Beaver Run Resort Floorplan

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This meeting took place in 2017



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Omics Strategies to Study the Proteome (A8)


Organizer(s) Alan Saghatelian, Chuan He and Ileana M. Cristea
January 29—February 2, 2017
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Sep 28, 2016
Abstract Deadline: Oct 27, 2016
Scholarship Deadline: Sep 28, 2016
Discounted Registration Deadline: Nov 29, 2016

Supported by the Directors' Fund

Summary of Meeting:
Proteins are responsible for controlling the majority of the processes necessary for life, and their translation and regulation are of fundamental and biomedical interest. A variety of different -omics strategies, including innovative sequencing and proteomics approaches, have provided fundamental insights into the composition and regulation of the proteome. This Keystone Symposia meeting will bring diverse group of scientists together to discuss topics ranging from the molecular biology of protein translation to the characterization of enzymes in cell and tissue systems through the development and application of genomics and proteomics methods. Key topics of emphasis include transcriptome and epitranscriptome regulation of translation, proteogenomics and the discovery of novel proteins, quantitative proteomics, protein interactions, and activity-based proteomics.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, January 29 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 2 with a closing plenary session and keynote address from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 3 in order to fully experience the meeting.

SUNDAY, JANUARY 29

4:00—8:00 PM
Arrival and Registration

Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, JANUARY 30

7:00—8:00 AM
Breakfast

Summit Gallery
8:00—9:00 AM
Welcome and Keynote Address (Organizers)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Jonathan S. Weissman, University of California, San Francisco, USA
Ribosome Profiling

9:00—11:15 AM
Global RNA and Protein Regulation and Dynamics
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Chuan He, University of Chicago, USA

Xiang-Dong Fu, University of California, San Diego, USA
Novel Mechanism for microRNAs to Target Protein Coding Sequences to Regulate Translation

Coffee Break

Frank L. Conlon, University of North Carolina at Chapel Hill, USA
Initiating Events in Direct Cardiomyocyte Reprogramming

Zijun Zhang, University of California, Los Angeles, USA
Short Talk: CLIP-Seq Analysis of Multi-Mapped Reads Identifies Novel Functional RNA Regulatory Sites in the Human Transcriptome

Manuel D. Leonetti, HHMI/University of California, San Francisco, USA
Short Talk: A Scalable, Cloning-Free Strategy for Endogenous Protein Tagging: Construction of A Genome-Wide Collection of GFP-Tagged Human Cell Lines

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Peaks 1-3
1:00—10:00 PM
Poster Viewing

Peaks 1-3
2:30—4:30 PM
Workshop 1: Protein-Protein Interaction

Peaks 4-5
* Steven P. Gygi, Harvard Medical School, USA

Simeon Andrews, Weill Cornell Medicine - Qatar, USA
AVA-Seq: Rapid All-vs-All Proteome Interactions Probed with Next-Generation Sequencing

Tom Casimir Bamberger, The Scripps Research Institute, USA
In vivo, Proteome-Wide Assessment of Protein Surface Accessibility as a Measure of Protein Structure and Interaction

Kevin Drew, University of Texas at Austin, USA
Human Protein Complex Map: Integration of 10k Mass Spectrometry Experiments

Ruth Huttenhain, University of California, San Francisco, USA
A Proximity Labeling Approach to Capture Temporal and Spatially Resolved Protein Interaction Networks in Living Cells

Edward L. Huttlin, Harvard Medical School, USA
BioPlex: A Global Map of the Human Interactome

Julian Mintseris, Harvard Medical School, USA
High-Density Chemical Cross-Linking for Modeling Protein Interactions

4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Regulation and Functions of RNAs
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Jonathan S. Weissman, University of California, San Francisco, USA

Chuan He, University of Chicago, USA
RNA Methylation in Gene Expression regulation

Christine Mayr, Memorial Sloan Kettering Cancer Center, USA
3'UTR-Mediated Protein-Protein Interactions Regulate Protein Functions

Tao Pan, University of Chicago, USA
Functional Genomics of tRNA in Translation

Jagannath Swaminathan, University of Texas, Austin, USA
Short Talk: Single Molecule Peptide Sequencing

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
7:30—10:00 PM
Poster Session 1

Peaks 1-3

TUESDAY, JANUARY 31

7:00—8:00 AM
Breakfast

Summit Gallery
8:00—11:00 AM
Omics Discovery of Novel Polypeptides
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Alan Saghatelian, The Salk Institute for Biological Studies, USA

Pinchas Cohen, University of Southern California, USA
Mitochondrial ORFomics and Peptidomics

Alice Y. Ting, Stanford University, USA
Spatially-Resolved Proteomic and Transcriptomic Mapping in Living Cells

Coffee Break

Kate Carroll, The Scripps Research Institute, USA
Cysteine-Mediated Redox Signaling: Chemical Tools for Biology Discovery

Yishai Levin, Weizmann Institute of Science, Israel
Short Talk: Database Independent Protein Sequencing (DiPS) Enables Full-Length De-Novo Protein and Antibody Sequence Determination

Jennie R. Lill, Genentech, Inc., USA
Short Talk: Defining the mutated Ligandome: Characterizing MHC Class I and Class II Peptides

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Peaks 1-3
1:00—10:00 PM
Poster Viewing

Peaks 1-3
4:30—5:00 PM
Coffee Available

Foyer
5:00—7:15 PM
Quantitative Proteomics and Informatics
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada

John R. Yates III, The Scripps Research Institute, USA
Protein-Protein Interactions Studies of Disease Networks

Olga Vitek, Purdue University, USA
Statistical Methods for Quantitative Proteomics

Alexey I. Nesvizhskii, University of Michigan, USA
Computational Approaches for Proteomics

Olga G. Troyanskaya, Princeton University, USA
Tissue-Specific Protein Networks for the Study of Human Disease

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
7:30—10:00 PM
Poster Session 2

Peaks 1-3

WEDNESDAY, FEBRUARY 1

7:00—8:00 AM
Breakfast

Summit Gallery
8:00—11:15 AM
Biological and Clinical Applications of Proteomics
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Vicki H. Wysocki, Ohio State University, USA

Ileana M. Cristea, Princeton University, USA
Virology Meets Proteomics: The Human Organelle Proteome in Space and Time during Viral Infection

Michael Washburn, Stowers Institute for Medical Research, USA
Integrated Analyses of Epigenetic Complexes and Networks

Coffee Break

David C. Muddiman, North Carolina State University, USA
Novel Discoveries in Ovarian Cancer and ALS: From Proteome Profiling to Proteoforms

Rosa Viner, Thermo Fisher Scientific Inc, USA
The Cellular Interactome by Proteome-Wide Cross-Linking Mass Spectrometry

Marie Anne Brunet, Université de Sherbrooke, Canada
Short Talk: Discovery of a Novel Peptide Encoded in an Alternative Open Reading Frame of FUS Gene and its Importance in ALS

Gary Wilson, University of Wisconsin-Madison, USA
Short Talk: Improved Plasma Proteomics Enables the Investigation into Alzheimer's Disease Progression

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Peaks 1-3
1:00—10:00 PM
Poster Viewing

Peaks 1-3
2:30—4:30 PM
Workshop 2: Novel Omics Strategy

Peaks 4-5
* Alan Saghatelian, The Salk Institute for Biological Studies, USA

Christian H. Ahrens, Agroscope, Switzerland
A Generic, Integrative Proteogenomics Approach to Identify the Entire Protein Coding Potential of Prokaryotic Genomes

Christopher M. Rose, Genentech, USA
Real-Time Data Analysis Strategies for Targeted and Discovery Proteomics

Mark D. Biggin, Lawrence Berkeley National Laboratory, USA
Quantitating Translational Control: mRNA Abundance-Dependent and Independent Contributions

Brian K. Erickson, Harvard Medical School, USA
High-Throughput Targeted Proteomics: Combining Sample and Peptide Multiplexing for Drug Discovery and Biomarker Validation

Paul A. Grimsrud, Duke University Medical Center, USA
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Protein Interactions and Structure
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Joshua J. Coon, University of Wisconsin, USA

Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
A Physical Map of a Human Cell

Thomas Kodadek, The Scripps Research Institute, USA
Surveying the Immunoproteome Using DNA-Encoded Combinatorial Libraries

Vicki H. Wysocki, Ohio State University, USA
Development of Native MS: Surface-Induced Dissociation as a Structural Biology Tool

Nadia Martinez-Martin, Genentech, Inc., USA
Short Talk: Decoding Extracellular Protein-Protein Interactions using Genome-Wide Libraries and Complementary Receptor Discovery Platforms

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
7:30—10:00 PM
Poster Session 3

Peaks 1-3

THURSDAY, FEBRUARY 2

7:00—8:00 AM
Breakfast

Summit Gallery
8:00—11:00 AM
Functional Proteomics
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Ileana M. Cristea, Princeton University, USA

Alan Saghatelian, The Salk Institute for Biological Studies, USA
Cell Biology of sORF Polypeptides

Steven P. Gygi, Harvard Medical School, USA
A Powerful Mouse Model Illuminates the Consequences of Genetic Variation on a Proteome-Wide Scale

Coffee Break

Joshua J. Coon, University of Wisconsin, USA
One-Hour Proteome Analysis

Christopher G. Parker, The Scripps Research Institute, USA
Short Talk: Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Elyse Freiberger, University of Wisconsin-Madison, USA
Short Talk: Deep Proteome Analysis of Murine Islets

11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Foyer
5:00—6:15 PM
Emerging Strategies in Proteomics
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* John R. Yates III, The Scripps Research Institute, USA

James A. Wells, University of California, San Francisco, USA
Discovering and Modulating How Cell Surfaces Remodel with RAS Transformation

Bernd Wollscheid, ETH Zürich, Switzerland
Decoding Ligand Receptor Interactions

6:15—7:00 PM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Alan Saghatelian, The Salk Institute for Biological Studies, USA

Brenda J. Andrews, University of Toronto, Canada
Yeast Proteome Dynamics and Subcellular Morphology from Single Cell Imaging and Automated Analysis

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Peaks 1-3

FRIDAY, FEBRUARY 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676