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This meeting took place in 2017



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Cell Plasticity within the Tumor Microenvironment (A1)


Organizer(s) Sergei Grivennikov, Florian R. Greten and Mikala Egeblad
January 8—12, 2017
Big Sky Resort • Big Sky, Montana USA
Discounted Abstract Deadline: Sep 19, 2016
Abstract Deadline: Oct 6, 2016
Scholarship Deadline: Sep 19, 2016
Discounted Registration Deadline: Nov 8, 2016

Sponsored by Journal of Molecular Cell Biology (JMCB) and Roche

Summary of Meeting:
During the last decade, it has become unequivocally evident that tumor development is not a cell-autonomous process but rather depends on the intricate reciprocal interplay of mutant tumor cells with their local and distant environments. Composition and polarization of cells in the tumor microenvironment depends on genetic as well as environmental factors and is directly influenced by tumor therapy. Indeed, therapies that aim to shape the local immune milieu and consecutive signaling pathways in both stromal and tumor/stem cells address the complex pathophysiology of tumors more adequately and may therefore add substantial benefits for therapy. An absolute pre-requisite for such an endeavor is a comprehensive understanding of the exact molecular basis of the complex signaling networks in the tumor microenvironment that control the plasticity of both stromal and tumor cells, thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this symposium aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. It will bring together experts in cancer, stromal and immune cells to synthesize scientific knowledge about the phenomenon of cell plasticity within the tumor microenvironment, to define molecular and cellular pathways mediating plasticity and to propose approaches to interfere with cell plasticity for a new generation of effective therapeutic approaches in cancer and chronic injury. Importantly, it will bring together interdisciplinary groups of scientists or investigators who normally would not have an opportunity to meet (classical cancer biologists, tumor immunobiologists, stem cell experts and scientists working on stromal cells).

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, January 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 12 with a closing plenary session and keynote address from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, January 13 in order to fully experience the meeting.

SUNDAY, JANUARY 8

4:00—8:00 PM
Arrival and Registration

Lower Atrium
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Jefferson

MONDAY, JANUARY 9

7:00—8:00 AM
Breakfast

Gallatin
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Sergei Grivennikov, Fox Chase Cancer Center, USA

* Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany

* Mikala Egeblad, Cold Spring Harbor Laboratory, USA

Michael Karin, University of California, San Diego, USA
Tumor-Elicited Inflammation and the Initiation of Colorectal Cancer

9:00—11:45 AM
Plasticity of Epithelial, Cancer and Stem Cells
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Cédric Blanpain, Universite Libre de Bruxelles, Belgium

* Shelly Peyton, University of Massachusetts, USA

Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Inflammatory Signaling in Intestinal Stem Cell Plasticity

John Cassidy, University of Cambridge, UK
Short Talk: The Development of Tamoxifen Resistance is Linked to Oct4 Driven Transcriptional Plasticity

Coffee Break

Andrew J. Ewald, Johns Hopkins University School of Medicine, USA
Phenotypic Plasticity during Cell Invasion and Metastasis

Kristiaan Lenos, Amsterdam Medical Center, Netherlands
Short Talk: Spatiotemporal Regulation of Stem Cell Function in Colon Cancer

Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Intestinal Stem Cells in Cancer

Brian Bierie, Whitehead Institute for Biomedical Research, USA
Poster Teaser: Integrin-Beta4 Identifies Cancer Stem Cell-Enriched Populations of Partially-Mesenchymal Carcinoma Cells

Jessica L. Christenson, University of Colorado, USA
Poster Teaser: The Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression: Tumor-Intrinsic and Tumor-Extrinsic Mechanisms

Ryan Carpenter, University of Massachusetts, Amherst, USA
Poster Teaser: Capturing Microenvironmental Regulation of Metastatic Dormancy and Recurrence

Sara E. Berkey, University of Pittsburgh, USA
Poster Teaser: The IL17+Foxp3+ and exTh17 Foxp3+ Plastic T Cells Comprise Novel Immunosuppressive Regulatory T Cell Subsets in Tumors

Oxana Dmitrieva, Fox Chase Cancer Center, USA
Poster Teaser: The Role of IL-1R-Signaling in Tumor Elicited Inflammation and Colon Cancer

11:45 AM—2:30 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Gallatin
1:00—10:00 PM
Poster Viewing

Gallatin
2:30—4:30 PM
Workshop 1: Plasticity and the Cancer Stem Cell Niche

Jefferson/Madison
* Diana Leigh Avery, University of Pennsylvania School of Medicine, USA
Matrix Mechanics and Composition Dictate Stromal Cell Differentiation in Lung Tumorigenesis

Ikbale El Ayachi, University of Tennessee Health Science Center, USA
The Absence of Wnt10b Expression Inhibits Tumor Initiation and Metastasis Modulating Stroma-Tumor Microenvironment Homeostasis

* Loukia Georgiou Karacosta, Stanford University, USA
Identifying Dynamic EMT Transition States in Lung Cancer Using Single Cell Multidimensional Analysis

Hazel Quinn, Max Delbruck Centre, Germany
Genetically Interfering with the Tumor Microenvironment via Shh in Wnt-Met driven Mouse Triple Negative Breast Cancer

Michael Buchert, Olivia Newton-John Cancer Research Institute, Australia
Insights into the Role of DCLK1 as a Novel Driver of Gastric Cancer

Toni Celia-Terrassa, Princeton University, USA
Pathways Regulating the Evasion of Normal and Cancer Stem Cells from Interferon-Imposed Constraint

Dejan Maglic, Boston Children's Hospital, USA
The Hedgehog and Hippo Pathways Cooperate in BCC Initiation and Progression

Hélène Salmon, Icahn School of Medicine at Mount Sinai, USA
The Tumor Microenvironment Controls Tumor Response to Checkpoint Blockade

4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—7:00 PM
Plasticity and the (Cancer) Stem Cell Niche
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany

* Louis Vermeulen, CEMM, Netherlands

Jing Yang, University of California, San Diego, USA
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis

Cédric Blanpain, Universite Libre de Bruxelles, Belgium
Skin Tumor Stemness and Progression

Ekrem Emrah Er, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Pericytic Spreading of Disseminated Cancer Cells Initiate Multi-Organ Metastasis

Mathias Florian Heikenwälder, German Cancer Research Center, DKFZ, Germany
Kupffer-Cell Derived TNF Preferentially Triggers Cholangiocellular Carcinoma through JNK under Chronic Mitochondrial Dysfunction and ROS

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
7:30—10:00 PM
Poster Session 1

Gallatin

TUESDAY, JANUARY 10

7:00—8:00 AM
Breakfast

Gallatin
8:00—11:30 AM
Cell Types Contributing to the Plasticity of the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Jing Yang, University of California, San Diego, USA

* Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA

Thomas Tüting, Otto-von-Guericke University, Germany
Inflammation-Induced Phenotypic Plasticity of Tumor and Immune Cells as a Mechanism of Disease Progression and Therapy Resistance in Melanoma

Neta Erez, Tel Aviv University, Israel
Short Talk: Cancer-Associated Fibroblasts Link Tissue Damage with Tumor-Promoting Inflammation in Breast Cancer

Brian W. Wong, Vesalius Research Center, Belgium
Endothelial versus Cancer Cell Metabolism

Coffee Break

Valerie M. Weaver, University of California, San Francisco, USA
Extracellular Matrix and Tumor Mechanics

Shelly Peyton, University of Massachusetts, USA
Short Talk: Dynamics of Fibronectin Assembly and Tumor Cell Latency

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
The Functional Role of EMT and Exosomes in Pancreatic Cancer

Chen Hao Lo, Moffitt Cancer Center, USA
Poster Teaser: Temporal Dynamics of Macrophage Plasticity in Bone Metastatic Prostate Cancer

Magdolna Djurec, Spanish National Cancer Research Center, Spain
Poster Teaser: Reprogramming Cancer Associated Fibroblasts as a Therapeutic Approach against Pancreatic Ductal Adenocarcinoma

Ayse Nihan Kilinc, University of Basel, Switzerland
Poster Teaser: The Contribution of Epithelial-Mesenchymal Plasticity to Cancer Stemness

Lennart Kester, Hubrecht Institute, Netherlands
Poster Teaser: Clonal Dynamics with Single Cell Resolution in Different Stages of Colon Carcinoma

Natsuko Kimura, University of Tokyo, Japan
Poster Teaser: Maintenance of Stemness and Niche Environment of Breast Cancer Cells by FRS2beta, a Feedback Inhibitor for HER2-ERK Pathway, during Mammary Tumorigenesis

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Gallatin
1:00—10:00 PM
Poster Viewing

Gallatin
4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—7:00 PM
Plasticity of Immune Cells within the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Mikala Egeblad, Cold Spring Harbor Laboratory, USA

* Alana L. Welm, Huntsman Cancer Institute, University of Utah School of Medicine, USA

Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Serial Killing of Tumor Cells – Impact of the Microenvironment

Giorgio Trinchieri, NCI, National Institutes of Health, USA
Cancer as a Meta-Organism – Fine-Tuning of Tumor Progression and Response to Therapy by Microbiota-Regulated Immune Cells

Melissa A. Meyer, Washington University in St. Louis, USA
Short Talk: Tumor-Induced IRF8 Deficiency Interrupts BATF3-Dependent Dendritic Cells Development

Sergei Grivennikov, Fox Chase Cancer Center, USA
Tumor-Elicited Inflammation and Cytokines at Crossroads in Wound Healing and Tumor Progression

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
7:30—10:00 PM
Poster Session 2

Gallatin

WEDNESDAY, JANUARY 11

7:00—8:00 AM
Breakfast

Gallatin
8:00—11:30 AM
Parallels between Normal Tissue Repair Response and Oncogenesis
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Carla V. Rothlin, Yale University, USA

* Neta Erez, Tel Aviv University, Israel

Erik A. Sahai, Cancer Research UK London Research Institute, UK
Tumor-Stroma Cross-Talk in Metastasis and Therapy Failure

Andreas Trumpp, German Cancer Research Center, Germany
Stratification and Resistance Mechanisms in Pancreatic Cancer

Annelise Snyder, University of Washington, USA
Short Talk: Necroptotic Cell Death within the Tumor Microenvironment Promotes Tumor Control

Coffee Break

Alana L. Welm, Huntsman Cancer Institute, University of Utah School of Medicine, USA
Ron Kinase in Bone Remodeling and Bone Metastasis

Sheila A. Stewart, Washington University School of Medicine, USA
Short Talk: Inhibition of Stromal p38MAPK Abrogates Breast Cancer Metastases

Robert F. Schwabe, Columbia University, USA
Fibrosis Promotes the Development of Liver Cancer

Mario A. Shields, Cold Spring Harbor Laboratory, USA
Poster Teaser: Lysyl Oxidases Suppress Pancreatic Cancer Progression and Inhibit FAK and ERK Signaling

Suzanne M. Ponik, University of Wisconsin-Madison, USA
Poster Teaser: Collagen Matrix Density Drives the Metabolic Profile Shift of Breast Cancer Cells

Daniel C. Rabe, University of Chicago, USA
Poster Teaser: Exosome Crosstalk between Tumors and Tumor-Associated Macrophages Drives Pro-Invasive Plasticity

Julia Varga, Georg Speyer Haus, Germany
Poster Teaser: Notch3 Activation in Response to Aberrant Akt Signaling Contributes to Colorectal Cancer Progression

11:30 AM—2:30 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Gallatin
1:00—10:00 PM
Poster Viewing

Gallatin
2:30—4:30 PM
Workshop 2: Therapy Resistance Mediated by Adaptive Responses in the Tumor Microenvironment

Jefferson/Madison
* Weizhou Zhang, University of Iowa, USA

Saran Kumar, Hebrew University, Israel
Adjacency to Blood Vessels as a Generator of Tumor Cell Metabolic and Phenotypic Heterogeneities

Mihaela Skobe, Icahn School of Medicine at Mount Sinai, USA
Lymphatic Endothelium Protects Breast Cancer Cells from Death by Inducing Metabolic Adaptations

Melissa R. Junttila, Genentech, Inc., USA
Identification of a Non-Genomic Resistance Mechanism to Vemurafenib in a BRAF Mutant Melanoma Model

Peter Chockley, University of Michigan Medical School, USA
EMT Confers Susceptibility to Metastasis-Specific Immune Surveillance in Lung Cancer

Alex Swarbrick, Garvan Institute of Medical Research, Australia
The Paracrine Hedgehog-FGF Axis Mediates Cancer Stem Cell Plasticity in Triple Negative Breast Cancer

* Ela Elyada, Cold Spring Harbor Laboratory, USA
Pancreatic Stellate Cell Dynamics in PDAC

Michael Timaner, Technion-Israel Institute of Technology, Israel
Tumor-Associated Mesenchymal Stem Cells Preserve Cancer Stem Cells Niche in the Tumor Microenvironment Following Chemotherapy

4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—7:00 PM
Approaches to Visualize and Study Dynamics of the Tumor Microenvironment (“Imaging”)
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Sergei Grivennikov, Fox Chase Cancer Center, USA

* Stefani Spranger, University of Chicago, USA

Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Imaging Reveals Tumor and Stromal Contributions to Formation of Metastases

Danielle Seinstra, Hubrecht Institute, Netherlands
Plasticity Between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Tracy W. Liu, MD Anderson Cancer Center, USA
Short Talk: Imaging the Dynamics of Tumor NF-kB Transcriptional Activation and the Microenvironment In Vivo

Matthew F. Krummel, University of California, San Francisco, USA
Imaging and Deconvolving Tumor Antigen Flow in Primary and Metastatic Tumor Sites

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
7:30—10:00 PM
Poster Session 3

Gallatin

THURSDAY, JANUARY 12

7:00—8:00 AM
Breakfast

Gallatin
8:00—11:15 AM
Targeting the Changing Tumor Microenvironment for Anti-Cancer Therapies
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Sheila A. Stewart, Washington University School of Medicine, USA

* Andrew J. Ewald, Johns Hopkins University School of Medicine, USA

Karin E. de Visser, Netherlands Cancer Institute, Netherlands
EMBO Young Investigator Lecture: Targeting Tumor-Induced Systemic Inflammation to Fight Metastatic Breast Cancer

Carla V. Rothlin, Yale University, USA
Innate Immune Checkpoints in Anti-Tumor Immunity

Deepak Nagrath, University of Michigan, USA
Short Talk: Targeting Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

Coffee Break

Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Systemic Regulation of Tumor and Stromal Cell Plasticity

Lionel J. Apetoh, Centre Georges Francois Leclerc, France
Short Talk: Selective Degradation of the PU.1 Transcription Factor by Autophagy Represses TH9 Cell Differentiation

Paula D. Bos, Virginia Commonwealth University, USA
Short Talk: Treg-ulation of the Breast Tumor Microenvironment

Weizhou Zhang, University of Iowa, USA
Short Talk: Obesity-Related NLRC4 Inflammasome Activation and Angiogenesis in Breast Cancer

11:15 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Lower Atrium
5:00—6:15 PM
Therapy Resistance Mediated by Adaptive Responses in the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Karin E. de Visser, Netherlands Cancer Institute, Netherlands

* Erik A. Sahai, Cancer Research UK London Research Institute, UK

Francois Ghiringhelli, Centre de Recherche, INSERM U866, France
Chemotherapy and Reprogramming Immune and Cancer Cells

Stefani Spranger, University of Chicago, USA
Impact of Tumor Cell-Intrinsic Signaling on Anti-Tumor Immune Responses in the Tumor Microenvironment

6:15—7:00 PM
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Sergei Grivennikov, Fox Chase Cancer Center, USA

* Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany

* Mikala Egeblad, Cold Spring Harbor Laboratory, USA

Robert A. Weinberg, Massachusetts Institute of Technology, USA
The Epithelial-Mesenchymal Transition and Malignant Progression

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Gallatin

FRIDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Journal of Molecular Cell Biology (JMCB) Roche

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA210497-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


Genentech, Inc.


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