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Genome Sequence Variation and the Inherited Basis of Common Disease and Complex Traits (A2)

Organizer(s): David M. Altshuler, Peter Donnelly and Trudy F.C. MacKay
January 8 - 13, 2006
Big Sky Resort  ·  Big Sky, Montana
Abstract Deadline: October 4, 2005
Late Abstract Deadline: October 4, 2005
Scholarship Deadline: September 13, 2005
Early Registration Deadline: November 7, 2005


Supported by The Director's Fund



This meeting took place in the 2006 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Common human diseases and most other traits vary in a continuous manner, modified by multiple genes and environmental influences. Rapidly expanding information about genome sequence variation is making it possible, for the first time, to conduct well-powered searches for the inherited contributors to common diseases and other complex phenotypes. Success will provide insight into the genetic architecture of quantitative characters, the evolutionary history of trait variation, and the etiology of common human diseases. This meeting aims to bring together investigators from population genetics, genomics, quantitative genetics, epidemiology and medical research to examine these problems from a variety of perspectives.

Sunday, January 8
3:00 - 7:30 PM Registration Lower Atrium
6:30 - 7:30 PM Refreshments Lower Atrium
7:30 - 9:30 PM Overview Session: Progress and Prospects Gallatin/Madison
* Peter Donnelly, University of Oxford
Trudy F.C. Mackay, North Carolina State University
Genetic Analysis of Complex Traits in Drosophila
David M. Altshuler, Massachusetts General Hospital
Genetic Analysis of Complex Traits in Humans
Monday, January 9
7:00 - 8:00 AM Breakfast Jefferson/Lake/Canyon
8:00 - 11:00 AM Genome Sequence Variation Gallatin/Madison
* Charles H. Langley, University of California, Davis
Genomic Patterns of Polymorphism and Divergence: Models and Observations
Kelly A. Frazer, The Scripps Research Institute
Human DNA Variation and Complex Traits
Deborah A. Nickerson, University of Washington
SNPs in Candidate Genes
Charles Lee, Brigham and Women's Hospital
Structural Variations in the Human Genome
Penelope E. Bonnen, Rockefeller University
Short Talk: Evaluating Potential for Whole Genome Studies in Kosrae - an Isolated Population in Micronesia
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 1:00 PM Poster Setup Jefferson
1:00 - 10:00 PM Poster Viewing Jefferson
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Determinants of Variation: Recombination, Demography, Selection Gallatin/Madison
* Peter Donnelly, University of Oxford
Recombination in the Human Genome
Molly Przeworski, University of Chicago
The Signature of Directional Selection on Standing Genetic Variation
Jonathan K. Pritchard, University Of Chicago
A High-Resolution Survey of Deletion Polymorphism in the Human Genome.
Steven A. McCarroll, Harvard Medical School
Short Talk: A Genome-Wide Map of Common Human Deletion Polymorphisms
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Lower Atrium
7:30 - 10:00 PM Poster Session 1 Jefferson
Tuesday, January 10
7:00 - 8:00 AM Breakfast Jefferson/Lake/Canyon
8:00 - 11:00 AM Computational Approaches Linking Genotype and Phenotype Gallatin/Madison
* Heather Cordell, University of Cambridge
Multiple Imputation Methods for Genetic Association Analysis of Complex Traits
Zhao-Bang Zeng, North Carolina State University
QTL Analysis, eQTL Analysis and Genetic Architecture of Complex Traits
Andrew G. Clark, Cornell University
Population Genetic Methods for Genotype-Phenotype Association
Jonathan L. Marchini, University of Oxford
Short Talk: A Novel Bayesian Approach to Localising Disease Genes
Dan Arking, Johns Hopkins School of Medicine
Short Talk
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 1:00 PM Poster Setup Jefferson
1:00 - 10:00 PM Poster Viewing Jefferson
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Short Talks Gallatin/Madison
* Trudy F.C. Mackay, North Carolina State University
Jared Drake, Children's Hospital Boston
Conserved Non-Coding Sequences are Selectively Constrained and not Mutation Cold Spots
Benjamin F. Voight, University of Chicago
A Genome-Wide Scan for Targets of Recent and On-Going Directional Selection in Humans
Melanie Bahlo, Walter and Eliza Hall Institute of Medical Research
Linkage Disequilibrium Mapping Malaria Susceptibility Loci in Papua New Guinea
Julian T. Forton, University of Oxford
Exploiting Allele-Specific Transcript Quantification and the HAPMAP Resource to Localise Long Range Cis-Regulatory Polymorphism
Keyan Zhao, Cornell University
Genome-Wide Association Mapping in a Structured Population of A. thaliana
Minerva M. Carrasquillo, Mayo Clinic
A Set of Putative Functional IDE Variants Shows Simple, Replicable Association with Alzheimer’s Disease and has an Estimated Population Attributable Risk of 46%
Dana C. Crawford, Vanderbilt University
Genetic Variation is Associated with C-Reactive Protein Levels in a Survey of 7,000 Americans
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Lower Atrium
7:30 - 10:00 PM Poster Session 2 Jefferson
Wednesday, January 11
7:00 - 8:00 AM Breakfast Jefferson/Lake/Canyon
8:00 - 11:00 AM Architecture of Complex Trait Variation Gallatin/Madison
* Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center
Genetic Analysis of Behavioral Differences Between Sympatric Stickleback Species
Rachel B. Brem, University of California, Berkeley
Transcript Phenotypes and Sequence Variation in Yeast Genomes
Wolfgang Stephan, University of Munich
The Role of Selection in Shaping Polymorphism
Justin Fay, Washington University
Evolution of Transcriptional Regulation
Justin P. Gerke, Washington University
Short Talk: Analysis of Natural Variation in Yeast Sporulation Efficiency
Chao-Qiang Lai, JM-USDA-HNRCA at Tufts University
Short Talk: Microarray-based Mapping of QTLs Affecting Lifespan in Drosophila melanogaster
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 1:00 PM Poster Setup Jefferson
1:00 - 10:00 PM Poster Viewing Jefferson
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Modeling Human Complex Disease Traits in Other Species Gallatin/Madison
* Gary A. Churchill, The Jackson Laboratory
Co-Adaptated Alleles and the Evolution of Complex Traits
Joseph Nadeau, Case Western Reserve University
J. Lawrence Marsh, University of California, Irvine
Identification of Genetic Factors that Affect Huntington’s Disease Pathology in Drosophila
Justin O. Borevitz, University of Chicago
Short Talk: Genome Wide Association Mapping in Arabidopsis thaliana
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Lower Atrium
7:30 - 10:00 PM Poster Session 3 Jefferson
Thursday, January 12
7:00 - 8:00 AM Breakfast Jefferson/Lake/Canyon
8:00 - 11:00 AM Genetic Basis of Human Disease Gallatin/Madison
Richard P. Lifton, Yale University School of Medicine
Genetic Basis of Blood Pressure Variation
Jonathan Cohen, University of Texas Southwestern Medical Center
Genetic Determinants of Plasma Lipoprotein Levels
Leena P. Peltonen, University of Helsinki and National Public Health Inst
From Families to Populations: Example of Finland
Augie Kong, deCODE genetics
Complex Diseases and Association Studies
Jenny C. Lee, University of California, Los Angeles
Short Talk: Human Sequence Variation Data Facilitates the Fine Mapping of a Low High-Density Lipoprotein Cholesterol Region on Chromosome 16q23-24
9:20 - 9:40 AM Coffee Break Lower Atrium
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Genetics, Medicine and Society Gallatin/Madison
* David M. Altshuler, Massachusetts General Hospital
Joel N. Hirschhorn, Children's Hospital
New Insights into the Genetics of Obesity and Cardiovascular Traits
Kang Zhang, University of Utah
Short Talk: Genetic Study of Diabetic Complications, Age-Related Macular Degeneration, and Glaucoma Using the Utah Population Database
Nicole M. Walley, Duke University
Short Talk
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Lower Atrium
8:00 - 11:00 PM Entertainment Jefferson
Friday, January 13
Departure
*Session Chair   †Speaker invited, not yet responded.



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