| Sunday, March 21 |
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3:00 - 7:30 PM
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Registration
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Van Horne Foyer
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6:15 - 7:15 PM
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Refreshments
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Van Horne Foyer
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7:15 - 7:30 PM
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Orientation for New Attendees and New Investigators (Joint)
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.
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Van Horne Ballroom A-B
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7:30 - 9:30 PM
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Keynote Session (Joint)
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Van Horne Ballroom A-B
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Bruce D. Walker,
Ragon Institute of MGH, MIT and Harvard
Durable Control of HIV Infection: Implications for Vaccine Design
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Peter C. Doherty,
University of Melbourne
Anti-Viral Immunity: Lessons from Influenza Virus
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| Monday, March 22 |
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6:30 - 8:00 AM
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Breakfast
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Mezzanine 2
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8:00 - 11:15 AM
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Innate Recognition of Virus Infection
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Van Horne C/Shaughnessy
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*
Herbert (Skip) W. Virgin IV,
Washington University School of Medicine
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Ruslan M. Medzhitov,
Yale University School of Medicine
Innate Recognition of Endogenous Retroviruses
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Nelson Cesar Di Paolo,
University of Washington
Short Talk: Adenovirus Binding to beta3 Integrins Activates Innate Antiviral Immunity Independently of the Virus DNA Recognition by Intracellular Sensors
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Michael J. Gale Jr.,
University of Washington
Regulation of Pathogen Recognition Receptor Signaling and Innate Immunity by Hepatitis C Virus
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Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital
NLRs in Innate Immunity to Influenza Virus
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Sammy Bedoui,
University of Melbourne
Short Talk: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression in vivo
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Akiko Iwasaki,
Yale University School of Medicine
Toll-Like Receptors in Viral Immunity
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Mezzanine 2
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1:00 - 10:00 PM
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Poster Viewing
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Mezzanine 2
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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Innate Immunity to Viruses
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Van Horne C/Shaughnessy
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*
Akiko Iwasaki,
Yale University School of Medicine
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Herbert (Skip) W. Virgin IV,
Washington University School of Medicine
'Virus-Host Susceptibility Gene' Interactions Control Chronic Inflammatory Disease
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Doris Wilflingseder,
Innsbruck Medical University
Short Talk: Complement as an Endogenous Adjuvant for Dendritic Cell-Mediated Induction of Retrovirus-Specific CTLs
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Ofer Mandelboim,
Hebrew University of Jerusalem
Cellular and Viral microRNAs Controlling Immune Response to Stress
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Wayne M. Yokoyama,
Washington University School of Medicine
NK Cells, CTLs, and Virus Infection: Missing-Self in Action?
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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7:30 - 10:00 PM
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Poster Session 1
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Mezzanine 2
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| Tuesday, March 23 |
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6:30 - 8:00 AM
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Breakfast
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Mezzanine 2
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8:00 - 11:15 AM
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T-Cell Immunity to Viruses
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Van Horne C/Shaughnessy
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*
Jack R. Bennink,
NIAID, National Institutes of Health
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Nicole L. La Gruta,
University of Melbourne
Dissection of CTL Immunodominance Determinants Following Viral Infection
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Guna Karupiah,
John Curtin School of Medical Research, Australian National University
Short Talk: The Biological Significance of Proliferation-Independent Expansion of Antigen-Specific CD8+ T Cells through Receptor Sharing
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Andrea Lynn Cox,
Johns Hopkins University
Analysis of T Cells Chasing Hepatitis C Virus Escape Variants
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Ann B. Hill,
Oregon Health & Science University
CD8+ T Cells and Cytomegalovirus: A Dangerous Obsession?
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Linda S. Cauley,
University of Connecticut Health Center
Short Talk: Cause and Effects of Prolonged Lymph Node Hypertrophy after Influenza Infection
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J. Lindsay Whitton,
The Scripps Research Institute
CD8+ T Cell Responses To Infection: A Tale Of Two Viruses
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Mezzanine 2
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1:00 - 10:00 PM
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Poster Viewing
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 1: ANTI-VIRAL CD8 T CELL RESPONSES
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Van Horne Ballroom C
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*
Tania H. Watts,
University of Toronto
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David C. Tscharke,
Australian National University
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2:30 - 3:30 PM
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Workshop 1A: CD8 T Cell Memory
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Van Horne Ballroom C
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Jeffrey C. Nolz,
University of Iowa
Multiple Antigen Encounters Decrease the Protective Capacity of the Ensuing Memory CD8 T Cell Population Against Chronic LCMV Infection
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John Rutigliano,
St. Jude Children's Research Hospital
Development and Differentiation of Memory CD8+ T Cells in Influenza Infection
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Hélène Decaluwe,
Pasteur Institute
Gamma c Deficiency Precludes CD8+ T Cell Memory Despite Formation of Potent Anti-Viral T Cell Effectors
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Amol Suryawanshi,
University of Tennessee
Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8+T Cell Response
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3:30 - 4:30 PM
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Workshop 1B: Virus Specific CD8 T Cells
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Van Horne Ballroom C
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Alice E. Denton,
University of Melbourne
Epigenetic Regulation in CD8+ T Cell Differentiation
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Bailey E. Freeman,
Oregon Health & Science University
Cytokine-Mediated Regulation of CD8+ T Cell Responses during LCMV Infection
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Lila Ann Farrington,
Oregon Health and Sciences University
Virus-Infected Cells are Extremely Resistant to CTL-Mediated Killing
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Silvia Ariotti,
Netherlands Cancer Institute
In vivo Imaging of Target Localization by Virus-Specific Cytotoxic T Lymphocytes
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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Routes of Antigen Presentation
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Van Horne C/Shaughnessy
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*
Nicole L. La Gruta,
University of Melbourne
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Laurence C. Eisenlohr,
Thomas Jefferson University
A Proteasome- and TAP-Dependent MHC Class II-Restricted Presentation Pathway that Stimulates a Substantial Portion of the Antiviral CD4+ T Cell Response: Part 2
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Margarita Del Val,
Instituto de Salud Carlos III
Short Talk: Furin-Processed Antigens Targeted to the Secretory Route Elicit Functional TAP1-/- CD8+ T Lymphocytes in vivo
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Sylvie Le Gall,
Massachusetts General Hospital, Harvard Medical School
Deciphering HIV Epitope Production: Implications for Immunogen Design
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William R. Heath,
University of Melbourne
Viral Antigen Presentation to Naïve and Memory CD8+ T Cells
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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7:30 - 10:00 PM
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Poster Session 2
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Mezzanine 2
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| Wednesday, March 24 |
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6:30 - 8:00 AM
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Breakfast
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Mezzanine 2
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8:00 - 11:15 AM
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Vaccines: Immunologic Mechanisms of Action (Joint)
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Van Horne Ballroom A-B
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*
Kim J. Hasenkrug,
NIAID, National Institutes of Health
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Bali Pulendran,
Emory University
Lessons from Yellow Fever Vaccine
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Ian H. Frazer,
University of Queensland
Lessons from the Human Papillomavirus Vaccines
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Shane Crotty,
La Jolla Institute for Allergy and Immunology
Lessons from the Smallpox Vaccine: Follicular Helper CD4+ T Cell (Tfh) Differentiation and Neutralizing Antibodies
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Mark Stephen de Souza,
AFRIMS
Short Talk: Immunogenicity of the Thai Phase III (RV144) HIV Vaccine Regimen
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Monica Vaccari,
National Cancer Institute, National Institutes of Health
Short Talk: HIV/SIV Vaccine Efficacy Dependent on the Dose of SIVmac251 Challenge Exposure in Macaques
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M. Juliana McElrath,
Fred Hutchinson Cancer Research Center
Lessons from the STEP Trial and the Current Clinical Pipeline
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9:50 - 10:10 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Mezzanine 2
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1:00 - 10:00 PM
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Poster Viewing
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Mezzanine 2
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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Imaging of the Antiviral Immune Response (Joint)
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Van Horne Ballroom A-B
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*
Jonathan W. Yewdell,
National Institutes of Health
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Heather D. Hickman,
NIAID, National Institutes of Health
Intravital Imaging of the CD8+ T Cell Response to Virus
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Matteo Iannacone,
Harvard Medical School
Short Talk: Lymph Node Subcapsular Sinus Macrophages Confer Resistance to CNS
Invasion Upon Peripheral Infection With a Neurotropic Virus
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Ashley T. Haase,
University of Minnesota
In Vivo Imaging of the Cellular Immune Response to Viral Infections
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Ronald N. Germain,
NIAID, National Institutes of Health
Intravital Imaging of Adaptive Immune Effector Activity
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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7:30 - 10:00 PM
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Poster Session 3
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Mezzanine 2
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| Thursday, March 25 |
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6:30 - 8:00 AM
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Breakfast
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Mezzanine 2
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7:00 AM - 12:00 PM
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Poster Setup
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Mezzanine 2
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7:00 AM - 12:00 PM
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Poster Viewing
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Mezzanine 2
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8:00 - 11:15 AM
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Immunity to Chronic and Persistent Viral Infections
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Van Horne C/Shaughnessy
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*
Peter C. Doherty,
University of Melbourne
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Marcia A. Blackman,
Trudeau Institute
Establishment, Maintenance and Immune Control of gamma-Herpesvirus Latency
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Ilhem Messaoudi,
Oregon Health & Science University
Short Talk: Elucidating the Role of T Cell Immunity in the Control of VZV Replication using a Novel Nonhuman Primate Model
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Emmanuel J. Wiertz,
University Medical Center Utrecht
Herpesvirus Interference with T-Cell Immunity
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Elina I. Zuniga,
University of California, San Diego
Short Talk: Sustained-Cell-Intrinsic Transforming Growth Factor-beta Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence in vivo
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Barbara Rehermann,
National Institutes of Health, DHHS
Immunity to Hepatitis C Virus
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Francis V. Chisari,
The Scripps Research Institute
Induction and Evasion of the Innate Host Response to HCV
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM - 12:00 PM
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Lunch
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Mezzanine 2
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12:00 - 2:30 PM
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Poster Session 4
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 2: Anti-Viral T and B-Cells
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Shaughnessy
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*
Connie C. Bergmann,
Cleveland Clinic Foundation
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*
Kevin L. Legge,
University of Iowa Carver College of Medicine
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2:30 - 3:30 PM
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Workshop 2A: Anti-Viral CD4 and CD8 T Cell Responses
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Shaughnessy
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Anna Haas,
Swiss Federal Institute of Technology
HIV-1 Replication Activates CD4+ T Cells with Specificities for Persistent Herpes Viruses
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Mickael J. Ploquin,
National Institute for Medical Research
B Cells Shape the T Helper Response to Retroviral Infection
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David E. Verhoeven,
University of Maryland at Baltimore
Memory CD4+ T-Cells Mediate Enhanced Immunopathology during Influenza Infection
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Jennifer Bomberger,
Dartmouth Medical School
The Pseudomonas aeruginosa Toxin Cif Reduces MHC Class I Antigen Presentation and Viral Immunity
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3:30 - 4:30 PM
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Workshop 2B: B Cell Responses to Viruses
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Shaughnessy
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Matthew R. Vogt,
Washington University School of Medicine
Non-Neutralizing Antibodies Protect against Lethal West Nile Virus Infection via Fc-gamma Receptor and Complement–dependent Mechanisms
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Santiago F. Gonzalez,
Immune Disease Institute
Capture of Influenza by Medullary Dendritic Cells is Essential for Humoral Immunity in Draining Lymph Nodes
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Denise A. Kaminski,
University of Rochester
Antiviral Activity of Influenza Nucleoprotein-Specific Antibodies
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Luis J. Sigal,
Fox Chase Cancer Center
Not just Neutralizing Abs: Prevention and Cure of a Viral Disease by Antibodies that Block the Biological Function of a Virulence Factor
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2:30 - 4:30 PM
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Workshop 3: Innate Immunity to Virus Infection
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Van Horne Ballroom C
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*
Hans-Gustaf Ljunggren,
Karolinska Institutet
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*
Adolfo Garcia-Sastre,
Mount Sinai School of Medicine
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2:30 - 3:30 PM
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Workshop 3A: Immunity to Viruses
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Van Horne Ballroom C
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Maulik Patel,
Fred Hutchinson Cancer Research Center
Evolution as a Guide to Molecular Mechanisms of Pathogen Resistance
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Helene Minyi Liu,
University of Washinton, Seattle
RIG-I Membrane-Association Controls Innate Antiviral Immunity
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Alina Baum,
Mount Sinai School of Medicine
Characterization of Endogenous RIG-I Substrates from Virus Infected Cells
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Irving Coy Allen,
University of North Carolina at Chapel Hill
NLRX1 is a Regulator of the Innate Immune Response to Influenza A Virus Infection
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3:30 - 4:30 PM
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Workshop 3B: Innate Cellular Responses to Viruses
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Van Horne Ballroom C
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Karyl Kopaskie,
University of Chicago
Evasion of the Immune Response by Retroviriuses
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Mark T. Orr,
University of California, San Francisco
“Unlicensed” NK Cells Dominate the Response to Cytomegalovirus Infection
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Stephen A. McCartney,
Washington University School of Medicine
Distinct Functions of MDA5 and TLR3 in poly-I:C-mediated Activation of Murine NK Cells
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Stephanie Jost,
Ragon Institute of MGH, MIT and Harvard
Modulation of 2B4 and NKp46 Expression at the Surface of NK Cells in Response to Influenza Virus
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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Antigenic Variation (Joint)
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Van Horne Ballroom A-B
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*
Wayne C. Koff,
International AIDS Vaccine Initiative
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David I. Watkins,
University of Wisconsin-Madison
The Effect of Vaccine-Induced SIV-Specific Immune Response on Viral Acquisition and Replication
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Arnaud Moris,
UPMC - Hôpital Pitié-Salpêtrière
Short Talk: The Antiviral Factor APOBEC3G Improves CTL Recognition of HIV-Infected T Cells: Linking Intrinsic and Adaptive Immune Responses
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Dennis R. Burton,
The Scripps Research Institute
HIV Env and Approaches to Neutralizing Abs
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Jonathan W. Yewdell,
National Institutes of Health
Still Drifting: Mechanisms of Influenza A Virus Hemagglutinin Immune Escape
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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8:00 - 11:00 PM
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Entertainment
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Mezzanine 2
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| Friday, March 26 |
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Departure
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