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Epigenetic Basis of Neurodevelopmental Disorders (X2)

Organizer(s): Xinyu Zhao and Peng Jin
March 6 - 10, 2009
Keystone Resort  ·  Keystone, Colorado
Abstract Deadline: November 6, 2008
Late Abstract Deadline: December 4, 2008
Scholarship Deadline: November 6, 2008
Early Registration Deadline: January 6, 2009


Supported by the Directors' Fund

Joint meeting: The Molecular Basis of Schizophrenia and Bipolar Disorder (X1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).



This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Neurodevelopmental disorders are highly heterogeneous constellations of disorders, both in terms of etiology and clinical manifestations. Past effort has focused on identifying the genetic basis of these disorders with minimal success. Epigenetic modulations, mediated by DNA methylation, RNA-associated silencing, and histone modification, can imprint dynamic environmental experiences on the “fixed” genome, resulting in stable alterations in phenotypes. This conference will focus on an emerging area of biomedical research: how epigenetic modulation shapes brain development and disorders. The meeting will examine the common molecular pathways affected in several related neurodevelopmental disorders and discuss how pre- and postnatal exposures to pollutants, alcohol, drug, nutrition, and parental care, etc., may affect neurodevelopment via epigenetic pathways. The overall goal of the meeting is to gain insight into the common molecular pathways affected among these disorders and to discover potential therapeutic targets that have been missed by looking at one disorder at a time.

Friday, March 6
3:00 - 7:30 PM Registration Longs Peak Foyer
6:30 - 7:30 PM Refreshments Longs Peak Foyer
8:30 - 9:30 PM Keynote Address Grays 1 & 2
* Xinyu Zhao, University of New Mexico
and
* Peng Jin, Emory University School of Medicine
Opening Remarks
Fred H. Gage, The Salk Institute for Biological Studies
L1 Retrotransposition and Neuronal Diversity
Saturday, March 7
7:00 - 8:00 AM Breakfast Longs Peak
8:00 - 11:15 AM Epigenetic Mechanisms in Human Biology Quandary 1 & 2
Peter A. Jones, University of Southern California
Epigenetic Regulation in Cancer
* Joseph F. Costello, University of California, San Francisco
Role of Intragenic DNA Methylation in Gene Expression
Guoping Fan, University of California, Los Angeles
Epigenetic Regulation in Neuronal Survival and Brain Development
John A. Stamatoyannopoulos, University of Washington
Profiling Chromatin Structure Across Cell Lineages
Dengke Ma, Johns Hopkins University
Short Talk: Neuronal Induction of Gadd45b Links Epigenetic DNA Demethylation to Activity-Dependent Adult Neurogenesis
Jing Wang, Hospital for Sick Children
Short Talk: The Histone Acetyltransferase Activity of the CBP Transcriptional Coactivator, which is Haploinsufficient in Rubinstein-Taybi Syndrome, is Essential for Differentiation of Developing Neural Stem Cells
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM - On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Longs Peak
1:00 - 10:00 PM Poster Viewing Longs Peak
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Psychiatric Epigenetics Quandary 1 & 2
* Art Petronis, Centre for Addiction and Mental Health
Epigenomics of Major Psychosis
Schahram Akbarian, University of Massachusetts Medical School
Epigenetic Regulation in Human and Mouse Brain - Focus on Histone Lysine Methylation
Yue Feng, Emory University
Talk Title to be Determined
Anne H. O'Donnell, Columbia University
Short Talk: Whole Genome DNA Methylation Profiling of Major Depression
Fatemeh G. Haghighi, Columbia University
Short Talk: DNA Methylation Profiling of Schizophrenia
7:00 - 8:00 PM Social Hour w/ Lite Bites Longs Peak
7:30 - 10:00 PM Poster Session 1 Longs Peak
Sunday, March 8
7:00 - 8:00 AM Breakfast Longs Peak
8:00 - 11:00 AM Autism Quandary 1 & 2
Daniel H. Geschwind, University of California, Los Angeles
Autism: From Genes to Brain
David H. Ledbetter, Emory University School of Medicine
Early Identification of Genetic Sub-Types of Autism Spectrum Disorders (ASDs) by Clinical aCGH Testing and Establishment of an International Public Database
* Janine M. LaSalle, University of California, Davis
Epigenetic Etiologies of Autism Spectrum Disorders
Addie May Ingrid Nesbitt, University of Connecticut
Short Talk: Genomic Imprinting of the X-Linked Gene Transketolase-like 1 in Mouse and Human
Rodney C. Samaco, Baylor College of Medicine
Short Talk: Haploinsufficiency of Crh Ameliorates the Autistic-Like Features in a Mouse Model of MECP2 Duplication Syndrome
Steven W. Long, University of Illinois
Short Talk: Purification of a Novel MeCP2 Complex from Rat Brain
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:15 AM - On Own for Lunch
1:00 - 10:00 PM Poster Viewing Longs Peak
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Imprinting Disorders Quandary 1 & 2
* Arthur L. Beaudet, Baylor College of Medicine
Molecular Basis of Angelman Syndrome
Laura Herzing, Children's Memorial Research Center
Epigenetic Consequences of Fetal Alcohol Exposure
Edwin J. Weeber, University of South Florida
Synaptic Plasticity Defects in Angelman Syndrome
Jon F. Wilkins, Santa Fe Institute
Short Talk: Imprinted Genes, Risk Preferences, and Delay Discounting
7:00 - 8:00 PM Social Hour w/ Lite Bites Longs Peak
Monday, March 9
7:00 - 8:00 AM Breakfast Longs Peak
8:00 - 9:20 AM Monogenic Neurodevelopmental Disorders: Rett Syndrome Quandary 1 & 2
David Katz, Case Western Reserve University School of Medicine
Dysregulation of Neuronal Excitability in Mecp2 Null Mice
Xinyu Zhao, University of New Mexico
Methyl-CpG Binding Proteins in Neurogenesis and Autism Spectrum Disorders
9:40 - 11:15 AM Monogenic Neurodevelopmental Disorders: Fragile X Syndrome Quandary 1 & 2
Stephen T. Warren, Emory University School of Medicine
Newborn and Conventional Mutation Screening in Fragile X
* David L. Nelson, Baylor College of Medicine
Development of Animal Models for Fragile X Syndrome
Peng Jin, Emory University School of Medicine
Fragile X Mental Retardation Protein and Stem Cells
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM - On Own for Lunch
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Lessons, Conclusions, and Perspectives Quandary 1 & 2
* Xinyu Zhao, University of New Mexico
* Peng Jin, Emory University School of Medicine
Jeffrey M. Besterman, MethylGene Inc.
Epigenetic Therapy of Neurodegenerative Diseases
Bing Ren, University of California, San Diego
Global Chromatin Modifications at Transcriptional Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome
7:00 - 8:00 PM Social Hour w/ Lite Bites Longs Peak
8:00 - 11:00 PM Entertainment Longs Peak
Tuesday, March 10
Departure
*Session Chair   †Speaker invited, not yet responded.



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