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Epigenetics and Chromatin Remodeling in Development (A7)

Organizer(s): Renato Paro and Peter Fraser
January 19 - 24, 2006
Keystone Resort  ·  Keystone, Colorado
Abstract Deadline: September 19, 2005
Late Abstract Deadline: October 12, 2005
Scholarship Deadline: September 19, 2005
Early Registration Deadline: November 18, 2005


Supported by The Director's Fund



This meeting took place in the 2006 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
The stability of gene expression patterns, which define different cellular states, is highly dependent on chromatin structure and function. Regulatory features invoked by, for example, particular histone modifications or nuclear architecture greatly influence the way genetic information is interpreted during developmental processes. Such an epigenetic constitution of the nucleus is heritable, providing the basis for mechanisms like the permanent inactivation of an X chromosome or genomic imprinting in mammalian cells. The recent identification of many components of epigenetic regulation has created enormous excitement in the field, not only because we foresee a better understanding of the basic mechanisms on how developmental decisions are maintained, but also because we might learn how aberrant cases, like cancer cells, change their epigenetic hallmarks. Epigenetic gene control also needs to be considered to better understand and approach more applied topics like nuclear cloning, stem cells and tissue engineering. This meeting will bring together scientists who have identified epigenetic constituents and studied their regulatory contributions at the molecular level, with scientists who study, in more complex organisms, epigenetic programming of cellular fates during normal developmental and in the disease case.

Thursday, January 19
3:00 - 7:30 PM Registration Shavano Peak Foyer
6:30 - 7:30 PM Refreshments Shavano Peak Foyer
7:30 - 8:30 PM Keynote Address Shavano Peak
M. Azim Surani, University of Cambridge
Epigenetic Programming of the Genome in the Embryo and Germ Cells
Friday, January 20
7:00 - 8:00 AM Breakfast Torreys 1-4
8:00 - 11:15 AM Chromatin Structure and Function Shavano Peak
C. David Allis, Rockefeller University
Beyond the Double Helix: Reading and Writing the 'Histone Code'
* Peter B. Becker, University of Munich
Site-Specific Acetylation Defines an Embryonic form of ISWI Associated with Mitotic Chromatin
Zhiguo Zhang, Mayo Clinic
Short Talk: Rtt106p is a Novel Histone Chaperone Involved in Epigenetic Silencing
Stefan Kubicek, Institute of Molecular Pathology
Epigenetic Control by Histone Methylation
Robert Martienssen, Cold Spring Harbor Laboratory
Regulation of Histone Methylation Patterns by RNAi in Plants and Fission Yeast
Kevin V. Morris, The Scripps Research Institute
Short Talk: The Antisense Strand of Small Interfering RNAs Directs Histone Methylation and Transcriptional Gene Silencing in Human Cells
9:20 - 9:40 AM Coffee Break Shavano Peak Foyer
11:00 AM - 1:00 PM Poster Setup Torreys 1-4
1:00 - 10:00 PM Poster Viewing Torreys 1-4
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Establishing Epigenetic Marks Shavano Peak
* Steven Henikoff, Fred Hutchinson Cancer Research Center
Epigenetic Patterns Generated by Assembly of Histone Variants into Nucleosomes
Caline Karam, Johns Hopkins University
Short Talk: The Role of JIL-1 Mediated Histone H3 Phosphorylation in Transcriptional Activation
En Li, Novartis Institutes for BioMedical Research
Role of DNA Methyltransferases in Mammalian Development
Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory
A New Role of Genome Organizer SATB1 in Breast Cancer Mestastasis
7:00 - 8:00 PM Social Hour w/ Lite Bites Torreys 1-4
7:30 - 10:00 PM Poster Session 1 Torreys 1-4
Saturday, January 21
7:00 - 8:00 AM Breakfast Torreys 1-4
8:00 - 11:15 AM Chromatin-Controlled Gene Regulation in Development Shavano Peak
* Vicki L. Chandler, Gordon and Betty Moore Foundation
Heritable Chromatin Structures are Established through Trans-Interactions between Tandem Repeats
Jeannie T. Lee, Massachusetts General Hospital
Cis-Regulatory Chromatin Dynamics at the X-Inactivation Center
Dominic John Ciavatta, University of North Carolina at Chapel Hill
Short Talk: DNA Insulators Prevent Repression of a Targeted X-linked Transgene but not Its Random or Imprinted X-Inactivation
Kami Ahmad, Harvard Medical School
Replication-Independent Histone Replacement, Histone Variants and Maintaining Epogenetic States
Laurie Jackson-Grusby, Harvard Medical School
Reprogramming Epigenetic Imprinting
Nora I. Engel, University of Pennsylvania
Insulators, Mathylation and Transcriptional Regulation: Complesities of Imprinting Control
9:20 - 9:40 AM Coffee Break Shavano Peak Foyer
11:00 AM - 1:00 PM Poster Setup Torreys 1-4
1:00 - 10:00 PM Poster Viewing Torreys 1-4
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Nuclear Positioning Shavano Peak
* Peter Fraser, Babraham Institute
Nuclear Organization of Transcription
Giacomo Cavalli, Institute of Human Genetics
Association of Polycomb Group Response Elements in the Nuclear Space
Wendy A. Bickmore, MRC Human Genetics Unit
Nuclear Re-Organization during Embryonic Development
Daryl Gohl, Princeton University
Short Talk: Analyzing Boundary Element Pairing and Competiton
7:00 - 8:00 PM Social Hour w/ Lite Bites Torreys 1-4
7:30 - 10:00 PM Poster Session 2 Torreys 1-4
Sunday, January 22
7:00 - 8:00 AM Breakfast Torreys 1-4
8:00 - 11:15 AM Mechanisms of Cellular Memory Shavano Peak
Renato Paro, ETH Zurich
Epigenetic Control of Tissue Regeneration in Drosophila
Maxim Nekrasov, European Molecular Biology Laboratory
Short Talk: Characterization of the Drosophila PRC2 HMTase
Alexander (Sasha) Tarakhovsky, Rockefeller University
Protein Lysine Methylation and Signal Transduction
Keji Zhao, National Institutes of Health
Short Talk: Identification and Characterization of Human Polycomb Response Elements
* Ueli Grossniklaus, University of Zürich
Epigenetic Inheritance during Arabidopsis Seed Development
Peter Verrijzer, Erasmus University Medical Center
PREs are CIS-Regulatory Elements That Mediate Function of PcG and TRXG Proteins
9:20 - 9:40 AM Coffee Break Shavano Peak Foyer
11:00 AM - 1:00 PM Poster Setup Torreys 1-4
1:00 - 10:00 PM Poster Viewing Torreys 1-4
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Cellular Plasticity and Tissue Reprogramming Shavano Peak
* Eric N. Olson, University of Texas Southwestern Medical Center
Signfalling to the Genome: Lessons from the Heart
Meinrad Busslinger, Research Institute of Molecular Pathology
Transcriptional Control of B Cell Identity by Pax5
Jiang Wu, Stanford University/HHMI
Short Talk: An Essential Epigenetic Switch for Progenitor-to-Post-Mitotic Neural Development
Rudolf Jaenisch, Whitehead Institute for Biomedical Research
Molecular Control of Pluripotency and Self-Renewal
7:00 - 8:00 PM Social Hour w/ Lite Bites Torreys 1-4
7:30 - 10:00 PM Poster Session 3 Torreys 1-4
Monday, January 23
7:00 - 8:00 AM Breakfast Torreys 1-4
8:00 - 11:15 AM Cancer Epigenetics Shavano Peak
* Peter A. Jones, University of Southern California
DNA Footprinting of CpG Islands at Single Molecule Resolution
Tom Latham, Westerb General Hospital
Short Talk: Transgenic Mice Overexpressing DNA Methyltransferase Dnmt3b Develop Abnormal Cpg Island Methylation and Increased Progression of Apc min Intestinal Tumours
Stephen B. Baylin, Johns Hopkins School of Medicine
Epigenetic Control of Cancer or Questions of Epigenetic Networks Gone Wrong
Michael J. Boland, University of Nebraska Medical Center
Short Talk: Initial Characterization of an Interaction between C5-DNA Methyltransferase, Dnmt3b, and Thymine DNA Glycosylase
Maarten Van Lohuizen, Netherlands Cancer Institute
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development
Trang Hoang, Université de Montréal
Integration of Proliferative Signals from EED and BMI1 Proteins
9:20 - 9:40 AM Coffee Break Shavano Peak Foyer
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Stem Cell Programming Shavano Peak
Allan C. Spradling, Howard Hughes Medical Institute/Carnegie Institute
The Lighten-up/p68 RNA Helicase Regulates Transcriptional Deactivation by Promoting RNA Release from Chromatin
* Emma Whitelaw, Queensland Institute of Medical Research
An ENU Screen for Modifiers of Epigenetic Gene Silencing in the Mouse
David John Katz, Emory University
Short Talk: Histone H3 Lysine 4 Methylation Guards the Germ Cell Lineage
Wolf Reik, Babraham Institute
Imprinting and Epigenetic Reprogramming in Mammalian Development
7:00 - 8:00 PM Social Hour w/ Lite Bites Torreys 1-4
8:00 - 11:00 PM Entertainment Torreys 1-4
Tuesday, January 24
Departure
*Session Chair   †Speaker invited, not yet responded.



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