| Wednesday, March 5 |
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3:00 - 7:00 PM
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Registration
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Shavano Peak Office
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6:45 - 7:45 PM
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Welcome
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Shavano Peak Foyer
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7:45 - 8:00 PM
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Orientation
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Shavano/Torreys
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| Thursday, March 6 |
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7:00 - 8:00 AM
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Breakfast
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Crestone/Red Cloud
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8:00 - 11:00 AM
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Transmission of Signals to the Nucleus: General Principles (Joint)
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Shavano/Torreys
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Joseph Schlessinger,
Yale University School of Medicine
Tyrosine Kinases
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Amer A. Beg,
Moffitt Cancer Center
NF-kappaB Signaling in Dendritic Cells
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Richard A. Flavell,
Yale University School of Medicine
Signal-Mediated Control of Transcription
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Gioacchino Natoli,
IEO, European Institute of Oncology
Close-Ups of NF-kappa B Recruitment to Target Genes in DCs
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Takashi Kobayashi,
University of Pennsylvania
Short Talk: TRAF6 Regulates Dendritic Cell Development and Function
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Salome Landmann,
Centre Medical Universitaire
Short Talk: The Role of the Class II Transactivator (CIITA) in Dendritic Cells
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM - 1:00 PM
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Poster Setup
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Longs Peak/Grays Peak
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1:00 - 10:00 PM
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Poster Viewing
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Longs Peak/Grays Peak
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2:00 - 4:30 PM
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Workshop 3: Rafts: Fact or Fiction? (Joint)
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Shavano/Torreys
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Derek Toomre†,
Yale University School of Medicine
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Christian O. Meyer zum Buschenfelde†,
Yale University
Recruitment of CD28 and CD86 to Lipid Rafts during DC-T Cell Interaction Results in Efficient T Cell Priming
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Jeoung-Sook Shin,
Yale University School of Medicine
Mast Cell Endo/Exocytosis of Particulate Allergens
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Neil J. Poloso,
National Cancer Institute, National Institutes of Health
Kinetics of MHC Class II Complex Association with Lipid Rafts
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Lee Leserman,
Centre d'Immunologie de Marseille-Luminy
MHC Class II/Peptide Complexes in Lipid Microdomains at The Dendritic Cell Surface Initiate the TH1 CD4 T Cell Phenotype
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Richard M. Siegel,
National Institutes of Health
Lipid Microdomains and Receptor Clustering in Fas/CD95 Signaling
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Alessandra Cambi,
Max Planck Institute for Biophysical Chemistry
Distribution of LFA-1 and DC-SIGN in Microdomains on DC by High Resolution Microscopy: Consequences for Cell-Adhesion and Ligand Binding
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Juli J. Unternaehrer,
Children's Hospital Boston
Surface MHC-II I-E Associates with I-A in Dendritic Cells but Not in B Cells
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4:30 - 5:00 PM
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Coffee & Snacks Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Signal Transduction and Antigen Presentation (Joint)
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Shavano/Torreys
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Richard A. Flavell,
Yale University School of Medicine
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Tsuneyasu Kaisho,
RIKEN Research Center for Allergy and Immunology
Pleiotropic Function of Toll-Like Receptors on Dendritic Cells
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Alan Aderem,
Institute for Systems Biology
Macrophage Phagocytosis: from Genes to Function
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Ruslan M. Medzhitov,
Yale University School of Medicine
Toll Pathway of Host Defense
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Caetano Reis e Sousa,
Cancer Research UK, London Research Institute
Short Talk: Non-Plasmacytoid Dendritic Cells Act as Interferon-Producing Cells in Response to Cytosolic Double-Stranded RNA
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7:00 - 8:00 PM
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Social Hour
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Longs Peak/Grays Peak
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8:00 - 10:00 PM
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Poster Session 3: Signal Transduction
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Longs Peak/Grays Peak
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| Friday, March 7 |
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7:00 - 8:00 AM
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Breakfast
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Crestone/Red Cloud
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8:00 - 11:00 AM
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Endocytosis and Lysosomal Transport (Joint)
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Shavano/Torreys
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Ira Mellman,
Genentech, Inc.
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Scott D. Emr,
Cornell University
Receptor Down-Regulation and Protein Sorting at the Multivesicular Body
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Margaret S. Robinson,
University of Cambridge
Coat proteins and sorting
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Suzanne R. Pfeffer,
Stanford University
Rab GTPases in Receptor Trafficking
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Giorgio Scita,
IFOM Foundation at Campus IFOM-IEO
Integration of Signals Leading to Actin Remodeling and Endocytosis
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Angela Stoddart,
University of California, San Francisco
Short Talk: Deciphering the Roles of Lipid Rafts and Clathrin in BCR Internalization
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Haoran Zhao,
Rigel Pharmaceuticals, Inc.
Short Talk: TRAC-1, A Novel Lymphocyte-Specific E3 Ubiquitin Ligase, Regulates T Cell Activation Downstream of TCR Engagement
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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4:30 - 5:00 PM
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Coffee & Snacks Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Mechanisms of Proteolysis in the Cytosol (Joint)
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Shavano/Torreys
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Ira Mellman,
Genentech, Inc.
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Wolfgang P. Baumeister,
Max Planck Institute of Biochemistry
Electron Tomography: Visualizing Macromolecular Complexes in Intact Cells
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Jack R. Bennink,
NIAID, National Institutes of Health
The Origin of Antigenic Peptides and Proteasomal Degradation of Newly Synthesized Proteins
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Alfred L. Goldberg,
Harvard Medical School
Peptidases that Function after the Proteasome and Regulate Antigen Presentation
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7:00 - 8:00 PM
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Social Hour
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Grays Peak
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8:00 - 11:00 PM
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Entertainment
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Torrey's Peak
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| Saturday, March 8 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud
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8:00 - 11:00 AM
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Functional Specializations of the Endocytic Pathway
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Shavano
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Ralph M. Steinman,
Rockefeller University
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Christopher V. Nicchitta,
Duke University Medical Center
Heat Shock Proteins and Antigen Presentation
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Sergio Grinstein,
Hospital for Sick Children
Role of Phosphoinositides in Phagosome Formation and in Bacterial Invasion
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Dorothee Schmid,
Rockefeller University
Short Talk: A Novel Pathway for Endogenous MHC Class II Presentation of a Nuclear Viral Antigen that Involves Autophagy
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Dan R. Littman,
New York University School of Medicine
DC-SIGN and Transmission of HIV-1 Following Endocytosis
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Eduardo Sergio Trombetta,
Yale University
Regulation of Lysosomal Function in Dendritic Cells
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Thomas J. Hope,
Northwestern University, Feinberg School of Medicine
Short Talk: Enhancement of HIV Infection by Dendritic Cells: Transfer of HIV to Target Cells Through an Infectious Synapse
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9:20 - 9:40 AM
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Coffee Break
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Shavano Peak Foyer
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11:00 AM - 1:00 PM
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Poster Setup
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Torreys Peak
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1:00 - 10:00 PM
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Poster Viewing
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Torreys Peak
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2:00 - 4:30 PM
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Workshop 4: Mechanisms of Antigen Processing and Presentation
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Shavano
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Ira Mellman,
Genentech, Inc.
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Hans-Georg Rammensee,
University of Tuebingen
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Deborah Palliser,
Massachusetts Institute of Technology
Delineation of the Pathway Taken by a Heat Shock Fusion Protein to Gain Access to the MHC Class I Processing Pathway in Dendritic Cells
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Dorian B. McGavern,
National Institutes of Health
Visualizing Antigen-Specific T Cells Involved in Immunopathogenesis
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Scott A. Wetzel,
Oregon Health & Science University
Peptide Specific Transfer of MHC From APC to T cells Through the Immunological Synapse
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Heiichiro Udono,
Nagasaki University
Two Distinct Pathways Mediated by PA28 and hsp90 in Antigen Processing that is Linked with MHC I Polymorphism
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Michael F. Princiotta,
SUNY Upstate Medical University
Quantitating Viral Protein Synthesis, Degradation and Endogenous Antigen Processing
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Ona E. Bloom,
Yale University School of Medicine
Spinophilin, a Neuronal Protein at the Immunological Synapse
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Julie Magarian Blander,
Mount Sinai School of Medicine
Signals from Toll-Like Receptors Control Phagolysosomal Fusion
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Babak Javid,
Harvard School of Public Health
Efficient Cross-Presentation of Mycobacterial Heat Shock Protein / Antigen Complexes by Human Dendritic Cells
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Wilfred A. Jefferies,
University of British Columbia
The Cytoplasmic Domain of MHC Class I Proteins Controls Intracellular Trafficking and Cross-Presentation
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Marco A. Purbhoo,
Howard Hughes Medical Institute
Differential Dynamics of CD8, TCR, and MHC at the Immunological Synapse
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4:30 - 5:00 PM
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Coffee & Snacks Available
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Shavano Peak Foyer
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5:00 - 7:00 PM
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Cell Migration
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Shavano
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*
Ralph M. Steinman,
Rockefeller University
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Ulrich H. Von Andrian,
Harvard Medical School
T Cell Traffic and Interactions With DC in Lymphoid Tissues
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Gwendalyn J. Randolph,
Mount Sinai School of Medicine
Dendritic Cell Migration from the Periphery to Lymph Nodes and Spleen: Insights from Analysis during Atherosclerotic Disease
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Tatyana Svitkina,
University of Pennsylvania
Actin Machinery at the Leading Edge of Migrating Cells
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Smita Nair,
Duke University Medical Center
Short Talk: Injection of Immature Dendritic Cells into Adjuvant Treated Skin Obviates the Need for ex vivo Maturation.
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7:00 - 8:00 PM
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Social Hour
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Torreys Peak
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8:00 - 10:00 PM
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Poster Session 4: Antigen Presentation and Dendritic Cell Migration
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Torreys Peak
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| Sunday, March 9 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud
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8:00 - 11:00 AM
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Consequences of Cell Adhesion
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Shavano
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Ralph M. Steinman,
Rockefeller University
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Gillian Griffiths,
Cambridge Institute for Medical Research
The Genetics of Cytotoxic T Cell Polarization and Secretion
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Michael O. Hengartner,
University of Zurich
C. elegans CED Proteins and Engulfment of Apoptotic Cells
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Josef M. Penninger,
Institute for Molecular Biotechnology of the Austrian Academy of Sciences
Dendritic Cells, Autoimmunity and Infectious Stimuli
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Thomas M. Moran,
Mount Sinai School of Medicine
Short Talk: Influenza Virus Induced Dendritic Cell Maturation In Vivo Correlates with Induction of Immune Responses to Co-Administered Antigen
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Matthew F. Krummel,
University of California, San Francisco
Short Talk: Functional Motor Proteins in T Cell Synapse Formation
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9:20 - 9:40 AM
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Coffee Break
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Shavano Peak Foyer
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2:00 - 4:30 PM
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Workshop 5: Harnessing Cell Biology During Vaccination and Immunotherapy
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Shavano
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Ralph M. Steinman,
Rockefeller University
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Jacques F. Banchereau,
Baylor Institute for Immunology Research
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Wei Chen,
University of Minnesota
CpG ODN Activates Human Natural Killer Cells Predominantly via an Indirect Mechanism Through Plasmacytoid Dendritic Cells
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Venky Ramakrishna,
Medarex, Inc.
Targeting Antigens via CD206 Expressed on Human DCs Enables Cross-Presentation to CD8+ and CD4+ Effector T Cells
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Clotilde Théry,
Institut Curie
Role of MFG-E8/lactadherin in T cell Activation by Dendritic Cell-Derived Exosomes
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Raphael Clynes,
Columbia University
Role of FcgammaRII on Dendritic Cells in the Retention of Immune Complexes: A Possible Antigen-Recycling Pathway
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Kate C. Agopsowicz,
AltaRex Corporation
Opsonization with Specific Antibodies Enhances Dendritic cell Presentation of Apoptotic Tumor Cells and Induction of CTL
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Holger Kanzler,
Dynavax Technologies
ISS-Antigen Conjugates Enhance MHC Class I Antigen Presentation
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Hua E. Yu,
Beckman Research Institute, City of Hope
STAT3 Activity in Tumor Cells Negatively Regulates Dendritic Cell Activation and Maturation
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Shin-Ichiro Fujii†,
Rockefeller University
Activation of Natural Killer Cells by alpha Galactosyl Ceramide Rapidly Induces the Full Maturation of Dendritic Cells in Mice and Thereby Acts as an Adjuvant for CD4 and CD8 T Cell Immunity to a Co-Administered Protein
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Jan C. Dudda,
Twincore
Targeting of CD8+ T Cells to Inflamed Skin by DC Immunization
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John P. Vasilakos,
Biothera
Differential Activation of Human Innate Immune Cells using Small Molecule TLR Agonists
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Gaetan Jego,
Baylor Institute for Immunology Research
Plasmacytoid Dendritic Cells Induce B and T Cell Memory Responses
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Beatrice Laupeze†,
Baylor Institute for Immunology Research
Different Dendritic Cells can Induce Different Types of T Cell Responses
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4:30 - 5:00 PM
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Coffee & Snacks Available
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Shavano Peak Foyer
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5:00 - 7:00 PM
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Cellular Mechanisms of Immune Evasion
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Shavano
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*
Ralph M. Steinman,
Rockefeller University
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Robert D. Schreiber,
Washington University School of Medicine
The Three E’s of Cancer Immunoediting
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Tak W. Mak,
Campbell Family Institute for Breast Cancer Research at PMH, UHN
Genetic Dissection of Lymphocyte Activation
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Benoît J. Van den Eynde,
University of Louvain
A Novel Tumor Immune Escape Mechanism based on tryptophan Degradation by Indoleamine 2,3 Dioxygenase
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Eric C. Bartee,
Oregon Health & Science University
Short Talk: Downregulation of Cell Surface Receptors by a Family of Human Ubiquitin Ligases Homologous to Viral Immune Evasion Proteins
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7:00 - 8:00 PM
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Social Hour
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Torreys Peak
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| Monday, March 10 |
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Departure
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