaf, Erasmus MC, Netherlands
Short Talk: AMH Signaling Deficiency Causes Sex-Dependent Metabolic Alterations in Mice

11:45 AM—2:30 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Bay
1:00—10:00 PM
Poster Viewing

Bay
2:30—4:30 PM
Workshop 1: Designing Pre-Clinical Studies to Conduct Research on Sex Differences

Mountain/Lake
* Karen Reue, University of California, Los Angeles, USA

Franck Mauvais-Jarvis, Tulane University Health Sciences Center, USA

Arthur P. Arnold, University of California, Los Angeles, USA

4:30—5:00 PM
Coffee Available

Pre Function
5:00—7:00 PM
Sex Differences in Metabolic Homeostasis II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Darleen A. Sandoval, University of Michigan, USA

Miriam Bredella, Massachusetts General Hospital, USA
Sex Differences in Body Composition

Jean-François Gautier, Paris VII University School of Medicine, France
Sex Differences in Diabetes Risk in Offspring after Fetal Exposure to Maternal Diabetes

Christopher B. Newgard, Duke University Medical Center, USA
Sex Differences in the Human Metabolome

Kirstie K. Danielson, University of Illinois at Chicago, USA
Short Talk: Sex Differences in, and Associations of Estrogen with, Human Islet Survival and Function Following Islet Cell Transplant

7:00—8:00 PM
Dinner
No registration fees are used to fund alcohol served at this function.

Granhall
7:30—10:00 PM
Poster Session 1

Bay
8:00—9:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

TUESDAY, MARCH 21

7:00—8:00 AM
Breakfast

Granhall
8:00—11:15 AM
Estrogens and Metabolic Homeostasis
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* John M. Stafford, Vanderbilt University, USA

Deborah Clegg, Cedars-Sinai Medical Center, USA
Estrogens, through Activation of Membrane Estrogen Receptor Alpha, Potentiate Beiging of Adipose Tissues

Holly A. Ingraham, University of California, San Francisco, USA
Sex–Specific Modulation of Energy Homeostasis via Estrogen-Responsive Neurocircuits

Coffee Break

Andrea L. Hevener, University of California, Los Angeles, USA
The Impact of ER-alpha in the Regulation of Mitochondrial and Metabolic Health

Miguel López, Universidad de Santiago de Compostela, Spain
Estrogen Regulation of Brown Adipose Tissue Thermogenesis

Yong Xu, Baylor College of Medicine, USA
Short Talk: TAp63 Contributes to Sexual Dimorphism in POMC Neuron Firing and Diet-Induced Obesity

Lin Zhu, Vanderbilt University School of Medicine, USA
Short Talk: Absence of Liver Estrogen Alpha Signaling Predisposes Mice to Atherosclerosis during Western-Type Diet Feeding

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Bay
1:00—10:00 PM
Poster Viewing

Bay
2:30—4:30 PM
Workshop 2

Mountain/Lake
* Pierre Gourdy, INSERM DRTLS, France

Alexandra L. Cara, University of Michigan, USA
Androgen Receptor Expression in Chemically Defined Hypothalamic Nuclei Associated with Energy Balance

Sebastian I. Arriola Apelo, University of Wisconsin-Madison, USA
Male and Female Sex Hormones Determine Metabolic Effects of Hepatic mTORC2

Aurèle Besse-Patin, Institut de Recherches Cliniques de Montréal, IRCM, Canada
Estrogen Signals through PGC-1alpha to Reduce Oxidative Stress Associated with Diet-Induced Fatty Liver Disease

Marion M.C. Korach-André, Karolinska Institute, Sweden
Differential Fatty Acids and Lysophospholipids Composition in Adipose Depots and in Liver May Drive the Sexual Dimorphism in Obesity

Samantha Laber, University of Oxford, UK
Do Functional Elements within the Fto Locus Have Sex-Specific Effects?

Kanakadurga Singer, University of Michigan, USA
Androgens Potentiate Myeloid Inflammatory Responses to Diet-Induced Obesity

Matthew A. Quinn, NIEHS, National Institutes of Health, USA
Estrogen Deficiency Promotes Hepatic Steatosis via Aberrant Glucocorticoid Receptor Signaling

Yukitomo Arao, NIEHS, National Institutes of Health, USA
Estrogen and Androgen Signaling in Female Hepatic Steatosis

4:30—5:00 PM
Coffee Available

Pre Function
5:00—7:00 PM
Androgen and Metabolic Homeostasis
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Charles T. Roberts, Oregon National Primate Research Center, USA

Franck Mauvais-Jarvis, Tulane University Health Sciences Center, USA
Role of Estrogen and Androgen in Pancreatic Islet Dysfunction in Males and Females

Vasantha Padmanabhan, University of Michigan, USA
Developmental Programming of Insulin Resistance in Female Sheep: Is Androgen the Culprit?

Andrea Dunaif, Northwestern University Feinberg School of Medicine, USA
Androgens and Metabolic Dysfunction in Women

Farid Saad, Bayer AG, Germany
Short Talk: Prevalence of Type 2 Diabetes (T2DM) and Prediabetes in Hypogonadal Men with or without Testosterone Treatment for up to 12 Years, and Effects on Anthropometric Parameters and Glycemic Control

7:00—8:00 PM
Dinner
No registration fees are used to fund alcohol served at this function.

Granhall
7:30—10:00 PM
Poster Session 2

Bay
8:00—9:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

WEDNESDAY, MARCH 22

7:00—8:00 AM
Breakfast

Granhall
8:00—11:15 AM
Genetics, Metabolomics and Systems Biology of Sex Differences
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Holly A. Ingraham, University of California, San Francisco, USA

Marc-Andre Cornier, University of Colorado, USA
Sex Differences in Brain Response to Food

Karen Reue, University of California, Los Angeles, USA
The XX Chromosome Complement Is an Obesity Risk Factor

Coffee Break

Cecilia Lindgren, Oxford University, UK
Sexual Dimorphisms in Genetic Loci Linked to Body Fat Distribution

Arthur P. Arnold, University of California, Los Angeles, USA
Sex Differences in Systems Biology: The Sexome

Nyrie E. Israelian, University of Toronto, Canada
Short Talk: Impact of Sex on Gut Microbial Composition and Mucosal Immunity

Eija Laakkonen, University of Jyväskylä, Finland
Short Talk: Serum exomiR Content in Aging Women - Effects of Estrogenic Hormone Replacement Therapy

11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Pre Function
5:00—6:45 PM
Drug Design and Gender-Specific Medicine
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Farid Saad, Bayer AG, Germany

James Trevaskis, MedImmune, USA
Enhanced Metabolic Actions of Amylin in Estrogen-Deficiency

Alan J. Russell, GlaxoSmithKline plc., USA
Development of Selective Androgen Receptor Modulators (SARMs) and their Sex-Selective Actions

Richard D. DiMarchi, Indiana University, USA
Chemical Biotechnology Applied to Metabolic Diseases

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
7:00—8:00 PM
Dinner
No registration fees are used to fund alcohol served at this function.

Granhall
7:00—8:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

THURSDAY, MARCH 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK112660-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Molecular Metabolism (Elsevier GmbH)


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676