Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

The Molecular Basis of Schizophrenia and Bipolar Disorder (X1)

Organizer(s): Pamela Sklar, David J. Porteous and Christopher A. Ross
March 6 - 10, 2009
Keystone Resort · Keystone, Colorado
Abstract Deadline: November 6, 2008
Late Abstract Deadline: December 4, 2008
Scholarship Deadline: November 6, 2008
Early Registration Deadline: January 6, 2009

Sponsored by Johnson & Johnson Pharmaceutical Research and Development, L.L.C.

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The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Epigenetic Basis of Neurodevelopmental Disorders (X2)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
This meeting brings together experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, psychiatry, and chemical biology to discuss the molecular bases of bipolar disorder and schizophrenia. The time is opportune, since new methods in genetics are identifying plausible candidate genes, which can be studied by sophisticated techniques of cell biology and neuroscience, in both laboratory and clinical settings. Bipolar disorder and schizophrenia are severe psychiatric syndromes characterized by mood and cognitive disorders and psychosis. Both genetic and environmental factors are believed to contribute. New findings in genetics and neuroscience will likely help redefine the phenotypes and make possible the development of new therapeutic targets. Among the topics to be explored include emerging data from genetics implicating new genes and genetic variation in disease; the current status of the epidemiology, including environmental factors, and boundaries of the disorders; the genetics and neurobiology of several current candidate genes and pathways; and the relevance of advances in neurogenesis, fast-evolving brain genes, and cerebral circuitry development. Finally, prospects for new approaches to therapeutics will be covered. The overall goal of this meeting is to integrate molecular studies across basic and clinical disciplines and facilitate the development of new approaches.

Friday, March 6
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address	Grays 1 & 2
	* Pamela Sklar, Harvard Medical School, Massachusetts General Hospital
	Thomas R. Insel, National Institute of Mental Health The Molecular Basis of Schizophrenia and Bipolar Disorder: What Do We Know? What Do We Need?
Saturday, March 7
7:00 - 8:00 AM	Breakfast	Longs Peak
8:00 - 11:00 AM	Genome-Wide Studies of Disease-Related Variation	Grays 1 & 2

	Shaun Purcell, Massachusetts General Hospital Varieties of Genetic Variation of Neuropsychiatric Disease
	* Pamela Sklar, Harvard Medical School, Massachusetts General Hospital Genetics and Genomics of Schizophrenia and Bipolar Disorder
	Patrick F. Sullivan, University of North Carolina SCZ GWAS - Update 3/09
	Jonathan Sebat, Cold Spring Harbor Laboratory Microduplication of 16p11.2 is Associated with Schizophrenia
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Longs Peak
1:00 - 10:00 PM	Poster Viewing	Longs Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Clinical Epidemiology and Etiology	Grays 1 & 2
	Peter B. Jones, Cambridge University Epidemiology and Risk Factors, Shared or Not?
	Nick J. Craddock, Cardiff University School of Medicine Boundaries of the phenotypes: Reconstructing and Rethinking Psychosis
	* Christopher A. Ross, Johns Hopkins University School of Medicine Neurogenetics: Insights from Neurodegeneration, Approaches to Psychiatric Disease

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Longs Peak
7:30 - 10:00 PM	Poster Session 1	Longs Peak
Sunday, March 8
7:00 - 8:00 AM	Breakfast	Longs Peak
8:00 - 11:00 AM	Genes and Pathways	Grays 1 & 2
	* David J. Porteous, University of Edinburgh DISC1: Approaching Causality
	Hongjun Song, Johns Hopkins University School of Medicine Regulation of Development of Dentate Granule Neurons by Disrupted-In-Schizophrenia 1 (DISC1)
	Li-Huei Tsai, Massachusetts Institute of Technology Disrupted In Schizophrenia 1 (DISC1) Regulates Neural Progenitor Proliferation via beta-Catenin/GSKbeta Signaling

	Jonathan D. Wood, University of Sheffield Medical School Short Talk: Schizophrenia Susceptibility Genes in Zebrafish

	Gianluca De Rienzo, Whitehead Institute Short Talk: DISC-1 is an Essential Modulator of the Wnt Signaling Pathway
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Longs Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Genes and Pathways II	Grays 1 & 2
	Marc G. Caron, Duke University Medical Center D2 Dopamine Receptor-Mediated Akt/GSK3 Signaling: Behavioral and Therapeutic Implications
	Ricardo E. Dolmetsch, Stanford University From Calcium Channels to Autism

	* Daniel R. Weinberger, NIMH/National Institutes of Health Genetic and Molecular Studies of NRG1/ErbB4
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Longs Peak
Monday, March 9
7:00 - 8:00 AM	Breakfast	Longs Peak
8:00 - 11:00 AM	Evolution and Development of the Brain	Grays 1 & 2
	* David J. Porteous, University of Edinburgh
	Fred H. Gage, The Salk Institute for Biological Studies L1 Retrotransposons During Neurogenesis
	Bruce T. Lahn, University of Chicago Fast-Evolving Genes of the Human Brain

	Vann Bennett, Duke University Medical Center Facile Evolution of Ankyrin-Binding Activity as a Mechanism for Co-Localization of Functionally Related Proteins at Axon Initial Segments

	Judith L. Rapoport, NIMH, National Institutes of Health Genetics and Brain Development of Childhood Onset Schizophrenia: Update 2009
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Chemical Biology and Therapeutic Strategies	Grays 1 & 2
	* Christopher A. Ross, Johns Hopkins University School of Medicine
	John R. Kelsoe, University of California, San Diego Perspectives on Pharmacogenomics: Medication Response in Bipolar Disorder as an Endophenotype



	Edward M. Scolnick, MIT Broad Institute Clinical Applications of Emerging Psychiatric Genetics
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Longs Peak
8:00 - 11:00 PM	Entertainment	Longs Peak
Tuesday, March 10
	Departure

*Session Chair †Speaker invited, not yet responded.