Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Advances in Molecular Mechanisms of Atherosclerosis (J7)

Organizer(s): Russell A. DeBose-Boyd and Christopher K. Glass
February 12 - 17, 2010
Fairmont Banff Springs · Banff, Alberta
Abstract Deadline: October 12, 2009
Late Abstract Deadline: November 13, 2009
Scholarship Deadline: October 12, 2009
Early Registration Deadline: December 14, 2009

Supported by The Directors' Fund

Joint meeting: The Macrophage: Intersection of Pathogenic and Protective Inflammation (J8)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Atherosclerosis, a disease that affects arterial blood vessels, is the major cause of death in developed countries and emerging economies worldwide. The disease is initiated when cholesterol-rich low-density lipoproteins adhere to the walls of arteries, triggering a complex set of reactions involving a variety of cell types including macrophages, endothelial cells, smooth muscle cells, and lymphocytes. This initial lesion progresses to a more complicated atherosclerotic plaque through subsequent cell-cell and cell-lipid interactions that cause chronic inflammation, extracellular alterations, and necrosis. These responses promote plaque disruption, which triggers acute thrombosis resulting in vascular occlusion and myocardial infarction. The goal of this meeting is to provide attendees with the latest advances in the understanding of cellular processes that contribute to atherosclerosis, with particular emphasis on cholesterol metabolism and foam cell formation, genetics, and the immune system. These goals will be significantly enhanced by holding the meeting concurrently with the meeting, The Macrophage: Intersection of Pathogenic and Protective Inflammation. In addition to four atherosclerosis-specific plenary sessions, four joint sessions are planned to highlight major developments in areas of mutual interest to investigators in the fields of atherosclerosis and macrophage biology. Elucidation of mechanisms underlying development of atherosclerosis may reveal new therapeutic strategies to combat the disease. This program will stimulate interactions that are likely to augment and accelerate this process.

Friday, February 12
3:00 - 7:30 PM	Registration	Van Horne Foyer
6:30 - 7:30 PM	Refreshments	Van Horne Foyer
7:30 - 8:30 PM	Keynote Address (Joint)	Van Horne Ballroom A-B
	Carl F. Nathan, Weill Cornell Medical College Non-Resolving Inflammation: Disease, Defense and Therapy
Saturday, February 13
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Genetics and Functional Genomics of Atherosclerosis	Van Horne Ballroom C
	Sekar Kathiresan, Massachusetts General Hospital Mapping Genes for Plasma Lipids and Myocardial Infarction in Humans

	Eric Schadt, Pacific Biosciences Moving Toward a Systems Biology Understanding of Complex Human Diseases
	Karen Reue, University of California, Los Angeles Identification of Novel Lipid Metabolism Genes from Spontaneous Mouse Mutants

	* Daniel J. Rader, University of Pennsylvania Medical Center Functional Characterization of Novel Loci Associated with Plasma Lipids
	Yajaira Suárez, New York University School of Medicine Short Talk: TNF-Induced microRNAs Regulate TNF-Induce Expression of E-Selectin and ICAM-1 in Human Endothelial Cells
	Johan Lars Markus Björkegren, Karolinska University Hospital Short Talk: Multi-Organ Expression Profiling to Uncover Gene Networks and Modules of Importance to Coronary Artery Disease
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:15 PM	Signaling and Gene Expression (Joint)	Van Horne Ballroom A-B

	* Linda K. Curtiss, The Scripps Research Institute Atherosclerosis: An Unfortunate Mix of Lipids and Inflammation Whipped Up by Toll-Like Receptors
	Joachim Herz, University of Texas Southwestern Medical Center Importance of cholesterol homeostasis in vascular smooth muscle cells

	Petra Keul, University of Duisburg-Essen Short Talk: Deletion of the S1P Receptor S1P3 Attenuates Macrophage-Driven Inflammation in Atherosclerotic Lesions of S1P3-/-/ApoE -/- Double Knockout Mice
	Jay W. Heinecke, University of Washington School of Medicine Short Talk: Defining the Proteome of the Macrophage Foam Cell
	Ruslan M. Medzhitov, Yale University School of Medicine Regulation of Inflammatory Gene Expression in Macrophages
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 1	Mezzanine 2
Sunday, February 14
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Immune Mechanisms and Atherosclerosis	Van Horne Ballroom C
	Göran K. Hansson, Karolinska University Hospital Interplay of Innate and Adaptive Immune Mechanisms in Atherosclerosis
	* Joseph L. Witztum, University of California, San Diego Oxidation-Specific Epitopes are a Major Target of Innate Immunity
	Ziad Mallat, Inserm U970, Paris Cardiovascular Research Center Regulatory T Cell Immunity in Atherosclerosis
	Gwendalyn J. Randolph, Mount Sinai School of Medicine Fate of Monocyte-Derived Cells in Atherosclerotic Plaques versus Sites of Resolving Inflammation
	David Weismann, Center for Molecular Medicine of the Austrian Academy of Sciences Short Talk: Discovery of a novel malondialdehyde (MDA) binding protein
	Yue Zhao, University of Kentucky Short Talk: The NR4A Orphan Nuclear Receptor NOR1 Mediates Monocyte Adhesion and Atherosclerosis Formation in Mice
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Macrophage Movement (Joint)	Van Horne Ballroom A-B
	* Gerald Krystal, British Columbia Cancer Research Center
	Israel F. Charo, Gladstone Institute of Cardiovascular Disease CCR2 in atherosclerosis, insulin resistance, and hematopoietic stem cell trafficking
	Frederic Geissmann, Kings College London : Function of the mononuclear phagocyte system: in vivo in human and model organisms

	Steven L. Kunkel, University of Michigan Medical School Writers, Readers, and Erasers: Dynamic Epigenetic Regulation of the Macrophage Phenotype
	Andrea L. Hevener, University of California, Los Angeles Short Talk: Myeloid-specific Deletion of Estrogen Receptor-alpha (ERalpha) Promotes Obesity and Insulin Resistance in Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 2	Mezzanine 2
Monday, February 15
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	The Vulnerable Plaque	Van Horne Ballroom C

	Philippe Boucher, UMR CNRS 7213, University of Strasbourg PPAR-gamma Inhibits Vascular Calcification by Controlling an LRP1/beta-Catenin Signaling Pathway
	Peter Libby, Brigham and Women's Hospital Extracellular Matrix Metabolism and Determinants of Plaque Stability
	Garret A. FitzGerald, University of Pennsylvania Cardiovascular Complexity in the Prostanoid System
	* Ira Tabas, Columbia University Mechanisms and Consequences of Macrophage Apoptosis in Atherosclerosis
	Kristiina Satu Susanna Rajamäki, Wihuri Research Institute Short Talk: Cholesterol Crystals Activate Inflammasome Signaling in Human Macrophages
	Walter S. Speidl, Medical University of Vienna Short Talk: The Complement Component C5a Induces the Expression of MMP-1 and MMP-9 in Human Macrophages
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Deactivating Macrophage Activity (Joint)	Van Horne Ballroom A-B
	Peter J. Murray, St. Jude Children's Research Hospital Cytokine-Mediated Deactivation of the Activated Macrophage
	Gerald Krystal, British Columbia Cancer Research Center The Role of SHIP in Macrophage Skewing and Activation
	* Christopher K. Glass, University of California, San Diego Nuclear Receptor Repression Pathways that Regulate Inflammation
	Tim Ian Smallie, Kennedy Institute of Rheumatology Division Short Talk: IL-10 Negatively Regulates Macrophage Activation by Inhibiting Transcription Elongation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 3	Mezzanine 2
Tuesday, February 16
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Cholesterol Homeostasis/Foam Cell Formation	Van Horne Ballroom C
	* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center Cholesterol Homeostasis and Sterol-Accelerated Degradation of HMG CoA Reductase
	Alan R. Tall, Columbia University HDL, ABC Transporters and Atherosclerosis
	Kathryn J. Moore, New York University Medical Center Micro-Managing Macrophage Cholesterol Metabolism

	Edward A. Fisher, New York University School of Medicine HDL and Atherosclerosis Regression: Effects on the Quantity and Quality of Monocyte-Derived Cells in Plaques
	Prakash Gopaldas Chandak, Institute of Molecular Biology and Biochemistry Short Talk: Adipose Triglyceride Lipase Deficiency Affects Macrophage Morphology and Function and Significantly Reduces Atherosclerosis in LDLR -/- Mice
	Shunxing Rong, Wake Forest University School of Medicine Short Talk: High Polyunsaturated fatty acid (PUFA) diet unmasks role of 12/15 lipoxygenase in lipid metabolism
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:00 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Metabolism and Macrophages at the Intersection of Metabolic Control (Joint)	Van Horne Ballroom A-B
	* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center
	* Ajay Chawla, Stanford University Medical Center Immune regulation of nutrient metabolism and aging

	William A. Muller, Northwestern University Feinberg School of Medicine All Roads Lead to the LBRC: A common mechanism for leukocyte transendothelial migration

	Ebru Erbay, Harvard University School of Public Health The Role of Endoplasmic Reticulum Stress in Atherosclerosis and its Regulation by Lipids
	Hwee Ying Lim, National University of Singapore Short Talk: Ezetimibe Restores lymphatic vessel function and dendritic cell migration, in hypercholesterolemic apoE deficient mice

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
8:00 - 11:00 PM	Entertainment	Mezzanine 2
Wednesday, February 17
	Departure

*Session Chair †Speaker invited, not yet responded.