Clarion Hotel Sign Floorplan

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This meeting took place in 2017



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Single Cell Omics (E3)


Organizer(s) Sarah Teichmann, Evan W. Newell and William J. Greenleaf
May 26—30, 2017
Clarion Hotel Sign • Stockholm, Sweden
Discounted Abstract Deadline: Jan 26, 2017
Abstract Deadline: Feb 28, 2017
Scholarship Deadline: Jan 26, 2017
Discounted Registration Deadline: Mar 28, 2017

Organized in collaboration with Knut and Alice Wallenberg Foundation and Science for Life Laboratory. Sponsored by Janssen R&D: Pharmaceutical Companies of Johnson & Johnson, Regeneron Pharmaceuticals, Inc. and Vertex Pharmaceuticals Incorporated.

Summary of Meeting:
Single cell omics is a new frontier in biology where genome-wide data is captured at the resolution of individual cells. Single cell high-throughput technologies are being developed in the areas of imaging, mass spectrometry and DNA- and RNA-sequencing, and combinations thereof. In addition, the corresponding software and visualization tools are an active field of research. Single cell omics has important implications for all areas of development, differentiation and cellular decision-making because these can now be studied at unprecedented resolution. Single cell omics methods are also shedding new light on immunity and cancer, due to the heterogeneous cell populations involved in both areas of biology. Therefore, these approaches are revolutionizing basic biology, our understanding of disease and technologies involved in translation to medicine. Since the field is in its infancy and there are few meetings dedicated to this topic, there is an unmet need in the community. This conference enables scientists in the field to congregate and exchange ideas and information about new methods and biological insights. A conference such as this will be of continuing importance until single cell omics technologies become commonplace and integrated into all areas of biology. Single cell omics has important implications for all areas of development, differentiation and cellular decision-making, because these can now be studied at unprecedented resolution. Equally, single cell omics methods are shedding new light on immunity and cancer, due to the heterogeneous cell populations involved in both areas of biology. Therefore, these approaches are revolutionizing both basic biology as well as our understanding of disease, and technologies involved in translation to medicine. Since the field is in its infancy, and there are few meetings dedicated to this topic, there is a huge unmet need in the community to congregate and exchange ideas and information about new methods and the biological insights gained. A meeting such as this will be of continuing importance until single cell omics technologies become commonplace and established, and integrated into all areas of biology.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Friday, May 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, May 30 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, May 31 in order to fully experience the meeting.

FRIDAY, MAY 26

4:00—8:00 PM
Arrival and Registration

Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

SATURDAY, MAY 27

7:30—8:30 AM
Breakfast

Individual Hotel
8:30—9:30 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Sarah Teichmann, Wellcome Trust Sanger Institute, UK

Alexander van Oudenaarden, Hubrecht Institute, Netherlands
Revealing New Cell Types and Interactions Using Single Cell Omics

9:30 AM—12:00 PM
Single Cell DNA Sequencing and Cancer
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Evan W. Newell, Singapore Immunology Network, SigN, Singapore

Anna Marciniak-Czochra, University of Heidelberg, Germany
Mathematical Modeling of Heterogeneity, Clonal Selection and Emergence of Resistance in Acute Leukemias

Coffee Break

Michael Stratton, Wellcome Trust Sanger Institute, UK
Clonal Evolution of Cancers

Samuel Aparicio, University of British Columbia, Canada
Clonal Dynamics in Cancer at Single Cell Resolution

Massimiliano Pagani, Fondazione INGM, Italy
Short Talk: Single Cell Transcriptome Analysis of Human Tumor-Infiltrating T Regulatory Cells

Joanna Hård, Karolinska Institutet, Sweden
Short Talk: Identification of Clonal Somatic Mutations in DNA Sequencing Data from Single Cells

12:00—1:00 PM
Path to Publication
This panel discussion and workshop, featuring editors from AAAS/Science, Cell Press, EMBO and Springer Nature, will provide insights to attendees on getting their work published in scientific journals and should be especially useful for early-career investigators.

* Barbara Cheifet, SpringerNature, USA

12:00—2:30 PM
On Own for Lunch

1:00—2:00 PM
Poster Setup

B 3
2:00—10:00 PM
Poster Viewing

B 3
2:30—4:30 PM
Workshop 1: Making Sense of Single Cell Data (Visualization, Analysis)

B 1-2
* Alexander van Oudenaarden, Hubrecht Institute, Netherlands

Joshua D. Campbell, Boston University, USA
Don't Fear the Zeros: Identifying Transcriptional States and Cellular Populations in Sparse Single-Cell RNA-Seq Data with Bayesian Hierarchical Modeling

Dominic Grün, Max Planck Institute for Immunobiology and Epigenetics, Germany
Single Cell RNA-Seq Reveals Cell Fate Bias of Multipotent Lymphoid Progenitors

Sue Hammoud, University of Michigan, USA
Functional Heterogeneity of Spermatogenesis Revealed by >27,000 Single Cells of Mouse Testis

Martin Hemberg, Wellcome Trust Sanger Institute, UK
VR Genome Browser - Using Virtual Reality to Visualize Complex Genomic Data

Bojan Losic, Icahn School of Medicine at Sinai, USA
Predicting Peanut Allergic Reaction with Integrative Single Cell Models of T Cell Immuno-Synapse

Santiago J. Carmona, University of Lausanne, Switzerland
Single-Cell Transcriptomics of Zebrafish Immune Cells Provides Insight into the Evolution of Vertebrate Immune Cell Types

4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
High-Throughput Imaging for Single Cell Analysis
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany

Rahul Satija, New York University, USA
Learning the "Metadata" of a Cell with Single Cell Genomics

Long Cai, California Institute of Technology, USA
Single Cell Expression Profiling and Lineage Dynamics by seqFISH and MEMOIR

Xiaowei Zhuang, Harvard University, USA
In situ Transcriptome and Genome Imaging in Single Cells

Johan Elf, Uppsala University, Sweden
Short Talk: Characterizing a library of cells at single molecule sensitivity

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
7:30—10:00 PM
Poster Session 1

B 3

SUNDAY, MAY 28

7:30—8:30 AM
Breakfast

Individual Hotel
8:30—11:45 AM
Single Cell Epigenomes
Meeting has ended...abstracts no longer viewable online.

B 1-2
* X. Sunney Xie, Harvard University, USA

Edith Heard, Institut Curie, France
X Inactivation

William J. Greenleaf, Stanford University, USA
Methods for Single Cell Epigenome Analysis

Coffee Break

Arjun Raj, University of Pennsylvania, USA
Single Cell Gene Expression

Oliver Stegle, European Bioinformatics Institute, UK
Methods and Applications for Single Cell Epigenetics

Steffen Rulands, Max Planck Institute for the Physics of Complex Systems, Germany
Short Talk: Genome Scale Oscillations of DNA Methylation during Exit from Pluripotency

Yasuyuki Ohkawa, Kyushu University, Japan
Short Talk: ChILT - an Immunoprecipitation-Free Epigenome Profiling Technology

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

B 3
1:00—10:00 PM
Poster Viewing

B 3
4:30—5:00 PM
Coffee Available

Foyer
5:00—7:15 PM
Single Cell Transcriptomes
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Dana Pe'er, Sloan Kettering Institute, USA

Sarah Teichmann, Wellcome Trust Sanger Institute, UK
Understanding Cellular Heterogeneity

Alexandra-Chloé Villani, Broad Institute of MIT and Harvard, USA
Discovery of Human Immune Cell Populations by Single Cell Profiling

Rickard Sandberg, Karolinska Institutet, Sweden
Single Cell Gene Expression Analyses with Allelic Resolution

Sten Linnarsson, Karolinska Institutet, Sweden
An Atlas of Mouse Brain Cell Types

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
7:30—10:00 PM
Poster Session 2

B 3

MONDAY, MAY 29

7:30—8:30 AM
Breakfast

Individual Hotel
8:30—11:45 AM
Single Cell Nuclear Architecture
Meeting has ended...abstracts no longer viewable online.

B 1-2
* William J. Greenleaf, Stanford University, USA

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping, a New Single Cell Approach to Map Chromatin Contacts

X. Sunney Xie, Harvard University, USA
Single Cell Genomics: When Stochasticity Meets Precision

Coffee Break

Ulrike Litzenburger, Stanford University, USA
Short Talk: Single-Cell Epigenomic Variability Reveals Functional Cancer Heterogeneity

Christoph Bock, Austrian Academy of Sciences, Austria
Short Talk: CRISPR Screening with Single Cell Transcriptome Readout Establishes a High-Throughput Method for Dissecting Gene-Regulatory Mechanisms

Suman Bose, Massachusetts Institute of Technology, USA
Short Talk: A Microfluidic Platform for High-Throughput Micro-RNA Profiling of Single Cells

Anita Göndör, Karolinska Institute, Sweden
Short Talk: Novel Feedback Loops between 3D Genome Organizers and the Circadian Clock Regulate Rhythmic Chromatin Transitions in the Nuclear Architecture

Thomas Norman, University of California, San Francisco, USA
Short Talk: Interpreting Genetic Screens using Perturb-seq

Jeanette Baran-Gale, University of Edinburgh, UK
Short Talk: The Complexity of Promiscuous Gene Expression in Medullary Thymic Epithelial Cells

11:45 AM—5:00 PM
On Own for Lunch

12:00—2:00 PM
SOLD OUT-Presentations and Posters by SciLifeLab with Complimentary Lunch (Must Register in Advance)
Advanced registration is needed. Click here to sign up for the lunch presentations.

B 1-3
2:00—3:45 PM
SOLD OUT-On Location Tour of SciLifeLab Facilities
Advanced registration is needed and space is SEVERELY LIMITED. Registrations will be taken on a first come first served basis. Click here to sign up for the on location tour.

SciLifeLab Solna
3:00—4:00 PM
Poster Setup

B 3
4:00—10:00 PM
Poster Viewing

B 3
4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Spatial Omics
Meeting has ended...abstracts no longer viewable online.

B 1-2
Mark D. Lynch, Fluidigm Corporation, USA
Single Cell Omics and Functional Analysis

* John Marioni, European Bioinformatics Institute, EMBL-EBI, UK
Modeling Cell Fate Decisions during Early Development

Je H. Lee, Cold Spring Harbor Laboratory, USA
In situ Sequencing Platforms for Investigating Cellular Variations and Lineage

Mats Nilsson, Science for Life Laboratory, Sweden
Short Talk: Spatial Neuron Cell-Type Mapping in Mouse Brain by in situ Sequencing

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
7:30—10:00 PM
Poster Session 3

B 3

TUESDAY, MAY 30

7:30—8:30 AM
Breakfast

Individual Hotel
8:00—8:30 AM
Poster Setup

B 3
8:30 AM—5:00 PM
Poster Viewing

B 3
8:30—11:45 AM
Single Cell Proteomics
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Shalin H. Naik, Walter & Eliza Hall Institute, Australia

Evan W. Newell, Singapore Immunology Network, SigN, Singapore
High-Dimensional Cellular Immune Profiling in Health and Disease

Garry P. Nolan, Stanford University, USA
System-Wide Order, from Disorder, at the Cancer-Immune Interface

Coffee Break

Dana Pe'er, Sloan Kettering Institute, USA
Machine Learning for Data Analysis and Visualization

J. Christopher Love, Massachusetts Institute of Technology, USA
Integrated Single Cell Analysis for Discovery and Development

Bogdan Budnik, Harvard University, USA
Short Talk: Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS) New Technique for Quantification Proteomes of Single Mammalian Cells

Emma K. Lundberg, SciLifeLab Stockholm and School of Biotechnology, KTH, Sweden
Short Talk: The Cell Atlas of the Human Protein Atlas

11:45 AM—12:15 PM
Lunch

B3/Atrium
12:00—2:30 PM
Poster Session 4

B 3
2:30—4:30 PM
Workshop 2: Technology

B 1-2
* Emma K. Lundberg, SciLifeLab Stockholm and School of Biotechnology, KTH, Sweden

Kylie R. James, Wellcome Trust Sanger Institute, UK
Resolving CD4+ T Helper Fate Bifurcation during Malaria

Nemanja Despot Marjanovic, Massachusetts Institute of Technology, USA
Longitudinal Profiling of Tumor Evolution in Autochthonous Mouse Models of Kras-Driven Human Lung Adenocarcinoma

Wissam H. Hamou, Icahn School of Medicine at Mount Sinai, USA
Flexible Single Cell Isolation Technologies Combined with High-Throughput Targeted Sequencing Enable the Characterization of Intratumor Heterogeneity

Linda Kvastad, Royal Institute of Technology, Sweden
In Situ Quality Control Assay Generates a Spatial Heat Map of RNA Integrity with Single Cell Resolution

Leeat Keren, Stanford University, USA
Characterization of Tumor Immune Microenvironment in Breast Cancer using Multiplexed Imaging

Amina Ann Qutub, Rice University, USA
Communication between Developing Neural Cells

4:30—5:00 PM
Coffee Available

Foyer
5:00—6:45 PM
Single Cell Immunology
Meeting has ended...abstracts no longer viewable online.

B 1-2
* Garry P. Nolan, Stanford University, USA

Richard Conroy, NIH Common Fund, USA
HuBMap

Nir Friedman, Weizmann Institute of Science, Israel
Clonal Expansion under the Microscope: Imaging Collective T Cell Responses with Single Cell Resolution

Shalin H. Naik, Walter & Eliza Hall Institute, Australia
Clonal Multi-Omics

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

B 1-2
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

B 3

WEDNESDAY, MAY 31

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Janssen R&D: Pharmaceutical Companies of Johnson & Johnson Knut and Alice Wallenberg Foundation
Regeneron Pharmaceuticals, Inc. Science for Life Laboratory
Vertex Pharmaceuticals Incorporated
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Dolomite Bio

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

American Association for the Advancement of Science (AAAS)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676