Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Multi-Protein Complexes Involved in Cell Regulation (E6)

Organizer(s): Tom L. Blundell, Carol V. Robinson and Ralph A. Bradshaw
August 18 - 23, 2006
St. John's College - Cambridge · University of Cambridge, Cambridge
Abstract Deadline: May 9, 2006
Late Abstract Deadline: May 26, 2006
Scholarship Deadline: April 18, 2006
Early Registration Deadline: June 19, 2006

Supported by The Director's Fund

This meeting took place in the 2006 season.

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Summary of Meeting
As knowledge of protein structure advances it has become increasingly clear that protein interactions, both transient and stable, are far more extensive than originally appreciated and that the resulting complexes, with a very wide range of stabilities, form highly coordinated networks that govern biological processes. Understanding the fluxes of information that are transmitted by these protein-protein contacts is the essence of systems biology and is dependent, at least to a first approximation, on determining the structures of the proteins involved. There have been multiple approaches to this challenging problem ranging from crystallography and 2D NMR to hybridization and mass spectrometry. This meeting will assess the state of determining the structural and functional bases for protein-protein interactions with the view of exploring how these approaches augment and extend each other.

Friday, August 18
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 9:30 PM	Keynote Session	Palmerston
	Tom L. Blundell, University of Cambridge Multiprotein Assemblies: Structural Biology and Drug Discovery
	Carol V. Robinson, University of Cambridge Multi-Protein Complexes – New Insights from Old Tools
Saturday, August 19
7:30 - 8:30 AM	Breakfast	Buttery
8:30 - 11:30 AM	Technological Approaches: Studying Macromolecular Interactions and Dynamics I	Palmerston
	* Wolfgang P. Baumeister, Max Planck Institute of Biochemistry Mapping Molecular Landscapes inside Cells by Cryoelectron Tomography
	Keiichi Namba, Osaka University Molecular Mechanisms of Swimming and Tumbling in Bacterial Motility

	F. Ulrich Hartl, Max Planck Institut Protein Folding Machines: Interactions between Chaperones and their Clients

	James A. Wells, University of California, San Francisco Discovering Inhibitors of Protein Complexes
9:40 - 10:00 AM	Coffee Break	Foyer
11:30 AM - 12:30 PM	Lunch	The Hall
11:30 AM - 12:00 PM	Poster Setup	Castlereagh Room/Foyer
12:30 - 2:30 PM	Poster Session 1	Castlereagh Room/Foyer
2:30 - 4:30 PM	Workshop 1: Dynamics and Regulation of Protein-Protein Interactions	Palmerston
	* Nicholas J. Harmer,

	* Marko Hyvönen, University of Cambridge
	Ludovic Bannwarth, Centre National de la Recherche Scientifique, University Paris 6 Disabling a Protein Dimer with Rationally Designed Interface Peptidomimetics
	Nadia Milech, University of Western Australia Anti-Apoptotic Phylomer Peptides: Disruptors from Protein Folds
	Alexis Gautreau, Centre National de la Recherche Scientifique, Institut Curie Structural Conversion of Brick1 from a Free Trimer to a Single Subunit during the Assembly of the Wave Complex
	Eric S. Underbakke, University of Wisconsin, Madison Illuminating Protein-Protein Interactions in Signal Transduction: Footprinting a Reconstituted Escherichia coli Chemotaxis Signaling Lattice

	Angela Manegold Svendsen, Hagedorn Research Institute Kinetics of Insulin-Like Peptide 3 (INSL3) Binding to the Leucine-Rich Repeat-Containing G-Protein-Coupled Receptor 8 (LGR8): Evidence for Negative Cooperativity
	Roopa Thapar, Hauptman-Woodward Institute Allosteric Regulation of the SLBP-Histone mRNA Complex by Phosphorylation-Dependent Proline Isomerization
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Technological Approaches: Studying Macromolecular Interactions and Dynamics II	Palmerston
	* Christopher M. Dobson, University of Cambridge
	Alexander Grishaev, National Institutes of Health Combining Solution NMR and Small Angle Scattering for Macromolecular Structure Determination

	Laura S. Itzhaki, Hutchison/MRC Research Centre Analysis of the assembly and dynamics of the multi-subunit ubiquitin ligase SCFSkp2
	Elizabeth A. Komives, University of California, San Diego Dynamics of the NF-kappaB - IkappaB Interaction
Sunday, August 20
7:30 - 8:30 AM	Breakfast	Buttery
8:30 - 11:30 AM	Cell Surface Receptors	Palmerston
	* John E. Ladbury, University College London Protein assemblies dictate specificity in tyrosine kinase-mediated signal transduction
	Colin W. Ward, University of New South Wales Structural Insights into Signaling by the EGF and Insulin Receptor Families
	Nicholas J. Harmer, Signaling Clusters in the Fibroblast Growth Factor System
	Johanna Mari Ivaska, University of Turku Integrating Matrix Messages and Motility
9:40 - 10:00 AM	Coffee Break	Foyer
11:30 - 12:30 PM	Lunch	The Hall
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Signaling Pathways	Palmerston
	* Peter J. Parker, Cancer Research UK Multiple signalling pathways regulate the assembly of a PKCepsilon complex
	Yosef Yarden, Weizmann Institute of Science Oncogenic growth factor signaling: a system perspective
	Bertrand Séraphin, Universite Paris 6 Structural and Functional Analysis of Protein Complexes Involved in Pathways Controlling Gene Expression
Monday, August 21
7:30 - 8:30 AM	Breakfast	Buttery
8:30 - 11:30 AM	Intracellular Signaling – Structural Aspects	Palmerston
	* Louise N. Johnson, University of Oxford Why Do Mammalian Cells Need More Than One Cyclin?
	John Kuriyan, University of California, Berkeley Structural Insights Into the Regulation of Tyrosine Kinase Signaling
	David Barford, Institute of Cancer Research Function and Structure of the Anaphase Promoting Complex, a Multi-Subunit Ubiquitin Ligase
	Stephen W. Fesik, Abbott Laboratories Apoptosis: Structural Biology and Drug Design

9:40 - 10:00 AM	Coffee Break	Foyer
11:30 AM - 12:30 PM	Lunch	The Hall
11:30 AM - 12:00 PM	Poster Setup	Castlereagh Room/Foyer
12:30 - 2:30 PM	Poster Session 2	Castlereagh Room/Foyer
2:30 - 4:30 PM	Workshop 2: Diverse Methods for the Study of Protein-Protein Interactions	Palmerston
	* Jane Clarke, University of Cambridge
	Ananth Krupa, London Research Institute, Cancer Research UK Substrate Recognition by CDKs: Role of Consensus Sequence Motifs and Implications for Identification of Novel Substrates
	Yingnan Zhang, Genentech, Inc. Genome-Wide Analysis of the PDZ Domain Family
	Jacqui M. Matthews, University of Sydney The Assembly Of A Transcriptional Complex
	Ricardo M. Biondi, University of Saarland Modulation of Phosphorylation-Dependent Protein Kinase Conformational Transitions with Low Molecular Weight Compounds
	Narayanaswamy Srinivasan, Indian Institute of Science Interaction Interfaces of Protein Domains are not Topologically Equivalent Across Families within Superfamilies: Evolutionary Dynamics and Implications for Metabolic and Signalling Pathways
	Carla F. Cervantes, University of California, San Diego Dynamics of IkappaBalpha Probed by NMR
	Franca Fraternali, King's College London Molecular Dynamics Study of Hydration Properties of Prion Proteins
	Lan Huang, University of California, Irvine Proteomic Analysis of Human 26S Proteasome Complex Using Mass Spectrometry
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Cellular Processes	Palmerston
	* Dale B. Wigley, Cancer Research UK, Clare Hall Laboratories Crystal Structure of RecBCD: A Machine for Processing DNA Breaks
	Andrej Sali, University of California, San Francisco Modeling the Structures of Proteins and Macromolecular Assemblies
	Marko Hyvönen, University of Cambridge Extracellular Regulation of TGFbeta Family Growth Factors
Tuesday, August 22
7:30 - 8:30 AM	Breakfast	Buttery
8:30 - 11:30 AM	Computational Analyses: Docking and Protein-Protein Interactions	Palmerston
	* Janet M. Thornton, European Bioinformatics Institute Structure to Function: Recognising Interaction Partners
	Robert B. Russell, EMBL-Heidelberg Predicting Molecular Details for Protein-Interaction Networks
	Joël Janin, CNRS/Université Paris-Sud Protein-protein recognition sites: structural analysis and prediction
	Juan Fernandez-Recio, Institute of Biomedical Research (IRB-PCB) Computational Protein-Protein Docking: Present and Future Challenges
9:40 - 10:00 AM	Coffee Break	Foyer
11:30 AM - 12:30 PM	Lunch	The Hall
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Protein Folding, Aggregation and Diseases	Palmerston
	* Christopher M. Dobson, University of Cambridge Protein Folding , Molecular Evolution and Human Disease
	David Eisenberg, University of California, Los Angeles Structures of Febryl-Forming Segments from Amyloid Proteins
	Sheena E. Radford, University of Leeds Life on a knife edge: Tipping the balance between folding and aggregation
7:00 - 8:00 PM	Dinner	The Hall
8:00 - 11:00 PM	Entertainment	The Hall
Wednesday, August 23
	Departure

*Session Chair †Speaker invited, not yet responded.