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This meeting took place in 2017



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Viral Immunity: Mechanisms and Consequences (B4)


Organizer(s) Akiko Iwasaki, Daniel B. Stetson and E. John Wherry
February 19—23, 2017
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 18, 2016
Abstract Deadline: Nov 17, 2016
Scholarship Deadline: Oct 18, 2016
Discounted Registration Deadline: Dec 19, 2016

Sponsored by Gilead Sciences, Inc.

Summary of Meeting:
A clear understanding of the mechanisms of host immunity to virus infection will guide efforts to design better treatments for some of the most devastating diseases of humanity. The fields of virology and immunology often convene their own specialized meetings. However, each of these fields has matured to the point where the most transformative advances are likely to arise from cross-disciplinary insights, rather than from continued progress in an isolated area. This meeting will foster new interactions and generate new ideas by assembling international experts in the areas of evolutionary perspectives on the host-virus relationship, innate immune detection and control of endogenous and exogenous viruses, memory cell control of viruses at mucosal surfaces, immunological consequences of prior viral exposure, and new approaches to vaccines and therapeutics. This comprehensive and inclusive approach should spur new thinking. For example, a solution to the medically important issue of chronic viral infection and immune exhaustion may emerge from a better understanding of the history of these viruses and how they have shaped the immune response and vice versa over evolutionary time. Similarly, a rational approach to vaccine design must be rooted in the innate immune mechanisms by which cells detect and respond to virus infection. This Keystone Symposia meeting offers a unique opportunity to bring about the next advances in viral immunity through cross-disciplinary interactions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 23 with a closing plenary session and keynote address from 17:00 to 20:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 24 in order to fully experience the meeting.

SUNDAY, FEBRUARY 19

4:00—8:00 PM
Arrival and Registration

Promenade
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Promenade

MONDAY, FEBRUARY 20

7:00—8:00 AM
Breakfast

Pecos/Canyon
7:30—8:00 AM
Poster Setup

Mesa C
8:00 AM—5:00 PM
Poster Viewing

Mesa C
8:00—9:00 AM
Welcome and Keynote Address (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Stephen P. Goff, Columbia University, USA
Host Regulation of Retroviruses

9:00—11:30 AM
Sensing Endogenous Viruses
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Nels C. Elde, University of Utah, USA

Daniel B. Stetson, University of Washington, USA
Regulating Endogenous Retroviral Sensing

Marco De Cecco, Brown University, USA
Short Talk: LINE-1 Elements Escape Repression in Senescent Cells and Trigger a Type-I Interferon Response

Coffee Break

Maria Tokuyama, Yale University School of Medicine, USA
Short Talk: Genome-Wide Endogenous Retrovirus Profiling Reveals Interferon-Independent Lupus Signature

John V. Moran, University of Michigan Medical School, USA
Studies of a Human Retrotransposon

George Kassiotis, Francis Crick Institute, UK
Immunity to Endogenous Retroviruses

11:30 AM—12:30 PM
Lunch

Pecos/Canyon
12:00—2:30 PM
Poster Session 1

Mesa C
2:30—4:30 PM
Workshop 1

Mesa A-B
* Jennifer M. Lund, Fred Hutchinson Cancer Research Center, USA

Pavla Brachova, University of Kansas Medical Center, USA
RNA-Editing and Sensing in Mammalian Oocytes

Hannah Burgess, New York University School of Medicine, USA
The Stress Granule Component G3BP1 Opposes an HSV-1 Endoribonuclease to Regulate PKR Activation and Interferon Induction

Oya Cingoz, Columbia University Medical Center, USA
CDK Inhibition Blocks Nucleic Acid Induced Innate Immune Responses

Jessica Graham, Fred Hutchinson Cancer Research Center, USA
West Nile Virus Infection in the Collaborative Cross Mouse Model Recapitulates Unique Human Disease States

Tzachi Hagai, EMBL - European Bioinformatics Institute, UK
The Architecture of Cellular Antiviral Immunity

Tania Lebratti, Washington University in St. Louis, USA
Neutrophils Regulate Pathogenesis in Genital HSV-2 Infection

Takuma Shibata, Institute of Medical Science, University of Tokyo, Japan
Nucleosides are endogenous ligands for TLR7 and TLR8

Gilad Sivan, NIAID, National Institutes of Health, USA
A Reverse Evolution Approach for Identification of Novel Antiviral Pathways

4:30—5:00 PM
Coffee Available

Promenade
5:00—7:00 PM
Evolutionary Arms Race with Viruses
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Daniel B. Stetson, University of Washington, USA

Nels C. Elde, University of Utah, USA
Retrogenes as Antivirals

Nicolas Manel, Institut Curie, France
Interactions of Dendritic Cells with Viruses

Rossana Colon-Thillet, Fred Hutchinson Cancer Research Center, USA
Short Talk: An Unbiased Approach to Evaluate the Contribution of Rapidly Evolving Sites at Antiviral Interfaces

Beatrice H. Hahn, University of Pennsylvania, USA
Determinants of HIV-1 Transmission Fitness

7:00 PM
On Own for Dinner


TUESDAY, FEBRUARY 21

7:00—8:00 AM
Breakfast

Pecos/Canyon
8:00—11:15 AM
Innate Antiviral Defense
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Ken H. Cadwell, New York University School of Medicine, USA

Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Cellular Factors that Regulate Viral Pathogenesis

John W. Schoggins, University of Texas Southwestern Medical Center, USA
Modulation of Viral Infection by Interferon-Stimulated Genes

Andrew Oberst, University of Washington, USA
Short Talk: Death-Independent Roles of the Necroptotic Pathway in the Restriction of Flavivirus Pathogenesis

Coffee Break

Shomyseh Sanjabi, Gladstone Institutes, University of California, San Francisco, USA
Short Talk: Dampened Antiviral Immunity to Intravaginal Exposure to RNA Viral Pathogens Allows Enhanced Viral Replication

Michael S. Diamond, Washington University School of Medicine, USA
Using Mouse Models to Study the Pathogenesis and Immune Response to Zika Virus

Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Innate Antiviral Defense

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mesa C
1:00—10:00 PM
Poster Viewing

Mesa C
4:30—5:00 PM
Coffee Available

Promenade
5:00—7:00 PM
Viral Sensors: Structure and Function
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Owen Pornillos, University of Virginia, USA

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
DNA Sensor

Sun Hur, Harvard Medical School, USA
Structure and Function of RNA Sensors

Seong-Wook Oh, Kyoto University, Japan
Short Talk: Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules

Toshiyuki Shimizu, University of Tokyo, Japan
Structural Study of TLRs Sensing Single-Stranded RNA in Innate Immune System

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pecos/Canyon
7:30—10:00 PM
Poster Session 2

Mesa C

WEDNESDAY, FEBRUARY 22

7:00—8:00 AM
Breakfast

Pecos/Canyon
8:00—11:15 AM
Memory Responses in Peripheral Tissue
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* E. John Wherry, University of Pennsylvania, USA

Ulrich H. Von Andrian, Harvard Medical School, USA
Memory T Cells in the Uterus

Susan M. Kaech, Yale University School of Medicine, USA
Memory T Cell Programming

Jessica K. Fiege, University of Minnesota, USA
Short Talk: How and Why Lung Epithelial Cells Survive Influenza A Virus Infection

Coffee Break

Susan L. Swain, University of Massachusetts Medical School, USA
Short Talk: Ag Recognition at a Checkpoint During the CD4 Effector Phase Drives Generation of CD4 Memory  

Rachael A. Clark, Brigham and Women's Hospital, Harvard Medical School, USA
Resident Memory T cells in Human Health and Disease

Laura K. Mackay, University of Melbourne, Australia
Molecular Regulation of Tissue-Resident Lymphocytes

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mesa C
1:00—10:00 PM
Poster Viewing

Mesa C
4:30—5:00 PM
Coffee Available

Promenade
5:00—7:00 PM
Consequences of Virus Infection on Immunity
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Sara R. Cherry, University of Pennsylvania School of Medicine, USA

Ken H. Cadwell, New York University School of Medicine, USA
Virus-Host Interactions and the Gut Microbiota

Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA
Coinfection and Disease Tolerance

Megan T. Baldridge, Washington University School of Medicine, USA
Short Talk: Interferon-lambda Responses to Norovirus Infection are Mediated Through Epithelial Cell Signaling and Governed by HOIL-1

Tatyana V. Golovkina, University of Chicago, USA
Genetic Basis for the Inhibition of Retrovirus Neutralizing Antibody Responses

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pecos/Canyon
7:30—10:00 PM
Poster Session 3

Mesa C

THURSDAY, FEBRUARY 23

7:00—8:00 AM
Breakfast

Pecos/Canyon
8:00—11:15 AM
Vaccines Against Viruses
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Ulrich H. Von Andrian, Harvard Medical School, USA

Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA
Exploiting the Adjuvanting Effects of Antibody Glycosylation in Vaccination

Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Universal Vaccines for Influenza Viruses

Nicolas Chevrier, Harvard University, USA
Short Talk: Organism-Level Analysis of Vaccination Reveals Networks of Protection Across Tissues

Coffee Break

Jens P. Wrammert, Emory University, USA
Short Talk: Human Antibody Responses After Dengue Virus Infection are Highly Cross-Reactive to Zika Virus

Gary J. Nabel, Sanofi, USA
Novel Approaches to Broadly Neutralizing Ab Combinations for HIV Prevention and Treatment

Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
HIV Vaccines – Lessons from Infection

11:15 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2

Mesa A-B
* Tania H. Watts, University of Toronto, Canada

Shannon Renee Barbour, University of Pennsylvania, USA
Defining the Specificity of Antibodies Elicited by Primary and Secondary Flavivirus Infections

David R. Collins, Ragon Institute of MGH, MIT & Harvard, USA
Beyond Mutational Escape: Mechanisms of HIV Rebound After Control

Brian J. Laidlaw, University of California, San Francisco, USA
The Eph-Related Tyrosine Kinase Ligand Ephrin-B1 Marks Germinal Center and Memory Precursor B Cells

Yew Ann Leong, Monash University, Australia
CXCR5+ Follicular Cytotoxic T Cells Control Viral Infection in B Cell Follicles

Michal Caspi Tal, Stanford University School of Medicine, USA
Host Dependent Upregulation of CD47 is a Critical Component of Antiviral Immune responses

Andreas Wieland, Emory University, USA
Strategies for Efficient Fc{gamma}R-Mediated Antibody Effector Functions During Persistent Viral Infection

Angela C. Zhou, University of Toronto, Canada
Intrinsic 4-1BB Signals are Indispensable for Establishment of an Influenza-Specific CD8 Tissue-Resident Memory T Cell Population in the Lung

Vesselin T. Tomov, University of Pennsylvania, USA
Short Talk: Enteric MNV Persistence is Associated with a Unique CD8 T Cell Differentiation State and Rapid Immune Evasion

4:30—5:00 PM
Coffee Available

Promenade
5:00—6:15 PM
Chronic Viral Infection
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA

E. John Wherry, University of Pennsylvania, USA
Molecular Basis of T Cell Exhaustion: Insights for Immunotherapy

Daniel C. Douek, NIAID, National Institutes of Health, USA
Multiple Origins of Virus Persistence in HIV Controllers

6:15—7:00 PM
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* E. John Wherry, University of Pennsylvania, USA

Rafi Ahmed, Emory University School of Medicine, USA
Defining Stem-Like CD8 T Cells that Respond to PD-1 Therapy

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
8:15—9:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Promenade/Mesa Ballroom
8:15—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mesa Ballroom

FRIDAY, FEBRUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Gilead Sciences, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

eLife

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI129343-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676