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LANGUAGE NOTE: This meeting will be conducted in English.
**Meeting has ended.**



Meeting Program

To view program in "24 hour" time (international) click here.


Sunday, January 31
3:00 - 7:30 PM Registration Pre Function
6:30 - 7:30 PM Welcome and Buffet Dinner Granhall
7:30 - 8:30 PM Keynote Address
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Mountain/Lake
Andrzej Bartke, Southern Illinois University School of Medicine, USA
Growth Hormone: Elixir of Youth or Dangerous Snake Oil?
Monday, February 1
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Aging Pathways I
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Mountain/Lake
* Marc Tatar, Brown University, USA
Cynthia Kenyon, University of California, San Francisco, USA
Insulin and Aging
Leonard Guarente, Massachusetts Institute of Technology, USA
Sirtuins Aging and Disease
Daniel E.L. Promislow, University of Georgia, USA
Networks and the Evolution of Aging
Anne Brunet, Stanford University, USA
Role of FOXO in Aging
William Mair, The Salk Institute, USA
Short Talk: AMPK and Calcineurin extend lifespan via the CREB Regulated Transcription Co-activator (CRTC-1)
Maaike C. W. van den Berg, University Medical Center Utrecht, The Netherlands
Short Talk: Regulation of FOXO4 through ROS Regulated Ral-JIP1-JNK Complex Assembly
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM- On Own for Lunch and Recreation
11:15 AM- 1:00 PM Poster Setup Bay
1:00 - 10:00 PM Poster Viewing Bay
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Aging Pathways II
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Mountain/Lake
* Rolf Bodmer, Burnham Institute for Medical Research, USA
Jennifer Cermak, Sirtris, a GSK Company, USA
Targeting Sirtuins: Drug Development for Diseases of Aging
Robert S. Garofalo, , USA
Genomics and Aging
Sean M. Oldham, Burnham Institute for Medical Research, USA
Role of Nutrient Sensing TOR Pathway in Obesity and Aging
Matthew D. McGee, Buck Institute for Age Research, USA
Short Talk: 3D Digital Atlas of Aging in C. elegans
7:00 - 8:00 PM Dinner Granhall
8:00 - 10:00 PM Poster Session 1
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Bay
8:00 - 9:00 PM Social Hour Bay
Tuesday, February 2
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Molecules and Aging I
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Mountain/Lake
* David A. Sinclair, Harvard Medical School, USA
Jan Vijg, Albert Einstein College of Medicine, USA
Genomic Instability, Transcriptional Deregulation and Aging
Judith Campisi, Buck Institute for Age Research, USA
The Double Edged Sword of Cellular Senescence
George M. Martin, University of Washington, USA
The Aging-Disease Relationship
Norman E. Sharpless, University of North Carolina School of Medicine, USA
Cell Cycle Control and Mammalian Aging
Raul Mostoslavsky, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Functions as a Master Regulator of Glucose Homeostasis
Eduardo Nunes Chini, Mayo Clinic, USA
Short Talk: Role of the Nuclear Protein DBC1, an Inhibitor of the Longevity Related Enzyme SIRT1
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM- On Own for Lunch and Recreation
11:15 AM- 1:00 PM Poster Setup Bay
1:00 - 10:00 PM Poster Viewing Bay
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Molecules and Aging II
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Mountain/Lake
* Jan Vijg, Albert Einstein College of Medicine, USA
Heidi Scrable, Mayo Clinic, USA
p53 and Aging
David A. Sinclair, Harvard Medical School, USA
Regulation of the Spindle Checkpoint, Senescence and Aging by SIRT2
Rafael de Cabo, National Institute on Aging, NIH, USA
From Molecules to Nutritional Interventions for Healthy Aging
Philipp Oberdoerffer, National Cancer Institute, NIH, USA
Short Talk: A Mechanistic Link between DNA Damage, Chromatin and Aging
7:00 - 8:00 PM Dinner Granhall
8:00 - 10:00 PM Poster Session 2
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Bay
8:00 - 9:00 PM Social Hour Bay
Wednesday, February 3
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Cells and Organelles Aging
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Mountain/Lake
* Heidi Scrable, Mayo Clinic, USA
Thomas A. Rando, Stanford University School of Medicine, USA
Regulation of Wnt Signaling in Adult and Aged Stem Cells by Co-Activators and Epigenetic Modifications
Leanne Jones, The Salk Institute for Biological Studies, USA
Stem Cell-Niche Cell Interactions during Aging
Amy J. Wagers, Harvard University, USA
Reversing Dysfunction of Aged Tissue Stem Cells
Sean J. Morrison, University of Michigan/Howard Hughes Medical Institute, USA
A Transposon Mutagenesis Suppressor Screen for Genes that Regulate Stem Cell Maintenance
Pier Lorenzo Puri, Sanford/Burnham Institute and Dulbecco Telehton Institute, Italy
Short Talk: DNA Damage Signaling to MyoD and the Control of the Genomic Stability of Skeletal Muscles during Development and Aging
Giana Angelo, Fred Hutchinson Cancer Research Center, USA
Short Talk: Adult Worms Protect Germline Stem Cells and Extend their Reproductive Span in Response to Starvation
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM- On Own for Lunch and Recreation
11:15 AM- 1:00 PM Poster Setup Bay
1:00 - 10:00 PM Poster Viewing Bay
2:30 - 4:30 PM Workshop: Stress, Mitochondria, and Aging
Mountain/Lake
Nicholas Day, Buck Institute for Age Research, USA
A Novel Inducible Mouse Model of Endogenous Mitochondrial Oxidative Stress Causes Heart Disease
Hadise Kabil, University of Michigan, USA
Activity of the Transsulfuration Pathway Determines Lifespan Extension in Response to Dietary Restriction in Drosophila
* Pankaj Kapahi, Buck Institute for Age Research, USA
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
David B. Lombard, University of Michigan, USA
Mitochondrial Protein Acetylation in Calorie Restriction and Aging
Iain Scott, NHLBI, National Institutes of Health, USA
The Functional Characterization of SIRT3 Modulation of Complex V of the Electron Transfer Chain
Cristiano Simone, Consorzio Mario Negri Sud, Italy
FoxO3A Localizes to Mitochondria and Regulates the Expression of the Mitochondrial Genome in Response to Nutrient Deprivation
Michael C. Velarde, Buck Institute for Age Research, USA
Superoxide Dismutase 2 Deficiency Promotes Cellular Senescence and Excessive Differentiation in Mouse Epidermis
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Cells and Organelles Aging II
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Mountain/Lake
* Sean M. Oldham, Burnham Institute for Medical Research, USA
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy and Aging
Andrew G. Dillin, The Salk Institute for Biological Studies, USA
Aging as an Event of Proteostasis Decline
Michael S. Grotewiel, Virginia Commonwealth University, USA
Age-Related Locomotor Impairment in Drosophila
Theodore W. Peters, Buck Institute for Age Research, USA
Short Talk: Age-Dependent Accumulation of Insoluble Proteins is Conserved Across Taxa
7:00 - 8:00 PM Dinner Granhall
8:00 - 10:00 PM Poster Session 3
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009
Bay
8:00 - 9:00 PM Social Hour Bay
Thursday, February 4
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Physiological Systems, Aging and Disease I
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009

NOTE: Session is Sponsored by The Ellison Medical Foundation
Mountain/Lake
* Amy J. Wagers, Harvard University, USA
Paul Joseph Shaw, Washington University, USA
Sleep Aging
Michael O. Thorner, University of Virginia, USA
Potential Role of Ghrelin Mimetics in Preventing Frailty and Partially Reversing Sarcopenia of Aging
Marc Tatar, Brown University, USA
Drosophila as a Model for Analysis of Innate Immune Aging
Rolf Bodmer, Burnham Institute for Medical Research, USA
Cardiac Aging
Ursula M. Muñoz-Nájar, Brown University, USA
Short Talk: Telomere-Dysfunction Induced Senescence and Organismal Aging in the Mouse Model
Richard A. Kerber, University of Louisville, USA
Short Talk: Association of Gene Expression Patterns in Lymphoblastoid Cell Lines with Familial Longevity and Survival
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM- On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Physiological Systems, Aging and Disease II
Registered attendees for this meeting can view Abstracts for this session starting on 12/31/2009

NOTE: Session is Sponsored by The Ellison Medical Foundation
Mountain/Lake
* Anne Brunet, Stanford University, USA
Monica Driscoll, Rutgers University, USA
Genetic and Pharmacological Extension of Healthspan in a Simple Animal Model
Richard A. Miller, University of Michigan, USA
Cell Stress and Aging
Bradley J. Willcox, Pacific Health Research Institute, USA
Pathophysiological and Sociopsychological Evidence for Active and Resilient Centenarian
Floyd (Ski) Chilton, Wake Forest University School of Medicine, USA
Short Talk: Impact of the Varying Frequencies at Common Genetic Variants in the FADS Gene Cluster on Circulating Levels of Inflammatory Fatty Acids in African Americans and Caucasians
7:00 - 8:00 PM Social Hour Alumni
8:00 - 9:00 PM Dinner Granhall
8:00 - 11:00 PM Entertainment Granhall
Friday, February 5
Departure
      *=Session Chair     †=Speaker invited, not yet responded.



We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute on Aging (NIA)

Grant No. 1R13AG034755-01


The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

Aging can be defined as the gradual loss of the ability of the organism to maintain homeostasis. Our aim will be to focus on the molecular and cellular mechanisms by which tissue and organ function deteriorate and homeostasis fails rather than on longevity itself, which has been the theme of previous Keystone Symposia meetings on aging. Work from a variety of models is recognizing that organisms, especially humans, are complicated systems in which interventions that extend lifespan might not necessarily block the aging and loss of function in specific organs or tissues and vice versa. Continuing this approach will help us gain an understanding and appreciation of the complexity that underlies aging in humans. The aim of this meeting is to reveal the integration and communication between pathways and systems during functional aging and their relationship with longevity. This meeting will highlight important questions to address in future research. Most importantly, what are the common and disparate causes underlying the cellular and physiological mechanisms responsible for human senescent phenotypes?